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| 1 | DNA methylation and chromatin accessibility profiling of mouse and human fetal germ cells显示文摘染色质改变为人的初发的细菌房间的 epigenetic reprogramming 是重要的。然而,全面染色质状态还没为人的胎儿的细菌房间(FGC ) 被分析了。这里,我们使用 nucleosome 占有和 methylation 定序方法在人和老鼠在胎儿的细菌房间开发期间在一系列关键时间点分析染色体宽的染色质可接近性和 DNA methylome。我们在人和老鼠 FGC 发现 116 887 和 137 557 个弄空 nucleosome 的区域(NDR ) ,盖住 germline 特定、高度有活力的规章的 genomic 元素的一个大集合,例如 enhancers。而且,我们发现远侧的 NDR 在人的 FGC 为象 NANOG , SOX17 , AP2 和 OCT4 那样的 pluripotency 和细菌房间主人管理者的有约束力的主题明确地被充实,显示在pluripotency相关的基因和细菌之间的精细的规章的平衡的存在在人的 FGC 的房间特定的基因,并且为在 vivo 的细菌房间开发的这些基因的功能的意义。我们的工作为把提供一张全面、高分辨率的路线图染色质状态转变动力学在人和老鼠 FGC 的 epigenomic reprogramming 期间。 | Hongshan Guo Boqiang Hu Liying Yan Jun Yong Yan Wu Yun Gao Fan Guo Yu Hou Xiaoying Fan Ji Dong Xiaoye Wang Xiaohui Zhu Jie Yan Yuan Wei Hongyan Jin Wenxin Zhang Lu Wen FuchouTang Jie Qiao | 2017 | Cell Research2017，27，2： | 9 |
| 2 | Robust adaptive tracking control of robotic systems with uncertainties显示文摘To deal with the uncertainty factors of robotic systems,a robust adaptive tracking controller is proposed. The knowledge of the uncertainty factors is assumed to be unidentified; the proposed controller can guarantee robustness to parametric and dynamics uncertainties and can also reject any bounded,immeasurable disturbances entering the sys-tem. The stability of the proposed controller is proven by the Lyapunov method. The proposed controller can easily be implemented and the stability of the closed system can be ensured; the tracking error and adaptation parameter error are uniformly ultimately bounded (UUB). Finally,some simulation examples are utilized to illustrate the control performance. | Yaonan WANG Jinzhu PENG Wei SUN Hongshan YU Hui ZHANG | 2008 | 控制理论与应用(英文版)2008，6，3： | 4 |
| 3 | Homeobox B8 Targets Sterile Alpha Motif Domain-Containing Protein 9 and Drives Glioma Progression显示文摘Gliomas are the most commonly occurring tumors of the central nervous system. Glioblastoma multiforme (GBM) is the most malignant and aggressive brain cancer in adults. Further understanding of the mechanisms underlying the aggressive nature of GBM is urgently needed. Here we identified homeobox B8(HOXB8), a member of the homeobox family, as a crucial contributor to the aggressiveness of GBM. Data mining of publicly accessible RNA sequence datasets and our patient cohorts confirmed a higher expression of HOXB8 in the tumor tissue of GBM patients, and a strong positive correlation between the expression level and pathological grading of tumors and a negative correlation between the expression level and the overall survival rate. We next showed that HOXB8 promotes the proliferation and migration of glioblastoma cells and is crucial for the activation of the PI3K/AKT pathway and expression of epithelial–mesenchymal transition-related genes, possibly through direct binding to the promoter of SAMD9 (Sterile Alpha Motif Domain-Containing Protein 9) and activating its transcription. Collectively, we identified HOXB8 as a critical contributor to the aggressiveness of GBM, which provides insights into a potential therapeutic target for GBM and opens new avenues for improving its treatment outcome. | Wenping Ma Hongze Jin Wenjie Liu Xiaojuan Li Xingang Zhou Xinwu Guo Runfa Tian Qi Cui Junjie Luo Yueying Jiao Youtao Yu Haifeng Yang Hongshan Zhao | 2020 | Neuroscience Bulletin2020，36，4： | 2 |
