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| 1 | Emerging ultra-narrow-band cyan-emitting phosphor for white LEDs with enhanced color rendition显示文摘Phosphor-converted white LEDs rely on combining a blue-emitting InGaN chip with yellow and red-emitting luminescent materials.The discovery of cyan-emitting(470-500 nm)phosphors is a challenge to compensate for the spectral gap and produce full-spectrum white light.Na_(0.5)K_(0.5)Li_(3)SiO_(4):Eu^(2+)(NKLSO:Eu^(2+))phosphor was developed with impressive properties,providing cyan emission at 486 nm with a narrow full width at half maximum(FWHM)of only 20.7 nm,and good thermal stability with an integrated emission loss of only 7% at 150℃.The ultra-narrow-band cyan emission results from the high-symmetry cation sites,leading to almost ideal cubic coordination for UCr_(4)C_(4)-type compounds.NKLSO:Eu^(2+) phosphor allows the valley between the blue and yellow emission peaks in the white LED device to be filled,and the color-rendering index can be enhanced from 86 to 95.2,suggesting great applications in full-spectrum white LEDs. | Ming Zhao Hongxu Liao Maxim S.Molokeev Yayun Zhou Qinyuan Zhang Quanlin Liu Zhiguo Xia | 2019 | Light(Science & Applications)2019，8，1： | 21 |
| 2 | Antisense MMP-9 RNA inhibits malignant glioma cell growth in vitro and in vivo显示文摘The matrix-degrading metalloproteinases (MMPs), particularly MMP-9, play important roles in the pathogenesis and development of malignant gliomas. In the present study, the oncogenic role of MMP-9 in malignant glioma cells was investigated via antisense RNA blockade in vitro and in vivo. TJ905 malignant glioma cells were transfected with pcDNA3.0 vector expressing antisense MMP-9 RNA (pcDNA-AS-MMP9), which significantly decreased MMP-9 expression, and cell proliferation was assessed. For in vivo studies, U251 cells, a human malignant glioma cell line, were implanted subcutaneously into 4-to 6-week-old BALB/c nude mice. The mice bearing well-established U251 gliomas were treated with intratumoral pcDNA-AS-MMP9-Lipofectamine complex (AS-MMP-9-treated group), subcutaneous injection of endostatin (endostatin-treated group), or both (combined therapy group). Mice treated with pcDNA (empty vector)-Lipofectamine served as the control group. Four or eight weeks later, the volume and weight of tumor, MMP-9 expression, microvessel density and proliferative activity were assayed. We demonstrate that pcDNA-AS-MMP9 significantly decreased MMP-9 expression and inhibited glioma cell proliferation. Volume and weight of tumor, MMP-9 expression, microvessel density and proliferative activity in the antisense-MMP-9-treated and therapeutic alliance groups were significantly lower than those in the control group. The results suggest that MMP-9 not only promotes malignant glioma cell invasiveness, but also affects tumor cell proliferation. Blocking the expression of MMP-9 with antisense RNA substantially suppresses the malignant phenotype of glioma cells, and thus can be used as an effective therapeutic strategy for malignant gliomas. | Cuiyun Sun Qian Wang Hongxu Zhou Shizhu Yu Alain R. Simard Chunsheng Kang Yanyan Li Yanling Kong Tongling An Yanjun Wen Fudong Shi Junwei Hao | 2013 | Neuroscience Bulletin2013，29，1： | 14 |
| 3 | Primarily screening and analyzing ESTs differentially expressed in rats' primary liver cancer显示文摘Objective: To screen and analyze key express sequence tags (ESTs) which were differentially displayed in every period of SD rats' primary hepatic carcinoma and reveal the molecular mechanism of carcinogenesis. Methods: Using diethylnitrosamine (DENA) as a cancerigenic agent, animal models with different phases of primary hepatic cancer were constructed in SD rats. Rats were respectively sacrificed at d 14, d 28, d 56, d 77, d 105 and d 112 after the rats received DENA by gavage, then the livers were harvested. One part of the livers was classified according to their pathological changes, while the other was reserved for molecular mechanism studies on hepatocarcinogenesis. The differentially expressed genes were isolated from both normal and morbid tissues by mRNA differential display technique (DDRT-PCR). After the fragments were sequenced, bioinformatics