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| 1 | Prevalence and evolution of drug resistance HIV-1 variants in Henan, China显示文摘To understand the prevalence and evolution of drug resistant HIV strains in Henan China after the implementation of free antiretroviral therapy for AIDS patients. 45 drug nave AIDS patients, 118 AIDS patients who received three months antiretroviral therapy and 124 AIDS patients who received six months antiretroviral treatment were recruited in the southern part of Henan province. Information on general condition, antiretroviral medicines, adherence and clinical syndromes were collected by face to face interview. Meanwhile, 14ml EDTA anticoagulant blood was drawn. CD4/CD8 T cell count, viral load and genotypic drug resistance were tested. The rates of clinical improvement were 55.1% and 50.8% respectively three months and six months after antiretroviral therapy. The mean CD4 cell count after antiretroviral therapy was significantly higher than in drug nave patients. The prevalence rate of drug resistant HIV strains were 13. 9%, 45.4% and 62.7% in drug nave patients, three month treatment patients and six month treatment patients, respectively. The number of resistance mutation codons and the frequency of mutations increased significantly with continued antiretroviral therapy. The mutation sites were primarily at the 103, 106 and 215 codons in the three-month treatment group and they increased to 15 codon mutations in the six-month treatment group. From this result, the evolution of drug resistant strains was inferred to begin with the high level NNRTI resistant strain, and then develop low level resistant strains to NRTIs. The HIV strains with high level resistance to NVP and low level resistance to AZT and DDI were highly prevalent because of the AZT+DDI+NVP combination therapy. These HIV strains were also cross resistant to DLV, EFV, DDC and D4T. Poor adherence to therapy was believed to be the main reason for the emergence and prevalence of drug resistant HIV strains. The prevalence of drug resistant HIV strains was increased with the continu- ation of antiretroviral therapy in the southern part of Henan province. Measures, that could promote high level adherence, provide new drugs and change ART regimens in failing patients, should be implemented as soon as possible. | Jing Yun LI Han Ping LI Lin LI Hong LI Zhe WANG Kun YANG Zuo Yi BAO Dao Min ZHUANG Si Yang LIU Yong Jian LIU Hui XING Yi Ming SHAO | 2005 | Cell Research2005，15，11： | 34 |
| 2 | Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients显示文摘Human infection with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)causes coronavirus disease 2019(COVID-19)and there is no cure currently.The 3CL protease(3CLpro)is a highly conserved protease which is indispensable for CoVs replication,and is a promising target for development of broad-spectrum antiviral drugs.In this study we investigated the anti-SARS-CoV-2 potential of Shuanghuanglian preparation,a Chinese traditional patent medicine with a long history for treating respiratory tract infection in China.We showed that either the oral liquid of Shuanghuanglian,the lyophilized powder of Shuanghuanglian for injection or their bioactive components dose-dependently inhibited SARS-CoV-23CLpro as well as the replication of SARS-CoV-2 in Vero E6 cells.Baicalin and baicalein,two ingredients of Shuanghuanglian,were characterized as the first noncovalent,nonpeptidomimetic inhibitors of SARS-CoV-23CLpro and exhibited potent antiviral activities in a cell-based system.Remarkably,the binding mode of baicalein with SARS-CoV-23CLpro determined by X-ray protein crystallography was distinctly different from those of known 3CLpro inhibitors.Baicalein was productively ensconced in the core of the substrate-binding pocket by interacting with two catalytic residues,the crucial S1/S2 subsites and the oxyanion loop,acting as a“shield”in front of the catalytic dyad to effectively prevent substrate access to the catalytic dyad within the active site.Overall,this study provides an example for exploring the in vitro potency of Chinese traditional patent medicines and effectively identifying bioactive ingredients toward a specific target,and gains evidence supporting the in vivo studies of Shuanghuanglian oral liquid as well as two natural products for COVID-19 treatment. | Hai-xia Su Sheng Yao Wen-feng Zhao Min-jun Li Jia Liu Wei-juan Shang Hang Xie Chang-qiang Ke Hang-chen Hu Mei-na Gao Kun-qian Yu Hong Liu Jing-shan Shen Wei Tang Lei-ke Zhang Geng-fu Xiao Li Ni Dao-wen Wang Jian-ping Zuo Hua-liang Jiang Fang Bai Yan Wu Yang Ye Ye-chun Xu | 2020 | Acta Pharmacologica Sinica2020，41，9： | 32 |
