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| 1 | A complete sequence and comparative analysis of a SARS-associated virus(Isolate BJ01)显示文摘The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of transmission and pathogenesis, development of diagnostics, prevention by future vaccination, and treatment by developing new drugs. We report the complete genome sequence and comparative analysis of an isolate (BJ01) of the coronavirus that has been recognized as a pathogen for SARS. The genome is 29725 nt in size and has 11 ORFs (Open Reading Frames). It is composed of a stable region encoding an RNA-dependent RNA polymerase (composed of 2 ORFs) and a variable region representing 4 CDSs (coding sequences) for viral structural genes (the S, E, M, N proteins) and 5 PUPs (putative uncharacterized proteins). Its gene order is identical to that of other known coronaviruses. The sequence alignment with all known RNA viruses places this virus as a member in the family of Coronaviridae. Thirty putative substitutions have been identified by comparative analysis of the 5 SARS- associated virus genome sequences in GenBank. Fifteen of them lead to possible amino acid changes (non-synonymous mutations) in the proteins. Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to beinvolved in the immunoreactions between the virus and its host. Two amino acid changes have been detected in the Mprotein, which could be related to viral envelope formation. Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides noevidence that they are man-made. Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of otherpossible SARS-related pathogen(s). | QIN E'de ZHU Qingyu YU Man FAN Baochang CHANG Guohui SI Bingyin YANG Bao PENG Wenming JIANG Tao LIU Bohua DENG Yongqiang LIU Hong ZHANG Yu WANG Cui LI Yuquan GAN Yonghua LI Xiaoyu L Fushuang TAN Gang CAO Wuchun, YANG Ruifu Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, Beijing 100071, China WANG Jian, LI Wei, XU Zuyuan, LI Yan, WU Qingfa, LIN Wei, CHEN Weijun, TANG Lin, DENG Yajun, HAN Yujun, LI Changfeng, LEI Meng, LI Guoqing, LI Wenjie, L Hong, SHI Jianping, TONG Zongzhong, ZHANG Feng, LI Songgang, LIU Bin, LIU Siqi, DONG Wei, WANG Jun, Gane K-S Wong, YU Jun & YANG Huanming* Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300 National Center for Genome Information, Beijing 101300, China | 2003 | Chinese Science Bulletin2003，48，10： | 121 |
| 2 | Outcomes after arthroscopic repair of rotator cuff tears in the setting of mild to moderate glenohumeral osteoarthritis显示文摘BACKGROUND Rotator cuff pathology is a very common source of shoulder pain.Similarly,osteoarthritis of the glenohumeral joint can cause shoulder pain and produce similar symptoms.Surgical management can be indicated for both pathologies,however,outcomes data is limited when examining rotator cuff repair(RCR) in the setting of glenohumeral arthritis(GHOA).Thus,this study sought to determine outcomes for patients who undergo RCR in the setting of GHOA.AIM To evaluate if a relationship exists between outcomes of RCR in the setting of GHOA.METHODS This was a retrospective analysis of patients who underwent arthroscopic rotator cuff repair with concurrent glenohumeral osteoarthritis between 2010-2017.Patients were stratified based on rotator cuff tear size and glenohumeral osteoarthritis severity.Cohorts were paired 1:1 with patients without glenohumeral osteoarthritis.Patients included had a minimum two year follow-up.Rate of conversion to total shoulder arthroplasty,complication rates following initial surgery,and patient-reported outcome measures were collected.RESULTS A total of 142 patients were included.The