|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Strategy for treatment of nonerosive reflux disease in Asia显示文摘The paper is to review the clinical and pathophysiologic differences between of nonerosive reflux disease (NERD) and reflux esophagitis (RE), and to propose a treatment strategy for NERD, especially for patients in Asia. A Medline search was performed regarding the clinical and pathophysiologic differences between NERD and RE, and treatment of NERD and RE. The characteristics of NERD patients in Asia are as follows: (1) high proportion of female patients, (2) low frequency of hiatal hernia, (3) high frequency of H pylori infection, (4) severe glandular atrophy of the gastric mucosa, and (5) frequent resistance to proton pump inhibitor (PPI) therapy. In Asian NERD patients, exposure of the esophagus to acid is not increased, and esophageal motility is normal. These characteristics are similar to those of patients in Western countries. Our recommended first-choice treatment is administration of PPI in combination with a prokinetic agent. However, at present, because there is limited evidence regarding effective treatments for NERD, it is best to try several different treatment strategies to find the best treatment for each patient. | Toru Hiyama Masaharu Yoshihara Shinji Tanaka Ken Haruma Kazuaki Chayama | 2008 | World Journal of Gastroenterology2008，14，20： | 10 |
| 2 | Causal role of Helicobacter pylori infection and eradication therapy in gastric carcinogenesis显示文摘许多流行病学的报告显示感染玩的那 Helicobacter pylori (H pylori ) 在胃的致癌作用的一个重要角色。几基因、渐成说的改变以一种多步方式贡献癌症房间的开始,提升,和前进。H pylori 被知道在胃粘膜导致慢性炎。包括超级氧化物,它的产品参予开始跟随的 DNA 损坏,并且导出发炎的 cytokines 和生长因素贡献胃的致癌作用的提升。由根除 H pylori,胃的发炎能被治好;治疗减少不仅煽动性的房间渗入,而且 atrophy/intestinal 组织变形的层次部分地。使随机化的控制试用表明根除治疗减少了在没有癌症前期的条件的情况中的胃的癌症流行。另外,从日本组的最近的流行病学的研究证明特别肠的类型,胃的癌症的发展被成功的根除治疗减少,尽管这些以一种非使随机化的方式被设计。然而,内视镜的察觉是评估胃的致癌作用的度的唯一的方法,这应该被提及。我们报导了内视镜、组织学的形态学能被根除治疗修改,它可能贡献胃的癌症开发的流行。就癌症房间增长的生物性质而言,足够地长期的后续将是必要的讨论根除治疗的反癌症效果,这被考虑。 | Masanori Ito Shinji Tanaka Tomoari Kamada Ken Haruma Kazuaki Chayama | 2006 | World Journal of Gastroenterology2006，12，1： | 7 |
| 3 | Metachronous gastric cancer after successful Helicobacter pylori eradication显示文摘The high incidence of gastric cancer in Japan initially resulted in establishment of a country-wide gastric cancer screening program to detect early and treatable cancers. In 2013 countrywide Helicobacter pylori(H. pylori) eradication was approved coupled with endoscopy to assess for the presence of chronic gastritis. Current data support the notion that cure of the infection in those with non-atrophic gastritis will prevent development of gastric cancer. However, while progression to more severe damage is halted in those who have already developed, atrophic gastritis/gastric atrophy remain at risk for subsequent development of gastric cancer. That risk is directly related to the extent and severity of atrophic gastritis. Methods to stratify cancer risk include those based on endoscopic assessment of the atrophic border, histologic grading, and non-invasive methods based on serologic testing of pepsinogen levels. Continued surveillance is required because those with atrophic gastritis/gastric atrophy retain considerable gastric cancer risk even after H. pylori eradication. Those who have already experienced a resectable early gastric cancer are among those at highest risk as metachronous lesions are frequent even after H. pylorieradication. We review the role of H. pylori and effect of H. pylori eradication indicating the incidence and the predictive factors on development of metachronous cancer after endoscopic therapy of early gastric cancer. Studies to refine risk markers to stratify for risk, surveillance methods, intervals, and duration after successful H. pylori eradication, and whether adjuvant therapy would change risk are needed. | Akiko Shiotani Ken Haruma David Y Graham | 2014 | World Journal of Gastroenterology2014，20，33： | 5 |