| 3 | Arabidopsis Transcription Factor Genes NF-YA 1, 5, 6, and 9 Play Redundant Roles in Male Gametogenesis, Embryogenesis, and Seed Development显示文摘原子因素 Y (NF-Y ) 是在所有真核细胞的有机体介绍的一个高度保存的抄写因素,并且是由三个子单元组成的 heterotrimer:NF -- 你, NF-YB,和 NF-YC。在 Arabidopsis,这三个子单元被 multigene 家庭编码。NF-Y 抄写因素的学习最好的成员是叶状的 COTYLEDON1 (LEC1 ) ,一个 NF-YB 家庭成员,哪个戏在 embryogenesis 的一个关键角色和种子成熟。然而,大多数 NF-Y 基因的功能留下逃犯。这里,我们在 NF 报导四基因的描述 -- 你家庭。我们发现 NF-YA1 的 gain-of-function 异种在男 gametogenesis 和 embryogenesis 显示出缺点。一致地, NF-YA1 的 overexpression, 5, 6,和 9 影响男 gametogenesis, embryogenesis,种子形态学,和种子萌芽,与更强壮的显型什么时候 overexpressing NF-YA1 和 NF-YA9。而且,这些 NF 的 overexpression -- 你基因也在不同的度在种子萌芽,延迟的幼苗生长,和迟了的 flowering 期间引起超敏性到 abscisic 酸(骆驼毛的织物) 。有趣地, NF-YA1 的 overexpression, 5, 6,和 9 是足够的从植物的纸巾导致体的胚胎的形成。然而,挑选或加倍这些 NF 的异种 -- 你基因没有可检测的显型。一起,这些结果提供证据那 NF-YA1, 5, 6,和 9 在男配偶体开发, embryogenesis,种子发展,和 germinative 以后生长起冗余的作用。 | Jinye Mu Helin Tan Sulei Hong Yan Liang Jianru Zuo | 2013 | Molecular Plant2013，6，1： | 24 |
| 4 | Malate transported from chloroplast to mitochondrion triggers production of ROS and PCD in Arabidopsis thaliana显示文摘规划房间死亡(PCD ) 是一个基本生物过程。在马赛克死亡 1 的缺乏(MOD1 ) ,质体局部性的 enoyl-ACP reductase,导致反应的氧种类(ROS ) 和 PCD 的累积,它能被 mitochondrial 建筑群压制我变化,从叶绿体显示一个信号到线粒体。然而,这个信号尚待被阐明。在这研究,通过克隆并且分析一系列 mod1 suppressors,我们揭示调整 mitochondrial ROS 和扳机 PCD 的产生的一条全面细胞器通讯小径。我们证明在 PLASTIDIAL NAD 依赖的 MALATE 脱氢酶(plNAD-MDH ) 的变化, chloroplastic DICARBOXYLATE TRANSPORTER 1 (DiT1 ) 并且(mMDH1 ) MITOCHONDRIAL MALATE 脱氢酶 1 能各在 mod1 救 ROS 累积和 PCD 显型,经由 malate 梭从叶绿体表明直接通讯到线粒体。进一步的研究证明这些元素在不同光周期条件下面在氧化还原作用动态平衡和植物生长起关键作用。而且,我们表明 ROS 水平和 PCD 显著地在房间,它能是戏剧性地稀释了由的对待 malate 的 HeLa 被增加人的基因 MDH2 击倒, Arabidopsis mMDH1 的 ortholog。这些结果揭开在植物和动物系统的一条保存导致 malate 的 PCD 小径,革命化我们在细胞器之间的通讯的理解。 | Yannan Zhao Lilan Luo Jiesi Xu Peiyong Xin Hongyan Guo Jian Wu Lin Bai Guodong Wang Jinfang Chu Jianru Zuo Hong Yu Xun Huang Jiayang Li | 2018 | Cell Research2018，28，4： | 24 |
| 5 | New precut sphincterotomy for endoscopic retrograde cholangiopancreatography in difficult biliary duct cannulation显示文摘AIM:To retrospectively investigate the effect and safety of various new type precut sphincterotomy techniques (VNTPST) in endoscopic retrograde cholangiopancreato-graphy (ERCP) due to difficult biliary duct cannulation (DBC). METHODS:A plough-like pull-type sphincterotome (PLPTS) or improved short nose sphincterotome or improved needle knife was applied. VNTPST was carried out in 30 of 280 patients,whose biliary tract could not be exposed well or deep cannulation was difficult to perform during ERCP with traditional methods. Patients were followed up for short-term complications and the therapeutic effect of VNTPS was observed and compared with that of traditional endoscopic sphincterotomy (EST). RESULTS:A total 280 patients underwent ERCP,of which 3 failed in operation because of pathological features in stomch or duodenum,247 successfully underwent traditional ERCP (89.1%,247/277),30 failed (10.8%,30/277). VNTPS technique succeeded in 24 (80%,24/30) of 30 cases. The successful rate of deep biliary duct cannulation increased 8.6% (24/277),the total cannulation successful rate following precut was 97.7%. There was a significant difference between the two groups (97.7% vs 89.1%,χ2 = 17.1,P < 0.01). The incidence of complications was 9.3% (26/277) for traditional ERCP group and 13.3% (4/30) for VNTPS technique group. Guideline tip was broken in pancreatic duct (KPDGP) of one patient,and there was no pancreatitis,slight or moderate bleeding postoperatively occurred in 2 patients,1 patient had bleeding during operation (PDWN). There were no differences between VNTPS technique group and traditional ERCP (TRERCP)group (13.3% vs 9.3%,χ2 = 0.478,P > 0.05). CONCLUSION:VNTPS procedure and Deng's precut are highly effective methods to get biliary access during ERCP with DBC. With skillful techniques,it can increase the successful rate for deep cannulation of biliary duct and decrease complications. VNTPS technique,especially Deng's precut is as effective and safe as EST. This technique can be well performed in hospitals without particular equipments. | Deng-Hao Deng Hong-Nei Zuo Jia-Feng Wang Zhi-E Gu Hong Chen Yuan Luo Ming Chen Wen-Nuo Huang Lu Wang Wei Lu | 2007 | World Journal of Gastroenterology2007，13，32： | 20 |
