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| 1 | Platelets in hemostasis and thrombosis:Novel mechanisms of fibrinogen-independent platelet aggregation and fibronectin-mediated protein wave of hemostasis显示文摘Platelets are small anucleate cells generated from megakaryocytes in the bone marrow.Although platelet generation,maturation,and clearance are still not fully understood,significant progress has been made in the last 1-2 decades.In blood circulation,platelets can quickly adhere and aggregate at sites of vascular injury,forming the platelet plug(i.e.the first wave of hemostasis).Activated platelets can also provide negatively charged phosphatidylserinerich membrane surface that enhances cell-based thrombin generation,which facilitates blood coagulation(i.e.the second wave of hemostasis).Platelets therefore play central roles in hemostasis.However,the same process of hemostasis may also cause thrombosis and vessel occlusion,which are the most common mechanisms leading to heart attack and stroke following ruptured atherosclerotic lesions.In this review,we will introduce the classical mechanisms and newly discovered pathways of platelets in hemostasis and thrombosis,including fibrinogen-independent platelet aggregation and thrombosis,and the plasma fibronectin-mediated 'protein wave' of hemostasis that precedes the classical first wave of hemostasis.Furthermore,we briefly discuss the roles of platelets in inflammation and atherosclerosis and the potential strategies to control atherothrombosis. | Yan Hou Naadiya Carrim Yiming Wang Reid C.Gallant Alexandra Marshall Heyu Ni | 2015 | The Journal of Biomedical Research2015，29，6： | 21 |
| 2 | FAM19A4 is a novel cytokine ligand of formyl peptide receptor I (FPR 1) and is able to promote the migration and phagocytosis of macrophages显示文摘FAM19A4 是为有顺序类似 19 的家庭的缩写(chemokine (C-C 主题)-like) 成员 A4,它能分泌的蛋白质在正常纸巾在底层被表示。坚定的 FAM19A4 遗体的生物功能,和它的潜在的受体是 unclarified。在这研究,我们证明 FAM19A4 是古典能分泌的蛋白质,我们第一次证实它的成熟蛋白质由 95 氨基酸组成。我们发现这新奇 cytokine 的表示是 upregulated 在里面 lipopolysaccharide (LPS ) 刺激了单核白血球和巨噬细胞并且典型地在极化的 M1。FAM19A4 在巨噬细胞上显示出趋化性的活动并且随蛋白质 kinase B (Akt ) 的 phosphorylation 的显著增加在 vitro 并且在 vivo 提高 zymosan 的巨噬细胞吞噬作用。FAM19A4 能也在 zymosan 刺激之上增加反应的氧种类(ROS ) 的版本。基于受体成为主观,收音机 ligand 绑定试金和受体阻塞,而且,我们第一次证明 FAM19A4 是甲酰肽受体 1 的新奇 ligand (FPR1 ) 。上述数据显示在煽动性的刺激之上, monocyte/macrophage-derived FAM19A4 可以在病原的感染期间在巨噬细胞的移植和激活起一个关键作用。 | Wenyan Wang Ting Li Xiaolin Wang Wanxiong Yuan Yingying Cheng Heyu Zhang Enquan Xu Yingmei Zhang Shuang Shi Dalong Ma Wenling Han | 2015 | Cellular & Molecular Immunology2015，12，5： | 8 |
| 3 | Routing for predictable Multi-Layered Satellite Networks显示文摘Multi-Layered Satellite Network(MLSN),especially LEO/MEO satellite network,consisting of low and medium earth orbit satellites,is capable of providing higher coverage and better service than single-layered one.Its performance in deployment,however,is mainly encumbered by obsolete routing protocols and algorithms.This paper takes the predictability of satellite movements into consideration,based on which a novel routing protocol Predictable Satellite Network Routing Protocol(PSNRP)—is proposed.In this protocol,every topology change due to satellite movement is either described as a predictable or an unpredictable change.On the basis of PSNRP,we import a heuristic routing algorithm for satisfying Quality-of-Service(QoS)requirements from network users,which is convinced as a Non-deterministic Polynomial Complete problem.The QoS requirements in this paper mainly refer to end-to-end delay,bandwidth and package loss rate.In addition to obtaining better routing performance,PSNRP successfully allocates calculation tasks evenly among all nodes,separates user data from protocol control data and achieves stronger robustness against satellite failures and link congestions.The superiority of our routing scheme is proved by simulation results. | LIU HeYu SUN FuChun | 2013 | Science China(Information Sciences)2013，56，11： | 5 |
