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| 1 | Carcinogenic Helicobacter pylori in gastric pre-cancer and cancer lesions: Association with tobacco-chewing显示文摘AIM:To investigate the low gastric cancer incidence rate relative to the highly prevalent Helicobacter pylori(H.pylori)infection;data relevant to H.pylori infection during gastric carcinogenesis in Indian patients is currently lacking.METHODS:The present study examines the prevalence of H.pylori infection in DNA derived from 156endoscopic gastric biopsies of different disease groups that represent gastric pre-cancer[intestinal metaplasia(n=15),dysplasia(n=15)],cancer[diffuse adenocarcinoma(n=44),intestinal adenocarcinoma(n=21)],and symptomatic but histopathologically-normal controls(n=61).This was done by generic ureC polymerase chain reaction(PCR)and cagA-specific PCR that could specifically identify the carcinogenic H.pylori strain.RESULTS:Our analysis showed the presence of H.pylori infection in 61%of symptomatic histopathologically-normal individuals,however only 34%of control tissues were harboring the cagA+H.pylori strain.A similar proportion of H.pylori infection(52%)and cagA(26%)positivity was observed in the tumor tissue of the gastric cancer group.In comparison,H.pylori infection(90%)and cagA positivity(73%)were the highest in gastric pre-cancer lesions.In relation to tobacco and alcohol abuse,H.pylori infection showed an association with tobacco chewing,whereas we did not observe any association between tobacco smoking or alcohol abuse with prevalence of H.pylori infection in the tissue of any of the patient groups studied.CONCLUSION:High incidence of H.pylori infection and carcinogenic cagA positive strain in pre-cancer lesions during gastric carcinogenesis may be | Arvind Pandey Satyendra Chandra Tripathi Sutapa Mahata Kanchan Vishnoi Shirish Shukla Sri Prakash Misra Vatsala Misra Suresh Hedau Ravi Mehrotra Manisha DwivediZ Alok C Bharti | 2014 | World Journal of Gastroenterology2014，20，22： | 4 |
| 2 | p53 gene mutation and human papillomavirus(HPV) infection in eso-phageal carcinoma from three different endemic geographic regions of India 显示文摘 | Sanjay Katiyar Suresh Hedau Neeraj Jain | 2005 | Cancer Letters2005，，218： | 1 |
| 3 | Spindle cell carcinoma of head and neck: an immunohistechemical and molecular ap- proach to its pathogenesis 显示文摘 | Gupta R Singh S Hedau S | 2007 | J Clin Pathol2007，60，5： | 1 |
| 4 | p53 gene mutation and human papillomavirus (HPV) infection in esophageal carcinoma from three different endemic geographic regions of India显示文摘 | Sanjay Katiyar Suresh Hedau Neeraj Jain | 2005 | Cancer Letters2005，，218： | 1 |
| 5 | Assessment of possible tuberculous lymphadenopathy by PCR compared to non-moleoular methods显示文摘 | Pahwa R Hedau S Jain S | 2005 | J Med Microbiol2005，54，9： | 1 |
| 6 | Breast cancer and human papillomavirus infection: no evidence of HPV eti- ology of breast cancer in Indian women 显示文摘 | Hedau S Kumar U Hussain S | 2011 | BMC Cancer2011，11，： | 1 |
| 7 | Absence of human papillomavirus DNA in breast cancer as revealed by polymerase chain reaction显示文摘 | V. Gopalkrishna U. R. Singh P. Sodhani J. K. Sharma S. T. Hedau A. K. Mandal B. C. Das | 1996 | Breast Cancer Research and Treatment1996，，2： | 1 |
| 8 | p53 gene mutation and human papillomavirus (HPV) infection in esophageal carcinoma from three different endemic geographic regions of India显示文摘 | Sanjay Katiyat Suresh Hedau Neeraj Jain | 2005 | Cancer Letters2005，218，： | 1 |
| 9 | Value of high-risk human papillomavirus 16deoxyribonucleic acid testing with cytological entities in peri and postmenopausal women显示文摘 | Kashyap V Hedau S | 2013 | J Cytol2013，30，3： | 1 |
| 10 | Breast cancer and hu-man pap?illomavirus infection:no evidence of HPV etiology of breast cancer in Indian women显示文摘 | Hedau S Kumar U Hussain S | 2011 | BMC Cancer2011，11，： | 1 |
| 11 | Breast cancer and human papillomavirus infection:no evidence of HPV etiology of breast cancer in Indian women显示文摘 | Hedau S Kumar U Hussain S Shukla S Pande S Jain N Tyagi A Deshpande T Bhat D Mir MM Chakraborty S Singh YM Kumar R Somasundaram K Bharti AC Das BC | 2011 | BMC Cancer2011，11，： | 1 |
| 12 | Breast cancer and human papillomavirus infection: no evidence of HPV etiology of breast cancer in Indian women显示文摘 | Hedau S Kumar U Hussain S | 2011 | BMC Cancer2011，11，： | 1 |
| 13 | p53 gene mutation and human papillomavirus (HPV) infection in esophageal carcinoma from three different endemic geographic regions of India显示文摘 | Sanjay Katiyat Suresh Hedau Neeraj Jain | 2005 | Cancer Letters2005，218，： | 1 |
| 14 | Detection of human papillomavirus DNA sequences in cancer of the urinary bladder by in situ hybridisation and polymerase chain reaction显示文摘 | Gopalkrishna V Srivastava AN Hedau S | 1995 | Genitourin Med1995，71，4： | 1 |
| 15 | Esophageal Cancer, the Topmost Cancer at MTRH in the Rift Valley, Kenya, and Its Potential Risk Factors显示文摘 | Kirtika Patel Johnston Wakhisi Simeon Mining Ann Mwangi Radheka Patel S. T. Hedau Z. Suo | 2013 | ISRN Oncology2013，，： | 1 |
| 16 | Assessment of possible tuberculous lymphadenopathy by PCR compared to noranolecular melhods显示文摘 | Pahwa R Hedau S Jain S | 2005 | J Med Microbiol2005，54，： | 1 |
| 17 | p53 gene mutation and human papillomavirus(HPV) infection in esophageal carcinoma from three different endemic geographic regions of India 显示文摘 | Katiyar S Hedau S Jain N | 2005 | Cancer Lett2005，218，1： | 1 |
| 18 | Novel germline mutations in breast cancer susceptibility genes BRCA1,BRCA2 and P53 gene in breast cancer patients from India显示文摘 | Hedau S Jain N Husain SA | 2004 | Breast Cancer Res Treat2004，88，2： | 1 |
| 19 | Novel germline mutations in breast cancer susceptibility genes BRCA1,BRCA2 and p53 gene in breast cancer patients from India显示文摘 | Hedau S Jain N Husain SA | | 0，，02： | 1 |
| 20 | Breast cancer and human papillomavirus Infection: No evidence of HPV etiology of breast cancer in Indian women 显示文摘 | Hedau S Kumar U Hussain S | 2011 | BMC Cancer2011，11，： | 1 |
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