| 6 | Inhibitory effects of miRNA-200c on chemotherapy-resistance and cell proliferation of gastric cancer SGC7901/DDP cells显示文摘Background and Objective: miRNA-200c can not only inhibit the aggressiveness of cancer cells but also increase the sensitivity of cells to antitumor drugs. However, some mechanisms are still unclear. Recent researches revealed that E-cadherin is more than an inhibitor of metastasis, and it also plays important roles in reversing drug resistance. We had previously found that miRNA-200c could not only induce the expression of E-cadherin but also increase the sensitivity of gastric cancer SGC7901/DDP cells to cisplatin (DDP). This study aimed to explore the effects of miRNA-200c on biological characteristics of SGC7901/DDP cells and the roles of E-cadherin in the regulatory pathway of miRNA-200c. Methods: SGC7901/DDP cells and its parental cell line SGC7901 cells were transfected with miRNA-200c precursor (Pre-200c) and E-cadherin siRNA, respectively. Real-time RT-PCR was used to detect miRNA-200c expression after transfection with Pre-200c in SGC7901/DDP cell line. Drug sensitivities to DDP, 5-fluorouracil (5-FU), paclitaxel, and adriamycin (ADR) after transfection were tested using MTT assay. The proliferation of SGC7901/DDP cells was also detected after transfection. The protein changes of E-cadherin, Bax, and Bcl-2 after transfection were detected by Western blot. Results: The miRNA-200c expression in SGC7901/DDP cells after transfection of Pre-200c was 7.128 ± 0.159 times of that in negative control (P < 0.05). The IC50 of DDP, 5-FU, paclitaxel, and ADR in Pre-200c-transfected group were significantly lower than that in negative control group (P < 0.05). Compared to the control group, cell proliferation was significantly decreased (P < 0.05). The relative protein expressions of E-cadherin and Bax in Pre-200c-transfected group were significantly higher than those in negative control group (P < 0.05), whereas Bcl-2 was significantly lower than that in control (P < 0.05). Additionally, E-cadherin protein expression was significantly inhibited after transfected with E-cadherin siRNA in SGC7901 cells. The Bax protein expression was significantly down-regulated by E-cadherin siRNA (P < 0.05), whereas the Bcl-2 expression was significantly up-regulated (P < 0.05). Conclusion: miRNA-200c can indirectly regulate apoptosis through E-cadherin in SGC7901/DDP cells, which may be a possible mechanism of miRNA-200c in reversing drug resistance and inhibiting proliferation. | Yong Chen Jing Zuo Ying Liu Hong Gao Wei Liu | 2010 | Chinese Journal of Cancer2010，29，12： | 18 |
| 7 | Chinese expert consensus statement on the diagnosis and treatment of fulminant myocarditis显示文摘Fulminant myocarditis is primarily caused by infection with any number of a variety of viruses. It arises quickly, progresses rapidly, and may lead to severe heart failure or circulatory failure presenting as rapid-onset hypotension and cardiogenic shock,with mortality rates as high as 50%–70%. Most importantly, there are no treatment options, guidelines or an expert consensus statement. Here, we provide the first expert consensus, the Chinese Society of Cardiology Expert Consensus Statement on the Diagnosis and Treatment of Fulminant Myocarditis, based on data from our recent clinical trial(NCT03268642). In this statement, we describe the clinical features and diagnostic criteria of fulminant myocarditis, and importantly, for the first time,we describe a new treatment regimen termed life support-based comprehensive treatment regimen. The core content of this treatment regimen includes(i) mechanical life support(applications of mechanical respirators and circulatory support systems,including intraaortic balloon pump and extracorporeal membrane oxygenation),(ii) immunological modulation by using sufficient doses of glucocorticoid, immunoglobulin and(iii) antiviral reagents using neuraminidase inhibitor. The proper application of this treatment regimen may and has helped to save the lives of many patients with fulminant myocarditis. | Daowen Wang Sheng Li Jiangang Jiang Jiangtao Yan Chunxia Zhao Yan Wang Yexin Ma Hesong Zeng Xiaomei Guo Hong Wang Jiarong Tang Houjuan Zuo Li Lin Guanglin Cui Section of Precision Medicine Group of Chinese Society of Cardiology,Editorial Board of Chinese Journal of Cardiology &Working Group of Adult Fulminant Myocarditis | 2019 | Science China(Life Sciences)2019，62，2： | 18 |
