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| 1 | Evaluation of safety for hepatectomy in a novel mouse model with nonalcoholic-steatohepatitis显示文摘AIM To investigate whether the liver resection volume in a newly developed nonalcoholic steatohepatitis(NASH) model influences surgical outcome.METHODS For establishment of a NASH model, mice were fed a high-fat diet for 4 wk, administered CCl_4 for the last 2 wk, and administered T0901317 for the last 5 d. We divided these mice into two groups: A 30% partial hepatectomy(PH) of NASH liver group and a 70% PH of NASH liver group. In addition, a 70% PH of normal liver group served as the control. Each group was evaluated for survival rate, regeneration, apoptosis, necrosis and DNA expression after PH.RESULTS In the 70% PH of NASH group, the survival rate was significantly decreased compared with that in the control and 30% PH of NASH groups(P < 0.01). 10 of 32 mice in the NASH 70% PH group died within 48 h after PH. Serum aspartate aminotransferase(AST) levels and total bilirubin(T-Bil) in the NASH 70% PH group were significantly higher than the levels in the other two groups(AST: P < 0.05, T-Bil: P < 0.01). In both PH of NASH groups, signaling proteins involved in regeneration were expressed at lower levels than those in the control group(P < 0.01). The 70% PH of NASH group also exhibited a lower number of Ki-67-positive cells and higher rates of apoptosis and necrosis than the NASH 30% PH group(P < 0.01). In addition, DNA microarray assays showed differences in gene expression associated with cell cycle arrest and apoptosis.CONCLUSION The function of the residual liver is impaired in fatty liver compared to normal liver. A larger residual volume is required to maintain liver functions in mice with NASH. | Yusuke Ozawa Takafumi Tamura Yohei Owada Yoshio Shimizu Akira Kemmochi Katsuji Hisakura Takashi Matsuzaka Hitoshi Shimano Hiroko Isoda Nobuhiro Ohkohchi | 2018 | World Journal of Gastroenterology2018，24，15： | 2 |
| 2 | Role of platelets on liver regeneration after 90% hepatectomy in mice显示文摘 | Andriy Myronovych Soichiro Murata Mitsuru Chiba Ryota Matsuo Osamu Ikeda Motonobu Watanabe Katsuji Hisakura Yoritaka Nakano Keisuke Kohno Takuya Kawasaki Ikuka Hashimoto Yuki Shibasaki Hiroshi Yasue Nobuhiro Ohkohchi | 2008 | Journal of Hepatology2008，，3： | 1 |
| 3 | Activation of human liver sinusoidal endothelial cell by human platelets induces hepatocyte proliferation显示文摘 | Takuya Kawasaki Soichiro Murata Kazuhiro Takahashi Reiji Nozaki Yukio Ohshiro Naoya Ikeda Sugiru Pak Andriy Myronovych Katsuji Hisakura Kiyoshi Fukunaga Tatsuya Oda Ryoko Sasaki Nobuhiro Ohkohchi | 2010 | Journal of Hepatology2010，，4： | 1 |
| 4 | Evaluation of serum high‐density lipoprotein cholesterol levels as a prognostic factor in gastric cancer patients显示文摘 | Takafumi Tamura Satoshi Inagawa Katsuji Hisakura Tsuyoshi Enomoto Nobuhiro Ohkohchi | 2012 | Journal of Gastroenterology and Hepatology2012，，10： | 1 |
| 5 | Evaluation of serum high-density lipoprotein cholesterol levels as a prognostic factor in gastriccancer patients显示文摘 | Tamura T Inagawa S Hisakura K | | 0，，： | 1 |
| 6 | Evaluation of serum high-density lipoprotein cholesterol levels as a prognostic factor in gastric cancer patients 显示文摘 | Tamura T Inagawa S Hisakura K | 2012 | J Gastroenterol Hepatol2012，27，10： | 1 |
| 7 | Conversion hepatectomy for hepatocellular carcinoma with main portal vein tumour thrombus after lenvatinib treatment: A case report显示文摘BACKGROUND Hepatocellular carcinoma(HCC)accompanied by portal vein tumour thrombus(PVTT)presents an aggressive disease course,worsening liver function reserve,and a high recurrence rate.Clinical practice guidelines recommend systemic therapy as the first-line option for HCC with portal invasion.However,to achieve longer survival in these patients,the treatment strategy should be concluded with removal of the tumour by locoregional therapy.We experienced a case of initially unresectable HCC with main PVTT converted to radical hepatectomy after lenvatinib treatment.CASE SUMMARY A 59-year-old male with chronic hepatitis C infection visited our clinic as a regular post-surgery follow-up.Contrast-enhanced abdominal computed tomography revealed a liver mass diffusely located at the lateral segment with a massive PVTT extending from the umbilical portion to the main and contralateral third-order portal branches.With the diagnosis of unresectable HCC with Vp4(main trunk/contralateral branch)PVTT,lenvatinib was started at 12 mg/d.The computed tomography taken 3 mo after starting lenvatinib showed regression of the PVTT,which had retreated to the contralateral first-order portal branch.He tolerated the full dose without major adverse effects.With cessation of lenvatinib for 7 d,radical left lobectomy and PVTT thrombectomy were conducted.The patient’s postoperative course was uneventful.Microscopically,the primary lesion showed fibrotic changes,with moderately to poorly differentiated tumour cells surrounded by granulation tissues in some areas.The majority of the PVTT showed necrosis.He was alive without recurrence for 8 mo.CONCLUSION This is the first case of HCC with Vp4 PVTT in which radical conversion hepatectomy was succeeded after lenvatinib treatment. | Kazuhiro Takahashi Jaejeong Kim Amane Takahashi Shinji Hashimoto Manami Doi Kinji Furuya Ryosuke Hashimoto Yohei Owada Koichi Ogawa Yusuke Ohara Yoshimasa Akashi Katsuji Hisakura Tsuyoshi Enomoto Osamu Shimomura Masayuki Noguchi Tatsuya Oda | 2021 | World Journal of Hepatology2021，13，3： | 1 |
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