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| 1 | A life support-based comprehensive treatment regimen dramatically lowers the in-hospital mortality of patients with fulminant myocarditis: a multiple center study显示文摘Fulminant myocarditis(FM) has unacceptable high mortality. This study aimed to evaluate the therapeutic efficacy of a life support-based comprehensive treatment regimen(LSBCTR), a completely novel treatment regimen, for FM. A total of 169 FM patients recruited from January 2008 to December 2018 were divided into two groups: patients receiving LSBCTR(81 cases),which includes(i) mechanical life support(positive pressure respiration, intra-aortic balloon pump with or without extracorporeal membrane oxygenation),(ii) immunomodulation therapy using sufficient doses of glucocorticoids and immunoglobulins, and(iii) application of neuraminidase inhibitors, and those receiving conventional treatment(88 cases). The endpoints were in-hospital death and heart-transplantation. Of all the population, 44 patients(26.0%) died in hospitals. Inhospital mortality was 3.7%(3/81) for LSBCTR group and 46.6%(41/88) for traditional treatment(P<0.001). Early application of LSBCTR, mechanical life support, neuraminidase inhibitors, and immunomodulation therapy significantly contributed to reduction in in-hospital mortality. This study describes a novel treatment regimen for FM patients that dramatically reduces inhospital mortality. Its generalization and clinical application will efficiently save lives although further optimization is needed.This study offers an insight that virus infection induced inflammatory waterfall results in cardiac injury and cardiogenic shock and is the therapeutic target. | Sheng Li Shengyong Xu Chenze Li Xiao Ran Guanglin Cui Mengying He Kun Miao Chunxia Zhao Jiangtao Yan Rutai Hui Ning Zhou Yan Wang Jiangang Jiang Jing Zhang Daowen Wang | 2019 | Science China(Life Sciences)2019，62，3： | 43 |
| 2 | Chinese expert consensus statement on the diagnosis and treatment of fulminant myocarditis显示文摘Fulminant myocarditis is primarily caused by infection with any number of a variety of viruses. It arises quickly, progresses rapidly, and may lead to severe heart failure or circulatory failure presenting as rapid-onset hypotension and cardiogenic shock,with mortality rates as high as 50%–70%. Most importantly, there are no treatment options, guidelines or an expert consensus statement. Here, we provide the first expert consensus, the Chinese Society of Cardiology Expert Consensus Statement on the Diagnosis and Treatment of Fulminant Myocarditis, based on data from our recent clinical trial(NCT03268642). In this statement, we describe the clinical features and diagnostic criteria of fulminant myocarditis, and importantly, for the first time,we describe a new treatment regimen termed life support-based comprehensive treatment regimen. The core content of this treatment regimen includes(i) mechanical life support(applications of mechanical respirators and circulatory support systems,including intraaortic balloon pump and extracorporeal membrane oxygenation),(ii) immunological modulation by using sufficient doses of glucocorticoid, immunoglobulin and(iii) antiviral reagents using neuraminidase inhibitor. The proper application of this treatment regimen may and has helped to save the lives of many patients with fulminant myocarditis. | Daowen Wang Sheng Li Jiangang Jiang Jiangtao Yan Chunxia Zhao Yan Wang Yexin Ma Hesong Zeng Xiaomei Guo Hong Wang Jiarong Tang Houjuan Zuo Li Lin Guanglin Cui Section of Precision Medicine Group of Chinese Society of Cardiology,Editorial Board of Chinese Journal of Cardiology &Working Group of Adult Fulminant Myocarditis | 2019 | Science China(Life Sciences)2019，62，2： | 18 |
| 3 | Synthesizing double haploid hexaploid wheat populations based on a spontaneous alloploidization process显示文摘加倍的 haploid (DH ) 人口在庄稼改进和基本研究对科学家和 breeders 有用。生产 DH 的当前的方法通常为为染色体加倍提取 haploids 和化学处理在 vitro 需要文化。这份报告为综合描述一个简单方法特别为由利用 meiotic 归还基因的 allopolyploid 种类的 DH (SynDH ) 。方法包含三个步骤:杂交将导致再结合,提取 haploids 的种间的杂交,和由 selfing 加倍种间的 F1s 的自发的染色体。这样生产的 DH 在对一个同类的背景的兴趣的染色体包含 recombinant 染色体。没有特殊设备或处理涉及 DH 生产,它能容易在任何繁殖或基因节目被使用。Triticum turgidum L。并且 Aegilops tauschii Coss,普通小麦(Triticum aestivum L.) 的二祖先的种和分子的标记被用来表明 SynDH 方法。 | Lianquan Zhang Li Zhang Jiangtao Luo Wenjie Chen Ming Hao Baolong Liu Zehong Yan Bo Zhang Huaigang Zhang Youliang Zheng Dengcai Liu Yang Yen | 2011 | Journal of Genetics and Genomics2011，38，2： | 5 |
