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| 1 | Achalasia: A review of clinical diagnosis, epidemiology,treatment and outcomes显示文摘Achalasia is a neurodegenerative motility disorder of the oesophagus resulting in deranged oesophageal peristalsis and loss of lower oesophageal sphincter function.Historically,annual achalasia incidence rates were believed to be low,approximately 0.5-1.2 per 100000.More recent reports suggest that annual incidence rates have risen to 1.6 per 100000 in some populations.The aetiology of achalasia is still unclear but is likely to be multi-factorial.Suggested causes include environmental or viral exposures resulting in inflammation of the oesophageal myenteric plexus,which elicits an autoimmune response.Risk of achalasia may be elevated in a sub-group of genetically susceptible people.Improvement in the diagnosis of achalasia,through the introduction of high resolution manometry with pressure topography plotting,has resulted in the development of a novel classification system for achalasia.This classification system can evaluate patient prognosis and predict responsiveness to treatment.There is currently much debate over whether pneumatic dilatation is a superior method compared to the Heller’s myotomy procedure in the treatment of achalasia.A recent com-parative study found equal efficacy,suggesting that patient preference and local expertise should guide the choice.Although achalasia is a relatively rare condition,it carries a risk of complications,including aspiration pneumonia and oesophageal cancer.The risk of both squamous cell carcinoma and adenocarcinoma of the oesophagus is believed to be significantly increased in patients with achalasia,however the absolute excess risk is small.Therefore,it is currently unknown whether a surveillance programme in achalasia patients would be effective or cost-effective. | Orla M O'Neill Brian T Johnston Helen G Coleman | 2013 | World Journal of Gastroenterology2013，19，35： | 26 |
| 2 | Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trial显示文摘 | Pierre J Guillou Philip Quirke Helen Thorpe Joanne Walker David G Jayne Adrian MH Smith Richard M Heath Julia M Brown | 2005 | The Lancet . 2005 (9472)2005，，9472： | 6 |
| 3 | Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trial显示文摘 | Pierre J Guillou Philip Quirke Helen Thorpe Joanne Walker David G Jayne Adrian MH Smith Richard M Heath Julia M Brown | 2005 | The Lancet2005，，9472： | 4 |
| 4 | Diagnostic accuracy of tests for Helicobacter pylori in an Alaska Native population显示文摘AIM:To evaluate the accuracy of two non-invasivetests in a population of Alaska Native persons. Highrates of Helico bacter pylori(H. pylori) infection,H. pylori treatment failure,and gastric cancer in this population necessitate documentation of infection status atmultiple time points over a patient's life.METHODS:In 280 patients undergoing endoscopy,H. pylori was diagnosed by culture,histology,rapidurease test,13C urea breath test(UBT) ,and immuno-globulin G antibodies to H. pylori in serum. The performances of 13C-UBT and antibody test were compared to a gold standard defined by a positive H. pylori testby culture or,in case of a negative culture result,bypositive histology and a positive rapid urease test.RESULTS:The sensitivity and specificity of the 13C-UBT were 93% and 88%,respectively,relative to thegold standard. The antibody test had an equivalents ensitivity of 93% with a reduced specificity of 68%.The false positive results for the antibody test were as-sociated with previous treatment for an H. pylori infection [relative risk(RR) = 2.8]. High levels of antibodiesto H. pylori were associated with chronic gastritis and male gender,while high scores in the 13C-UBT testwere associated with older age and with the H. pyloribacteria load on histological examination(RR = 4.4) .CONCLUSION:The 13C-UBT out performed the anti-body test for H. pylori and could be used when a non-invasive test is clinically necessary to document treatment out come or when monitoring for reinfection. | Dana L Bruden Michael G Bruce Karen M Miernyk Julie Morris Debby Hurlburt Thomas W Hennessy Helen Peters Frank Sacco Alan J Parkinson Brian J McMahon | 2011 | World Journal of Gastroenterology2011，17，42： | 3 |