| 4 | Hepatitis B:Who should be treated?-managing patients with chronic hepatitis B during the immune-tolerant and immunoactive phases显示文摘New hepatitis B virus(HBV)infections are decreasing owing to improved antiviral therapy and increased HBV vaccination worldwide;however,the number of HBV infections remains a major cause of liver carcinogenesis.HBV triggers cytotoxic immunity to eliminate HBV-infected cells.Therefore,the HBV pathophysiology changes in persistently infected individuals depending on host immune responses and HBV DNA proliferation state.To prevent liver cirrhosis and carcinogenesis caused by HBV,it is important to treat HBV infection at an early stage.Active treatment is recommended for the immunoactive hepatitis B surface-antigen-positive and-negative phase,but not during the immune-inactive phase or immune-tolerant phase;instead,follow-up is recommended.However,these patients should be monitored through regular blood tests to accurately diagnose the immune-inactive or-tolerant phases.The treatment regimen should be determined based on the age,sex,family history of liver cancer,and liver fibrosis status of patients.Early treatment is often recommended due to various problems during the immune-tolerant phase.This review compares the four major international practice guidelines,including those from the Japanese Society of Hepatology,and discusses strategies for chronic hepatitis B treatment during the immune-tolerant,immune-inactive,and resolved phases.Finally,recommended hepatitis B antiviral therapy and follow-up protocols are discussed. | Miwa Kawanaka Ken Nishino Hirofumi Kawamoto Ken Haruma | 2021 | World Journal of Gastroenterology2021，27，43： | 5 |
| 5 | Development and validation of a simple and multifaceted instrument,GERD-TEST,for the clinical evaluation of gastroesophageal reflux and dyspeptic symptoms显示文摘AIM To evaluate the psychometric properties of a newly developed questionnaire,known as the gastroesophageal reflux and dyspepsia therapeutic efficacy and satisfaction test(GERD-TEST),in patients with GERD.METHODS Japanese patients with predominant GERD symptoms recruited according to the Montreal definition were treated for 4 wk using a standard dose of proton pump inhibitor(PPI). The GERD-TEST and the Medical Outcome Study Short Form-8 Health Survey(SF-8) were administered at baseline and after 4 wk of treatment. The GERD-TEST contains three domains: the severity of GERD and functional dyspepsia(FD) symptoms(5 items),the level of dissatisfaction with daily life(DS)(4 items),and the therapeutic efficacy as assessed by the patients and medication compliance(4 items).RESULTS A total of 290 patients were eligible at baseline; 198 of these patients completed 4 wk of PPI therapy. The internal consistency reliability as evaluated using the Cronbach's α values for the GERD,FD and DS subscales ranged from 0.75 to 0.82. The scores for the GERD,FD and DS items/subscales were significantly correlated with the physical and mental component summary scores of the SF-8. After 4 wk of PPI treatment,the scores for the GERD items/subscales were greatly reduced,ranging in value from 1.51 to 1.87 and with a large effect size(P < 0.0001,Cohen's d; 1.29-1.63). Statistically significant differences in the changes in the scores for the GERD items/subscales were observed between treatment responders and non-responders(P < 0.0001).CONCLUSION The GERD-TEST has a good reliability,a good convergent and concurrent validity,and is responsive to the effects of treatment. The GERD-TEST is a simple,easy to understand,and multifaceted PRO instrument applicable to both clinical trials and the primary care of GERD patients. | Koji Nakada Nobuyuki Matsuhashi Katsuhiko Iwakiri Atsushi Oshio Takashi Joh Kazuhide Higuchi Ken Haruma | 2017 | World Journal of Gastroenterology2017，23，28： | 3 |