| 4 | A targeted sequencing approach to find novel pathogenic genes associated with sporadic aortic dissection显示文摘Aortic dissection(AD) is a heterogeneous genetic disease of the aorta with high mortality and poor prognosis. However, only few genetic causes of AD have been explored till date. After conducting a broad literature review focused on identifying potential pathogenic pathways, we designed a panel containing 152 AD-associated genes to conduct massively parallel targeted nextgeneration sequencing of 702 sporadic aortic dissection patients and 163 matched healthy controls. After validation by Sanger sequencing, we identified 21 definitely pathogenic and 635 likely pathogenic variants in 61.25%(430/702) of patients. In these patients, 34.88%(150/430) harbored more than one variant that was either definitely or likely to be pathogenic. Among the candidate genes, we identified 546 likely pathogenic variants in 47.72%(335/702) of patients. Importantly, we identified 94 lossof-function(LOF) variants in 45 genes in AD patients, but only five LOF variants in the controls(P=1.34×10^(-4)). With a burden test, we highlighted RNF213 as an important new gene for AD pathogenesis. We also performed transcriptome sequencing of human aorta tissues to evaluate the expression levels of these newly identified genes. Our study has compiled a comprehensive genetic map of sporadic AD in the Han Chinese population. We believe it will facilitate risk predicting and genetic diagnosis of this severe disease in the future. | Zongzhe Li Chengming Zhou Lun Tan Peng Chen Yanyan Cao Xianqing Li Jiangtao Yan Hesong Zeng Dao-Wu Wang Dao-Wen Wang | 2018 | Science China(Life Sciences)2018，61，12： | 4 |
| 5 | Rolling up MXene sheets into scrolls to promote their anode performance in lithium-ion batteries显示文摘Although Ti3 C2 MXene sheets have attracted extensive attention in lithium-ion storage techniques,their restacking makes against and even hinders the Li ions diffusion within them,thereby decreasing the capacity as well as rate performance of conventional MXene anode.Here,for the first time,we roll up the Ti3 C2 Tx sheets into scrolls with unclosed topological structure and the interlayer galleries to alleviate the restacking problem.Thus,Ti3 C2 Tx scrolls as anode materials in lithium-ion batteries(LIBs)have higher capacity and better rate performance than Ti3 C2 Tx sheets.On the bases of these,high-capacity silicon nanoparticles are added during the rolling process to in-situ produce Ti3 C2 Tx/Si composite scrolls.The addition of 10%silicon nanoparticles shows the best overall improvement among capacity,rate capability and cyclic stability for Ti3 C2 Tx scrolls. | Jianing Meng Fangfang Zhang Li Zhang Lingyang Liu Jiangtao Chen Bingjun Yang Xingbin Yan | 2020 | Journal of Energy Chemistry2020，29，7： | 4 |
| 6 | Triple discriminator generative adversarial network for zero-shot image classification显示文摘One key challenge in zero-shot classification(ZSC)is the exploration of knowledge hidden in unseen classes.Generative methods such as generative adversarial networks(GANs)are typically employed to generate the visual information of unseen classes.However,the majority of these methods exploit global semantic features while neglecting the discriminative differences of local semantic features when synthesizing images,which may lead to sub-optimal results.In fact,local semantic information can provide more discriminative knowledge than global information can.To this end,this paper presents a new triple discriminator GAN for ZSC called TDGAN,which incorporates a text-reconstruction network into a dual discriminator GAN(D2GAN),allowing to realize cross-modal mapping from text descriptions to their visual representations.The text-reconstruction network focuses on key text descriptions for aligning semantic relationships to enable synthetic visual features to effectively represent images.Sharma-Mittal entropy is exploited in the loss function to make the distribution of synthetic classes be as close as possible to the distribution of real classes.The results of extensive experiments over the Caltech-UCSD Birds-2011 and North America Birds datasets demonstrate that the proposed TDGAN method consistently yields competitive performance compared to several state-of-the-art ZSC methods. | Zhong JI Jiangtao YAN Qiang WANG Yanwei PANG Xuelong LI | 2021 | Science China(Information Sciences)2021，64，2： | 4 |
