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| 1 | RNA-seq analysis of prostate cancer in the Chinese population identifies recurrent gene fusions, cancer-associated long noncoding RNAs and aberrant alternative splicings显示文摘在有前列腺癌症的不同赛跑的病人之中有显著不同;然而,位于这差别下面的机制仍然保持不清楚。这里,我们在场 transcriptome 的一处全面风景用 RNA-seq,越过关于基因熔化的前列腺癌症 transcriptomes 的揭示巨大的差异,长 noncoding RNA (长 ncRNA ) ,其他的拼接和体的变化从中国人口 14 主要前列腺癌症和他们的配对的正常对应物介绍。14 个肿瘤(21.4%) 中的三个在中国病人怀有 TMPRSS2 尔格熔化,和这熔化的低流行进一步在一个另外的肿瘤集合(10/54=18.5%) 被证实。尤其是,二新奇基因熔化, CTAGE5-KHDRBS3 (20/54=37%) 和 USP9Y-TTTY15 (19/54=35.2%) ,在我们的耐心的队经常发生了。介绍的进一步系统的 transcriptional 识别了是在肿瘤表示的差别的众多的长 ncRNAs。在长 ncRNA 和基因的表示之间的关联的分析建议长 ncRNAs 可以在 transcriptional 规定以外有功能。这研究在中国人口产出新卓见进前列腺癌症的致病。 | Shancheng Ren Zhiyu Peng Jian-Hua Mao Yongwei Yu Changjun Yin Xin Gao Zilian Cui Jibin Zhang Kang Yi Weidong Xu Chao Chen Fubo Wang Xinwu Guo Ji Lu Jun Yang Min Wei Zhijian Tian Yinghui Guan Liang Tang Chuanliang Xu Linhui Wang Xu Gao Wei Tian Jian Wang Huanming Yang Jun Wang Yinghao Sun | 2012 | Cell Research2012，22，5： | 66 |
| 2 | Yushu earthquake synergic analysis using multimodal SAR datasets显示文摘The large earthquake measuring 7.1 on the Richter scale that occurred in Yushu County,Qinghai Province,China,on April 14,2010,caused a huge loss of life and major damage to people's properties.Using three modal synthetic-aperture radar(SAR) datasets,wide-swath SAR,interferometric SAR and polarimetric SAR,the following studies were conducted:(1) From Radarsat-2 wide swath SAR data,the regional geological structures and lithologic distribution characteristics of the Yushu earthquake were analyzed.(2) Using advanced land observing satellite/phased array L-band interferometric SAR data,the coseismic deformation field of the Yushu earthquake was obtained,and the size and spatial distribution of deformation were studied combining with the result of regional geological background analysis.(3) From Radarsat-2 polarimetric SAR data,the H-α-ρ method was used to extract the spatial distribution of building collapse caused by the earthquake in the Yushu urban area,and the reasons for the severe earthquake damage to buildings are also discussed and assessed.The study results demonstrate the effectiveness and important potential of using multimodal SAR data for synergic analysis and assessment of earthquake disasters. | GUO HuaDong WANG XinYuan LI XinWu LIU Guang ZHANG Lu YAN ShiYong | 2010 | Chinese Science Bulletin2010，55，31： | 9 |
| 3 | Research on global change scientific satellites显示文摘Global change now poses a severe threat to the survival and development of mankind.Large-scale,real-time,highly accurate Earth observation from space has become a key technology used to observe global change.China is one of the most influential countries affecting and being affected by global change,yet it has no scientific satellite for global change research so far.Developing global change scientific satellites not only would meet an important demand of China,but also would be a valuable contribution to the world.By analyzing the mechanisms of space-based observation of variables sensitive to global change,this paper explores the concept of global change scientific satellites,and proposes a series of global change scientific satellites to establish a scientific observation system for global environmental change monitoring from space. | GUO HuaDong FU WenXue LI XinWu CHEN Pei LIU Guang LI Zhen WANG Cheng DONG Qing LEI LiPing BAI LinYan LIU QingJie | 2014 | Science China Earth Sciences2014，57，2： | 5 |
| 4 | Homeobox B8 Targets Sterile Alpha Motif Domain-Containing Protein 9 and Drives Glioma Progression显示文摘Gliomas are the most commonly occurring tumors of the central nervous system. Glioblastoma multiforme (GBM) is the most malignant and aggressive brain cancer in adults. Further understanding of the mechanisms underlying the aggressive nature of GBM is urgently needed. Here we identified homeobox B8(HOXB8), a member of the homeobox family, as a crucial contributor to the aggressiveness of GBM. Data mining of publicly accessible RNA sequence datasets and our patient cohorts confirmed a higher expression of HOXB8 in the tumor tissue of GBM patients, and a strong positive correlation between the expression level and pathological grading of tumors and a negative correlation between the expression level and the overall survival rate. We next showed that HOXB8 promotes the proliferation and migration of glioblastoma cells and is crucial for the activation of the PI3K/AKT pathway and expression of epithelial–mesenchymal transition-related genes, possibly through direct binding to the promoter of SAMD9 (Sterile Alpha Motif Domain-Containing Protein 9) and activating its transcription. Collectively, we identified HOXB8 as a critical contributor to the aggressiveness of GBM, which provides insights into a potential therapeutic target for GBM and opens new avenues for improving its treatment outcome. | Wenping Ma Hongze Jin Wenjie Liu Xiaojuan Li Xingang Zhou Xinwu Guo Runfa Tian Qi Cui Junjie Luo Yueying Jiao Youtao Yu Haifeng Yang Hongshan Zhao | 2020 | Neuroscience Bulletin2020，36，4： | 2 |
| 5 | DEM generation and error analysis using the first Chinese airborne dual-antenna interferometric SAR data显示文摘 | Zhongchang Sun Huadong Guo Xinwu Li Xijuan Yue Qingni Huang | 2011 | International Journal of Remote Sensing2011，，23： | 1 |