were used to analyze the results. Results: Twelve differentially expressed cDNA fragments were obtained. Nine fragments had the homology with known cDNA clones, especially EST-7 was similar to BN/SsNHsdMCW mitochondrion gene and the identity was 100% which suggested EST-7 may be the part of BN/SsNHsdMCW mitochondrion gene. In contrast, other three fragments (EST-1, EST-3 and EST-5) had extremely low identity to any genes registered in GENBANK databases. Conclusions: BN/SsNHsdMCW mitochondrion gene was expressed in different periods of hepatocarcinogenesis. Moreover, EST-1, EST-3 and EST-5 were suggested to contribute to the development of rat hepatocarcinogenesis, and thus may be candidates of new targets of oncogenes or cancer suppressor genes. | Dandan Liu Lijuan Zhi Mingxia Ma Dan Qiao Meijuan Wang Yawei Wang Baijie Jin Anqi Li Guting Liu Yiqing Zhang Yanyan Song Hongxu Zhang | 2013 | Chinese Journal of Cancer Research2013，25，1： | 9 |
| 4 | Distributed and Weighted Extreme Learning Machine for Imbalanced Big Data Learning显示文摘The Extreme Learning Machine(ELM) and its variants are effective in many machine learning applications such as Imbalanced Learning(IL) or Big Data(BD) learning. However, they are unable to solve both imbalanced and large-volume data learning problems. This study addresses the IL problem in BD applications. The Distributed and Weighted ELM(DW-ELM) algorithm is proposed, which is based on the Map Reduce framework. To confirm the feasibility of parallel computation, first, the fact that matrix multiplication operators are decomposable is illustrated.Then, to further improve the computational efficiency, an Improved DW-ELM algorithm(IDW-ELM) is developed using only one Map Reduce job. The successful operations of the proposed DW-ELM and IDW-ELM algorithms are finally validated through experiments. | Zhiqiong Wang Junchang Xin Hongxu Yang Shuo Tian Ge Yu Chenren Xu Yudong Yao | 2017 | Tsinghua Science and Technology2017，22，2： | 8 |
| 5 | Estimating Soil Salinity in the Yellow River Delta, Eastern China——An Integrated Approach Using Spectral and Terrain Indices with the Generalized Additive Model显示文摘Soil salinity is one of the most severe environmental problems worldwide. It is necessary to develop a soil-salinity-estimation model to project the spatial distribution of soil salinity. The aims of this study were to use remote sensed images and digital elevation model(DEM) to develop quantitative models for estimating soil salinity and to investigate the influence of vegetation on soil salinity estimation. Digital bands of Landsat Thematic Mapper(TM) images, vegetation indices, and terrain indices were selected as predictive variables for the estimation. The generalized additive model(GAM) was used to analyze the quantitative relationship between soil salt content, spectral properties, and terrain indices. Akaike's information criterion(AIC) was used to select relevant predictive variables for fitted GAMs. A correlation analysis and root mean square error between predicted and observed soil salt contents were used to validate the fitted GAMs. A high ratio of explained deviance suggests that an integrated approach using spectral and terrain indices with GAM was practical and efficient for estimating soil salinity. The performance of the fitted GAMs varied with changes in vegetation cover.Salinity in sparsely vegetated areas was estimated better than in densely vegetated areas. Visible red and near-infrared bands, and the second and third components of the tasseled cap transformation were the most important spectral variables for the estimation. Variable combinations in the fitted GAMs and their contribution varied with changes in vegetation cover. The contribution of terrain indices was smaller than that of spectral indices, possibly due to the low spatial resolution of DEM. This research may provide some beneficial references for regional soil salinity estimation. | SONG Chuangye REN Hongxu HUANG Chong | 2016 | Pedosphere2016，26，5： | 6 |
