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| 1 | Targets and molecular mechanisms of triptolide in cancer therapy显示文摘Triptolide(TPL/TL) is a natural drug with novel anticancer effects. Preclinical studies indicated that TPL inhibits cell proliferation, induces cell apoptosis, inhibits tumor metastasis and enhances the effect of other therapeutic methods in various cancer cell lines. Multiple molecules and signaling pathways, such as caspases, heat-shock proteins, NF-κB, and deoxyribonucleic acid(DNA) repair-associated factors, are associated with the anti-cancer effect. TPL also improves chemoradiosensitivity in cancer therapy. Phase I trials indicate the potential clinical value of TPL use. However, further trials with larger sample sizes are needed to confirm these results. | Cuicui Meng Hongcheng Zhu Hongmei Song Zhongming Wang Guanhong Huang Defan Li Zhaoming Ma Jianhua Ma Qin Qin Xinchen Sun Jianxin Ma | 2014 | Chinese Journal of Cancer Research2014，26，5： | 16 |
| 2 | MdGSTF6,activated by MdMYB1,plays an essential role in anthocyanin accumulation in apple显示文摘Anthocyanins are biosynthesized on the cytosolic surface of the endoplasmic reticulum and then transported into the vacuole for storage.Glutathione S-transferases(GSTs)are considered to be responsible for the transport of anthocyanins into the vacuole.However,the regulatory mechanisms of GSTs in plants are still unclear.Here,we performed a genome-wide analysis and identified 69 GST genes in apple.The expression of MdGSTF6 was positively correlated with the anthocyanin content(r=0.949)during‘Yanfu 8’fruit development.The overexpression of MdGSTF6 in the Arabidopsis thaliana tt19 mutant resulted in seedlings of 35S::MdGSTF6-GFP/tt19 that could accumulate anthocyanin and rescue its phenotype,suggesting that MdGSTF6 was an anthocyanin transporter.The silencing of MdGSTF6 affected anthocyanin accumulation in apple fruit.Moreover,the knockdown of MdGSTF6 by RNA interference in cultured‘Gala’seedlings inhibited anthocyanin accumulation.The interaction experiments showed that MdMYB1 could bind directly to the MdGSTF6 promoter to transcriptionally activate its expression.Collectively,our results demonstrate that MdGSTF6 encodes an important GST transporter of anthocyanins in apple fruit and provide evidence for the associated regulatory mechanisms.Therefore,MdMYB1 can not only regulate anthocyanin synthesis,but also control the transport of anthocyanin in apples.This information may be useful for further clarifying the regulation of anthocyanin transport in apple. | Shenghui Jiang Min Chen Naibo He Xiaoliu Chen Nan Wang Qingguo Sun Tianliang Zhang Haifeng Xu Hongcheng Fang Yicheng Wang Zongying Zhang Shujing Wu Xuesen Chen | 2019 | Horticulture Research2019，6，1： | 16 |
| 3 | A single center experience: post-transplantation adjuvant chemotherapy impacts the prognosis of hepatocellular carcinoma patients显示文摘 | Wu Junyi Sun Hongcheng Han Zhongbo Peng Zhihai | 2014 | Chinese Medical Journal2014，，3： | 6 |
| 4 | Immediate or delayed repair of pelvic fracture urethral disruption defects in young boys: twenty years of comparative experience显示文摘 | Qu Yanchao Zhang Weiping Sun Ning Huang Chengru Tian Jun Li Minglei, Song Hongcheng Li Ning | 2014 | Chinese Medical Journal2014，，19： | 2 |
| 5 | Construction of Redox Responsive Vesicles Based on a Supra-Amphiphile for Enzyme Confinement显示文摘 | Tiezheng Pan Huixin Zou Hongcheng Sun Yao Liu Shengda Liu Quan Luo Zeyuan Dong Jiayun Xu Junqiu Liu | 2017 | Chinese Journal of Chemistry2017，35，6： | 2 |
| 6 | A bi-leve model of dynamic traffic signal control withcontinuum approximation显示文摘 | Ke Han Yuqi Sun Hongcheng Liu et aI | 2015 | transportation research part C2015，55，： | 1 |
| 7 | Advanced traveler information system for metropolitan expressways in Shanghai,China显示文摘 | GAN Hongcheng SUN Lijun CHEN Jianyang | 2006 | Journal of Transportation Research Board2006，，1944： | 1 |