| 6 | Successful application of laparoscopic and endoscopic cooperative surgery (LECS) for a lateral-spreading mucosal gastric cancer显示文摘 | Souya Nunobe Naoki Hiki Takuji Gotoda Takahisa Murao Ken Haruma Hideo Matsumoto Toshihiro Hirai Shinya Tanimura Takeshi Sano Toshiharu Yamaguchi | 2012 | Gastric Cancer2012，，3： | 3 |
| 7 | Factors associated with complicated erosive esophagitis: A Japanese multicenter, prospective, cross-sectional study显示文摘AIM To assess the clinical characteristics of patients with complicated erosive esophagitis(EE) and their associated factors.METHODS This prospective, cross-sectional study included patients diagnosed with EE by upper gastrointestinal endoscopy between October 2014 and March 2015 at 106 Japanese hospitals. Data on medical history, general condition, gastrointestinal symptoms, lifestyle habits, comorbidities, and endoscopic findings were collected using a standard form to create a dedicated database. Logistic regression analysis was used to calculate adjusted odds ratios(aO R) and 95%CI for the association with complicated EE.RESULTS During the study period, 1749 patients diagnosed with EE, 38.3% of whom were prescribed proton pump inhibitors(PPIs) were included. Of them, 143(8.2%) had EE complications. Esophageal bleeding occurred in 84(4.8%) patients, esophageal strictures in 45(2.6%) patients, and 14(0.8%) patients experienced both. Multivariate analysis showed that increased age(a OR: 1.05; 95%CI: 1.03-1.08), concomitant use of psychotropic agents(a OR: 6.51; 95%CI: 3.01-13.61), and Los Angeles grades B(a OR: 2.69; 95%CI: 1.48-4.96), C(aO R: 15.38; 95%CI: 8.62-28.37), and D(aO R: 71.49; 95%CI: 37.47-142.01) were significantly associated with complications, whereas alcohol consumption 2-4 d/wk was negatively associated(a OR: 0.23; 95%CI: 0.06-0.61). Analyzing associated factors with each EE complication separately showed esophageal ulcer bleeding were associated with increased age(a OR: 1.05; 95%CI: 1.02-1.07) and Los Angeles grades B(aO R: 3.60; 95%CI: 1.52-8.50), C(a OR: 27.61; 95%CI: 12.34-61.80), and D(a OR: 119.09; 95%CI: 51.15-277.29), while esophageal strictures were associated with increased age(a OR: 1.07; 95%CI: 1.04-1.10), gastroesophageal reflux symptom(aO R: 2.51; 95%CI: 1.39-4.51), concomitantuse of psychotropic agents(a OR: 11.79; 95%CI: 5.06-27.48), Los Angeles grades C(aO R: 7.35; 95%CI: 3.32-16.25), and D(a OR: 20.34; 95%CI: 8.36-49.53) and long-segment Barrett's esophagus(a OR: 4.63; 95%CI: 1.64-13.05).CONCLUSION Aging and severe EE were common associated factors, although there were more associated factors in esophageal strictures than esophageal ulcer bleeding. Despite the availability and widespread use of PPIs, EE complications are likely to remain a problem in Japan owing to the aging population and high-stress society. | Masahiro Sakaguchi Noriaki Manabe Nobuo Ueki Jun Miwa Tomoki Inaba Norimasa Yoshida Kouichi Sakurai Masahiro Nakagawa Hajime Yamada Michiya Saito Koji Nakada Katsuhiko Iwakiri Takashi Joh Ken Haruma | 2017 | World Journal of Gastroenterology2017，23，2： | 3 |
| 8 | Randomized study of lafutidine vs lansoprazole in patients with mild gastroesophageal reflux disease显示文摘AIM: To compare the clinical efficacy of the secondgeneration H2 RA lafutidine with that of lansoprazole in Japanese patients with mild gastroesophageal reflux disease(GERD). METHODS: Patients with symptoms of GERD and a diagnosis of grade A reflux esophagitis(according to the Los Angeles classification) were randomized to receive lafutidine(10 mg, twice daily) or lansoprazole(30 mg, once daily) for an initial 8 wk, followed by maintenance treatment comprising half-doses of the assigned drug for 24 wk. The primary endpoint was the frequency and severity of heartburn during initial and maintenance treatment. The secondary endpoints were the sum score of questions 2 and 3 