| 8 | Numerical Calculation and Experimental Research on Residual Stresses in Precipitation-hardening Layer of NAK80 Steel for Shot Peening显示文摘Shot peening can improve fatigue strength of materials by creating compressive residual stress field in their surface layers,and offers a protection against crack initiation and propagation,corrosion,etc.And fatigue fracture and stress corrosion cracking of NAK80 steel parts are improved effectively.Currently there lacks in-depth research in which the beneficial effect of the residual stress may be offset by the surface damage associated with shot peening,especially in terms of the research on the effective control of shot peening intensity.In order to obtain the surface residual stress field of NAK80 steel after shot peening,the samples are shot peened by pneumatic shot peening machine with different rules.The residual stress in the precipitation-hardening layer of NAK80 steel is measured before and after a shot peening treatment by X-ray diffraction method.In order to obtain true residual stress field,integral compensation method is used to correct results.By setting up analytical model of the residual stress in the process of shot peening,the surface residual stress is calculated after shot peening,and mentioning the reason of errors occurred between calculated and experimental residual stresses,which is mainly caused by the measurement error of the shoot arc height.At the same time,micro hardness,microstructure and roughness in the precipitation-hardening layer of NAK80 steel before and after shot peening were measured and surveyed in order to obtain the relation between shot peening strength and surface quality in the precipitation-hardening layer.The results show that the surface quality of NAK80 steel is significantly improved by shot peening process.The over peening effect is produced when the shot peening intensity is too high,it is disadvantageous to improve sample's surface integrity,and leading to reduce the fatigue life.When arc high value of optimal shot peening is 0.40 mm,the surface quality is the best,and the depth of residual stress in the precipitation-hardening layer reaches to about 450 μm.Numerical calculation is very useful to define the process parameters when a specific residual stress profile is intended,either to quantify the benefits on a specific property like fatigue life or to help on modeling a forming process like shot peen forming.In particular,the proposed parameter optimization in the progress of shot peening and effective control of the surface texture provide new rules for the quantitative evaluations of shot peening surface modification of NAK80 steel. | MIAO Hong ZUO Dunwen WANG Min ZHANG Ruihong WANG Hongfeng | 2011 | Chinese Journal of Mechanical Engineering2011，24，3： | 17 |
| 9 | Microwave Exposure Impairs Synaptic Plasticity in the Rat Hippocampus and PC12 Cells through Over-activation of the NMDA Receptor Signaling Pathway显示文摘Objective The aim of this study is to investigate whether microwave exposure would affect the N-methyl-D-aspartate receptor(NMDAR) signaling pathway to establish whether this plays a role in synaptic plasticity impairment. Methods 48 male Wistar rats were exposed to 30 m W/cm2 microwave for 10 min every other day for three times. Hippocampal structure was observed through H&E staining and transmission electron microscope. PC12 cells were exposed to 30 m W/cm2 microwave for 5 min and the synapse morphology was visualized with scanning electron microscope and atomic force microscope. The release of amino acid neurotransmitters and calcium influx were detected. The expressions of several key NMDAR signaling molecules were evaluated. Results Microwave exposure caused injury in rat hippocampal structure and PC12 cells, especially the structure and quantity of synapses. The ratio of glutamic acid and gamma-aminobutyric acid neurotransmitters was increased and the intracellular calcium level was elevated in PC12 cells. A significant change in NMDAR subunits(NR1, NR2 A, and NR2B) and related signaling molecules(Ca2+/calmodulin-dependent kinase II gamma and phosphorylated c AMP-response element binding protein) were examined. Conclusion 30 m W/cm2 microwave exposure resulted in alterations of synaptic structure, amino acid neurotransmitter release and calcium influx. NMDAR signaling molecules were closely associated with impaired synaptic plasticity. | XIONG Lu SUN Cheng Feng ZHANG Jing GAO Ya Bing WANG Li Feng ZUO Hong Yan WANG Shui Ming ZHOU Hong Mei XU Xin Ping DONG Ji YAO Bin Wei ZHAO Li PENG Rui Yun | 2015 | Biomedical and Environmental Sciences2015，28，1： | 16 |