| 7 | Variants of genes encoding collagens and matrix metalloproteinase system increased the risk of aortic dissection显示文摘Aortic dissection(AD) is a devastating,heterogeneous condition of aorta.The homeostasis between collagens and matrix metalloproteases(MMPs)/tissue inhibitors of MMPs(TIMPs) system in the extracellular matrix plays an important role for structure and functions of aorta.However,our knowledge on association between variants of genes in this system and pathogenesis of AD is very limited.We analyzed all yet known coding human genes of collagens(45 genes),MMPs/TIMPs(27genes) in 702 sporadic AD patients and in 163 matched healthy controls,by using massively targeted next-generation and Sanger sequencing.To define the pathogenesis of potential disease-causing candidate genes,we performed transcriptome sequencing and pedigree co-segregation analysis in some genes and generated Col5a2 knockout rats.We identified 257 pathogenic or likely pathogenic variants which involved 88.89%(64/72) genes in collagens-MMPs/TIMPs system and accounted for 31.05%(218/702) sporadic AD patients.In them,84.86%patients(185/218) carried one variant,12.84%two variants and 2.30%more than two variants.Importantly,we identified 52 novel probably pathogenic loss-of-function(LOF) variants(20 nonsense,16 frameshift,14 splice sites,one stop-loss,one initiation codon) in 11.06%(50/452) AD patients,which were absent in 163controls(P=2.5×10^(-5)).Transcriptome sequencing revealed that identified variants induced dyshomeostasis in expression of collagens-TIMPs/MMPs systems.The Col5α2^(-/-) rats manifested growth retardation and aortic dysplasia.Our study provides a first comprehensive map of genetic alterations in collagens-MMPs/TIMPs system in sporadic AD patients and suggests that variants of these genes contribute largely to AD pathogenesis. | Zongzhe Li Chengming Zhou Lun Tan Peng Chen Yanyan Cao Chenze Li Xianqing Li Jiangtao Yan Hesong Zeng Dao-Wu Wang Dao-Wen Wang | 2017 | Science China(Life Sciences)2017，60，1： | 4 |
| 8 | Trending IC design directions in 2022显示文摘For the non-stop demands for a better and smarter society, the number of electronic devices keeps increasing exponentially;and the computation power, communication data rate, smart sensing capability and intelligence are always not enough. Hardware supports software, while the integrated circuit(IC) is the core of hardware. In this long review paper, we summarize and discuss recent trending IC design directions and challenges, and try to give the readers big/cool pictures on each selected small/hot topics. We divide the trends into the following six categories, namely, 1) machine learning and artificial intelligence(AI) chips, 2) communication ICs, 3) data converters, 4) power converters, 5) imagers and range sensors, 6) emerging directions. Hope you find this paper useful for your future research and works. | Chi-Hang Chan Lin Cheng Wei Deng Peng Feng Li Geng Mo Huang Haikun Jia Lu Jie Ka-Meng Lei Xihao Liu Xun Liu Yongpan Liu Yan Lu Kaiming Nie Dongfang Pan Nan Qi Sai-Weng Sin Nan Sun Wenyu Sun Jiangtao Xu Jinshan Yue Milin Zhang Zhao Zhang | 2022 | Journal of Semiconductors2022，43，7： | 3 |
| 9 | DC-CIK联合化疗治疗非小细胞肺癌的临床疗效评价(英文)显示文摘Objective: The aim of the study was to evaluate the safety and therapeutic effects of autologous dendritic cells co-cultured with cytokine-induced killer cells (DC-CIK) combined with chemotherapy in advanced non-small cell lung cancer (NSCLC) patients. Methods: Fifty patients with advanced NSCLC (stages III to IV), who had received therapies in our Center (Department of Biotherapy, Affiliated to Cancer Hospital of Shanxi Medical University, Taiyuan, China) from August 2008 to January 2010, were treated by DC-CIK + chemotherapy as the combined treatment group; fifty advanced NSCLC patients treated with chemotherapy at the same time served as controls. The immunologic function, short-term therapeutic effects, the 1-year survival rate, the life quality, the chemotherapy side effects were compared between the two groups, the safety and therapeutic effects of DC-CIK cells therapy were observed too. Results: There was no obvious change of subsets of T cells in peripheral blood before and after therapy in DC-CIK + chemotherapy group, and IFN-γ was improved after therapy in this group (P < 0.05); in chemotherapy alone group, the ratios of CD3+CD4+, CD3+CD8+, CD3-CD56+ cells and the secretion of IL-2, TNF-α decreased significantly