| 6 | Effect of Short-term Forest Bathing in Urban Parks on Perceived Anxiety of Young-adults: A Pilot Study in Guiyang, Southwest China显示文摘Forest can be taken as a natural therapy to alleviate perceived anxiety of visitors. Given the geographical difference between urban and rural forest environments, little is known about the urban forest therapy effect of anxiety alleviation with reference to the rural forest. In this study, forty-three university students(aged from 19 to 23) were recruited as participants to visit the forest parks at urban and rural areas of Guiyang City on 21 and 23 December 2016. The forest experience was separated by four sceneries. Participants were asked to complete questionnaires by self-evaluating specific anxiety change from 12 questions with scores from 1 to 10 at both entrance and exit of the parks. The Wilcoxon signed-rank test and paired t-test were used to compare the change of anti-anxiety scores during forest bathing and between urban and rural forests, respectively. Results revealed that forest bathing in the urban park can alleviate the anxiety from financial state(P = 0.0028), exam-pass pressure(P = 0.0040) and love-affair relationship(P = 0.0286). Although rural forest bathing can also alleviate the anxiety from financial state(P = 0.0222), meanwhile, it maintained the anxiety about campus life(P < 0.0001). Forest tree richness tended to be higher in the rural forest park than in the urban one, which in contrast decreased the anxiety alleviation from inter-communication in the rural forest park(P = 0.0487). Principle component analysis indicated that participants tended to perceive more decline of anxiety from social contact in the urban forest. In conclusion, university students were recommended to pay a short visit to the urban forest with partners if they felt anxious about personal affairs and felt necessary to talk with others. For general people's visiting, urban forest trees can be controlled in diversity to some extent to look orderly and alleviate perceived anxiety. | ZHOU Changwei YAN Lingbin YU Lifei WEI Hongxu GUAN Haoming SHANG Chongfei CHEN Feiyu BAO Junzhou | 2019 | Chinese Geographical Science2019，29，1： | 5 |
| 7 | Using MaxEnt Model to Guide Marsh Conservation in the Nenjiang River Basin, Northeast China显示文摘Incorporating private and working lands into protected area networks could mitigate the isolation state of protected areas(PAs) and improve the efficiency of conservation.But how to select patches of land for conservation is still a troublesome issue.In this study, the MaxEnt model and irreplaceability index were applied to guide marsh conservation in the Nenjiang River Basin, Northeast China.According to the high accuracy of the MaxEnt model predictions(i.e., the average AUC value = 0.933), the Wuyuer River and Zhalong marshes in the downstream reaches of Wuyuer River are the optimal habitat for the Red-crowned crane and migratory waterfowls.There are 22 marsh patches selected by the patch irreplaceability index for conservation, of which 12 patches had been included in the current network of protected areas.The other 10 patches of marsh(amounting to 1096 km^2) far from human disturbances with high NDVI(up to 0.8) and close distance to water(less than 100 m), which are excluded from the existing network of PAs, should be implemented conservation easement programs to improve the protection efficiency of conservation.Specifically, the marshes at Taha, Tangchi, and Lamadian should be given priority for conservation and restoration to reintroduce migratory waterfowls, as this would lessen the current isolation state of the Zhalong National Nature Reserve. | WANG Zhiliang ZHANG Bai ZHANG Xuezhen Tian Hongxu | 2019 | Chinese Geographical Science2019，29，6： | 5 |
| 8 | Interaction effects between estrogen receptor α and vitamin D receptor genes on age at menarche in Chinese women显示文摘Aim: To evaluate whether estrogen receptor α (ER-α) and vitamin D receptor (VDR) genes are associated with the age at menarche in Chinese women. Methods: A total of 390 pre-menopausal Chinese women were genotyped at the ER-α PvuII, XbaI, and VDR ApaI loci using polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP). Results: Neither the ER-α gene nor the VDR gene individually had significant effects on the age at menarche in our subjects (P>0.10). However, evidence of interaction effects between the two genes were observed: with the aa genotype at the VDR ApaI locus, subjects with haplotype PX at the ER-α gene had, on average, 6 months later onset of menarche than the non-carriers (P=0.01). Conclusion: We found that neither the ER-α gene or the VDR gene had a significant association with the age at menarche individually. However, potential interaction effects between the two genes were observed in Chinese women. | HongXU Ji-rongLONG Miao-xinLI | 2005 | Acta Pharmacologica Sinica2005，26，7： | 5 |
