4篇
您的检索式：作者名="HeLin Zhou"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Delivery of pOXR1 through an injectable liposomal nanoparticle enhances spinal cord injury regeneration by alleviating oxidative stress显示文摘Oxidation resistance 1(OXR1)is regarded as a critical regulator of cellular homeostasis in response to oxidative stress.However,the role of OXR1 in the neuronal response to spinal cord injury(SCI)remains undefined.On the other hand,gene therapy for SCI has shown limited success to date due in part to the poor utility of conventional gene vectors.In this study,we evaluated the function of OXR1 in SCI and developed an available carrier for delivering the OXR1 plasmid(pOXR1).We found that OXR1 expression is remarkably increased after SCI and that this regulation is protective after SCI.Meanwhile,we assembled cationic nanoparticles with vitamin E succinate-graftedε-polylysine(VES-g-PLL)(Nps).The pOXR1 was precompressed with Nps and then encapsulated into cationic liposomes.The particle size of pOXR1 was compressed to 58 nm,which suggests that pOXR1 can be encapsulated inside liposomes with high encapsulation efficiency and stability to enhance the transfection efficiency.The agarose gel results indicated that Nps-pOXR1-Lip eliminated the degradation of DNA by DNase I and maintained its activity,and the cytotoxicity results indicated that pOXR1 was successfully transported into cells and exhibited lower cytotoxicity.Finally,Nps-pOXR1-Lip promoted functional recovery by alleviating neuronal apoptosis,attenuating oxidative stress and inhibiting inflammation.Therefore,our study provides considerable evidence that OXR1 is a beneficial factor in resistance to SCI and that Nps-Lip-pOXR1 exerts therapeutic effects in acute traumatic SCI. | Jing Zhang Yao Li Jun Xiong Helin Xu Guanghen Xiang Mingqiao Fan Kailiang Zhou Yutian Lin Xiangxiang Chen Lin Xie Hongyu Zhang Jian Wang Jian Xiao | 2021 | Bioactive Materials2021，6，10： | 2 |
| 2 | A comparative study of the electrical characteristics of positive and negative narrow bipolar events显示文摘Narrow bipolar events(NBEs)are intriguing intra-cloud discharge that have attracted enormous interest in the lightning community.They come with two polarities that dominate at different altitudes in thunderclouds.The sources of negative NBEs are usually located near the top of thunderclouds;those of positive NBEs are at the middle levels.NBEs may occur at the onset of lightning.The electrical properties of NBEs remain poorly understood.We present here the first comparative study of the electrical characteristics of negative and positive NBEs.To derive electrical parameters from the fast electric field change waveforms of 1673 positive NBEs and 364 negative NBEs recorded by the Jianghuai Area Sferic Array(JASA)in China,we use an improved method based on the transmission line model.This approach concludes that negative NBEs occurring at high altitudes tend to produce a narrower current pulse and take a shorter time to traverse the channel than their positive counterparts.Moreover,compared to positive NBEs,a larger portion of negative NBEs are associated with slightly greater peak current moments but smaller overall charge moments.The differences reported herein between electrical properties of negative and positive NBEs suggest that charge distribution in NBE-producing thunderstorms tends to vary systematically with altitude. | FeiFan Liu BaoYou Zhu HeLin Zhou GaoPeng Lu Ming Ma JiuHou Lei | 2023 | Earth and Planetary Physics2023，7，6： | 0 |
| 3 | In situ growth of NiSe_(2) nanocrystalline array on graphene for efficient hydrogen evolution reaction显示文摘Nickel selenide electrocatalysts for hydrogen evolution reaction(HER)with a high efficiency and a lowcost have a significant potential in the development of water splitting.However,the inferiority of the high overpotential and poor stability restricts their practical applications.Herein,a composite nanostructure consists of ultrasmall NiSe_(2) nanocrystals embedded on graphene by microwave reaction is reported.The prepared NiSe_(2)/reduced graphite oxide(rGO)electrocatalyst exhibited a high HER activity with an overpotential of 158 mV at a current density of 10 mA/cm^(2) and a corresponding moderate Tafel slope of 56 mV/dec in alkaline electrolyte.In addition,a high retention of electrochemical properties(approximately 100%)was demonstrated with an unchangeable microstructure after 100 h of continuous operation. | Shuai JI Changgan LAI Huan ZHOU Helin WANG Ling MA Cong WANG Keying ZHANG Fajun LI Lixu LEI | 2022 | Frontiers in Energy2022，16，4： | 0 |
| 4 | The development of A-DA’D-A type nonfullerene acceptors containing non-halogenated end groups显示文摘Compared with perovskite solar cells and silicon solar cells,the excessive voltage loss(Vloss)becomes a stubborn stone that seriously hinders the further improvement of organic photovoltaic(OPV).Thus,many researchers focus on finding an effective material system to achieve high-performance OPVs with low Vloss.In recent 5 years,acceptor-donor-acceptor’-donor-acceptor(A-DA’D-A)type non-fullerene acceptors(NFAs)have attracted great attention because of their promising photovoltaic performance.Among them,A-DA’D-A type NFAs containing non-halogenated end group(NHEG)exhibit the large potential to achieve high open-circuit voltage(VOC)for the state-of-the-art OPVs,because of high-lying molecular energy levels and decreasing Vloss.In this review,we systematically summarize the recent development of A-DA’D-A type NHEG-NFAs and the impact of different NHEGs on the optoelectronic properties as well as the photovoltaic performance.In addition,we especially analyze the Vloss of NHEG-NFAs in the binary and ternary OPV devices.At last,we provide perspectives on the further molecular design and future challenges for this kind of materials as well as suggested solutions. | Hongxing Liu Tingting Dai Jialing Zhou Helin Wang Qing Guo Qiang Guo Erjun Zhou | 2023 | Nano Research2023，16，12： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员