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| 1 | Early effects of oral administration of omeprazole and roxatidine on intragastric pH显示文摘Objective:The ideal medication for the treatment of acid-related diseases,e.g.,peptic ulcers,stress-related gastric bleeding,functional dyspepsia,and gastroesophageal reflux disease,should have a rapid onset of action to promote hemostasis and relieve the symptoms.The aim of our study was to investigate the inhibitory effects on gastric acid secretion of a single oral administration of a proton pump inhibitor,omeprazole 20 mg,and an H2-receptor antagonist,roxatidine 75 mg.Methods:Ten Helicobacter pylori-negative male subjects participated in this randomized,two-way crossover study.Intragastric pH was monitored continuously for 6 h after single oral administration of omeprazole 20 mg and roxatidine 75 mg.Each administration was separated by a 7-d washout period.Results:During the 6-h study period,the average pH after administration of roxatidine was higher than that after administration of omeprazole(median:4.45 vs.2.65;P=0.0367).Also during the 6-h study period,a longer duration of maintenance at pH above 2,5,and 6 was observed after administration of roxatidine 75 mg than after administration of omeprazole 20 mg(median:90.6% vs.55.2%,P=0.0284;43.7% vs.10.6%,P=0.0125;40.3% vs.3.3%,P=0.0125;respectively).Conclusions:In Helicobacter pylori-negative healthy male subjects,oral administration of roxatidine 75 mg increased the intragastric pH more rapidly than that of omeprazole 20 mg. | Hiroshi IIDA Shingo KATO Yusuke SEKINO Eiji SAKAI Takashi UCHIYAMA Hiroki ENDO Kunihiro HOSONO Yasunari SAKAMOTO Koji FUJITA Masato YONEDA Tomoko KOIDE Hirokazu TAKAHASHI Chikako TOKORO Ayumu GOTO Yasunobu ABE Noritoshi KOBAYASHI Kensuke KUBOTA Eiji GOTOH Shin MAEDA Atsushi NAKAJIMA Masahiko INAMORI | 2012 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2012，13，1： | 6 |
| 2 | Shape of Barrett's epithelium is associated with prevalence of erosive esophagitis显示文摘AIM:To test the hypothesis that the shape and length of Barrett's epithelium are associated with prevalence of erosive esophagitis.METHODS:A total study population comprised 869 patients who underwent endoscopy during a health checkup at our hospital.The presence and extent of Barrett's epithelium were diagnosed based on the Prague C & M Criteria.We originally classified cases of Barrett's epithelium into two types based on its shape,namely,flamelike and lotus-like Barrett's epithelium,and into two groups based on its length,its C extent < 2 cm,and ≥ 2 cm.Correlation of shape and length of Barrett's epithelium with erosive esophagitis was examined.RESULTS:Barrett's epithelium was diagnosed in 374 cases(43%).Most of these were diagnosed as shortsegment Barrett's epithelium.The prevalence of erosive esophagitis was significantly higher in subjects with flame-like than lotus-like Barrett's epithelium,and in those with a C extent of ≥ 2 cm than < 2 cm.CONCLUSION:Flame-like rather than lotus-like Barrett's epithelium,and Barrett's epithelium with a longer segment were more strongly associated with erosive esophagitis. | Tomoyuki Akiyama Masahiko Inamori Hiroshi Iida Hiroki Endo Kunihiro Hosono Yasunari Sakamoto Koji Fujita Masato Yoneda Hirokazu Takahashi Tomoko Koide Chikako Tokoro Ayumu Goto Yasunobu Abe Takeshi Shimamura Noritoshi Kobayashi Kensuke Kubota Satoru Saito Atsushi Nakajima | 2010 | World Journal of Gastroenterology2010，16，4： | 4 |