after therapy (P < 0.05); the ratios of CD3+CD8+, CD3+CD56+ were improved after cell culture (P < 0.05). The disease control rate (DCR) of DC-CIK + chemotherapy group was higher than that in the chemotherapy alone group (78.0% vs 56.0%, P < 0.05); the 1-year survival rates of DC-CIK + chemotherapy group and chemotherapy alone group were 50% and 44% respectively, had no significant difference. Compared with chemotherapy alone group, the occurrence of chemotherapy side effects (including bone marrow suppression, nausea and vomiting, peripheral nerve toxicity) was less in the DC-CIK + chemotherapy group (P < 0.05). The physical and appetite were better in DC-CIK + chemotherapy group after therapy. Conclusion: To compare with simple chemotherapy, DC-CIK + chemotherapy for advanced NSCLC is safe and effective, and it can improve patients' life quality and remission rate, and prolong their survival time. | Junping Zhang Guanghua Mao Yaping Han Xiaoling Yang Huijing Feng Linzi Jia Ting Zhi Yan Xiao Libin Zhang Jiangtao Wang Tianliang Shi | 2012 | The Chinese-German Journal of Clinical Oncology2012，11，2： | 3 |
| 10 | Where do flare ribbons stop?显示文摘The standard flare model,which was proposed based on observations and magnetohydrodynamic theory,can successfully explain many observational features of solar flares.However,this model is just a framework,with many details awaiting to be filled in, including how reconnection is triggered.In this paper,we address an unanswered question:where do flare ribbons stop?With the data analysis of the 2003 May 29 flare event,we tentatively confirmed our conjecture that flare ribbons finally stop at the intersection of separatrices(or quasi-separatrix layer in a general case)with the solar surface.Once verified,such a conjecture can be used to predict the final size and even the lifetime of solar flares. | CHEN PengFei SU JiangTao GUO Yan DENG YuanYong | 2012 | Chinese Science Bulletin2012，57，12： | 2 |
| 11 | Excellent adsorption and desorption characteristics of polypyrrole/TiO 2 composite for Methylene Blue显示文摘 | Jingjing Li Jiangtao Feng Wei Yan | 2013 | Applied Surface Science2013，，： | 2 |
| 12 | An imputed whole-genome sequence-based GWAS approach pinpoints causal mutations for complex traits in a specific swine population显示文摘Sequencing-based genome-wide association studies(GWAS) have facilitated the identification of causal associations between genetic variants and traits in diverse species. However, it is cost-prohibitive for the majority of research groups to sequence a large number of samples. Here, we carried out genotype imputation to increase the density of single nucleotide polymorphisms in a large-scale Swine F;population using a reference panel including 117 individuals, followed by a series of GWAS analyses. The imputation accuracies reached 0.89 and 0.86 for allelic concordance and correlation, respectively. A quantitative trait nucleotide(QTN) affecting the chest vertebrate was detected directly, while the investigation of another QTN affecting the residual glucose failed due to the presence of similar haplotypes carrying wild-type and mutant allelesin the reference panel used in this study. A high imputation accuracy was confirmed by Sanger sequencing technology for the most significant loci. Two candidate genes,CPNE5 and MYH3, affecting meat-related traits were proposed. Collectively, we illustrated four scenarios in imputation-based GWAS that may be encountered by researchers, and our results will provide an extensive reference for future genotype imputation-based GWAS analyses in the future. | Guorong Yan Xianxian Liu Shijun Xiao Wenshui Xin Wenwu Xu Yiping Li Tao Huang Jiangtao Qin Lei Xie Junwu Ma Zhiyan Zhang Lusheng Huang | 2022 | Science China(Life Sciences)2022，65，4： | 2 |
| 13 | The roles of graphene in advanced Li-ion hybrid supercapacitors显示文摘Lithium-ion hybrid supercapacitors(LIHSs), also called Li-ion capacitors, are electrochemical energy storage devices that combining the advantages of high power density of supercapacitor and high energy density of Li-ion battery. However, high power density and long cycle life are still challenges for the current LIHSs due to the imbalance of charge-storage capacity and electrode kinetics between capacitor-type cathode and battery-type anode. Therefore, great efforts have been made on designing novel cathode materials with high storage capacity and anode material with enhanced kinetic behavior