| 4 | Significance of Vibrio species in the marine organic carbon cycle-A review显示文摘The genus Vibrio,belonging to Gammaproteobacteria of the phylum Proteobacteria,is a genetically and ecologically diverse group of heterotrophic bacteria,that are ubiquitous in marine environments,especially in coastal areas.In particular,vibrios dominate,i.e.up to 10%of the readily culturable marine bacteria in these habitats.The distribution of Vibrio spp.is shaped by various environmental parameters,notably temperature,salinity and dissolved organic carbon.Vibriospp.may utilize a wide range of organic carbon compounds,including chitin(this may be metabolized by most Vibrio spp.),alginic acid and agar.Many Vibrio spp.have very short replication times(as short as~10 min),which could facilitate them developing into high biomass content albeit for relatively short durations.Although Vibriospp.usually comprise a minor portion(typically^1%of the total bacterioplankton in coastal waters)of the total microbial population,they have been shown to proliferate explosively in response to various nutrient pulses,e.g.,organic nutrients from algae blooms and iron from Saharan dust.Thus,Vibrio spp.may exert large impacts on marine organic carbon cycling especially in marginal seas.Genomics and related areas of investigation will reveal more about the molecular components and mechanisms involved in Vibrio-mediated biotransformation and remineralization processes. | Xiaohua ZHANG Heyu LIN Xiaolei WANG Brian AUSTIN | 2018 | Science China Earth Sciences2018，61，10： | 5 |
| 5 | Some results on numerical divided difference formulas显示文摘The remainder estimates of numerical divided difference formula are given for the functions of lower and higher smoothness, respectively. Then several divided difference formulas with super-convergence are derived with their remainder expressions. | Wang Xinghua,Wang Heyu & Ming-Jun Lai Department of Mathematics, Zhejiang University, Hangzhou 310028, China Computing Center, Zhejiang University, Hangzhou 310012, China Department of Mathematics, University of Georgia, Athens, GA 30602-7403, USA | 2005 | Science China Mathematics2005，48，11： | 4 |
| 6 | Fish forewarning of comprehensive toxicity in water environment based on Bayesian sequential method显示文摘Environmental impact of pollutants can be analyzed effectively by acquiring fish behavioral signals in water with biological behavior sensors. However, a variety of factors, such as the complexity of biological organisms themselves, the device error and the environmental noise, may compromise the accuracy and timeliness of model predictions. The current methods lack prior knowledge about the fish behavioral signals corresponding to characteristic pollutants, and in the event of a pollutant invasion, the fish behavioral signals are poorly discriminated. Therefore, we propose a novel method based on Bayesian sequential,which utilizes multi-channel prior knowledge to calculate the outlier sequence based on wavelet feature followed by calculating the anomaly probability of observed values. Furthermore, the relationship between the anomaly probability and toxicity is analyzed in order to achieve forewarning effectively. At last, our algorithm for fish toxicity detection is verified by integrating the data on laboratory acceptance of characteristic pollutants. The results show that only one false positive occurred in the six experiments, the present algorithm is effective in suppressing false positives and negatives, which increases the reliability of toxicity detections, and thereby has certain applicability and universality in engineering applications. | Kaifeng Rao Li Tang Xin Zhang Heyu Xiang Liang Tang Yong Liu Wei Wang Jie Jiang Mei Ma Yiping Xu Zijian Wang | 2021 | Journal of Environmental Sciences2021，33，12： | 2 |