| 3 | characteristics of intestinal pseudo-obstruction in patients with mitochondrial diseases显示文摘AIM: To reveal the frequency, characteristics and prognosis of chronic intestinal pseudo-obstruction (CIP) in mitochondrial disease patients. METHODS: Between January 2000 and December 2010, 31 patients (13 males and 18 females) were di-agnosed with mitochondrial diseases at our hospital. We conducted a retrospective review of the patients' sex, subclass of mitochondrial disease, age at onset of mitochondrial disease, frequency of CIP and the age at its onset, and the duration of survival. The age at onset or at the first diagnosis of the disorder that led to the clinical suspicion of mitochondrial disease was also examined. RESULTS: Twenty patients were sub-classified with mitochondrial encephalopathy with lactic acidosis and stroke-like episodes (MELAS), 8 with chronic progressive external ophthalmoplegia (CPEO), and 3 with myoclonus epilepsy associated with ragged-red fibers (MERRF). Nine patients were diagnosed with CIP, 8 of the 20 (40.0%) patients with MELAS, 0 of the 8 (0.0%) patients with CPEO, and 1 of the 3 (33.3%) patients with MERRF. The median age (range) at the diagnosis and the median age at onset of mitochondrial disease were 40 (17-69) and 25 (12-63) years in patients with CIP, and 49 (17-81) and 40 (11-71) years in patients without CIP. During the survey period, 5 patients (4 patients with MELAS and 1 with CPEO) died. The cause of death was cardiomyopathy in 2 patients with MELAS, cerebral infarction in 1 patient with MELAS, epilepsy and aspiration pneumonia in 1 patient with MELAS, and multiple metastases from gastric cancer and aspiration pneumonia in 1 patient with CPEO. CONCLUSION: Patients with CIP tend to have disorders that are suspected to be related to mitochondrial diseases at younger ages than are patients without CIP. | Yusuke Sekino Masahiko Inamori Eiji Yamada Hidenori Ohkubo Eiji Sakai Takuma Higurashi Hiroshi Iida Kunihiro Hosono Hiroki Endo Takashi Nonaka Hirokazu Takahashi Tomoko Koide Yasunobu Abe Eiji Gotoh Shigeru Koyano Yoshiyuki Kuroiwa Shin Maeda Atsushi Nakajima | 2012 | World Journal of Gastroenterology2012，18，33： | 3 |
| 4 | Clinicopathological Characteristics of Remnant Gastric Cancer After a Distal Gastrectomy显示文摘 | Toshiyasu Ojima Makoto Iwahashi Mikihito Nakamori Masaki Nakamura Teiji Naka Masahiro Katsuda Takeshi Iida Toshiaki Tsuji Keiji Hayata Katsunari Takifuji Hiroki Yamaue | 2010 | Journal of Gastrointestinal Surgery2010，，2： | 2 |
| 5 | Reconstruction after proximal gastrectomy for early gastric cancer in the upper third of the stomach: An analysis of our 13-year experience显示文摘 | Masaki Nakamura Mikihito Nakamori Toshiyasu Ojima Masahiro Katsuda Takeshi Iida Keiji Hayata Shuuichi Matsumura Tomoya Kato Junya Kitadani Makoto Iwahashi Hiroki Yamaue | 2014 | Surgery2014，，： | 2 |
| 6 | Redox - triggered Switching of Helical Chirality of Poly (Phenylacetylene) s Bearing Ri- boflavin Pendants显示文摘 | Hiroki Iida Tomohisa Mizoguchi Seong - Dae Oh | 2010 | Polymer Chemistry2010，1，6： | 1 |
| 7 | An analysis of the factors contributing to a reduction in the incidence of pulmonary complications following an esophagectomy for esophageal cancer显示文摘 | Masaki Nakamura Makoto Iwahashi Mikihito Nakamori Koichiro Ishida Teiji Naka Takeshi Iida Masahiro Katsuda Toshiaki Tsuji Yoshihiro Nakatani Hiroki Yamaue | 2008 | Langenbeck’s Archives of Surgery2008，，2： | 1 |
| 8 | Association of Allogeneic Blood Transfusions and Long-Term Survival of Patients with Gastric Cancer after Curative Gastrectomy显示文摘 | Toshiyasu Ojima Makoto Iwahashi Mikihito Nakamori Masaki Nakamura Teiji Naka Masahiro Katsuda Takeshi Iida Keiji Hayata Hiroki Yamaue | 2009 | Journal of Gastrointestinal Surgery2009，，10： | 1 |
| 9 | Adenosquamous carcinoma of the pancreas associated with humoral hypercalcemia of malignancy (HHM)显示文摘 | Noritoshi Kobayashi Takuma Higurashi Hiroshi Iida Hironori Mawatari Hiroki Endo Yuichi Nozaki Ayako Tomimoto Kyoko Yoneda Tomoyuki Akiyama Koji Fujita Hirokazu Takahashi Masato Yoneda Masahiko Inamori Yasunobu Abe Hiroyuki Kirikoshi Kensuke Kubota Satoru | 2008 | Journal of Hepato-Biliary-Pancreatic Surgery2008，，5： | 1 |