| 9 | Interactive effects of irrigation and exponential fertilization on nutritional characteristics in Populus 3 euramericana cv. ‘74/76' cuttings in an open-air nursery in Beijing, China显示文摘Nutritional characteristics determine tree stock quality to a considerable extent. Exponential fertilization can induce nutrient reserves within juvenile trees, but its validity on poplar is contingent on interaction with a scientific irrigation regime due to limited water resources under global warming. In the present study, we raised 3200 Populus 9 euramericana cv. ‘74/76' cuttings under four irrigation regimes of 0(I0), 60 %(I60), 80 %(I80), and100 %(I100) of field capacity for soil moisture content with or without(control) the employment of nitrogen(N) addition delivered as exponential fertilization at the rate of 8 g N cutting^(-1)(E8) in an open-air nursery in Beijing, China. Both height and diameter increased with the increment of soil moisture ratio or in response to exponential fertilization(EF) without any interactive effects. In general, concentrations of N, phosphorus(P),and potassium(K) declined with time in stem but foliar N concentration did not change. Under the I100 regime, EF increased foliar N concentration relative to the control but failed to affect N concentration in stem in September, when both N concentration and N content were increased by EF under the I80 regime. Stem-K content and concentration by EF under the I80 regime also increased in September,therefore EF-treated cuttings had a higher ratio of K content in stem to that in whole plant(%ANAR). Vector diagnosis for nutritional status indicated that EF resulted in dilution of K concentration but induced a steady-state P uptake in leaves under all irrigation regimes. Therefore, EF of N addition could promote N uptake to leaves of P. 9 euramericana cv. ‘74/76' cuttings, but it had a null effect on N and P reserves in stem and impaired K reserves.In conclusion, the irrigation regime of 80 % field capacity of soil moisture content was suggested for the culture of juvenile P. 9 euramericana cv. ‘74/76' cuttings. As the interactive meaning, EF was also suggested for its excellent promotion on both N and K uptakes. | Zi Wang Luyi Ma Zhongkui Jia Hongxu Wei Jie Duan | 2016 | Journal of Forestry Research2016，27，3： | 5 |
| 10 | Thermochemical properties and thermokinetic behavior of energetic triazole ionic salts显示文摘The properties of dissolution in different solvents,the specific heat capacity and thermal decomposition process under the non-isothermal conditions for energetic triazole ionic salts 1,2,4-triazolium nitrate(1a),1,2,3-triazolium nitrate(1b),3,4,5triamino-1,2,4-triazolium nitrate(2a),3,4,5-triamino-1,2,4-triazolium dinitramide(2b)were precisely measured using a Calvet Microcalorimeter.The thermochemical equation,differential enthalpies of dissolution(△difH m ),standard molar enthalpies of dissolution(△difH m ),apparent activation energy(E),pre-exponential constant(A),kinetic equation,linear relationship of specific heat capacity with temperature over the temperature range from 283 to 353 K,standard molar heat capacity(C p,m)and enthalpy,entropy and Gibbs free energy at 283–353 K,taking 298.15 K as the benchmark for 1a,1b,2a and 2b were obtained with treating experimental data and theoretical calculation method.The kinetic and thermodynamic parameters of thermal decomposition reaction,critical temperature of thermal explosion(Tb),self-accelerating decomposition temperature(TSADT)and adiabatic time-to-explosion(t)of 1a,1b,2a and 2b were calculated.Their heat-resistance abilities were evaluated.Information was obtained on the relation between molecular structures and properties of 1a,1b,2a and 2b. | ZHAO FengQi XUE Liang XING XiaoLing HU RongZu ZHOU ZhiMing GAO HongXu YI JianHua XU SiYu PEI Qing | 2011 | Science China Chemistry2011，54，3： | 4 |
