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| 1 | Resected case of eosinophilic cholangiopathy presenting with secondary sclerosing cholangitis显示文摘Eosinophilic cholangiopathy is a rare condition characterized by eosinophilic infiltration of the biliary tract and causes sclerosing cholangitis.We report a patient with secondary sclerosing cholangitis with eosinophilic cholecystitis.A 46-year-old Japanese man was admitted to our hospital with jaundice. Computed tomography revealed dilatation of both the intrahepatic and extrahepatic bile ducts,diffuse thickening of the wall of the extrahepatic bile duct,and thickening of the gallbladder wall.Under the diagnosis of lower bile duct carcinoma,he underwent pyloruspreserving pancreatoduodenectomy and liver biopsy. On histopathological examination,conspicuous fibrosis was seen in the lower bile duct wall.In the gallbladder wall,marked eosinophilic infiltration was seen.Liver biopsy revealed mild portal fibrosis.He was diagnosed as definite eosinophilic cholecystitis with sclerosing cholangitis with unknown etiology.The possible etiology of sclerosing cholangitis was consequent fibrosis from previous eosinophilic infiltration in the bile duct.The clinicopathological findings of our case and a literature review indicated that eosinophilic cholangiopathy could cause a condition mimicking primary sclerosing cholangitis(PSC).Bile duct wall thickening in patientswith eosinophilic cholangitis might be due to fibrosis of the bile duct wall.Eosinophilic cholangiopathy might be confused as PSC with eosinophilia. | Fumihiko Miura Takehide Asano Hodaka Amano Masahiro Yoshida Naoyuki Toyota Keita Wada Kenichiro Kato Tadahiro Takada Junichi Fukushima Fukuo Kondo Hajime Takikawa | 2009 | World Journal of Gastroenterology2009，15，11： | 4 |
| 2 | Arterio-biliary fistula as rare complication of chemoradiation therapy for intrahepatic cholangiocarcinoma显示文摘Significant hemobilia due to arterio-biliary fistula is a very rare complication of chemoradiation therapy(CRT) for unresectable intrahepatic cholangiocarcinoma(ICC).Here we report a case of arterio-biliary fistula after CRT for unresectable ICC demonstrated by angiographic examinations.This fistula was successfully treated by endovascular embolization.Hemobilia is a rare complication,but arterio-biliary fistula should be considered after CRT of ICC. | Koichi Hayano Fumihiko Miura Hodaka Amano Naoyuki Toyota Keita Wada Kenichiro Kato Tadahiro Takada Takehide Asano | 2010 | World Journal of Radiology2010，2，9： | 3 |
| 3 | Is pancreatectomy with arterial reconstruction a safe and useful procedure for locally advanced pancreatic cancer?显示文摘 | Hodaka Amano Fumihiko Miura Naoyuki Toyota Keita Wada Ken-ichirou Katoh Kouichi Hayano Susumu Kadowaki Makoto Shibuya Sawako Maeno Tomoaki Eguchi Tadahiro Takada Takehide Asano | 2009 | Journal of Hepato - Biliary - Pancreatic Surgery2009，，6： | 2 |
| 4 | Hemoperfusion with polymyxin B-immobilized fiber column improves liver function after ischemia-reperfusion injury显示文摘AIM:To investigate the usefulness of direct hemoperfusion with a polymyxin B-immobilized fiber column (DHP-PMX therapy)for warm hepatic ischemia-reperfusion(I/R)injury after total hepatic vascular exclusion (THVE)using a porcine model. METHODS:Eleven Mexican hairless pigs weighing 22-38 kg were subjected to THVE for 120 min and then observed for 360 min.The animals were divided into two groups randomly:the DHP-PMX group(n=5)underwent DHP-PMX at a flow rate of 80 mL/min for 120 min(beginning 10 min before reperfusion),while the control group did not(n=6).The rate pressure product (RPP):heart rate×end-systolic arterial blood pressure, hepatic tissue blood