in the Gastrointestinal Symptom Rating Scale(GSRS), and the satisfaction score.RESULTS: Between April 2012 and March 2013, a total of 53 patients were enrolled, of whom 24 and 29 received lafutidine and lansoprazole, respectively. After 8 wk, the frequency and severity of heartburn was significantly reduced in both groups. However, lafutidine was significantly inferior to lansoprazole with regard to the severity of heartburn during initial and maintenance treatment(P = 0.016). The sum score of questions 2 and 3 in the GSRS, and satisfaction scores were also significantly worse in the lafutidine group than the lansoprazole group(P = 0.0068 and P = 0.0048, respectively).CONCLUSION: The clinical efficacy of lafutidine was inferior to that of lansoprazole, even in Japanese patients with mild GERD. | Ryuta Takenaka Hiroyuki Okada Seiji Kawano Yoshinori Komazawa Fumiya Yoshinaga Shinji Nagata Masafumi Inoue Hirohisa Komatsu Seiji Onogawa Yoshinori Kushiyama Shinichi Mukai Hiroko Todo Hideharu Okanobu Noriaki Manabe Shinji Tanaka Ken Haruma Yoshikazu Kinoshita | 2016 | World Journal of Gastroenterology2016，22，23： | 2 |
| 9 | Reduction in gastric cancer mortality by screening based on serum pepsinogen concentration: A case-control study显示文摘 | Masaharu Yoshihara Toru Hiyama Shigeto Yoshida Masanori Ito Shinji Tanaka Yoshiyuki Watanabe Ken Haruma | 2007 | Scandinavian Journal of Gastroenterology2007，，6： | 2 |
| 10 | Clinical significance of vascular endothelial growth factor C expression and angiogenesis at the deepest invasive site of advanced colorectal carcinoma显示文摘 | Furudoi A Tanaka S Haruma K | | 0，，： | 2 |
| 11 | A double-blind, controlled study comparing lafutidine with placebo and famotidine in Japanese patients with mild reflux esophagitis显示文摘 | Shuichi Ohara Ken Haruma Yoshikazu Kinoshita Motoyasu Kusano | 2010 | Journal of Gastroenterology2010，，12： | 2 |
| 12 | Magnifying video endoscopy is useful to diagnose histologicai gastritis--applicable to the estimation of Helicobacter pylori(HP) eradication显示文摘 | Sunjin K Haruma K Ito N | 2001 | Gastrointest Endosc2001，53，： | 2 |
| 13 | H. pylori eradication did not improve dysregulation of specific oncogenic miRNAs in intestinal metaplastic glands显示文摘 | Akiko Shiotani Noriya Uedo Hiroyasu Iishi Takahisa Murao Tomoko Kanzaki Yoshiki Kimura Tomoari Kamada Hiroaki Kusunoki Kazuhiko Inoue Ken Haruma | 2012 | Journal of Gastroenterology2012，，9： | 2 |
| 14 | Signifiance of vessel count and vascular endothelial growth factor in human esophageal carcinomas显示文摘 | Kitadai Y Haruma K Tokuyomi T | 1998 | Clin Cancer Res1998，4，9： | 1 |
| 15 | Clinicopathologic features and endoscopic treatment of superficially spreading colorectal neoplasms larger than 20 mm 显示文摘 | Tanaka S Haruma K Oka S | 2001 | Gastrointest Endosc2001，54，7： | 1 |
| 16 | Clinicopathological significance of vascular endothelial growth factor (VEGF) - C in human esophageal squmous cell carcinoma显示文摘 | KITADAI Y AMIOKA T HARUMA K | 2001 | Int J Cancer2001，93，5： | 1 |
| 17 | Clinical significance of vascular endothelial growth factor C expression and angiogenesis at the deepest invasive site of advanced colorectal carcinoma 显示文摘 | Furodoi A Tanaka S Haruma K | 2002 | Oncology2002，62，2： | 1 |
| 18 | Significance of vessel count and vascular endothelial growth factor in human esophageal carcinomas显示文摘 | Kitadai Y Haruma K Tokutomi T | 1998 | Clin Cancer Res1998，4，9： | 1 |
| 19 | Correlation of ratio of serum pepsinogen Ⅰ and Ⅱ with prevalence of gastric cancer and adenoma in Japanese subjects显示文摘 | Yoshihara M Sumii K Haruma K | 1998 | Am J Gastroenterol1998，93，： | 1 |
| 20 | Clinical significance of vascular endothelial growth factor C expression and angiogenesis at thedeepest invasive site of advanced eoloreetal carcinoma显示文摘 | Furudoi A Tanaka S Haruma K | 2002 | Oneology2002，62，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员