| 11 | Association between VDR Apal Polymorphism and Hip Bone Mineral Density Can Be Modified by Body Mass Index:A Study on Postmenopausal Chinese Women显示文摘Osteoporosis is a major public health problem for old people. Genetic factors are considered to be major contributors to the pathogenesis of postmenopausal osteoporosis. The vitamin D receptor (VDR) gene is a prominent candidate gene for the regulation of postmenopausal bone mass; however, despite extensive studies, controversy remains regarding its association with postmenopausal body mineral density (BMD) variation. In this study, a total of 260 healthy postmenopausal Chinese women were genotyped at the VDR ApaI locus using polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP). Raw hip BMD was significantly associated with VDR ApaI polymorphism with and without adjusting for age (P=0.015 and 0.040, respectively). This genetic effect can explain 3.32% of hip BMD variation. However, the significant association vanished after correcting for both age and body mass index (BMI) (P=0.169). In addition, we observed a significant association between VDR ApaI polymorphism with unadjusted BMI(P=0.042) or BMI adjusted for age (P=0.049). The raw hip BMD was also found to be significantly correlated with BMI (r=0.517, P=0.0001), with BMI explaining 26.35% of the variation of hip BMD. All of these facts prompt us to conclude that the significant association between the VDR ApaI genotype and hip BMD may be modified by BMI in postmenopausal Chinese women. Our findings may partially explain the earlier inconsistent association results concerning the VDR gene and BMD, and highlight the importance of incorporating covariates such as BMI into osteoporosis association studies. | HongXU Dong-HaiXIONG Fu-HuaXU Yuan-YuanZHANG Shu-FengLEI | 2005 | Acta Biochimica et Biophysica Sinica2005，37，1： | 4 |
| 12 | Clinical characteristics of 310 SARS-CoV-2 Omicron variant patients and comparison with Delta and Beta variant patients in China显示文摘Although the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)Omicron variant has spread,data on the clinical characteristics of infected patients are limited.In this study,the demographic,clinical characteristics,and laboratory data of 310 SARS-CoV-2 Omicron variant patients treated at Haihe Hospital of Tianjin were collected and analyzed.Information on these patients was compared to 96 patients with the Delta variant of concern(VOC)and 326 patients with the Beta VOC during the previous coronavirus disease 2019(COVID-19)outbreak in Harbin.Of the 310 patients infected with the Omicron variant,the median age was 35 years.Most patients were clinically classified as mild(57.74%),and the most common symptoms were cough(48.71%),fever(39.35%),and sore throat(38.26%).The results for different vaccination groups in the Omicron group showed that the median of“SARS-CoV-2 specific IgG”after 2 or 3 doses of vaccination was higher than the unvaccinated group(all Ps<0.05).Older age was associated with a higher proportion of moderate cases and lower asymptomatic and mild cases based on clinical classifications.Compared to the Delta and Beta groups,the median age of the Omicron group was younger.The total number of asymptomatic patients and mild patients in the Omicron virus group was higher than the Delta and Beta groups(60.97%vs.54.17%vs.47.55%).This study presented the clinical characteristics of the first group of patients infected with the Omicron variant in Tianjin,China,and compared their clinical features with patients infected by the Delta and Beta variants,which would increase our understanding of the characteristics of SARS-CoV-2 Omicron variant. | Wei Yang Songliu Yang Lei Wang Yuxin Zhou Yu Xin Hongxu Li Wenjing Mu Qi Wu Lei Xu Mingyan Zhao Changsong Wang Kaijiang Yu | 2022 | Virologica Sinica2022，37，5： | 4 |
