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| 1 | Lesion-symptom mapping with NIHSS sub-scores in ischemic stroke patients显示文摘Background Lesion-symptom mapping(LSM)is a statistical technique to investigate the population-specific relationship between structural integrity and post-stroke clinical outcome.In clinical practice,patients are commonly evaluated using the National Institutes of Health Stroke Scale(NIHSS),an 11-domain clinical score to quantitate neurological deficits due to stroke.So far,LSM studies have mostly used the total NIHSS score for analysis,which might not uncover subtle structure–function relationships associated with the specific sub-domains of the NIHSS evaluation.Thus,the aim of this work was to investigate the feasibility to perform LSM analyses with sub-score information to reveal category-specific structure–function relationships that a total score may not reveal.Methods Employing a multivariate technique,LSM analyses were conducted using a sample of 180 patients with NIHSS assessment at 48-hour post-stroke from the ESCAPE trial.The NIHSS domains were grouped into six categories using two schemes.LSM was conducted for each category of the two groupings and the total NIHSS score.Results Sub-score LSMs not only identify most of the brain regions that are identified as critical by the total NIHSS score but also reveal additional brain regions critical to each function category of the NIHSS assessment without requiring extensive,specialised assessments.Conclusion These findings show that widely available sub-scores of clinical outcome assessments can be used to investigate more specific structure–function relationships,which may improve predictive modelling of stroke outcomes in the context of modern clinical stroke assessments and neuroimaging. | Deepthi Rajashekar Matthias Wilms M Ethan MacDonald Serena Schimert Michael D Hill Andrew Demchuk Mayank Goyal Sean P Dukelow Nils Daniel Forkert | 2022 | Stroke & Vascular Neurology2022，7，2： | 7 |
| 2 | Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density显示文摘 | W.S Simonet D.L Lacey C.R Dunstan M Kelley M.-S Chang R Lüthy H.Q Nguyen S Wooden L Bennett T Boone G Shimamoto M DeRose R Elliott A Colombero H.-L Tan G Trail J Sullivan E Davy N Bucay L Renshaw-Gegg T.M Hughes D Hill W Pattison P Campbell S Sander G Van | 1997 | Cell1997，，2： | 6 |
| 3 | Senescent human hepatocytes express a unique secretory phenotype and promote macrophage migration显示文摘AIM:To develop a model of stress-induced senescence to study the hepatocyte senescence associated secretory phenotype(SASP).METHODS:Hydrogen peroxide treatment was used to induce senescence in the human Hep G2 hepatocyte cell line.Senescence was confirmed by cytochemical staining for a panel of markers including Ki67,p21,heterochromatin protein 1β,and senescence-associated-β-galactosidase activity.Senescent hepatocytes were characterised by gene expression arrays and quantitative polymerase chain reaction(q PCR),and conditioned media was used in proteomic analyses,a human chemokine protein array,and cell migration assays to characterise the composition and function of the hepatocyte SASP.RESULTS:Senescent hepatocytes induced classical markers of senescence(p21,heterochromatin protein1β,and senescence-associated-β-galactosidase activity);and downregulated the proliferation marker,Ki67.Hepatocyte senescence induced a 4.6-fold increase in total secreted protein(P=0.06)without major alterations in the protein profile.Senescence-induced genes were identified by microarray(Benjamini Hochbergcorrected P<0.05);and,consistent with the increase in secreted protein,gene ontology analysis revealed a significant enrichment of secreted proteins among inducible genes.The hepatocyte SASP included characteristic factors such as interleukin(IL)-8 and IL-6,as well as novel components such as SAA4,IL-32and Fibrinogen,which were validated by q PCR and/or chemokine protein