| 4 | Effective method for tracking multiple objects in real-time visual surveillance systems显示文摘An object model-based tracking method is useful for tracking multiple objects, but the main difficulties are modeling objects reliably and tracking objects via models in successive frames. An effective tracking method using the object models is proposed to track multiple objects in a real-time visual surveillance system. Firstly, for detecting objects, an adaptive kernel density estimation method is utilized, which uses an adaptive bandwidth and features combining colour and gradient. Secondly, some models of objects are built for describing motion, shape and colour features. Then, a matching matrix is formed to analyze tracking situations. If objects are tracked under occlusions, the optimal 'visual' object is found to represent the occluded object, and the posterior probability of pixel is used to determine which pixel is utilized for updating object models. Extensive experiments show that this method improves the accuracy and validity of tracking objects even under occlusions and is used in real-time visual surveillance systems. | Wang Yaonan Wan Qin Yu Hongshan | 2009 | Journal of Systems Engineering and Electronics2009，20，6： | 2 |
| 5 | Purification and characterization of gypenoside-α-L-rhanmosidase hydrolysing gypenoside-5 into gnsenoside Rd显示文摘 | YU Hongshan LIU Hai ZHANG Chunzhi | 2004 | Process Biochemistry2004，39，7： | 1 |
| 6 | Purification and characterization of ginsenoside-α-rhamnosidase显示文摘 | GONG Jinmei ZHANG Chunzhi | 2002 | Chem Pharm Bull2002，50，2： | 1 |
| 7 | Purification and characterization of ginsenoside-β-glucosidase from ginseng显示文摘 | YU Hongshan BAO Ynongming | 2001 | Chem Pharm Bull2001，49，7： | 1 |
| 8 | Purification and characterization of ginsenosidase hydrolyzing malti-glycosides of protopanaxadiol ginsenoside:ginsenoside type Ⅰ显示文摘 | ZHANG Chunzhi LU Mingchun | 2007 | Chem Pharm Bull2007，55，： | 1 |
| 9 | Purification and characterization of picied-β-glucosidase from Aspergillus niger显示文摘 | LI Dai YU Hongshan | 2007 | Process Biochem2007，42，： | 1 |
| 10 | A novel ginsenosidase from an Aspergillus strain hydrolyzing 6-O-multi-glycosides of protopanaxatriol-type ginsen- osides, named ginsenosidase type IV 显示文摘 | Wang Dortgrning Yu Hongshan Song Jiangguo | 2011 | J Microbiol Bio- technol2011，21，10： | 1 |
| 11 | Purification and characterization of dioscin-alpha-L-rharnnosidase from pig live显示文摘 | YU Hongshan ZHANG Chunzhi | 2005 | Chem Pharm Bull2005，53，8： | 1 |
| 12 | Purification and characterization of ginsenoside-α-L-rhamnosidase显示文摘 | GONG Jinmei ZHANG Chunzhi | 2002 | Chem Pharm Bull2002，50，2： | 1 |
| 13 | Enzyme synthesis of salidoside purification and characterization of salidosidase from Aspergillus niger显示文摘 | ZHANG Chunzhi YU Hongshan LU Mingchun | 2005 | Process Biochem2005，40，： | 1 |
| 14 | Purification and characterization of ginsenosidase hydrolyzing malti-glycosides of protopanaxadiol ginsenoside: ginsenoside type I 显示文摘 | YU Hongshan ZHANG Chunzhi LU Mingchun | 2007 | Chem Pharm Bull2007，55，： | 1 |
| 15 | A new gin- senosidase from Aspergillus strain hydrolyzing 20-O-multi-glyco- side of PPD ginsenoside 显示文摘 | Yu Hongshan Liu Qingmei Zhang Chunzhi | 2009 | Process Siochem2009，，44： | 1 |
| 16 | Purification and characterization of picied-β-D-glucosi- dase from Aspergillus niger显示文摘 | ZHANG Chunzhi LI Dai YU Hongshan | 2007 | Process Biochem2007，42，： | 1 |
| 17 | Purification and characterization of gingsenoside-β-glucosidase from ginseng显示文摘 | YU Hongshan BAO Yongming | 2001 | Chem Pharm Bull2001，49，7： | 1 |
| 18 | Purification and characterization of ginsenosidase hydrolyzing malti-glycosides of protopanaxadiol ginsenoside,ginsenoside type Ⅰ显示文摘 | ZHANG Chunzhi LU Mingchun | 2007 | Chem Pharm Bull2007，55，2： | 1 |
| 19 | Purification and characterization on ginsenosid Rhamnosidase显示文摘 | YU Hongshan GONG Jinmei ZHANG Chunzhi | 2002 | Chemical and Pharmaceutical Bulletin2002，50，2： | 1 |
| 20 | Purifica- tion and characterization of piceid-b-D-glucosidase from As- pergillus oryzae显示文摘 | ChunZhi Zhang Dai Li HongShan Yu | 2006 | Process Biochemistry2006，，7： | 1 |
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