| 13 | ELASTIC DYNAMIC ANALYSIS OF MODERATELY THICK PLATE USING MESHLESS LRPIM显示文摘A meshless local radial point interpolation method (LRPIM) for solving elastic dy-namic problems of moderately thick plates is presented in this paper. The discretized system equation of the plate is obtained using a locally weighted residual method. It uses a radial basis function (RBF) coupled with a polynomial basis function as a trial function,and uses the quartic spline function as a test function of the weighted residual method. The shape function has the properties of the Kronecker delta function,and no additional treatment is done to impose essen-tial boundary conditions. The Newmark method for solving the dynamic problem is adopted in computation. Effects of sizes of the quadrature sub-domain and influence domain on the dynamic properties are investigated. The numerical results show that the presented method can give quite accurate results for the elastic dynamic problem of the moderately thick plate. | Ping Xia Shuyao Long Hongxue Cui | 2009 | Acta Mechanica Solida Sinica2009，22，2： | 3 |
| 14 | Dynamic analysis of heat extraction rate by supercritical carbon dioxide in fractured rock mass based on a thermal-hydraulic-mechanics coupled model显示文摘Heat production from geothermal reservoirs is a typical heat transfer process involving a cold working fluid contacting a hot rock formation.Compared to the thermal-physical characteristics of water,supercritical CO_(2)(scCO_(2))has a higher heat storage capacity over a wide temperature-pressure range and may be favored as a heat transfer fluid.Singularly characteristic of scCO_(2)-based heat extraction is that the hydraulic-thermal properties of the scCO_(2) vary dramatically and dynamically with the spatial pressure gradient during unsteady-state flow along fracture.This highly nonlinear behavior presents a challenge in the accurate estimation of heat extraction efficiency in scCO_(2)-based EGS.In this paper,a thermal-h ydraulic-mechanical(THM)coupled model is developed by considering deformation of the fractured reservoir,non-Darcy flow and the varying thermal-physical properties of scCO_(2).The proposed model is validated by matching the modeling temperature distribution with published data.The results show that during continuous injection of scCO_(2),the fracture first widens and then narrows,ultimately reopening over the long term.The sequential fracture deformation behaviors are in response to the combined impacts of mechanical compression and thermally-induced deformation.By controlling the injection parameters of the scCO_(2),it is found that the heat extraction rate is positively correlated to its pore pressure or mass flow rate.The heat extraction rate can be significantly enhanced,when the inlet temperature of scCO_(2) is below its critical temperature.As a result,the heat increment recovered per unit mass of scCO_(2) decreases as the hot rock is gradually cooled.Meanwhile,the heat increment recovered per unit mass of scCO_(2) decreases by increasing the inlet temperature of scCO_(2) or its mass flow rate,but increases as the outlet pressure rises.Furthermore,multi-linear regression indicates that controlling the inlet temperature of the scCO_(2) can significantly improve the thermodynamic efficiency of heat extraction. | Chunguang Wang Xingkai Shi Wei Zhang Derek Elsworth Guanglei Cui Shuqing Liu Hongxu Wang Weiqiang Song Songtao Hu Peng Zheng | 2022 | International Journal of Mining Science and Technology2022，32，2： | 3 |
| 15 | Hardware Design and Test of a Gear-Shifting Control System of a Multi-gear Transmission for Electric Vehicles显示文摘The performance of electric vehicles is affected by the shift quality of multi-gear transmission.The realization of dual-target tracking control requires the transmission control unit(TCU)to accurately measure and process the input signals of the gear-shifting control system and precisely control the drive motor torque and the position of shift motors.An electric-vehicle-dedicated TCU was designed to meet the above design requirements.Its function modules included a single-chip control circuit,shift position signal sampling circuit,signal conditioning circuit of the rotational speed and angle,controller area network communication circuit,and shift motor drive circuit.A hardware-in-the-loop simulation test system showed that the TCU design scheme met measurement accuracy requirements and coordinated the actions of the shift actuator and motor control unit to achieve fast and smooth shifting before the road test.The power interruption time of the shifting process was within 350 ms.The reliability of the TCU design was further verified in a 150,000-km vehicle road test. | Feng Tian Liqi Sui Yuanfan Zeng Bo Li Xingyue Zhou Lijun Wang Hongxu Chen | 2019 | Automotive Innovation2019，2，3： | 3 |
