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| 1 | Identifying high-risk individuals for gastric cancer surveillance from western and eastern perspectives: Lessons to learn and possibility to develop an integrated approach for daily practice显示文摘Current evidence shows that individuals with gastric dysplasia, severe and extensive gastric atrophy, extensive gastric intestinal metaplasia and the incomplete subtype of intestinal metaplasia are at high risk for gastric cancer(GC) development. There are several approaches to identifying these subjects,including noninvasive methods, esophagogastroduodenoscopy and histology.The main approach in Western countries is histology-based while that in Eastern countries with a high prevalence of GC is endoscopy-based. Regarding asymptomatic individuals, the key issues in selecting applicable approaches are the ability to reduce GC mortality and the cost-effectiveness of the approach. At present, population-based screening programs have only been applied in a few Asian countries with a high risk of GC. Pre-endoscopic risk assessment based on demographic and clinical features, such as ethnicity, age, gender, smoking and Helicobacter pylori status, is helpful for identifying subjects with high pre-test probability for a possibly cost-effective approach, especially in intermediate-and low-risk countries. Regarding symptomatic patients with indications for esophagogastroduodenoscopy, the importance of opportunistic screening should be emphasized. The combination of endoscopic and histological approaches should always be considered as endoscopy provides a real-time assessment of the patient’s risk level. In addition, imaging enhanced endoscopy(IEE) has been shown to facilitate targeted biopsies resulting in better correlation between endoscopic and histological findings. Currently, the use of IEE is recommended for endoscopic examinations, and the Operative Link for Gastric Intestinal Metaplasia or Operative Link on Gastritis Assessment grading systems are recommended for histological examinations whenever available. However,resource limitations are an important barrier in many regions worldwide. Thus,for an approach to be applicable in real-life practice, it should be not only evidence-based but also resource-sensitive. In this review, we discuss the current understanding and approaches to identifying high-risk individuals from western and eastern perspectives, as well as the possibility of an integrated, resourcesensitive approach. | Duc Trong Quach Toru Hiyama Takuji Gotoda | 2019 | World Journal of Gastroenterology2019，25，27： | 18 |
| 2 | Immunohistochemical molecular markers as predictors of curability of endoscopically resected submucosal colorectal cancer显示文摘AIM: To clarify the usefulness of immunohistochemical molecular markers in predicting lymph node metastasis of submucosal colorectal cancer. METHODS: We examined microvessel density, lymphatic vessel density, the Ki-67 labeling index, expression of MUC1 and Matrix metalloproteinase-7 (MMP-7) in tumor cells, and expression of cathepsin D in stromal cells at the invasive front by immunostaining of samples resected from 214 patients with submucosal colorectal cancer. Pathologic features were assessed on hematoxylin-eosin- stained samples. We evaluated the relations between clinicopathologic/immunohistochemical features and lymph node metastasis. RESULTS: Lesions of the superficial type, with an unfavorable histologic grade, budding, lymphatic involvement, high microvessel density (≥ 40), high lymphatic vessel density (≥ 9), high Ki-67 labeling index (≥ 42), and positivity of MUC1, cathepsin D, and MMP-7 showed a significantly high incidence of lymph node metastasis. Multivariate analysis revealed that high microvessel density, unfavorable histologic grade, cathepsin D positivity, high lymphatic vessel density, superficial type, budding, and MUC1 positivity were independent risk factors for lymph node metastasis.A combined examination with four independent immunohistochemical markers (microvessel density, cathepsin D, lymphatic vessel density, and MUC1) revealed that all lesions that were negative for all markers or positive for only one marker were negative for lymph node metastasis. CONCLUSION: Analysis of a combination of immuno- histochemical molecular markers in endoscopically resected specimens of submucosal colorectal cancer allows prediction of curability regardless of the pathologic features visible of hematoxylin-eosin-stained sections. | Iwao Kaneko Shinji Tanaka Shiro Oka Shigeto Yoshida Toru Hiyama Koji Arihiro Fumio Shimamoto Kazuaki Chayama | 2007 | World Journal of Gastroenterology2007，13，28： | 12 |