for LIHSs. With unique two-dimensional form and numerous appealing properties, for the past several years, the rational designed graphene and its composites materials exhibit greatly improved electrochemical performance as cathode or anode for LIHSs. Here, we summarized and discussed the latest advances of the stateof-art graphene-based materials for LIHSs applications. The major roles of graphene are highlighted as(1) a superior active material,(2) ultrathin 2D flexible support to remedy the sluggish reaction of the metal compound anode, and(3) good 2D building blocks for constructing macroscopic 3D porous carbon/graphene hybrids. In addition, some high performance aqueous LIHSs using graphene as electrode were also summarized. Finally, the perspectives and challenges are also proposed for further development of more advanced graphene-based LIHSs. | Junwei Lang Xu Zhang Bao Liu RutaoWang Jiangtao Chen Xingbin Yan | 2018 | Journal of Energy Chemistry2018，27，1： | 2 |
| 14 | Numerical study of fluid flow and heat transfer in micro-channel cooling passages显示文摘 | LIU Jiangtao PENG Xiaofeng YAN Weimon | 2007 | International Journal of Heat and Mass Transfer2007，50，910： | 1 |
| 15 | Synthesis of PPy-modified TiO 2 composite in H 2 SO 4 solution and its novel adsorption characteristics for organic dyes显示文摘 | Jingjing Li Qian Zhang Jiangtao Feng Wei Yan | 2013 | Chemical Engineering Journal2013，，： | 1 |
| 16 | Excellent adsorp-tion and desorption characteristics of polypyrrole/Ti02composite for Methylene Blue 显示文摘 | Li Jingjing Feng Jiangtao Yan Wei | 2013 | Appl Surf Sci、2013，279，15： | 1 |
| 17 | Synthesis of polypyrrole mi- cro/nanofibers via a self-assembly process 显示文摘 | Feng Jiangtao Yan Wei Zhang Linzi | 2009 | Microchim Acta2009，166，： | 1 |
| 18 | Relationship of Purity Gradient and Accumulation with Feed Composition in Two-Component Countercurrent Extraction System显示文摘Accumulation,abasicparameterinsolventextractionproces,wasintroducedinthedynamicsimulation.Purityofproducts,acumulationofeac... | Jia, Jiangtao Yan, Chunhua Liao, Chunsheng Wang, Mingwen Li, Biaoguo | 1999 | Journal of Rare Earths1999，17，2： | 1 |
| 19 | Claw-shaped flexible and low-impedance conductive polymer electrodes for EEG recordings: Anemone dry electrode显示文摘Electroencephalogram(EEG) signals provide important brain information in healthcare settings. Wet electrodes have several limitations, including their time-consuming preparation and no long-term acquisition, and dry electrodes have become a promising candidate. However, dry electrodes face several challenges related to signal quality, comfort, conductivity and cost.This study aims to develop and evaluate a novel dry electrode for EEG recordings. The electrode material properties are characterized by electrochemical, mechanical force, and skin measurements. The electrode performance is evaluated by comparing the impedance, signal-to-noise ratio(SNR), and EEG signal features of the proposed electrode with those of a wet electrode and two commercial dry electrodes. The dry electrode design is based on the biological structure of the sea anemone and demonstrates an improved scalp fit and reduced signal noise and motion artifacts. The electrode materials include advanced conducting polymers combined with thermoplastic elastomers(TPEs) and carbon nanotubes(CNTs), which exhibit good electrical conductivity, mechanical properties, and safety. A low-cost injection molding fabrication method is proposed. The dry electrodes show a scalp contact impedance of 7 kΩ at 20 Hz, which is lower than that of wet and commercial dry electrodes.Resting-state EEG and event-related potential signals collected by the anemone dry electrode achieved more than 90% similarity with signals acquired by wet electrodes. Thus, a low-cost, comfortable anemone dry electrode that exhibits excellent EEG recording performance is presented. The anemone dry electrode represents an important technological advance in material and structural design for EEG recording sensors. | SHI ZhongYan JIANG Bo LIANG ShiChao ZHANG JiangTao SUO DingJie WU JingLong CHEN DuanDuan PEI GuangYing YAN TianYi | 2023 | Science China(Technological Sciences)2023，66，1： | 1 |
| 20 | Numerical study of fluid flow and heat transfer in micro-channel cooling passages显示文摘 | Liu Jiangtao Peng Xiaofeng Yan Weimon | 2007 | International Journal of Heat and Mass Transfer2007，50，910： | 1 |
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