| 16 | Green Space System Planning in Shuangcheng City and Creation of the City's Characteristics显示文摘Characteristic urban construction has already become a trend of modern social development,in this context,components of characteristic urban green spaces,and ways of demonstrating features of urban green space system were analyzed.Shuangcheng City in Heilongjiang Province was taken for example to analyze planning objectives and principles of characteristic urban green space system.Moreover,the green space layout of 'A Hundred Years Old Castle,A Hundred of Enterprises and A Hundred of Gardens' was introduced.It was proposed that green space system planning suited to the development features and ecological conditions of the city should be developed from the perspective of greater regional environment,historical and cultural deposits,urban development pattern and lifestyle of the locals,so as to create urban green space system with regional features. | LI Hongxu DONG Yuxin LIU Huimin | 2012 | Journal of Landscape Research2012，4，9： | 2 |
| 17 | BPGM: A Big Graph Mining Tool显示文摘The design and implementation of a scalable parallel mining system target for big graph analysis has proven to be challenging. In this study, we propose a parallel data mining system for analyzing big graph data generated on a Bulk Synchronous Parallel(BSP) computing model named BSP-based Parallel Graph Mining(BPGM). This system has four sets of parallel graph mining algorithms programmed in the BSP parallel model and a well-designed workflow engine optimized for cloud computing to invoke these algorithms. Experimental results show that the graph mining algorithm components in BPGM are efficient and have better performance than big cloud-based parallel data miner and BC-BSP. | Yang Liu Bin Wu Hongxu Wang Pengjiang Ma | 2014 | Tsinghua Science and Technology2014，19，1： | 2 |
| 18 | The prognostic value of programmed cell death ligand 1expression in non-Hodgkin lymphoma:a meta-analysis显示文摘Objective: Although the prognostic value of programmed cell death-ligand 1(PD-L1) expression in non-Hodgkin lymphoma(NHL) has been evaluated in many studies, the results remain controversial. To investigate the prognostic role of PD-L1 expression and the association between PD-L1 expression and clinicopathological features of NHL, we performed a meta-analysis.Methods: The Pub Med, EMBASE, and Cochrane Library databases were searched up to November 30, 2017. The hazard ratio(HR), 95% confidence interval(CI), and odds ratios(OR) with 95% CIs were combined to evaluate the association of PD-L1 expression with overall survival(OS) and clinicopathological features. Review manager 5.3 and STATA 12.0 were used in this meta-analysis.Results: A total of 2,005 patients across nine studies were enrolled in our meta-analysis, and the pooled results showed that high PD-L1 expression was associated with a poor prognosis(HR=2.04, 95% CI: 1.18–3.54, P=0.01). In the subgroup analysis according to histology types, pooled results demonstrated that an increased PD-L1 expression was an unfavorable prognostic factor for diffuse large B-cell lymphoma(HR=1.92, 95% CI: 1.06–3.48, P=0.03) but not for natural killer/T-cell lymphoma(HR=2.41, 95%CI: 0.47–12.22, P=0.29). Pooled ORs indicated that PD-L1 expression was higher in NHL with international prognostic indices of≥3. However, PD-L1 expression had no correlation with gender, age, disease stage, lactate dehydrogenase level, B symptoms, and germinal center B-cell-like lymphoma.Conclusions: High PD-L1 expression was a poor prognostic biomarker in patients with NHL. Because of our limited sample size,high-quality studies with larger sample sizes are needed to validate our results. | Shu Zha Minghui Zhang Yu Zhang Hongxue Meng Yan Wang Yupeng Liu Jing Jing Lan Huang Mengqi Sun Yue Zhang Qingyuan Zhang | 2018 | Cancer Biology & Medicine2018，15，3： | 2 |