| 3 | Strategy for treatment of nonerosive reflux disease in Asia显示文摘The paper is to review the clinical and pathophysiologic differences between of nonerosive reflux disease (NERD) and reflux esophagitis (RE), and to propose a treatment strategy for NERD, especially for patients in Asia. A Medline search was performed regarding the clinical and pathophysiologic differences between NERD and RE, and treatment of NERD and RE. The characteristics of NERD patients in Asia are as follows: (1) high proportion of female patients, (2) low frequency of hiatal hernia, (3) high frequency of H pylori infection, (4) severe glandular atrophy of the gastric mucosa, and (5) frequent resistance to proton pump inhibitor (PPI) therapy. In Asian NERD patients, exposure of the esophagus to acid is not increased, and esophageal motility is normal. These characteristics are similar to those of patients in Western countries. Our recommended first-choice treatment is administration of PPI in combination with a prokinetic agent. However, at present, because there is limited evidence regarding effective treatments for NERD, it is best to try several different treatment strategies to find the best treatment for each patient. | Toru Hiyama Masaharu Yoshihara Shinji Tanaka Ken Haruma Kazuaki Chayama | 2008 | World Journal of Gastroenterology2008，14，20： | 10 |
| 4 | Defensive medicine practices among gastroenterologists in Japan显示文摘AIM: To clarify the prevalence of defensive medicine and the specific defensive medicine practices among gastro-enterologists in Japan.METHODS: A survey of gastroenterologists in Hiroshi-ma, Japan, was conducted by mail in March 2006. The number of gastroenterologists reporting defensive medi-cine behaviors or changes in their scope of practice and the reported defensive medicine practices, i.e., assurance and avoidance behaviors, were examined.RESULTS: A total of 131 (77%) out of 171 gastroenter-ologists completed the survey. Three (2%) respondents were sued, and most respondents (96%) had liability insurance. Nearly all respondents (98%) reported prac-ticing defensive medicine. Avoidance behaviors, such as avoiding certain procedures or interventions and avoiding caring for high-risk patients, were very common (96%). Seventy-five percent of respondents reported often avoiding certain procedures or interventions. However, seasoned gastroenterologists (those in practice for more than 20 years) adopted avoidance behaviors significantly less often than those in practice for less than 10 years. Assurance behaviors, i.e., supplying additional services of marginal or no medical value, were also widespread (91%). Sixty-eight percent of respondents reported that they sometimes or often referred patients to other spe-cialists unnecessarily.CONCLUSION: Defensive medicine may be highly prev-alent among gastroenterologists throughout Japan, withpotentially serious implications regarding costs, access, and both technical and interpersonal quality of care. | Toru Hiyama Masaharu Yoshihara Shinji Tanaka Yuji Urabe Yoshihiko Ikegami Tatsuma Fukuhara Kazuaki Chayama | 2006 | World Journal of Gastroenterology2006，12，47： | 7 |
| 5 | 1000MW单轴多缸汽轮发电机组的开发显示文摘为优化化石燃料电厂的建设投资,在保证高可靠性和高效率的同时,设备的布置应更加合理。因此,1000MW化石燃料汽轮发电机组的布置趋向于从双轴布置改为单轴布置。本文介绍了日立公司开发的1000MW单轴多缸汽轮发电机组部件技术的情况。目前,末级叶片分别为1016mm及1092.2mm的单轴多缸4排汽汽轮机已分别应用到60Hz和50Hz发电机上。 | Yuji Nameki, Takanori Murohoshi Futoshi Hiyama, Kiyoshi Namura -Hitachi Ltd. | 2000 | 国际电力2000，4，1： | 5 |