| 8 | Application of Spectra Accuracy for Analysis of Organic Explosive: 2,4,6‑trinitrotoluene by AccuTOF‑DART显示文摘This paper,through mass spectrometric(MS)analysis for nitro compound explosives on a direct analysis in a real‑time time‑of‑flight MS,indicates that even on a high‑resolution MS with accurate mass measurement capabilities,there is no guarantee to obtain the unique molecular formula of a compound.By calculating spectra accuracy,highly accurate isotope pattern matching can be conducted to significantly improve performance of compound confirmation or identification. | Zhanfang Liu Zhenwen Sun Guannan Zhang Jun Zhu Hongcheng Mei Haiyan Li Bin Li Jianzhong Xu Hong Zhou | 2016 | Journal of Forensic Science and Medicine2016，2，4： | 1 |
| 9 | Bioresponsive cisplatin crosslinked albumin hydrogel served for efficient cancer combination therapy显示文摘Combination therapy is one of the potential strategies for tackling complicated tumor treatments like drug resistance.In this work,we have generated a therapeutic cisplatin-crosslinked albumin hydrogel(BC-Gel)that allows the local release of L-Buthionine-sulfoximine(BSO),cisplatin,and glucose oxidase(GOx)with distinct release kinetics.The BC-Gel with favorable biostimuli degradability and injectability could release therapeutic agents in a programmed manner within the tumor microenvironment(TME).The preferentially released BSO significantly suppressed the glutathione(GSH)-related cisplatin resistance and sensitized the tumor cells to cisplatin by inhibiting theγ-glutamylcysteine synthetase.Meanwhile,cisplatin achieved a sequential release and long-term treatment following the bioresponsive gel degradation under the combined action of chloride ions(Cl−)and proteinase in the body.In addition,the overproduced H_(2)O_(2)of GOx-catalyzed glucose oxidation accelerated the depletion of existed GSH within cells and further weakened the cisplatin resistance,achieving enhanced tumor treatment together with a strong cell-killing effect.The above sequential drug release strategy based on the dual GSH depletion effect breaks the balance of the GSH-mediated redox TME and enhances the sensitivity of A549 cells to cisplatin forcefully,and provides a promising way for temporal control of drug release as well as efficient cancer combination therapy. | An Yan Zherui Zhang Jiamei Gu Xiaoran Ding Yongchen Chen Jingjing Du Shu Wei Hongcheng Sun Jiayun Xu Shuangjiang Yu Junqiu Liu | 2023 | Nano Research2023，16，2： | 1 |
| 10 | FOXM1 expression predicts the prognosis in hepatocellular carcinoma patients after orthotopic liver transplantation combined with the Milan criteria显示文摘 | Hongcheng Sun Mujian Teng Jie Liu Dong Jin Junyi Wu Dongwang Yan Junwei Fan Xuebin Qin Huamei Tang Zhihai Peng | 2011 | Cancer Letters2011，，2： | 1 |
| 11 | STAT3、CEA在人肺腺癌细胞A594中的相关性研究(英文)显示文摘Objective: The purpose of this study was to analyze the relationship between signal transducer and activator of transcription 3 (STAT3) and carcinoembryonic antigen (CEA) in lung adenocarcinoma cell A549, and to explore the value of STAT3 on early diagnosis of lung adenocarcinoma. Methods: The expression of CEA, STAT3 mRNA and it's protein in human lung adenocarcinoma cell A549 and normal human lung cells MRC-5 were tested by immunohistochemistry staining (PV) and quantitative real time fluorescent PCR. The correlation between STAT3 and CEA in human lung adenocarcinoma cell A549 was analyzed. Results: The protein and mRNA levels of STAT3, CEA in lung adenocarcinoma cell A549 were apparently higher than those in normal human lung cells MRC-5. The levels of STAT3 mRNA and it's protein were positively correlated with CEA in lung adenocarcinoma cell A549. Conclusion: STAT3 have the same value in diagnosis of lung adenocarcinoma. | Debin Sun Xiu Lan(Co-first author) Hongcheng Wang | 2012 | The Chinese-German Journal of Clinical Oncology2012，11，12： | 0 |