| 7 | Improvement in the risk assessment of oral leukoplakia through morphology-related copy number analysis显示文摘Oral leukoplakia is the most common type of oral potentially malignant disorders and considered a precursor lesion to oral squamous cell carcinoma.However,a predictor of oral leukoplakia prognosis has not yet been identified.We investigated whether copy number alteration patterns may effectively predict the prognostic outcomes of oral leukoplakia using routinely processed paraffin sections.Comparison of copy number alteration patterns between oral leukoplakia with hyperplasia(HOL,n=22)and dysplasia(DOL,n=21)showed that oral leukoplakia with dysplasia had a higher copy number alteration rate(86%)than oral leukoplakia with hyperplasia(46%).Oral leukoplakia with dysplasia exhibited a wider range of genomic variations across all chromosomes compared with oral leukoplakia with hyperplasia.We also examined a retrospective cohort of 477 patients with oral leukoplakia with hyperplasia with detailed follow-up information.The malignant transformation(MT,n=19)and leukoplakia recurrence(LR,n=253)groups had higher frequencies of aneuploidy events and copy number loss rate than the free of disease(FD,n=205)group.Together,our results revealed the association between the degree of copy number alterations and the histological grade of oral leukoplakia and demonstrated that copy number alteration may be effective for prognosis prediction in oral leukoplakia patients with hyperplasia. | Xiaotian Li Lu Liu Jianyun Zhang Ming Ma Lisha Sun Xuefen Li Heyu Zhang Jianbin Wang Yanyi Huang Tiejun Li | 2021 | Science China(Life Sciences)2021，64，9： | 2 |
| 8 | 2021 Chinese consensus on the diagnosis and management of primary immune thrombocytopenia in pregnancy显示文摘Immune thrombocytopenia(ITP)is an acquired disease characterized by isolated thrombocytopenia,which is one of the most common causes of thrombocytopenia during pregnancy.Women with ITP who have severe thrombocytopenia are at an increased risk for life-threatening obstetric complications.Therefore,we established this consensus statement on the diagnosis and management of ITP during pregnancy(detailed information is available in the Supplementary File,http://gffzz16e312a87a7141a5hcqo6bkvox5uq6con.ffgz.tsg.suse.edu.cn/A978). | Zhang Xiaohui Chen Fangping Chen Xiequn Cheng Yunfeng Fang Meiyun Feng Jianming Fu Haixia Gao Hong Han Yue He Aili Hou Ming Hu Yu Huang Ruibin Huang Wenrong Jing Zhicheng Kong Peiyan Liang Aibin Liang Meiying Liu Daihong Liu Junling Liu Lin Liu Xiaowei Ma Liangming Mei Heng Ni Heyu Niu Ting Peng Jun Qiao Jianlin Ren Jinhai Song Yongping Tang Liang V Tong Tong Wang Shaoyuan Wang Xin Wang Zhao Wei Hui Wu Depei Wu Guangsheng Xu Caigang Xu Xue Xu Yajing Yang Linhua Yang Renchi Yang Tonghua Yin Chenghong Yu Li Zhang Guangsen Zhang Lei Zhang Liansheng Zhang Xi Zhao Weili Zhao Yongqiang Zhou Daobin Zhou Hu Zhou Zeping Zhu Tienan Wang Jianliu Huang Xiaojun | 2022 | Chinese Medical Journal2022，，8： | 2 |
| 9 | A Symmetric Key Exchange Protocol Bsaed on Virtual S-Box显示文摘 | YIN Yifeng GAN Yong WEN Heyu LI Tianbao | 2014 | China Communications2014，11，A02： | 2 |
| 10 | Source apportionment of polycyclic aromatic hydrocarbons(PAHs) in a sediment core from Lake Dagze Co, Tibetan Plateau, China: Comparison of three receptor models显示文摘Receptor models are a useful tool for identifying sources of polycyclic aromatic hydrocarbons(PAHs) in multiple environmental media. In this study, three different receptor models(including the principal component analysis-multiple linear regression(PCA-MLR), positive matrix factorization(PMF), and Unmix models) were used to apportion the sources of 16 priority PAHs in a sediment core of Lake Dagze Co. The ΣPAHs(sum of all 16 measured PAHs) concentrations ranged from 51.89 to 132.82 ng/g with an average of 80.39 ng/g. TheΣ PAHs were dominated by 2-3 ring PAHs, accounting for 80.12% on average, thereby indicating that they mainly originated from biomass and coal combustion and/or from long-range atmospheric transportation. The three models produced consistent source apportionment results. The greatest contributor to ΣPAHs was biomass combustion, followed by coal combustion, vehicle emissions, and petrogenic sources. Moreover, the temporal variation of the common sources was well-correlated among models. The multi-method comparison and evaluation results showed that all three models were useful tools for source apportionment of PAHs, with the PMF model providing better results than the PCA-MLR and Unmix models. The temporal trends of factor contributions were verified by PAHs with different ring numbers. Significant correlations were found between the simulated concentrations of each source factor and the PAHs with different ring numbers(P<0.01), except for the petrogenic source identified by the Unmix model(P>0.05). This study can provide useful information for further investigation of source apportionment of PAHs in the sediment cores. | Yixin Bai Kunlin Shi Heyu Yu Nana Shang Weiyue Hao Chuan Wang Tao Huang Hao Yang Changchun Huang | 2022 | Journal of Environmental Sciences2022，34，11： | 2 |