flow(HTBF),portal vein blood flow (PVBF),and serum aspartate aminotransferase(AST) levels were compared between the two groups. RESULTS:RPP and HTBF were significantly(P< 0.05)higher in the DHP-PMX group than in the control group 240 and 360 min after reperfusion.PVBF in the DHP-PMX group was maintained at about 70%of the flow before ischemia and differed significantly(P <0.05)compared to the control group 360 min after reperfusion.The serum AST increased gradually afterreperfusion in both groups,but the AST was significantly(P<0.05)lower in the DHP-PMX group 360 min after reperfusion. CONCLUSION:DHP-PMX therapy reduced the hepatic warm I/R injury caused by THVE in a porcine model. | Hiroaki Sato Kiyohiro Oshima Katsumi Kobayashi Hodaka Yamazaki Yujin Suto Izumi Takeyoshi | 2009 | World Journal of Gastroenterology2009，15，36： | 2 |
| 5 | Direct hemoperfusion with a polymyxin B-immobilized cartridge in intestinal warm ischemia reperfusion显示文摘AIM: To investigate the effectiveness of direct hemo- perfusion with polymyxin B-immobilized fibers (DHP- PMX therapy) on warm ischemia-reperfusion (I/R) injury of the small intestine. METHODS: The proximal jejunum and distal ileum of mongrel dogs were resected. Warm ischemia was performed by clamping the superior mesenteric artery (SMA) and vein (SMV) for 2 h. Blood flow to the proximal small intestine was restored 1 h after reperfusion, and the distal small intestine was used as a stoma. The experiment was discontinued 6 h after reperfusion. The dogs were divided into two groups: the DHP-PMX group (n = 6, DHP-PMX was performed for 180 min; from 10 min prior to reperfusion to 170 min after reperfusion) and the control group (n = 5). The rate pressure product (RPP), SMA blood flow, mucosal tissue blood flow, and intramucosal pH (pHi) were compared between the two groups. The serum interleukin (IL)-10 levels measured 170 min after reperfusion were also compared. RESULTS: The RPP at 6 h after reperfusion was significantly higher in the PMX group than in the control group (12 174 ± 1832 mmHg/min vs 8929 ± 1797 mmHg/min, P < 0.05). The recovery rates ofthe SMA blood flow at 1 and 6 h after reperfusion were significantly better in the PMX group than in the control group (61% ± 7% vs 44% ± 4%, P < 0.05, and 59% ± 5% vs 35% ± 5%, P < 0.05, respectively). The recovery rate of the mucosal tissue blood flow and the pHi levels at 6 h after reperfusion were significantly higher in the PMX group (61% ± 8% vs 31% ± 3%, P < 0.05 and 7.91 ± 0.06 vs 7.69 ± 0.08, P < 0.05, respectively). In addition, the serum IL-10 levels just before DHP-PMX removal were significantly higher in the PMX group than in the control group (1 569 ± 253 pg/mL vs 211 ± 40 pg/mL, P < 0.05). CONCLUSION: DHP-PMX therapy reduced warm I/R injury of the small intestine. IL-10 may play a role in inhibiting I/R injury during DHP-PMX therapy. | Hiroaki Sato Kazuhisa Arakawa Katsumi Kobayashi Hodaka Yamazaki Yujin Suto Izumi Takeyoshi Kiyohiro Oshima | 2008 | World Journal of Gastroenterology2008，14，35： | 2 |
| 6 | Integrating GPS trajectory and topics from Twitter stream for human mobility estimation显示文摘Understanding urban dynamics and large-scale human mobility will play a vital role in building smart cities and sustainable urbanization. Existing research in this domain mainly focuses on a single data source (e.g., GPS data, CDR data, etc.). In this study, we collect big and heterogeneous data and aim to investigate and discover the relationship between spatiotemporal topics found in geo-tagged tweets and GPS traces from smartphones. We employ Latent Dirichlet Allocation-based topic modeling on geo-tagged tweets to extract and classify the topics. Then the extracted topics from tweets and temporal population distribution from GPS traces are jointly used to model urban dynamics and human crowd flow. The experimental results and validations demonstrate the efficiency of our approach and suggest that the fusion of cross-domain data for urban dynamics modeling is more practical than previously thought. | Satoshi MIYAZAWA Xuan SONG Tianqi XIA Ryosuke SHIBASAKI Hodaka KANEDA | 2019 | Frontiers of Computer Science2019，13，3： | 2 |