| 5 | Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trial显示文摘 | Pierre J Guillou Philip Quirke Helen Thorpe Joanne Walker David G Jayne Adrian MH Smith Richard M Heath Julia M Brown | 2005 | 2005 (9472)2005，，9472： | 2 |
| 6 | Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trial显示文摘 | Pierre J Guillou Philip Quirke Helen Thorpe Joanne Walker David G Jayne Adrian MH Smith Richard M Heath Julia M Brown | 2005 | The Lancet2005，，9472： | 2 |
| 7 | Corporate global culture as competitive advantage:learning from Germany and Japan in Alabama and Austria显示文摘 | HELEN J M | 2002 | Journal of Business2002，37，： | 1 |
| 8 | Analysis of nitrosamines in cosmetics显示文摘 | KANE I K-ETH G M HELENE C | 1990 | J Soc Cosmet Chem1990，41，： | 1 |
| 9 | BAI 3, CDX 2 and VIL 1: a panel of three antibodies to distinguish small cell from large cell neuroendocrine lung carcinomas显示文摘 | Muhammad F Bari Helen Brown Andrew G Nicholson Keith M Kerr John R Gosney William A Wallace Irshad Soomro Salli Muller Danielle Peat Jonathan D Moore Lesley A Ward Maxim B Freidin Eric Lim Manu Vatish David R J Snead | 2014 | Histopathology2014，，： | 1 |
| 10 | Antibody response to yersinia pestis flantigen expressed in Salmonella typhimurium aroA from in vivo-inducible promoters 显示文摘 | Helen L B Kate F G Steven M J | 2000 | Vaccine2000，，18： | 1 |
| 11 | Diversity of nitrifying bacteria in full-scale chloraminated distribution systems显示文摘 | Regan J M Harrington G W Banbeau Helene | 2003 | Water Research2003，37，1： | 1 |
| 12 | Schistosoma manso- ni-Biomphalaria glabrata:dynamics of the sporocyst population in rela- tion to the mimcidial dose and the host size 显示文摘 | Claudia G Helene M Andre Theron Therona | 1993 | Canadian Journal of Zoology1993，71，9： | 1 |
| 13 | Drying and rewetting effects on soil microbial community composition and nutrientleaching显示文摘 | Helen G Philip M H Richard D B | 2008 | Soil Biology and Biochemistry2008，40，2： | 1 |
| 14 | Evidence that the hexose-to-sucrose ratio does not control the switch to storage product accumulation in oilseeds:analysis of tobacco seed development and effects of overexpressing apoplastic invertase显示文摘 | KIM L T S M HELENE L JOHN L G | 2004 | Journal of Experimental Botany2004，55，： | 1 |
| 15 | Exposure and kinetics of polycyclic aromatic hydrocarbons( PAHs )in cigarette smokers显示文摘 | St Helen G Goniewicz M L Dempsey D | 2012 | Chem Res Toxicol2012，25，4： | 1 |
| 16 | eIF4E is a nexus of resistance to anti-BRAF and anti-MEK cancer thera- pies显示文摘 | Lise B Helene M M Isabelle G | 2014 | Nature2014，513，9： | 1 |
| 17 | Electromechanical modeling of piezoeeramic actuators for dynamic loading applieations 显示文摘 | HELEN M S G RIDHA B M | 2006 | Journal of dynamic systems measurement and control Transactions of the ASME2006，128，： | 1 |
| 18 | Cloning and characterization of a surface antigen of Eimeria tenella merozoites and expression using a recombinant vaceinia virus显示文摘 | Helen B M Hug D Weber G | 1993 | Mol Biochem Parasitol1993，61，2： | 1 |
| 19 | Stroke and nutrition:FOOD for thought 显示文摘 | Donnan G A Helen M Dewey | 2005 | Lancet2005，365，9461： | 1 |
| 20 | Carboxypeptidase G2 Rescue in Delayed Methotrexate Elimination in Renal Fail- ure显示文摘 | Mohamad M Helene P Cathetine G | 2000 | Leukemia and Lymphoma2000，37，34： | 1 |
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