| 10 | Effects of long-term,low-dose sex hormone replacement therapy on hippocampus and cognition of postmenopausal women of different apoE genotypes显示文摘瞄准:学习效果长期,体积和在带 apolipoprotein E ( apoE )的绝经后的女人的马头鱼尾的怪兽的生物化学的变化上的低剂量的性荷尔蒙代替治疗( HRT )基因 epsilon 3 或 epsilon 4 .Methods :使用 HRT 的低剂量超过 4 年了的 83 个绝经后的女人作为 HRT 组被选择,并且当控制 group.ApoE 等位基因被 PCR.Magnetic 回声成像分析,有匹配的年龄和教育的 99postmenopausal 女人被注册被执行决定 brainhippocampus.Proton 的卷磁性的回声光谱学被用来在 apoE epsilon 在前面的 cingulate 外皮和马头鱼尾的怪兽检测生物化学的变化 4 并且 epsilon 3 个搬运人。六普通认知测试被用来做认知 function.Results 的全面评估: 有 4 个搬运人显示出的 apoE epsilon 的分析控制组的马头鱼尾的怪兽的卷是比 HRT 组的那些显著地低的。生物化学的分析证明有 N-acetylaspartate (NAA )/total 肌酸(tCr ) 和 myoinositol (mI ) 的减少的增加在在 HRT 的 4 个搬运人组织的 apoE epsilon 的马头鱼尾的怪兽的 /tCr,与控制组相比。为 apoEepsilon 3 个搬运人, HRT 组的最少的广场工具(LSMEAN ) 比控制 group.Conclusion 的高: 这研究证明长期的、低剂量 HRT 可能为在脆弱的绝经后的女人减少广告开发的风险是有益的。同时, HRT 能增加 apoE epsilon 的 LSMEAN 3 个搬运人。 | Yun YUE Ling HU Qin-jie TIAN Jing-mei JIANG Yi-long DONG Zheng-yu JIN yu-hang CHENG Xia HONG Qin-sheng GE Ping-ping ZUO | 2007 | Acta Pharmacologica Sinica2007，28，8： | 15 |
| 11 | Deficient plastidic fatty acid synthesis triggers cell death by modulating mitochondrial reactive oxygen species显示文摘 | Jian Wu Yuefeng Sun Yannan Zhao Jian Zhang Lilan Luo Meng Li Jinlong Wang Hong Yu Guifu Liu Liusha Yang Guosheng Xiong Jian-Min Zhou Jianru Zuo Yonghong Wang Jiayang Li | 2015 | Cell Research2015，25，5： | 13 |
| 12 | Relationship of microstructure transformation and hardening behavior of type 17-4 PH stainless steel显示文摘The relationship between the microstructure transformation of type 17-4 PH stainless steel and the aging hardening be- havior was investigated. The results showed that, when 17-4 PH stainless steel aging at 595°C, the bulk hardness of samples attains its peak value (42.5 HRC) for about 20 min, and then decreases at all time. TEM revealed the microstructure corresponding with peak hardness is that the fine spheroid-shape copper with the fcc crystal structure and the fiber-shape secondary carbide M23C6 precipitated from the lath martensite matrix. Both precipitations of copper and M23C6 are the reasons for strengthening of the alloy at this tem- perature. With the extension of holding time at this temperature, the copper and secondary carbide grow and lose the coherent rela- tionship with the matrix, so the bulk hardness of samples decreases. | Jun Wang Hong Zou Cong Li Ruling Zuo Shaoyu Qiu Baoluo Shen | 2006 | Journal of University of Science and Technology Beijing2006，13，3： | 10 |
| 13 | Temporal echocardiography findings in patients with fulminant myocarditis: beyond ejection fraction decline显示文摘The features of myocardial strains from speckle-tracking echocardiography (STE) have not been well defined in fulminant myocarditis (FM) patients.In this study,changes in the left ventricular ejection fraction (LVEF) and global and layer-specific myocardial strains over time were monitored.We aimed to determine the echocardiographic patterns of FM and ascertain their significance in FM treatment.Twenty patients who were clinically diagnosed with FM and received mechanical life support were prospectively enrolled.Conventional echocardiographic measurements were obtained,and serial strain echocardiography was performed from admission to hospital discharge until LVEF recovery (> 50%).Global/regional peak systolic longitudinal strains (GLS/RLS) and layer-specific longitudinal strains were quantified,and their changes with time were monitored in 14 FM patients.All patients had severely impaired cardiac function.Steep improvement in LVEF and GLS were observed within 6 days.Layer-specific strain analysis showed that reduction at admission or recovery at discharge in the endocardium and epicardium strains were equal.In conclusion,FM patients who received mechanical circulatory supports exhibited steep improvement in ventricular function within 6 days.The patchy and diffused distribution pattern of reduced RLS and equally and severely impaired strain in the endocardium and epicardium are valuable features in the diagnosis of FM. | Houjuan Zuo Rui Li Fei Ma Jiangang Jiang Kun Miao Haojie Li Eike Nagel Marijana Tadic Hong Wang Dao Wen Wang | 2020 | Frontiers of Medicine2020，14，3： | 10 |