| 7 | Diagnosis of biliary tract and ampullary carcinomas显示文摘 | Kazuhiro Tsukada Tadahiro Takada Masaru Miyazaki Shuichi Miyakawa Masato Nagino Satoshi Kondo Junji Furuse Hiroya Saito Toshio Tsuyuguchi Fumio Kimura Hideyuki Yoshitomi Satoshi Nozawa Masahiro Yoshida Keita Wada Hodaka Amano Fumihiko Miura | 2008 | Journal of Hepato - Biliary - Pancreatic Surgery2008，，1： | 1 |
| 8 | Analysis of microvessels in pancreatic cancer: by light microscopy, confocal laser scan microscopy, and electron microscopy显示文摘 | Kenji Takagi Tadahiro Takada Hodaka Amano Masahiro Yoshida Humihiko Miura Naoyuki Toyota Keita Wada Ichirou Takahashi | 2008 | Journal of Hepato - Biliary - Pancreatic Surgery2008，，4： | 1 |
| 9 | Endocrine disrupter nonylphenol and bisphenol A contamination in okinawa and ishigaki islands, Japan-within coral reefs and adjacent river mouths显示文摘 | Hodaka Kawahata | 2004 | Chemosphere2004，55，11： | 1 |
| 10 | A high peripheral microvessel density count correlates with a poor prognosis in pancreatic cancer显示文摘 | Kenji Takagi Tadahiro Takada Hodaka Amano | 2005 | Journal of Gastroenterology2005，，4： | 1 |
| 11 | Therapeutic intervention and surgery of acute pancreatitis显示文摘 | Hodaka Amano Tadahiro Takada Shuji Isaji Yoshifumi Takeyama Koichi Hirata Masahiro Yoshida Toshihiko Mayumi Eigoro Yamanouchi Toshifumi Gabata Masumi Kadoya Takayuki Hattori Masahiko Hirota Yasutoshi Kimura Kazunori Takeda Keita Wada Miho Sekimoto Seiki K | 2010 | Journal of Hepato-Biliary-Pancreatic Sciences2010，，1： | 1 |
| 12 | Insights into the pathogenesis of multiple system atrophy: focus on glial cytoplasmic inclusions显示文摘Multiple system atrophy(MSA)is a debilitating and fatal neurodegenerative disorder.The disease severity warrants urgent development of disease-modifying therapy,but the disease pathogenesis is still enigmatic.Neurodegeneration in MSA brains is preceded by the emergence of glial cytoplasmic inclusions(GCIs),which are insoluble α-synuclein accumulations within oligodendrocytes(OLGs).Thus,preventive strategies against GCI formation may suppress disease progression.However,although numerous studies have tried to elucidate the molecular pathogenesis of GCI formation,difficulty remains in understanding the pathological interaction between the two pivotal aspects of GCIs;asynuclein and OLGs.The difficulty originates from several enigmas:1)what triggers the initial generation and possible propagation of pathogenic α-synuclein species?2)what contributes to OLG-specific accumulation of α-synuclein,which is abundantly expressed in neurons but not in OLGs?and 3)how are OLGs and other glial cells affected and contribute to neurodegeneration?The primary pathogenesis of GCIs may involve myelin dysfunaion and dyshomeostasis of the oligodendroglial cellular environment such as autophagy and iron metabolism.We have previously reported that oligodendrocyte precursor cells are more prone to develop intracellular inclusions in the presence of extracellular fibrillary α-synuclein.This finding implies a possibility that the propagation of GCI pathology in MSA brains is mediated through the internalization of pathological α-synuclein into oligodendrocyte precursor cells.In this review,in order