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| 1 | Caspase-1 activation by NLRP3 inflammasome dampens IL-33-dependent house dust mite-induced allergic lung inflammation显示文摘The cysteine protease caspase-1(Casp-1)contributes to innate immunity through the assembly of NLRP3,NLRC4,AIM2,and NLRP6 inflammasomes.Here we ask whether caspase-1 activation plays a regulatory role in house dust mite(HDM)-induced experimental allergic airway inflammation.We report enhanced airway inflammation in caspase-1-deficient mice exposed toHDMwith a marked eosinophil recruitment,increased expression of IL-4,IL-5,IL-13,aswell as full-length and bioactive IL-33.Furthermore,mice deficient for NLRP3 failed to control eosinophil influx in the airways and displayed augmented Th2 cytokine and chemokine levels,suggesting that the NLPR3 inflammasome complex controls HDM-induced inflammation.IL-33 neutralization by administration of soluble ST2 receptor inhibited the enhanced allergic inflammation,while administration of recombinant IL-33 during challenge phase enhanced allergic inflammation in caspase-1-deficient mice.Therefore,we show that caspase-1,NLRP3,and ASC,but not NLRC4,contribute to the upregulation of allergic lung inflammation.Moreover,we cannot exclude an effect of caspase-11,because caspase-1-deficient mice are deficient for both caspases.Mechanistically,absence of caspase-1 is associated with increased expression of IL-33,uric acid,and spleen tyrosine kinase(Syk)production.This study highlights acritical role of caspase-1 activation andNLPR3/ASCinflammasomecomplex in the down-modulation of IL-33 in vivo and in vitro,thereby regulating Th2 response in HDM-induced allergic lung inflammation. | Fahima Madouri Noelline Guillou Louis Fauconnier Tiffany Marchiol Nathalie Rouxel Pauline Chenuet Aurelie Ledru Lionel Apetoh Franc¸ois Ghiringhelli Mathias Chamaillard Song Guo Zheng Fabrice Trovero Valerie F.J.Quesniaux Bernhard Ryffel Dieudonnee Togbe | 2015 | Journal of Molecular Cell Biology2015，7，4： | 8 |
| 2 | Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trial显示文摘 | Pierre J Guillou Philip Quirke Helen Thorpe Joanne Walker David G Jayne Adrian MH Smith Richard M Heath Julia M Brown | 2005 | The Lancet . 2005 (9472)2005，，9472： | 6 |
| 3 | Long‐term follow‐up of the Medical Research Council CLASICC trial of conventional versus laparoscopically assisted resection in colorectal cancer显示文摘 | B. L. Green H. C. Marshall F. Collinson P. Quirke P. Guillou D. G. Jayne J. M. Brown | 2012 | Br J Surg2012，，1： | 5 |
| 4 | Successful outcome following resection of a pancreatic liposarcoma with solitary metastasis显示文摘Liposarcomas are rare soft tissue tumors, commonly affecting the lower limbs and less commonly the retroperitoneum. Although other organs can be affected,the pancreas is one of the rarest, and metastasis at presentation has never been reported. We describe the case of a 76-year-old gentleman presenting with abdominal pain and an abdominal mass. Imaging confirmed a primary tumor in the body and tail of the pancreas, with a metastatic deposit in the mesentery adjacent to the second part of the duodenum. Biopsy confirmed a liposarcoma, and subsequently a complete surgical excision was achieved. He then received adjuvant radiotherapy and has remained disease free for the next 26 mo. | IM Dodo JA Adamthwaite P Jain A Roy PJ Guillou KV Menon | 2005 | World Journal of Gastroenterology2005，11，48： | 5 |
| 5 | Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trial显示文摘 | Pierre J Guillou Philip Quirke Helen Thorpe Joanne Walker David G Jayne Adrian MH Smith Richard M Heath Julia M Brown | 2005 | The Lancet2005，，9472： | 4 |
