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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Moisture level and movement effects on methane production rates in landfill samples显示文摘 | Hartz K E Ham R K | 1983 | Waste management and research1983，，1： | 1 |
| 3 | Basin modelling of a transform margin setting: Structural, thermal and hydrocar bon evolution of the Tano Basin, Ghana显示文摘 | Rupke L Schmid D Hartz E | 2010 | Petroleum Geo science2010，16，3： | 1 |
| 4 | In situ hafnium and lead isotope analyses of detrital zircons from the Devonian sedimentray basin of NE Greenland: A record of repeated crustal reworking 显示文摘 | Kundsen T L Griffin W L Hartz E H | 2001 | Contrib Mineral Petrol2001，141，： | 1 |
| 5 | The Value of presidedress soil nitrate testing as a nitrogen management tool in irrigated vegetable production显示文摘 | Hartz T K Bendixen W E WierdsmaL | 2000 | Hort Science2000，35，4： | 1 |
| 6 | Role of halogen(I)cation-transfer mechanisms in water chlorination in the presence of bromide ion显示文摘 | Margerum D W Hartz K E H | 2002 | Journal of Environmental Monitoring2002，4，1： | 1 |
| 7 | In situ hafnium and lead isotope anlalyses of detrital zircon from the Devonian sedimentary basin of NE Greenland:A record of repeated crus- tal reworking显示文摘 | KnudSen T I Griffin W I Hartz E H | 2001 | Contribution to Mineralogy and Petrology2001，141，： | 1 |
| 8 | Temperature effects:methane generation from landfill samples显示文摘 | HARTZ K E KLINK R E HAM R K | 1982 | Journal of the Environmental Engineering Division1982，108，4： | 1 |
| 9 | Cell lines from kidney proximal tubules of a patient with Lowe syndrome lack OCRLinositol polyphosphate 5-phosphatase and accumulate phosphatidylinositol 4,5-bisphosphate显示文摘 | Zhang X Hartz PA Philip E | 1998 | J Biol Chem1998，273，： | 1 |
| 10 | Secondary organic aerosol from biogenic volatile organic compound mixtures显示文摘 | HATFIELD M L HUFF HARTZ K E | 2011 | Atmospheric Environment2011，45，22： | 1 |
| 11 | The neural cell adhesion molecule (NCAM) in development and plasticity of the nervous system 显示文摘 | Ronn LC Hartz BP Bock E | 1998 | Exp Gerontol1998，33，： | 1 |
| 12 | Location of death (in-hospital or out-of-hospital) and type of death (arrhythmic,nonarrhythmic,noncardiac) after inducible sustained ventricular tachyarrhythmias after syncope,sustained ventricular tachycardia,or nonfatal cardiac arrest (the ESVEM trial)显示文摘 | Olshansky B Hartz V Hahn E | | 0，，08： | 1 |
| 13 | Reaction during cure of a blocked isocyanateepoxy resin adhesive显示文摘 | ROY E HARTZ | 1975 | Journal of Applied Polymer Science1975，19，3： | 1 |
| 14 | Secondary organic aerosol frombiogenic volatile organic compound mixtures 显示文摘 | Hatfield M L Huff Hartz K E | 2011 | AtmosphericEnvironment2011，45，13： | 1 |
| 15 | The Value of Presidedress Soil Nitrate Tesing as a Nitrogen Management Tool in Irrigated Vegetables Production显示文摘 | Hartz T K W E Bendixen L Wierdsma | 2000 | Plant and Soil2000，35，1： | 1 |
| 16 | The value of presidedress soil nitrate testing as a nitrogen management tool in irrigated vegetable production显示文摘 | Hartz T K Bendixen W E Wierdsma L | 2000 | HortScience2000，35，： | 1 |
| 17 | In situ hafnium and lead isotope analysis of detrital zircons from the Devonian sedimentary basin of NE Greenland:a record of repeated crustal reworking显示文摘 | Kundsen T L Griffin W L Hartz E H | | 0，，： | 1 |
| 18 | Microzooplankton grazing impact in the western Arctic Ocean显示文摘 | Sherr E B Sherr B F Hartz A J | 2009 | Deep-Sea Research Part Ⅱ:Topical Studies in Oceanography2009，，17： | 1 |
| 19 | Secondary organic aerosol from biogenic volatile organic compound mixtures 显示文摘 | Hatfield M L Huff Hartz K E | 2011 | Atmospheric Environment2011，45，13： | 1 |
| 20 | In-situ hafnium and lead isotope analysis of detrital zircons from the Devonian sedimentary basin of NE Greenland: arecord of repeated crustal reworking显示文摘 | KNUDSEN T L GROFFIN W L HARTZ E H | 2001 | Contrib Mineral Petrol2001，141，1： | 1 |
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