number of patients that required total shoulder arthroplasty within two years after index surgery was low.2/71(2.8%) patients with GHOA,and 1/71(1.4%) without GHOA.Following rotator cuff repair,both groups showed favorable patientreported outcomes.CONCLUSION Patients with glenohumeral osteoarthritis who underwent arthroscopic rotator cuff repair showed comparable outcomes to patients without glenohumeral osteoarthritis. | Ian S Hong Allison J Rao Tyler L CarlLee Joshua D Meade Daniel J Hurwit Gregory Scarola David P Trofa Shadley C Schiffern Nady Hamid Patrick M Connor James E Fleischli Bryan Michael Saltzman | 2022 | World Journal of Orthopedics2022，13，7： | 2 |
| 3 | The spectral radius of trees on k pendent vertices显示文摘 | WU B F XIAO E L HONG Y | 2005 | Linear Algebra Appl2005，395，： | 1 |
| 4 | Wheat pentosans Ⅱ: estimating kernel hardness and pentosans in water extracts by Near-Infrared Reflectance 显示文摘 | Hong B H Rubenthater G L Allen R E | 1989 | Cereal Chem1989，66，5： | 1 |
| 5 | Wheat pentosans Ⅰ: cultivar variation and relationship to Kernel hardness 显示文摘 | Hong B H Rubent'hater G L Allen R E | 1989 | Cereal Chem1989，66，5： | 1 |
| 6 | Behavior of varied steel fi-ame connection types subjected to air blast, debris Impact, and/or post-blast progressive collapse load conditions 显示文摘 | Kams J E Houghton D L Hong J K | 2009 | Structures2009，，： | 1 |
| 7 | Anovelbiflavonoid from roots of glycyrrhiza uralensis cultivated in China 显示文摘 | Hong B A I Wei L I Kazuo K O K E | 2003 | Chemical and Pharmaceutical Bulletin2003，51，9： | 1 |
| 8 | Components of the heartwood of Populus euphratica from an ancient tomb 显示文摘 | Jian R L Hong E J You X Z | 2008 | Chem Nat Comp2008，44，1： | 1 |
| 9 | Low-carbon benefit analysis on IX} penetration distribution system显示文摘 | Shaoyun G E Li X U Hong L I U | | Journal of Modern Power Systems and Clean Energy0，3，13： | 1 |
| 10 | Evidence of missense muta-tions on the neuregulin-1 gene affecting function of prepulse inhi-bition显示文摘 | Hong L E Wonodi I Stine O C | 2008 | Biol Psychiatry2008，63，1： | 1 |
| 11 | The spectral radius of trees on k pendant vertices显示文摘 | WU B F XIAO E L HONG Y | 2005 | Linear Algebra Applications2005，395，： | 1 |
| 12 | Behavior of varied steel frame connection types subjected to air blast, debris Impact, and/or post-blast progressive collapse load conditions 显示文摘 | Karns J E Houghton D L Hong J K | 2009 | Structures2009，31，10： | 1 |
| 13 | Abolition of anaphylactic shock by Solanum lyratum THUNB 显示文摘 | Kang B Lee E Hong L | 1997 | Int J Immunopharmacol1997，19，11： | 1 |
| 14 | Structural, optical and photocatalytic properties of hafnium doped zinc oxide nanophoto- catalyst 显示文摘 | Ahmad M Ahmed E Hong Z L | 2013 | Ceram Int2013，39，8： | 1 |
| 15 | Im- proving the Efficiency and Efficacy of Controlled Sequen- tial Bifurcation for Simulation Factor Screening显示文摘 | Hong Wan Bruce E Ankenman Barry L Nelson | 2010 | In- forms Journal on Computing2010，22，3： | 1 |
| 16 | Dynamics of Internationalization and Out- ward Investment: Chinese Corporations' Strategies 显示文摘 | Hong E Sun L | 2006 | The China Quarterly2006，187，： | 1 |
| 17 | 显示文摘 | Colla E L Hong S Taylor D V | 1998 | Appl Phys Lett1998，72，： | 1 |
| 18 | The spectral radius of trees on к pendant vertices显示文摘 | WU B F XIAO E L HONG Y | 2005 | Linear Algebra Appl2005，395，： | 1 |
| 19 | The calpain system显示文摘 | Goll D E Thompson V F Hong Q L | 2003 | Physiol Rev2003，83，： | 1 |
| 20 | Overexpression of ABCAI re- duces amyloid deposition in the PDAPP mouse model of Alzheimer disease显示文摘 | Suzanne E Wahde L Hong J | 2008 | J Clin Invest2008，118，： | 1 |
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