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| 1 | 血脂、脂蛋白和载脂蛋白作为心肌梗死风险标志物(INTER-HEART研究):在52个国家进行的一项病例对照研究显示文摘背景载脂蛋白作为冠心痛的标志物是否优于血脂和脂蛋白,目前存在广泛争议。本研究旨在对载脂蛋白和胆固醇作为急性心肌梗死风险指标进行比较.
方法在52个国家的12461例急性心肌梗死患者和14637例年龄(±5岁)、性别匹配的对照者中进行了一项有关急性心肌梗死的大型、标准化病例对照研究。获得了9345例急性心肌梗死患者和12120例对照者的非空腹血液样本。测定了血脂、脂蛋白和载脂蛋白浓度,并计算了胆固醇和栽脂蛋白比值通过比较五分位数的上四位与最低位,计算每一总体测值和每一种族组的优势比(0R)及其95%CI以及人群归因危险度(PAR)。
结果载脂蛋白B100(ApoB)/载脂蛋白A1(ApoA1)比值的PAR最高(54%),其每一标准差差别的OR最高(1.59,95%CI1.53~1.64)。LDL胆固醇/HDL-胆固醇比值的PAR为37%;总胆固醇/HDL-胆固醇的PAR为32%,其显著低于ApoB/A1比值的PAR(P〈0.0001)。这些结果在所有种族组、男女两性组及所有年龄组均一致。
结论在所有种族组、男女两性组及所有年龄组,非空腹ApoB/A1比值在评估急性心肌梗死风险方面优于任何胆固醇比值,其应当被引入全世界的临床实践中。 | Matthew J McQueen Steven Hawken Xingyu Wang Stephanie Ounpuu Allan Sniderman Jeffrey Probstfield Krisela Steyn John E Sanderson Mahammad Hasani Emilia Volkova Khawar Kazmi Salim Yusuf 郭战宏(译) | 2008 | 世界临床医学2008，2，6： | 3 |
| 2 | Tobacco use and risk of myocardial infarction in 52 countries in the INTERHEART study: a case-control study显示文摘 | Koon K Teo Stephanie Ounpuu Steven Hawken MR Pandey Vicent Valentin David Hunt Rafael Diaz Wafa Rashed Rosario Freeman Lixin Jiang Xiaofei Zhang Salim Yusuf | 2006 | The Lancet . 2006 (9536)2006，，9536： | 2 |
| 3 | Contrast-dependent changes in spatial frequency tuning of macaque V1 neurons: Effects of a changing receptive field size显示文摘 | Sceniak M P Hawken M J Shapley R | 2002 | Journal of Neurophysiology2002，88，3： | 1 |
| 4 | Effect of potentially modifi- able risk factors associated with myocardial infarction in 52 countries ( the INTERHEART study) : case-control study 显示文摘 | Yusuf S Hawken S Ounpuu S | 2004 | Lancet2004，364，9438： | 1 |
| 5 | Incidence of adverse events in premature children following 2-mo vaccination 显示文摘 | Wilson K Hawken S | 2012 | Hum Vaccin Immunother2012，8，5： | 1 |
| 6 | Effect of potentiallymodifiable risk factors associated with myocardial infarction in52 countries(the INTERHEART study): case-control study显示文摘 | Yusuf S Hawken S Ounpuu S | 2004 | Lancet2004，364，： | 1 |
| 7 | Association of psychosocial risk factors with risk of acute myocardial infarction in 11 119 cases and 13 648 controls from 52 countries(the INTERHEART study):Case-control study显示文摘 | Rosengren A Hawken S Ounpuu S | 2004 | Lancet2004，364，： | 1 |
| 8 | Obesity and the risk of my- ocardial infarction in 27,000 participants from 52 countries: a case-control study显示文摘 | Yusuf S Hawken S Ounpuu S | 2005 | Lancet2005，366，9497： | 1 |
| 9 | Effect of potentially modifiable risk factors associated with myo- cardial infarction in 52 countries(the INTERHEART study):case-control study显示文摘 | Yusuf S Hawken S Ounpuu S | 2004 | Lancet2004，364，9438： | 1 |
| 10 | Effect of potentially modi- fiable risk factors associated with myocardial infarction in 52 countries ( the INTERHEART study) : case-control study 显示文摘 | Yusuf S Hawken S Ounpun S | 2004 | Lancet2004，364，9438： | 1 |
| 11 | Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study):case-control study显示文摘 | Yusuf S Hawken S ounpuu S | 2004 | The Lancet2004，364，9438： | 1 |
| 12 | Effect of potentially modifiable risk factors associated with myocardial infarction in 52countries(the INTERHEART study):case-control study显示文摘 | YUSUF S HAWKEN S OUNPUU S | 2004 | Lancet2004，364，： | 1 |
| 13 | Tobacco use and risk myocardial infarction in 52 countries in the INTERHEART study: a case-control study 显示文摘 | Teo KK Ounpuu S Hawken S | 2006 | Lancet2006，368，9536： | 1 |
| 14 | Effect of potentially modifiable risk factors associated with myo- cardial infarction in 52 countries (the INTERHEART study) : case control study显示文摘 | Yusuf S Hawken S Ounpuu S | 2004 | Lancet2004，364，9438： | 1 |
| 15 | Nucleotide diversity on the ovine Y chromosome 显示文摘 | MEADOWS J R S HAWKEN R J KIJAS J W | 2004 | Animal Genetics2004，35，5： | 1 |
| 16 | Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study显示文摘 | Yusuf S Hawken S Ounpuu S | 2004 | Lancet2004，364，9438： | 1 |
| 17 | Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study):case-control study显示文摘 | Yusuf S Hawken S Ounpuu S | 2004 | Lancet2004，364，9438： | 1 |
| 18 | Obesity and the risk of myocardial infartion in 27000 participants from 52 countries, a case-controlled study 显示文摘 | Ysulf S Hawken S Ounpuu S | 2005 | Lancet2005，366，9497： | 1 |
| 19 | Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries(the INTERHEART study):case-comrol study显示文摘 | Yusuf S Hawken S Ounpuu S | | 0，，9438： | 1 |
| 20 | Effect of potentially modifiable risk factors associated with myocardial infarc- tion in 52 countries(the INTERHEART study):case-con- trol study 显示文摘 | Yusuf S Hawken S Ounpuu S | 2004 | Lancet2004，364，9438： | 1 |
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