| 11 | 微卫星标记位点的分离及其在美洲剑线虫群体分类鉴定上的应用显示文摘在美洲剑线虫群体 (Xiphinemaamericanumgroup)上 ,应用简并寡核苷酸引物聚合酶链式反应 (DOP -PCR)技术 ,克服了基因组DNA样本不足的难题 ,成功在微量基因组DNA条件下分离和标记了微卫星重复子 (Mi crosatellite)。研究中 ,目标DNA片段被克隆前 ,DOP -PCR产物首先被连接到载体上 ,然后通过寡核苷酸 (CA) 9和载体上游引物 ,对包含微卫星位点的左侧DNA片段进行PCR扩增 ,该过程后的产物用于克隆和DNA序列分析 ;依据已分析的部分左侧序列 ,设计引物并与载体下游引物一起 ,对DOP -PCR产物再进行PCR扩增 ,使包含整个微卫星及其右侧连接部分被扩增 ,重复克隆和DNA序列分析并结合已分析的左侧序列 ,获得了包含全部微卫星重复子的DNA片段的完整序列。这种分离含微卫星标记位点DNA片段的路径新颖、高效 ,有效克隆率提高到了 93.3%。研究中 ,发现和分析了 9个包含微卫星重复子的片段 ,美洲剑线虫 (X .americanumsensustricto)和美洲剑线虫亚群组(X .americanumsubgroup)的标记性引物被设计和检测。 | 沈培垠 李红梅 HeYu MauriceMoens | 2004 | 检验检疫科学2004，14，4： | 1 |
| 12 | LILRB4 ITIMs mediate the T cell suppression and infiltration of acute myeloid leukemia cells显示文摘We recently demonstrated that leukocyte Ig-like receptor 4(LILRB4)expressed by monocytic acute myeloid leukemia(AML)cells mediates T-cell inhibition and leukemia cell infiltration via its intracellular domain.The cytoplasmic domain of LILRB4 contains three immunoreceptor tyrosine-based inhibitory motifs(ITIMs);the tyrosines at positions 360,412,and 442 are phosphorylation sites.Here,we analyzed how the ITIMs of LILRB4 in AML cells mediate its function.Our in vitro and in vivo data show that Y412 and Y442,but not Y360,of LILRB4 are required for T-cell inhibition,and all three ITIMs are needed for leukemia cell infiltration.We constructed chimeric proteins containing the extracellular domain of LILRB4 and the intracellular domain of LILRB1 and vice versa.The intracellular domain of LILRB4,but not that of LILRB1,mediates T-cell suppression and AML cell migration.Our studies thus defined the unique signaling roles of LILRB4 ITIMs in AML cells. | Zunling Li Mi Deng Fangfang Huang Changzhu Jin Shuang Sun Heyu Chen Xiaoye Liu Licai He Ali HSadek Cheng Cheng Zhang | 2020 | Cellular & Molecular Immunology2020，17，3： | 1 |
| 13 | A comparative study between China and IHRA for the vehicle-pedestrian impact 显示文摘 | CHEN Huipeng FU Lianxue ZHENG Heyue | 2009 | SAE International Journal of Passenger Cars-Mechanical Systems2009，2，1： | 1 |
| 14 | Mg-xonotlite and Its Coexisting Phases显示文摘 | Qian Guangren Xu Guangliang Li Heyu | 1997 | Cement and Concrete Research1997，27，3： | 1 |
| 15 | Decreased indoleamine 2,3-dioxygenase expression in dendritic cells and role of indoleamine 2,3-dioxygenase-expressing dendritic cells in immune thrombocytopenia显示文摘 | Shu-qian Xu Chun-yan Wang Xiao-juan Zhu Xiao-yuan Dong Yan Shi Jun Peng Ping Qin Jian-zhi Sun Chengshan Guo Heyu Ni Ming Hou | 2012 | Annals of Hematology2012，，： | 1 |
| 16 | A feasibility study of a prototype PET insert device to convert a general-purpose animal PET scanner to higher resolution显示文摘 | Wu Heyu Debashish Pal Joseph A | 2007 | Journal of Nuclear Medicine2007，49，： | 1 |
| 17 | Virtual-pinhole PET显示文摘 | Tai Yuan-Chuan Wu Heyu Debashish Pal | 2008 | Journal of Nuclear Medicine2008，49，3： | 1 |
| 18 | A simulation study the design of a prototype insert for whole-body PET scanners显示文摘 | Janecek M Wu Heyu Tai Yuan-Chuan | 2006 | IEEE Transactions on Nuclear Medicine2006，53，： | 1 |
| 19 | Emission Probabilities and Energy Spectra of Hydrogen Isotopes in Reactions ^(40)Ar+^(112,124)Sn at 30 MeV/u显示文摘Hot nuclei with differentN/Z ratio were produced by using^(40)Ar beam on^(112)Sn and^(124)Sn target,respectively.The energy spectra and the emission probabilities of hydrogen isotopes are analyzed in the 30 MeV/u^940)Ar+^(112,124)Sn reactions.Partial emission probability P_i of a certain species i is defined here | Xiao Zhigang, Jin Genming, Wu Heyu, Wei Zhiyong, Wang Hongwei, Duan Limin Hu Rongjiang, Li Zuyu, Zhang Baoguo, Zhu Yongtai and Wang Sufang | 2001 | IMP & HIRFL Annual Report2001，，1： | 1 |
| 20 | Efficient computation of dendritic growth with r-adaptive finite element methods显示文摘 | Wang Heyu Li Ruo Tang Tao | 2008 | J Comput Phys2008，227，： | 1 |
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