| 6 | Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trial显示文摘 | Pierre J Guillou Philip Quirke Helen Thorpe Joanne Walker David G Jayne Adrian MH Smith Richard M Heath Julia M Brown | 2005 | 2005 (9472)2005，，9472： | 2 |
| 7 | An international, multicentre, prospective, randomised, controlled, unblinded, parallel-group trial of robotic-assisted versus standard laparoscopic surgery for the curative treatment of rectal cancer显示文摘 | Fiona J. Collinson David G. Jayne Alessio Pigazzi Charles Tsang Jennifer M. Barrie Richard Edlin Christopher Garbett Pierre Guillou Ivana Holloway Helen Howard Helen Marshall Christopher McCabe Sue Pavitt Phil Quirke Carly S. Rivers Julia M. B. Brown | 2012 | International Journal of Colorectal Disease2012，，2： | 2 |
| 8 | Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trial显示文摘 | Pierre J Guillou Philip Quirke Helen Thorpe Joanne Walker David G Jayne Adrian MH Smith Richard M Heath Julia M Brown | 2005 | The Lancet2005，，9472： | 2 |
| 9 | Laparoscopic sigmoid colectomy: total laporascopic approach显示文摘 | Darzi A Super P Guillou PJ | 1994 | Dis Colon Rectum1994，37，： | 1 |
| 10 | Randomized trial of laparoscopic-assisted resection of colorectal carcinoma:3-year resultsof the UK MRC CLASICC Trial Group 显示文摘 | Jayne DG Guillou PJ Thorpe H | 2007 | J Clin Oncol2007，25，21： | 1 |
| 11 | MDM2 and CDK4 immu- nostainings are useful adjuncts in diagnosing well-differentiated and dedifferentiated liposarcoma subtypes: A comparative analysis of 559 soft tissue neoplasms with genetic data 显示文摘 | Binh MB Sastre Garau X Guillou L | 2005 | Am J Surgical Pathology2005，29，10： | 1 |
| 12 | On exponential representations of log-spacings of extreme order statistics显示文摘 | DIERCKX G GUILLOU A | 2002 | Extremes2002，5，2： | 1 |
| 13 | Kruppel-like factor 4 is involved in functional differentiation of testicular Sertoli cells显示文摘 | Godmann M Katz J P Guillou F | 2008 | Dev Biol2008，315，2： | 1 |
| 14 | The key roles of elongases and desaturases in mammalian fatty acid metabolism:insights from transgenic mice显示文摘 | GUILLOU H ZADRAVEC D MARTIN P G | | 0，，： | 1 |
| 15 | Short-term endpoints of con- ventional versus laparoscopic-assisted surgery in patients with colo- rectal cancer ( MRG CLASICC trial) : multicentre, randomised con- trolled trial 显示文摘 | Guillou P J Quirke P Thorpe H | 2005 | Lancet2005，365，9472： | 1 |
| 16 | Pulsed-light system as a novel food decontamination technology: a review显示文摘 | Elmnasser N Guillou S Leroi F | 2007 | Canadian Journal of Microbiology2007，53，7： | 1 |
| 17 | Evaluation of an enzy me-linked im munosorbent assay for detection and quantification of hepatitis B virus PreS1 envelope antigen in serum samples:comparison with two com mercial assays for monitoring hepatitis B virus DNA显示文摘 | Le Guillou DB Duclos-Vallee JC Eberle F | 2000 | Jviral Hepat2000，7，5： | 1 |
| 18 | Randomized trial of laparoscopic-assisted resection of colorectal carcinoma: 3-year results of the UK MRC CLASICC Trial Group显示文摘 | Jayne DG Guillou PJ Thorpe H | 2007 | J Clin Oncol2007，25，21： | 1 |
| 19 | Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer(MRC CLASICC trial):multicentre,randomised controlled trial显示文摘 | Guillou PJ Quirke P Thorpe H | 2005 | Lancet2005，365，9472： | 1 |
| 20 | Interstitial cell cyclooxygenase-2 expression is associated withincreased angiogenesis in human sporadic colorectal adenomas 显示文摘 | Chapple KS Scott N Guillou P J | 2002 | J Pathol2002，198，： | 1 |
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