array.Senescent hepatocyteconditioned medium elicited migration of inflammatory(granulocyte-macrophage colony stimulating factor,GM-CSF-derived),but not non-inflammatory(CSF-1-derived)human macrophages(P=0.022),which could contribute to a pro-inflammatory microenvironment in vivo,or facilitate the clearance of senescent cells.CONCLUSION:Our novel model of hepatocyte senescence provides insights into mechanisms by which senescent hepatocytes may promote chronic liver disease pathogenesis. | Katharine M Irvine Richard Skoien Nilesh J Bokil Michelle Melino Gethin P Thomas Dorothy Loo Brian Gabrielli Michelle M Hill Matthew J Sweet Andrew D Clouston Elizabeth E Powell | 2014 | World Journal of Gastroenterology2014，20，47： | 2 |
| 4 | Medical image registration显示文摘 | Hill DLG Batchelor PG Holden M | 2001 | Physics in Medicine and Biology2001，46，： | 2 |
| 5 | Manufacture of large glass honeycomb mirrors显示文摘 | ANGEL J R P HILL J M | 1982 | SPIE1982，332，： | 2 |
| 6 | MicroRNA-214 protects the mouse heart from ischemic injury by controlling Ca^sup 2+^ overload and cell death显示文摘 | Aurora Arin B Mahmoud Ahmed I Luo Xiang Johnson Brett A van Rooij Eva Matsuzaki Satoshi Humphries Kenneth M Hill Joseph A Bassel-Duby Rhonda Sadek Hesham A Olson Eric N | 2012 | EN2012，，4： | 2 |
| 7 | Transforming growth factor-beta regulates tubular epithelial-myofibroblast transdifferentiation in vitro 显示文摘 | Fan J M Ng Y Y Hill P A | 1999 | Kidney Int1999，56，4： | 2 |
| 8 | Preinoculation enrichment procedure enhances the performance of bacteriocinogenic Lactocoocus lactic meat starter culture 显示文摘 | Amalia G M Scannell Gerhard Schwarz Colin Hill | 2001 | International Journal of Food Microbiology2001，64，： | 1 |
| 9 | Patterns of species distribution in Britain elucidated by canonical correspondence analysis显示文摘 | HILL M O | 1991 | Journal of Biogeography1991，18，： | 1 |
| 10 | Cognitive strategies and learning from the world wide Web 显示文摘 | Hill J R Hannafin M J | 1997 | Educational Technology Research and Development1997，45，4： | 1 |
| 11 | Arabidopsis onset of leaf death mutants identify a regulatory pathway controlling leaf senescence显示文摘 | Jing H C Sturre M J Hille J | 2002 | Plant J2002，32，1： | 1 |
| 12 | Stability theory for differential/algebraic systems with application to power systems 显示文摘 | Hill D J Mareels I M Y | 1990 | IEEE Transactions on Circuits and Systems1990，37，11： | 1 |
| 13 | Integrated adrenal,somatotropic, and immune responses of growing pigs to treatment with lipopolysaccharide 显示文摘 | Balaji R Hill C M | 2000 | J Amm Sci2000，78，： | 1 |
| 14 | A annotated checklist of the mosses of Europe and Macaronesia 显示文摘 | Hill M O Bell N Bruggeman-Nannenga M A | 2006 | Journal of Bryology2006，28，： | 1 |
| 15 | Development and Evaluation of a Local Grid Refinement Method for Block-Centered Nite-Difference Ground- water Models Using Shared Nodes 显示文摘 | Mehl S Hill M C | 2002 | Advances in Water Resources2002，25，： | 1 |
| 16 | Viscosity of galactomannans during high temperature processing: influence of degradation and solubilisafion 显示文摘 | KOK M S Hill S E Mitchell J R | 1999 | Food Hydrocolloids1999，13，： | 1 |
| 17 | An improved scoring system for identifying patients at high early risk of stroke and functional impairment after an acute transient ischemic attack or minor stroke 显示文摘 | Courts SB Eliasziw M Hill MD | 2008 | Int J Stroke2008，3，1： | 1 |
| 18 | Oil well casing-evidence of the sensitivity to rapid failure in an H2S environment显示文摘 | Hill M Kawasaki E P Kronbach G E | 1972 | Materials Protection&Performance1972，，11： | 1 |
| 19 | Estimated global inci- dence of Japanese encephalitis: a systematic review 显示文摘 | Campbell GL Hills SL Fischer M | 2011 | Bull World Health Organ2011，89，10： | 1 |
| 20 | Managerial risk taking in diversified firms:An evolutionary perspective显示文摘 | Hoskisson R E Hitt M A Hill C W L | 1991 | Organization Science1991，，3： | 1 |
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