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| 1 | Analyses of oligodontia phenotypes and genetic etiologies显示文摘Oligodontia is the congenital absence of six or more teeth and comprises the more severe forms of tooth agenesis.Many genes have been implicated in the etiology of tooth agenesis,which is highly variable in its clinical presentation.The purpose of this study was to identify associations between genetic mutations and clinical features of oligodontia patients.An online systematic search of papers published from January 1992 to June 2021 identified 381 oligodontia cases meeting the eligibility criteria of causative gene mutation,phenotype description,and radiographic records.Additionally,ten families with oligodontia were recruited and their genetic etiologies were determined by whole-exome sequence analyses.We identified a novel mutation in WNT10A(c.99_105dup)and eight previously reported mutations in WNT10A(c.433 G>A;c.682 T>A;c.318 C>G;c.511.C>T;c.321 C>A),EDAR(c.581 C>T),and LRP6(c.1003 C>T,c.2747 G>T).Collectively,20 different causative genes were implicated among those 393 cases with oligodontia.For each causative gene,the mean number of missing teeth per case and the frequency of teeth missing at each position were calculated.Genotype–phenotype correlation analysis indicated that molars agenesis is more likely linked to PAX9 mutations,mandibular first premolar agenesis is least associated with PAX9 mutations. | Mengqi Zhou Hong Zhang Heather Camhi Figen Seymen Mine Koruyucu Yelda Kasimoglu Jung-Wook Kim Hera Kim-Berman Ninna M.R.Yuson Paul J.Benke Yiqun Wu Feng Wang Yaqin Zhu James P.Simmer Jan C-C.Hu | 2021 | International Journal of Oral Science2021，13，3： | 5 |
| 2 | A hierarchical multiresolution video shot transition detection scheme 显示文摘 | Hong Heather Yu | 1999 | Computer Vision and Image Understanding1999，75，12： | 1 |
| 3 | Multi-level data hiding for digital image and video显示文摘 | Min Wu Hong Heather Yu Alex Gelman | 2007 | IEEE Transactions on Image Processing2007，23，6： | 1 |
| 4 | Visual Image Retrieval on Compressed Domain with Q_Distance Image Signal Process显示文摘 | Yu Hong Heather | 2000 | International Journal of Computer Vision2000，31，1： | 1 |
| 5 | Multi-level data hiding for digital image and video显示文摘 | WU Min HONG Heather YU Alex Gelman | 2007 | IEEE Transactions on Image Processing2007，23，6： | 1 |
| 6 | A semi-fragile watermarking system for MPEG video authentication 显示文摘 | PENG Yinyu HEATHER Hong | 2002 | ICASSP IEEE International Conference on Acoustics Speech and Signal Processing2002，4，5： | 1 |
| 7 | Depletion of BBS Protein LZTFL1 Affects Growth and Causes Retinal Degeneration in Mice显示文摘Bardet-Biedl syndrome(BBS) is a heterogeneous disease characterized by deficiencies in various organs that are caused by defects in genes involved in the genesis, structural maintenance, and protein trafficking of cilia. Leucine zipper transcription factor-like 1(LZTFL1)has been identified as a BBS protein(BBS17), because patients with mutations in this gene exhibit the common BBS phenotypes. In this study, we generated a knockout mouse model to investigate the effects of LZTFL1 depletion. Lztfl1 knockout mice were born with low birth weight, reached similar weight to those of wild-type mice at 10 weeks of age, and later gained more weight than their wild-type counterparts. LZTFL1 was localized to the primary cilium of kidney cells, and the absence of LZTFL1 increased the ciliary localization of BBS9. Moreover, in the retinas of Lztfl1 knockout mice, the photoreceptor outer segment was shortened, the distal axoneme of photoreceptor connecting cilium was significantly enlarged, and rhodopsin was targeted to the outer nuclear layer. TUNEL assay showed that many of these abnormal photoreceptor cells in Lztfl1 knockout mice underwent apoptosis. Interestingly, the absence of LZTFL1 caused an abnormal increase of the adaptor protein complex 1(AP1) in some photoreceptor cells. Based on these data, we conclude that LZTFL1 is a cilium protein and regulates animal weight and photoreceptor connecting cilium function probably by controlling microtubule assembly and protein trafficking in cilia. | Jiangsong Jiang Kanyarat Promchan Hong Jiang Parirokh Awasthi Heather Marshall Adam Harned Ven Natarajan | 2016 | Journal of Genetics and Genomics2016，43，6： | 1 |
| 8 | Mitochondria Oxidative Stress, Connexin43 Remodeling, and Sudden Arrhythmic Death显示文摘 | Ali A. Sovari Cody A. Rutledge Euy-Myoung Jeong Elena Dolmatova Divya Arasu Hong Liu Nooshin Vahdani Lianzhi Gu Shadi Zandieh Lei Xiao Marcelo G. Bonini Heather S. Duffy Samuel C. Dudley | 2013 | Circulation: Arrhythmia and Electrophysiology2013，，： | 1 |
| 9 | Inhibition of c-Src Tyrosine Kinase Prevents Angiotensin II–Mediated Connexin-43 Remodeling and Sudden Cardiac Death显示文摘 | Ali A. Sovari Shahriar Iravanian Elena Dolmatova Zhe Jiao Hong Liu Shadi Zandieh Vibhash Kumar Kun Wang Kenneth E. Bernstein Marcelo G. Bonini Heather S. Duffy Samuel C. Dudley | 2011 | Journal of the American College of Cardiology2011，，： | 1 |
| 10 | Multimedia data recovery using information hiding显示文摘 | Hong Heather Yu Peng Yin | 2000 | IEEE Trans on Image Processing2000，6，4： | 1 |
| 11 | Surface properties of PEO–silicone composites: reducing protein adsorption显示文摘 | Hong Chen Michael A Brook Yang Chen Heather Sheardown | 2005 | Journal of Biomaterials Science Polymer Edition2005，，4： | 1 |
| 12 | Sex‐dependent associations of genetic variants identified by GWAS with indices of adiposity and obesity risk in a C hinese children population显示文摘 | Bo Xi Yue Shen Kathleen Heather Reilly Xiaoyuan Zhao Hong Cheng Dongqing Hou Xingyu Wang Jie Mi | 2013 | Clin Endocrinol2013，，4： | 1 |
| 13 | Multimedia Data Recovery Using Information Hiding显示文摘 | Yu Hong Heather Peng Y | 2000 | IEEE Trans Image Processing2000，6，4： | 1 |
| 14 | A hierarchical multiresolution video shot transition detection scheme 显示文摘 | HONG HEATHER Yu | 1999 | Computer Vision and Image Understanding1999，75，12： | 1 |
| 15 | Multi-level Data Hiding for Digital Image and Video 显示文摘 | Min Wu Hong Heather Yu Alex Gelman | 2007 | IEEE Transactions on Image Processing2007，23，6： | 1 |
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