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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Genomic change in hepatitis B virus associated with development of hepatocellular carcinoma显示文摘AIM: To determine the genomic changes in hepatitis B virus(HBV) and evaluate their role in the development of hepatocellular carcinoma(HCC) in patients chronically infected with genotype C HBV.METHODS: Two hundred and forty chronic hepatitis B(CHB) patients were subjected and followed for a median of 105 mo. HCC was diagnosed in accordance with AASLD guidelines. The whole X, S, basal core promoter(BCP), and precore regions of HBV were sequenced using the direct sequencing method.RESULTS: All of the subjects were infected with genotype C HBV. Out of 240 CHB patients, 25(10%) had C1653 T and 33(14%) had T1753 V mutation in X region; 157(65%) had A1762T/G1764 A mutations in BCP region, 50(21%) had G1896 A mutation in precore region and 67(28%) had pre-S deletions. HCC occurred in 6 patients(3%). The prevalence of T1753 V mutation was significantly higher in patients who developed HCC than in those without HCC. The cumulative occurrence rates of HCC were 5% and 19% at 10 and 15 years, respectively, in patients with T1753 V mutant, which were significantly higher than 1% and 1% in those with wild type HBV(P < 0.001).CONCLUSION: The presence of T1753 V mutation in HBV X-gene significantly increases the risk of HCC development in patients chronically infected with genotype C HBV. | Danbi Lee Heather Lyu Young-Hwa Chung Jeong A Kim Priya Mathews Elizabeth Jaffee Lei Zheng Eunsil Yu Young Joo Lee Soo Hyung Ryu | 2016 | World Journal of Gastroenterology2016，22，23： | 9 |
| 3 | Coronavirus Disease 2019 versus Influenza A in Children: An Observational Control Study in China显示文摘This study aimed to understand the differences in clinical,epidemiological,and laboratory features between the new coronavirus disease 2019(COVID-2019)and influenza A in children.Data of 23 hospitalized children with COVID-19(9 boys,5.7±3.8 years old)were compared with age-and sexmatched 69 hospitalized and 69 outpatient children with influenza A from a hospital in China. | ZHAO Yang SUN De Lin Heather CBouchard ZHANG Xin Xin WAN Gang HAO Yi Wei HE Shu Xin JIANG Yu Yong PANG Lin | 2020 | Biomedical and Environmental Sciences2020，33，8： | 2 |
| 4 | Green tea consumption, inflammation and the risk of primary hepatocellular carcinoma in a Chinese population显示文摘 | Yanli Li Shen-Chih Chang Binh Y. Goldstein William L. Scheider Lin Cai Nai-Chieh Y. You Heather P. Tarleton Baoguo Ding Jinkou Zhao Ming Wu Qingwu Jiang Shunzhang Yu Jianyu Rao Qing-Yi Lu Zuo-Feng Zhang Lina Mu | 2011 | Cancer Epidemiology2011，，4： | 2 |
| 5 | A hierarchical multiresolution video shot transition detection scheme 显示文摘 | Hong Heather Yu | 1999 | Computer Vision and Image Understanding1999，75，12： | 1 |
| 6 | Ethnicity and persistent symptom burden in breast cancer survivors显示文摘 | Olivia S. Fu Katherine D. Crew Judith S. Jacobson Heather Greenlee Gary Yu Julie Campbell Yvette Ortiz Dawn L. Hershman | 2009 | Journal of Cancer Survivorship2009，，4： | 1 |
| 7 | Multi-level data hiding for digital image and video显示文摘 | Min Wu Hong Heather Yu Alex Gelman | 2007 | IEEE Transactions on Image Processing2007，23，6： | 1 |
| 8 | Visual Image Retrieval on Compressed Domain with Q_Distance Image Signal Process显示文摘 | Yu Hong Heather | 2000 | International Journal of Computer Vision2000，31，1： | 1 |
| 9 | Data Hiding in Image and Video: Part II Designs and Applications 显示文摘 | Wu Min Yu Heather Liu B | 2003 | IEEE Transactions on Image Processing2003，12，6： | 1 |
| 10 | Data hiding in image and video:Part Ⅱ -designs and applications显示文摘 | Wu Min Yu Heather Liu Bede | 2003 | IEEE Transactions on Image Processing2003，12，6： | 1 |
| 11 | Multi-level data hiding for digital image and video显示文摘 | WU Min HONG Heather YU Alex Gelman | 2007 | IEEE Transactions on Image Processing2007，23，6： | 1 |
| 12 | Expression of Anthocyanins and Proanthocyanidins after Transformation of Alfalfa with Maize显示文摘 | Heather Ray Min Yu Patricia Auser | 2003 | Plant Physiology2003，132，： | 1 |
| 13 | Accelerated cellulose depolymefization catalyzed by paired metal chlorides in ionic liquid solvent显示文摘 | SU YU HEATHER M BROWN LI GUOSHENG | 2011 | Applied Catalysis A:General2011，391，： | 1 |
| 14 | Hypoxia alters progression of the erythroid program显示文摘 | Heather M. Rogers Xiaobing Yu Jie Wen Reginald Smith Eitan Fibach Constance Tom Noguchi | 2008 | Experimental Hematology2008，，1： | 1 |
| 15 | Data Hiding in Image and Video:Part II-Designs and Applications显示文摘 | Min Wu Heather Yu Bede Liu | 2003 | IEEE Transactions on Image Processing2003，12，6： | 1 |
| 16 | Multimedia data recovery using information hiding显示文摘 | Hong Heather Yu Peng Yin | 2000 | IEEE Trans on Image Processing2000，6，4： | 1 |
| 17 | Multimedia Data Recovery Using Information Hiding显示文摘 | Yu Hong Heather Peng Y | 2000 | IEEE Trans Image Processing2000，6，4： | 1 |
| 18 | A hierarchical multiresolution video shot transition detection scheme 显示文摘 | HONG HEATHER Yu | 1999 | Computer Vision and Image Understanding1999，75，12： | 1 |
| 19 | Data Hiding in Image and Video: PartII-Designs and Applications显示文摘 | Wu M Yu Heather Liu Bede | 2003 | IEEE Trasactions on Image Processing2003，12，6： | 1 |
| 20 | Multi-level Data Hiding for Digital Image and Video 显示文摘 | Min Wu Hong Heather Yu Alex Gelman | 2007 | IEEE Transactions on Image Processing2007，23，6： | 1 |
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