| 6 | A hybrid vegetation height estimation method using SIR-C polarimetric SAR interferometry data显示文摘 | Li Xinwu Guo Huadong Li Zhen | 2005 | IEEE2005，，： | 1 |
| 7 | Adaptivefourth-order partial differential equation filter for imagedenoising显示文摘 | Liu Xinwu Huang Lihong Guo Zhenyuan | 2011 | Applied Mathematics Letters2011，24，8： | 1 |
| 8 | Adaptive fourth-order pattial differential equation filter for image denoising 显示文摘 | Liu Xinwu Huang Lihong Guo Zhenyuan | 2011 | Applied Mathematics Letters2011，24，： | 1 |
| 9 | Research on SAR data integrated processing methodology oriented on earth environment factor inversions显示文摘As an important advanced technique in the field of Earth observations,Synthetic Aperture Radar(SAR)plays a key role in the study of global environmental change,resources exploration,disaster mitigation,urban environments,and even lunar exploration.However,studies on imaging,image processing,and Earth factor inversions have often been conducted independently for a long time,which significantly limits the application effectiveness of SAR remote sensing due to the lack of an overall integrated design scheme and integrated information processing.Focusing on this SAR application issue,this paper proposes and describes a new SAR data processing methodology–SAR data integrated processing(DIP)oriented on Earth environment factor inversions.The simple definition,typical integrated modes and overall implementation ideas are introduced.Finally,focusing on building information extraction(man-made targets)and sea ice classification(natural targets)applications,three SAR DIP methods and experiments are conducted.Improved results are obtained under the guidance of the SAR DIP framework.Therefore,the SAR DIP theoretical framework and methodology represent a new SAR science application mode that has the capability to improve the SAR remote sensing quantitative application level and promote the development of new theories and methodologies. | Huadong Guo Jie Chen Xinwu Li Lu Zhang Wenjin Wu Huiying Liu Kai Wang Zhuo Li Xinwei Gu Qingrong Hu Xinmin Wang Jun Li Chunming Han Junjie Zhu Guozhuang Shen Guang Liu Wenxue Fu Zhongchang Sun Xiaoyang Wen | 2017 | International Journal of Digital Earth2017，10，7： | 0 |
| 10 | Delayed Antarctic melt season reduces albedo feedback显示文摘Antarctica’s response to climate change varies greatly both spatially and temporally.Surface melting impacts mass balance and also lowers surface albedo.We use a 43-year record(from 1978 to 2020)of Antarctic snow melt seasons from space-borne microwave radiometers with a machine-learning algorithm to show that both the onset and the end of the melt season are being delayed.Granger-causality analysis shows that melt end is delayed due to increased heat flux from the ocean to the atmosphere at minimum sea-ice extent from warming oceans.Melt onset is Granger-caused primarily by the turbulent heat flux from ocean to atmosphere that is in turn driven by sea-ice variability.Delayed snowmelt season leads to a net decrease in the absorption of solar irradiance,as a delayed summer means that higher albedo occurs after the period of maximum solar radiation,which changes Antarctica’s radiation balance more than sea-ice cover. | Lei Liang Huadong Guo Shuang Liang Xichen Li John C.Moore Xinwu Li Xiao Cheng Wenjin Wu Yan Liu Annette Rinke Gensuo Jia Feifei Pan Chen Gong | 2023 | National Science Review2023，10，9： | 0 |
| 11 | Global Phenomenological Optical Model Potential for 6,7,8Li Projectiles显示文摘The optical model is one of the most fundamental theoretical models in nuclear reaction theory.The key point of the optical model is how to give the optical model potential.The global phenomenological optical model potential for ~6Li,~7Li,~8Li projectiles are obtained by simultaneously fitting the experimental data of the reaction cross sections and elastic | HAN Yinlu HU Jiaqi XU Yongli SU Xinwu LIANG Haiying WU Zhendong GUO Hairui CAI Chonghai | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
| 12 | Simulation analysis on the relationship between the leaf area index and polarimetric parameters of crops显示文摘The leaf area index(LAI)is an important parameter to quantitatively describe the structure of vegetation and crops.Uncertainty in the relationship between the LAI and polarimetric parameters is the key problem for LAI estimation from polarimetric synthetic aperture radar(POLSAR)data.However,the existing POLSAR data have difficulties meeting the demand of the aforementioned research.This paper analyses the correlations between the LAI and the polarimetric parameters derived from Cloude and Freeman decompositions using simulated POLSAR data based on a coherent scattering model for maize and wheat.The results show:(1)The POLSAR data at C-band with a large incidence angle(40 degrees)are very suitable for finding the LAI for maize and wheat.(2)For maize there is a strong correlation between the scattering type angle and the LAI at C-band with a large incidence angle,and the coherency entropy,anisotropy,and the power of the double-bounce scattering power component also have significant correlations with the LAI.(3)For wheat at Cband with a high incidence angle,although the correlation coefficient is low,there is still a correlation between the entropy,anisotropy and LAI.Besides,the volume scattering is suitable for extracting the LAI for wheat at X-band. | Lu Zhang Huadong Guo Xinwu Li | 2012 | International Journal of Digital Earth2012，5，4： | 0 |
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