| 10 | The impact of abdominal shape index of patients on laparoscopy-assisted distal gastrectomy for early gastric cancer显示文摘 | Toshiyasu Ojima Makoto Iwahashi Mikihito Nakamori Masaki Nakamura Katsunari Takifuji Masahiro Katsuda Takeshi Iida Toshiaki Tsuji Keiji Hayata Hiroki Yamaue | 2012 | Langenbeck’s Archives of Surgery2012，，3： | 1 |
| 11 | The Effect of Topical and IntravenousRopivacaine on Ca nine Pial Microcirculation显示文摘 | Tadahiko Ishiyama ShujiDohi Hiroki Iida | 1997 | Anesth Analg1997，，85： | 1 |
| 12 | Acute Appendicitis Associated with Peutz-Jeghers-Type Hamartoma of the Appendix显示文摘 | Hiroshi Iida Masahiko Inamori Yusuke Sekino Hiroki Endo Tomoyuki Akiyama Koji Fujita Hirokazu Takahashi Masato Yoneda Noritoshi Kobayashi Yasunobu Abe Hiroyuki Kirikoshi Kensuke Kubota Satoru Saito Hisashi Oshiro Yasushi Rino Atsushi Nakajma | 2008 | Digestive Diseases and Sciences2008，，10： | 1 |
| 13 | Serum Ferritin Is a Clinical Biomarker in Japanese Patients with Nonalcoholic Steatohepatitis (NASH) Independent of HFE Gene Mutation显示文摘 | Masato Yoneda Yuichi Nozaki Hiroki Endo Hironori Mawatari Hiroshi Iida Koji Fujita Kyoko Yoneda Hirokazu Takahashi Hiroyuki Kirikoshi Masahiko Inamori Noritoshi Kobayashi Kensuke Kubota Satoru Saito Shiro Maeyama Kikuko Hotta Atsushi Nakajima | 2010 | Digestive Diseases and Sciences2010，，3： | 1 |
| 14 | Factors predicting the presence of small bowel lesions in patients with obscure gastrointestinal bleeding显示文摘 | Eiji Sakai Hiroki Endo Leo Taniguchi Yasuo Hata Akiko Ezuka Hajime Nagase Eiji Yamada Hidenori Ohkubo Takuma Higurashi Yusuke Sekino Tomoko Koide Hiroshi Iida Kunihiro Hosono Takashi Nonaka Hirokazu Takahashi Masahiko Inamori Shin Maeda Atsushi Nakajima | 2013 | Digestive Endoscopy2013，，： | 1 |
| 15 | Study on a new method for reducing radon level in indoor air 显示文摘 | Takao Iida Takayuki Kato Hiroki Mochizuki | 2001 | The Science of the Total Environment2001，272，13： | 1 |
| 16 | Evaluation of Double Tract Reconstruction After Total Gastrectomy in Patients with Gastric Cancer: Prospective Randomized Controlled Trial显示文摘 | Makoto Iwahashi Mikihito Nakamori Masaki Nakamura Teiji Naka Toshiyasu Ojima Takeshi Iida Masahiro Katsuda Kentaro Ueda Hiroki Yamaue | 2009 | World Journal of Surgery2009，，9： | 1 |
| 17 | Tumor-infiltrating CD4+ Th17 cells produce IL-17 in tumor microenvironmentand promote tumor progression in human gastric cancer显示文摘 | Takeshi Iida Makoto Iwahashi Masahiro Katsuda Koichiro Ishida Mikihito Nakamori Masaki Nakamura Teiji Naka Toshiyasu Ojima Kentaro Ueda Keiji Hayata Yasushi Nakamura Hiroki Yamaue | 2011 | Oncology Reports2011，，5： | 1 |
| 18 | Tumor-infiltrating CD4+ Th17 cells produce IL-17 in tumor microenvironmentand promote tumor progression in human gastric cancer显示文摘 | Takeshi Iida Makoto Iwahashi Masahiro Katsuda Koichiro Ishida Mikihito Nakamori Masaki Nakamura Teiji Naka Toshiyasu Ojima Kentaro Ueda Keiji Hayata Yasushi Nakamura Hiroki Yamaue | 2011 | Oncology Reports2011，，5： | 1 |
| 19 | Colonic Metastasis from Hepatocellular Carcinoma: Manifested by Gastrointestinal Bleeding显示文摘 | Yuichi Nozaki Noritoshi Kobayashi Takeshi Shimamura Tomoyuki Akiyama Masahiko Inamori Hiroshi Iida Hiroki Endo Koji Fujita Masato Yoneda Hirokazu Takahashi Yasunobu Abe Hiroyuki Kirikoshi Kensuke Kubota Satoru Saito Takeshi Sasaki Atsushi Nakajima | 2008 | Digestive Diseases and Sciences2008，，12： | 1 |
| 20 | Association of Allogeneic Blood Transfusions and Long-Term Survival of Patients with Gastric Cancer after Curative Gastrectomy显示文摘 | Toshiyasu Ojima Makoto Iwahashi Mikihito Nakamori Masaki Nakamura Teiji Naka Masahiro Katsuda Takeshi Iida Keiji Hayata Hiroki Yamaue | 2009 | Journal of Gastrointestinal Surgery2009，，10： | 1 |
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