| 14 | Mechanical properties of rock under coupled static-dynamic loads显示文摘Rock drilling machine,INSTRON testing system,and SHPB device are updated to investigate the characteristics of rocks at great depth,with high loads from overburden,tectonic stresses and dynamic impacts due to blasting and boring.It is verified that these testing systems can be used to study the mechanical properties of rock material under coupled static and dynamic loading condition and give useful guidance for the deep mining and underground cavern excavation.Various tests to determine the rock strength,fragmentation behavior,and energy absorption were conducted using the updated testing systems.It is shown that under coupled static-dynamic loads,if the axial prestress is lower than its elastic limit,the rock strength is higher than the individual static or dynamic strength.At the same axial prestress,rock strength under coupled loads rises with the increasing strain rates.Under coupled static and dynamic loads,rock is observed to fail with tensile mode.While shear failure may exist if axial prestress is high enough.In addition,it is shown that the percentage of small particles increases with the increasing axial prestress and impact load based on the analysis of the particle-size distribution of fragments.It is also suggested that the energy absorption ratio of a specimen varies with coupled loads,and the maximum energy absorption ratio for a rock can be obtained with an appropriate combination of static and dynamic loads. | Xibing Li Zilong Zhou Fujun Zhao Yujun Zuo Chunde Ma Zhouyuan Ye Liang Hong | 2009 | Journal of Rock Mechanics and Geotechnical Engineering2009，1，1： | 8 |
| 15 | A multidisciplinary,integrated approach for the elimination of schistosomiasis:a longitudinal study in a historically hyperendemic region in the lower reaches of the Yangtze River,China from 2005 to 2014显示文摘Background:Although great success has been achieved,schistosomiasis remains a major public health concern in China,and the remaining core endemic regions are concentrated along the middle and lower reaches of the Yangtze River.In this longitudinal study,we evaluated the effectiveness of a multidisciplinary,integrated approach for schistosomiasis elimination in a historically hyper-endemic region in the lower reaches of the Yangtze River,China over the 10-year period from 2005 through 2014.Methods:A three-step roadmap for schistosomiasis elimination was designed in the study site,and multidisciplinary,integrated interventions were implemented by the health,agriculture,water resources development,land and resources,and forestry sectors from 2005 to 2014,including chemotherapy for infected individuals,health education,management of the source of Schistosoma japonicum infection,and intermediate host snail control.The annual number of schistosomiasis patients,S.japonicum infection in humans,bovines and Oncomelania hupensis snails,and water infectivity were observed to assess the effectiveness of the multidisciplinary,integrated approach for the elimination of schistosomiasis.Results:There was a tendency towards a gradual decline in both the number of schistosomiasis cases and the prevalence of S.japonicum human infection across the study period from 2005 through 2014.No S.japonicum human infection was detected since 2012,and no acute infection was seen since 2006.During the study period,no infection was found in bovines,and a 0.03%overall infection rate was observed in O.hupensis snails.Since 2009,no infected snails were identified,and the area of both snail habitats and infected snail habitats appeared a reduction over the study period.Following the 3-year multidisciplinary,integrated control,infection control was achieved,and transmission control was achieved after 6-year implementation,with all infected snails and water infectivity eliminated;in addition,the 10-year implementation resulted in interruption of schistosomiasis transmission in the study site in 2014.Conclusions:The results of the present 10-year longitudinal study demonstrate that the multidisciplinary,integrated approach is effective for the elimination of schistosomiasis as a public health problem in the lower reaches of the Yangtze River,China. | Le-Ping Sun Wei Wang Yin-Ping Zuo Qing-Biao Hong Guang-Lin Du Yu-Cai Ma Jian Wang Guo-Jing Yang Dao-Jian Zhu You-Sheng Liang | 2017 | Infectious Diseases of Poverty2017，6，1： | 8 |