to discuss the pathogenesis of GCIs,we will focus on the composition of neuronal and oligodendroglial inclusions in synucleinopathies.Furthermore,we will introduce some hypotheses on how α-synuclein pathology spreads among OLGs in MSA brains,in the light of our data from the experiments with primary oligodendrocyte lineage cell culture.While various reports have focused on the mysterious source of α-synuclein in GCIs,insights into the mechanism which regulates the uptake of pathological α-synuclein into oligodendroglial cells may yield the development of the disease-modifying therapy for MSA.The interaction between glial cells and asynuclein is also highlighted with previous studies of post-mortem human brains,cultured cells,and animal models,which provide comprehensive insight into GCIs and the MSA pathomechanisms. | Seiji Kaji Takakuni Maki Tomoyuki Ishimoto Hodaka Yamakado Ryosuke Takahashi | 2020 | Translational Neurodegeneration2020，9，1： | 1 |
| 13 | Arsenic resistance aand removal by marine and non- marine bacteria显示文摘 | Mio Takeuchi Hodaka Kawhata Lalan Prasad Gupta | 2003 | Journal of Biotechnology2003，5，11： | 1 |
| 14 | Management of postoperative arterial hemorrhage after pancreato-biliary surgery according to the site of bleeding: re-laparotomy or interventional radiology显示文摘 | Fumihiko Miura Takehide Asano Hodaka Amano Masahiro Yoshida Naoyuki Toyota Keita Wada Kenichiro Kato Eriko Yamazaki Susumu Kadowaki Makoto Shibuya Sawako Maeno Shigeru Furui Koji Takeshita Yutaka Kotake Tadahiro Takada | 2009 | Journal of Hepato - Biliary - Pancreatic Surgery2009，，1： | 1 |
| 15 | Post-ERCP pancreatitis显示文摘 | Shinju Arata Tadahiro Takada Koichi Hirata Masahiro Yoshida Toshihiko Mayumi Morihisa Hirota Masamichi Yokoe Masahiko Hirota Seiki Kiriyama Miho Sekimoto Hodaka Amano Keita Wada Yasutoshi Kimura Toshifumi Gabata Kazunori Takeda Keisho Kataoka Tetsuhide It | 2010 | Journal of Hepato-Biliary-Pancreatic Sciences2010，，1： | 1 |
| 16 | New prognostic factor influencing long-term survival of patients with advanced gallbladder carcinoma显示文摘 | Fumihiko Miura Takehide Asano Hodaka Amano Naoyuki Toyota Keita Wada Kenichiro Kato Tadahiro Takada Hiroshi Takami Gaku Ohira Hisahiro Matsubara | 2010 | Surgery2010，，2： | 1 |
| 17 | Stenting and interventional radiology for obstructive jaundice in patients with unresectable biliary tract carcinomas显示文摘 | Toshio Tsuyuguchi Tadahiro Takada Masaru Miyazaki Shuichi Miyakawa Kazuhiro Tsukada Masato Nagino Satoshi Kondo Junji Furuse Hiroya Saito Masafumi Suyama Fumio Kimura Hideyuki Yoshitomi Satoshi Nozawa Masahiro Yoshida Keita Wada Hodaka Amano Fumihiko Miur | 2008 | Journal of Hepato - Biliary - Pancreatic Surgery2008，，1： | 1 |
| 18 | A new in-vitro drug sensitivity test (collagen-gel droplet embedded-culture drug sensitivity test) in carcinomas of pancreas and biliary tract: possible clinical utility显示文摘 | Hideki Yasuda Tadahiro Takada Keita Wada Hodaka Amano Takahiro Isaka Masahiro Yoshida Toyohiko Uchida Naoyuki Toyota | 1998 | Journal of Hepato - Biliary - Pancreatic Surgery1998，，3： | 1 |
| 19 | Does 'clonal progression' relate to the development of intraductal papillary mucinous tumors of the pancreas?显示文摘 | Keita Wada M.D. Tadahiro Takada M.D. Hideki Yasuda M.D. Hodaka Amano M.D. Masahiro Yoshida M.D. Maki Sugimoto M.D. Hiroshi Irie M.D | 2004 | Journal of Gastrointestinal Surgery2004，，3： | 1 |
| 20 | Repeated Pancreatectomy after Pancreatoduodenectomy显示文摘 | Fumihiko Miura Tadahiro Takada Hodaka Amano Masahiro Yoshida Takahiro Isaka Naoyuki Toyota Keita Wada Kenji Takagi Kenichoro Kato | 2007 | Journal of Gastrointestinal Surgery2007，，2： | 1 |
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