| 19 | A new multi-scale analytic algorithm for edge extraction of strawberry leaf images in natural light显示文摘In this study,a new algorithm was proposed for edge extraction of greenhouse strawberry leaf in natural light based on the 4-level daubechies 5(‘db5’)wavelet decomposition.This algorithm adopts different segmentation methods for the reconstructed images at different scales to erase the external background and the internal leaf vein interference.There were two advantages of this method.One was that it can provide the abstraction from different spaces to express a same image.The other one was that some image features are hard to be acquired in some scale spaces,while the features are easy to be obtained in other scale spaces.In this image process methods,the Otsu threshold segmentation was to obtain the binary image areas,and the Canny segmentation is to obtain the accurate gradient edges,then the morphological methods and the logical calculus methods were to avoid the fragments inside the leaf area and the adhesions outside the leaf area.Since the strawberry leaf images were different respectively,and the greenhouse optical radiation and reflection may cause local non-uniform illumination of leaf image,the pseudo canny edges of leaf image ere divided into three categories in this research.The first category was the external pseudo canny edges area of the first layer reconstructed leaf image,the second category was the internal pseudo canny edges area in highlight of the third layer reconstructed leaf image,the third category was the internal pseudo canny edges area of significantly different grayscale of the third layer reconstructed leaf image.The different processing methods were constructed for the three kinds of different texture features based on the multi scale reconstructed images,then the complete and the accurate leaf edges without interference were obtained.Finally,the multi scale method was simplified and a remarkably effective segmentation algorithm was deduced for the greenhouse strawberry leaf in natural light. | Wang Jianlun Han Yu Zhao Shuangshuang Zheng Hongxu He Can Cui Xiaoying Xu Yun Chen Jianshu Wang Shuting | 2016 | International Journal of Agricultural and Biological Engineering2016，9，1： | 2 |
| 20 | Mineralogy,Fluid Inclusion and H-O-C-S Stable Isotopes of Mengqiguer Uranium Deposit in the Southern Yili Basin,Xinjiang:Implication for Ore Formation显示文摘The Mengqiguer deposit in the southern Yili basin Ili Basin is a large interlayer-oxidation-zone type uranium deposit.In this paper,we applied multiple methods including microscopic observation,scanning electron microscope and electronic probe,to analyze the systematical alteration characteristics of the ore-bearing sandstone layer.Fluid inclusion and stable isotope studies on the ore-bearing sandstone have also been carried out to discuss the internal relations between fluid activities,epigenetic alteration and the uranium mineralization.Major epigenetic alteration include clay alteration,carbonatization and pyritization,of which biogenetic pyritization is most closely related to the uranium mineralization.This suggests the existence of microorganism during the uranium mineralization process.The mineralization fluids of low temperature,medium density but varied salinities are suggested to be derived from multi-source,including the meteoric water and organic acidic vapor components from coal-bearing strata.Uranium mineralization,grain-dispersed kaolinite,limonite,colloidal pyrite,and the carbonate cements associated with sulfate-reducing bacteria were formed by meteoric water and vermicular-shaped kaolinite,autologous pyrite,and the carbonate cementation associated with the dehydroxylation of organic matter was formed by organic acidic.Based on these results,we consider that the uranium mineralization and epigenetic alteration both resulted from the reciprocity of organic–inorganic fluid and fluid–rock during the formation of the interlayer oxidation zone. | DING Bo LIU Hongxu ZHANG Chuang LIU Hongjun LI Ping ZHANG Bin | 2020 | Acta Geologica Sinica(English Edition)2020，94，5： | 2 |
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