| 16 | Inhibitive effects of chlortetracycline on performance of the nitritation-anaerobic ammonium oxidation(anammox)process and strategies for recovery显示文摘The short-and long-term effects of chlortetracycline(CTC) on the nitritation-anaerobic ammonium oxidation(anammox) process were evaluated. The half maximal inhibitory concentration of CTC in the batch tests of the nitritation-anammox process was 278.91 mg/L at an exposure time of 12 hr. The long-term effects of CTC on the process were examined in a continuous-flow nitritation-anammox reactor. Within 14 days, the nitrogen removal rate significantly decreased from 0.61 to 0.25 kg N/m^3/day with 60 mg/L CTC in the influent.The performance suppressed by CTC barely recovered, even after CTC was removed from the influent. Furthermore, the inhibition of CTC also reduced the relative abundance of ammonium oxidizing bacteria(AOB) and anaerobic ammonium oxidizing bacteria(An AOB)in the reactor, resulting in both a decreased amount of and an imbalance between AOB and An AOB. When fresh anammox sludge was reseeded into the nitritation-anammox reactor,the nitrogen removal rate recovered to 0.09 ± 0.03 kg N/m^3/day. | Hong Yao Huayu Li Jing Xu Lushen Zuo | 2018 | Journal of Environmental Sciences2018，30，8： | 8 |
| 17 | An integrated environmental improvement of marshlands:impact on control and elimination of schistosomiasis in marshland regions along the Yangtze River,China显示文摘Background:Schistosomiasis is a global snail-transmitted infectious disease of poverty.Transmission control had been achieved in China in 2015 after the control efforts for over 60 years.Currently,the remaining core regions endemic for Schistosoma japonicum are mainly located in the marshland and lake regions along the Yangtze River basin.Methods:During the period from 2001 through 2015,an integrated environmental improvement of the marshlands was carried out through the implementation of industrial,agricultural and resources development projects in Yizheng County along the Yangtze River.S.japonicum infection in humans,livestock and snails was estimated by serology,stool examination,hatching technique and microscopy during the 15-year study period to evaluate the effect of the integrated environmental improvement on control and elimination of schistosomiasis.Results:A 0.05%overall rate of S.japonicum infection was observed in snails during the 15-year study period,and no infected snails were detected since 2012.The overall prevalence of S.japonicum infection was 0.09%in humans during the study period,and no human infection was found since 2012.In addition,only 13 bovines were identified with S.japonicum infection in 2003 during the 15-year study period,and since 2004,no infection was found in livestock.Conclusion:The results of the present study demonstrate that the implementation of industrial,agricultural and water resources development projects,not only alters snail habitats in marshland regions,and promotes local economic development,which appears a win-to-win strategy to block the transmission of S.japonicum and accelerate socio-economic development along the Yangtze River. | Le-Ping Sun Wei Wang Yin-Ping Zuo Zheng-Qiu Zhang Qing-Biao Hong Guo-Jing Yang Hong-Ru Zhu You-Sheng Liang Hai-Tao Yang | 2017 | Infectious Diseases of Poverty2017，6，1： | 8 |
| 18 | Safety and efficacy of stent-assisted coiling for acutely ruptured wide-necked intracranial aneurysms:comparison of LVIS stents with laser-cut stents显示文摘Background:To compare the safety and efficacy of LVIS stent-assisted coiling with those of laser-cut stent-assisted coiling for the treatment of acutely ruptured wide-necked intracranial aneurysms.Methods:Patients with acutely ruptured wide-necked intracranial aneurysms treated with LVIS stent-assisted coiling(LVIS stent group)and laser-cut stent-assisted coiling(laser-cut stent group)were retrospectively reviewed from January 2014 to December 2017.Propensity score matching was used to adjust for potential differences in age,sex,aneurysm location,aneurysm size,neck width,Hunt-Hess grade,and modified Fisher grade.Perioperative procedure-related complications and clinical and angiographic follow-up outcomes were compared.Univariate and multivariate analyses were performed to determine the associations between procedure-related complications and potential risk factors.Results:A