| 6 | Value of a new stick-type rapid urine test for the diagnosis of Helicobacter pylori infection in the Vietnamese population显示文摘AIM:To assess the value of a new test for the diagnosis of Helicobacter pylori(H.pylori) infection,Rapirun H.pylori Antibody Stick(Rapirun Stick),in a Vietnamese population.METHODS:Eligible patients without previous history of H.pylori eradication were recruited.Rapid urease test(RUT) and histologic examination were used to diagnose the H.pylori infection.Patients were considered H.pylori positive when the RUT results were positive and/or the bacteria were detected histologically.Rapirun Stick tests were performed using urine samples,and the results were compared with the other 2 methods.RESULTS:We enrolled 200 patients with a mean age of 36(range,18-76) years.There were 116 females and 84 males.Of the 200 patients,111(55.5%) were diagnosed as being H.pylori positive.The sensitivity,specificity,and accuracy of the Stick test were 84.7%,89.9%,and 87.0%,respectively.There were 17(8.5%) falsenegative patients and 9(4.5%) false-positive patients.CONCLUSION:The Rapirun Stick test has high sensitivity,specificity,and accuracy for the diagnosis of H.pylori infection in the Vietnamese population.The test can be clinically applied in Vietnamese populations. | Duc T Quach Toru Hiyama Fumio Shimamoto Quang D Le Linh X Ho Nhu HT Vu Masaharu Yoshihara Naomi Uemura | 2014 | World Journal of Gastroenterology2014，20，17： | 4 |
| 7 | Relationship between Endoscopic and Histologic Gastric Atrophy and Intestinal Metaplasia显示文摘 | Duc Trong Quach Huy Minh Le Toru Hiyama Oanh Thuy Nguyen Trung Sao Nguyen Naomi Uemura | 2012 | Helicobacter2012，，2： | 2 |
| 8 | Comparing the carbon sequestration capacity of temperate deciduous forests between urban and rural landscapes in central Japan显示文摘 | M.A. Awal Takeshi Ohta Kazuho Matsumoto Tae Toba Kenichi Daikoku Shigeaki Hattori Tetsuya Hiyama Hotaek Park | 2010 | Urban Forestry & Urban Greening2010，，3： | 2 |
| 9 | Reduction in gastric cancer mortality by screening based on serum pepsinogen concentration: A case-control study显示文摘 | Masaharu Yoshihara Toru Hiyama Shigeto Yoshida Masanori Ito Shinji Tanaka Yoshiyuki Watanabe Ken Haruma | 2007 | Scandinavian Journal of Gastroenterology2007，，6： | 2 |
| 10 | Genetic variations in detoxification enzymes and HIF‐1α in Japanese patients with COPD显示文摘 | Andika Chandra Putra Keiji Tanimoto Marina Arifin Budhi Antariksa Keiko Hiyama | 2011 | The Clinical Respiratory Journal2011，，1： | 2 |
| 11 | Telomerase activity in gastric cancer显示文摘 | Hiyama E OKoyama T Tatsumoto N | 1995 | Cancer Res1995，55，： | 2 |
| 12 | Telomerase activity is detected in pancreatic cancer but not in benign tumors显示文摘 | Kodama T Shinbara K | 1999 | Cancer Res1999，57，2： | 1 |
| 13 | Three Body Model Study of A:6-7 Hypernuelei: Halo and Skin Structures 显示文摘 | HIYAMA E KAMIMURA M MOTOBA T | 1996 | Phys Rev C1996，53，： | 1 |
| 14 | Arterioportal shunts on dynamic computed tomography显示文摘 | Nakayarna T Hiyama Y Ohnishi K | 1983 | AJR1983，140，： | 1 |
| 15 | Risk factors for hepatoceHular carcinoma among patients with chronic liver disease显示文摘 | Tsu Ku Ma H Hiyama T Tanaka S | 1993 | Engl J Med1993，328，9： | 1 |
| 16 | Photoinactivation of photosystem Ⅰ in isolated chloroplasts显示文摘 | Inoue K Sakurai H Hiyama T | 1986 | Plant Cell Physiol1986，27，： | 1 |
| 17 | Advanced multi- channel audio systems with superior impression of presence and reality 显示文摘 | K Hamasaki K Hiyama | 2004 | AES ll6th Convention Berlin Germany2004，6053，： | 1 |
| 18 | Laparoscopic and open approach in perforated peptic ulcer显示文摘 | Tsumura H Ichikawa T Hiyama E | 2004 | Hepato Gastroenterology2004，51，59： | 1 |
| 19 | Telomerase activity for the preoperative diagnosis of pancreatic cancer 显示文摘 | Hiyama E Yokoyama T | 1997 | J Natl Cancer Inst1997，89，21： | 1 |
| 20 | Degradation of Gelatin and Collagen by Serine Proteinase of Asperginus sydowi显示文摘 | Masaaki Shinozuka Masaru Iizuka | 1996 | Journal of Fermentation And Bioengineering1996，81，5： | 1 |
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