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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Tumor necrosis factor alpha and endothelin-1 increase P-glycoprotein expression and transport activity at the blood-brain barrier显示文摘 | Bauer B Hartz A M Miller D S | | 0，，03： | 1 |
| 3 | Mortality study of 18 000 patients treated with omeprazole显示文摘 | Bateman DN Colin-Jones D Hartz S Langman M Logan RF Mant J | 2003 | Gut2003，52，： | 1 |
| 4 | Accurate value-at-risk forecasting based on the normal-GARCH model显示文摘 | Hartz C Mittnik S Paolella M | 2006 | Computational Statistics & Data Analysis2006，51，4： | 1 |
| 5 | Amyloid-p contributes to blood-brain barrier leakagein transgenic human amyloid precursor protein mice and inhumans with cerebral amyloid angiopathy显示文摘 | Anika M S Hartz Bjorn Bauer Emma L B Soldner | 2012 | Stroke2012，43，2： | 1 |
| 6 | Accurate value-at-risk forecasting based on the normal-GARCH model显示文摘 | Hartz C Mittnik S Paolella M | 2006 | Computational Statistics & Data Analysis2006，51，4： | 1 |
| 7 | Pregnane X receptor up-regulation of P-glycoprotein expression and transport function at the blood-brain barrier显示文摘 | Bauer B Hartz A M S Fricker G Miller D S | 2004 | Mol Pharmacol2004，66，： | 1 |
| 8 | Accurate Value-at-risk Forecasting Based on the Normal-GARCH Model显示文摘 | HARTZ C MITTNIK S Paolella M | | 0，，04： | 1 |
| 9 | Folate statusmodulates the induction of hepatic glycineN-methyhransferase and ho- mocysteine metabolismin diabetic rats 显示文摘 | Nieman K M Hartz C S Szegedi S S | 2006 | Am J Physiol Endocrinol Metab2006，291，： | 1 |
| 10 | Accurate value-at-risk forecasting based on the norrnal-GARCH model 显示文摘 | Hartz C Mitmik S Paolella M | 2006 | Computational Statistics & Data Analysis2006，51，4： | 1 |
| 11 | Antiviral activity of propolis extracts against feline calicivirus, canine adenovirus 2, and bovine viral diarrhea virus显示文摘 | Cueto A P Hartz S Pilau M | 2011 | Cienc Rural2011，41，： | 1 |
| 12 | Modulation of P-glyeopro- tein at the blood-brain barrier: opportunities to improve CNS pharmacotherapy显示文摘 | Miller D S Bauer B Hartz A M S | 2008 | Pharmacol Rev2008，60，2： | 1 |
| 13 | The condition factor and hepatosomatic index as an indicators of the spawning of Astyanazfasciatus at Lobo Reservoir, Sao Paulo (Osteichthyes, Characi dae)显示文摘 | Barbieri G Hartz S M Verani J R | 1996 | Iheringia Serie Zoologia1996，81，： | 1 |
| 14 | U-Pb Zircon Geochronology and Tectonostratigraphy of Southern Liverpool Land, East Greenland : Implications for Deformation in the Overriding Plates of Con- tinental Collisions 显示文摘 | JOHNSTON S M HARTZ E H BRUECKNER H K | 2010 | Earth and Planetary Science Letters2010，297，34： | 1 |
| 15 | On-farm assessment of soil quality in California's central valley显示文摘 | Andrews S A Mitchell J P Mancinelli R Karlen D L Hartz T K Horwath W R Pettygrove G S Scow K M Munk D S | | 0，，： | 1 |
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