total of 142 patients who underwent LVIS stent-assisted coiling and 93 patients who underwent laser-cut stent-assisted coiling were enrolled after 1:2 propensity score matching.The angiographic follow-up outcomes showed that the LVIS stent group had a slightly higher complete occlusion rate and lower recurrence rate than the laser-cut stent group(92.7%vs 80.6%;3.7%vs 9.7%,P=0.078).The clinical outcomes at discharge and follow-up between the two groups demonstrated no significant differences(P=0.495 and P=0.875,respectively).The rates of intraprocedural thrombosis,postprocedural thrombosis,postoperative early rebleeding,and procedure-related death were 0.7%(1/142),1.4%(2/142),2.8%(4/142),and 2.1%(3/142)in the LVIS stent group,respectively,and 4.3%(4/93),2.2%(2/93),1.1%(1/93),and 3.2%(3/93)in the laser-cut stent group,respectively(P=0.082,0.649,0.651,and 0.683).Nevertheless,the rates of overall procedure-related complications and intraprocedural rupture in the LVIS stent group were significantly lower than those in the laser-cut stent group(5.6%vs 14.0%,P=0.028;0.7%vs 6.5%,P=0.016).Multivariate analysis showed that laser-cut stent-assisted coiling was an independent predictor for overall procedurerelated complications(OR=2.727,P=0.037);a history of diabetes(OR=7.275,P=0.027)and other cerebrovascular diseases(OR=8.083,P=0.022)were independent predictors for ischemic complications,whereas none of the factors were predictors for hemorrhagic complications.Conclusions:Compared with laser-cut stent-assisted coiling,LVIS stent-assisted coiling for the treatment of acutely ruptured wide-necked intracranial aneurysms could reduce the rates of overall procedure-related complications and intraprocedural rupture. | Gaici Xue Qiao Zuo Xiaoxi Zhang Haishuang Tang Rui Zhao Qiang Li Yibin Fang Pengfei Yang Bo Hong Yi Xu Qinghai Huang Jianmin Liu | 2021 | Chinese Neurosurgical Journal2021，7，2： | 8 |
| 19 | Low Cycle Fatigue and Strengthening Mechanism of Cold Extruded Large Diameter Internal Thread of Q460 Steel显示文摘高张力钢(LDITHSS ) 的内部线由传统的方法生产了的大直径总是有低精确性和短生活的问题。与传统的方法相比,冷挤出过程是一个有效工具认识到更高的精确性和长寿。LDITHSS 的低周期的疲劳性质被实验获得,并且疲劳裂缝的开始和繁殖被扫描电子显微镜(SEM ) 观察。基于机械性质,表面微观结构和剩余应力,冷渗出的大直径的加强的机制内部线(LDIT ) 被讨论。结果证明新谷物或亚谷物能在冷挤出期间由于谷物分割和谷物精炼在 LDIT 的表面上被形成。含纤维的结构是伸长并且在渗出的表面上沿着导致剩余的牙齿表面的正常方向优化了压缩应力出现。在冷挤出以后的 LDIT 的最大的紧张压力被发现是 192.55 kN。在低应力骑车下面,线上的收益压力增加,裂缝还原剂的繁殖率,吗疲劳生活因此与减少的表面谷物直径和生活增加到 45.539 的平均疲劳显著地被改进???蟳?寪螥??????蟳??鲢駻?媣??鯣???????????廩?仙哠??????矙璣???吗??????????????????蟳龢駻???????辧????????鲥?????焀?焘?焘?? | MIAO Hong MEI Qing YUAN Jingyun ZHENG Zaixiang JIN Yifu ZUO Dunwen | 2016 | Chinese Journal of Mechanical Engineering2016，29，3： | 7 |
| 20 | Effects of Shuanghuanglian oral liquids on patients with COVID-19:a randomized,open-label,parallel-controlled,multicenter clinical trial显示文摘We conducted a randomized,open-label,parallel-controlled,multicenter trial on the use of Shuanghuanglian(SHL),a traditional Chinese patent medicine,in treating cases of COVID-19.A total of 176 patients received SHL by three doses(56 in low dose,61 in middle dose,and 59 in high dose)in addition to standard care.The control group was composed of 59 patients who received standard therapy alone.Treatment with SHL was not associated with a difference from standard care in the time to disease recovery.Patients with 14-day SHL treatment had significantly higher rate in negative conversion of SARS-CoV-2 in nucleic acid swab tests than the patients from the control group(93.4%vs.73.9%,P=0.006).Analysis of chest computed tomography images showed that treatment with high-dose SHL significantly promoted absorption of inflammatory focus of pneumonia,which was evaluated by density reduction of inflammatory focus from baseline,at day 7(mean difference(95%CI),−46.39(−86.83 to−5.94)HU;P=0.025)and day 14(mean difference(95%CI),−74.21(−133.35 to−15.08)HU;P=0.014).No serious adverse events occurred in the SHL groups.This study illustrated that SHL in combination with standard care was safe and partially effective for the treatment of COVID-19. | Li Ni Zheng Wen Xiaowen Hu Wei Tang Haisheng Wang Ling Zhou Lujin Wu Hong Wang Chang Xu Xizhen Xu Zhichao Xiao Zongzhe Li Chene Li Yujian Liu Jialin Duan Chen Chen Dan Li Runhua Zhang Jinliang Li Yongxiang Yi Wei Huang Yanyan Chen Jianping Zhao Jianping Zuo Jianping Weng Hualiang Jiang Dao Wen Wang | 2021 | Frontiers of Medicine2021，15，5： | 7 |
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