| 12 | Report of China's innovation increase and research growth in radiation oncology显示文摘Aims: To investigate the research status of radiation oncology in China through survey of literature in international radiation oncology journals and retrospectively compare the outputs of radiation oncology articles of the three major regions of China—Mainland(ML), Taiwan(TW) and Hong Kong(HK).Methods: Radiation oncology journals were selected from 'oncology' and 'radiology, nuclear & medical image' category from Science Citation Index Expand(SCIE). Articles from the ML, TW and HK were retrieved from MEDLINE. The number of total articles, clinical trials, case reports, impact factors(IF), institutions and articles published in each journals were conducted for quantity and quality comparisons.Results: A total 818 articles from 13 radiation oncology journals were searched, of which 427 are from ML, 259 from TW, and 132 from HK. Ninety-seven clinical trials and 5 case reports are reported in China. Accumulated IF of articles from ML(1,417.11) was much higher than that of TW(1,003.093) and HK(544.711), while the average IF of articles from ML is the lowest.Conclusions: The total number of articles from China especially ML increased significantly in the last decade. The number of articles published from the ML has exceeded those from TW and HK. However, the quality of articles from TW and HK is better than that from ML. | Hongcheng Zhu Xi Yang Qin Qin Kangqi Bian Chi Zhang Jia Liu Hongyan Cheng Xinchen Sun | 2014 | Chinese Journal of Cancer Research2014，26，3： | 0 |
| 13 | Artificial Photosynthesis(AP):From Molecular Catalysts to Heterogeneous Materials显示文摘The development of green and renewable energy sources is in high demand due to energy shortage and productivity development.Artificial photosynthesis(AP)is one of the most effective ways to address the energy shortage and the greenhouse effect by converting solar energy into hydrogen and other carbon-based high value-added products through the understanding of the mechanism,structural analysis,and functional simulation of natural photosynthesis.In this review,the development of AP from natural catalysts to artificial catalysts is described,and the processes of oxygen production,hydrogen production,and carbon fixation are sorted out to understand the properties and correlations of the core functional components in natural photosynthesis,to provide a better rational design and optimization for further development of advanced heterogeneous materials. | JI Yuancheng XU Jiayun SUN Hongcheng LIU Junqiu | 2022 | Chemical Research in Chinese Universities2022，38，3： | 0 |
| 14 | Low-Energy Protons in Strong-Field Dissociation of H_(2)^(+) via Dipole-Transitions at Large Bond Lengths显示文摘More than ten years ago,the observation of the low-energy structure in the photoelectron energy spectrum,regarded as an“ionization surprise,”has overthrown our understanding of strong-field physics.However,the similar low-energy nuclear fragment generation from dissociating molecules upon the photon energy absorption,one of the well-observed phenomena in light-molecule interaction,still lacks an unambiguous mechanism and remains mysterious.Here,we introduce a time-energy-resolved manner using a multicycle near-infrared femtosecond laser pulse to identify the physical origin of the light-induced ultrafast dynamics of molecules.By simultaneously measuring the bond-stretching times and photon numbers involved in the dissociation of H_(2)^(+) driven by a polarization-skewed laser pulse,we reveal that the low-energy protons(below 0.7 eV)are produced via dipole-transitions at large bond lengths.The observed low-energy protons originate from strong-field dissociation of high vibrational states rather than the low ones of H_(2)^(+) cation,which is distinct from the well-accepted bond-softening picture.Further numerical simulation of the time-dependent Schrödinger equation unveils that the electronic states are periodically distorted by the strong laser field,and the energy gap between the field-dressed transient electronic states may favor the one-or three-photon transitions at the internuclear distance larger than 5 a.u.The time-dependent scenario and our time-energy-resolved approach presented here can be extended to other molecules to understand the complex ultrafast dynamics. | Shengzhe Pan Chenxi Hu Zhaohan Zhang Peifen Lu Chenxu Lu Lianrong Zhou Jiawei Wang Fenghao Sun Junjie Qiang Hui Li Hongcheng Ni Xiaochun Gong Feng He Jian Wu | 2022 | Ultrafast Science2022，，2： | 0 |
| 15 | Multiporphyrinic architectures:Advances in structural design for photodynamic therapy显示文摘Rationally designed multiporphyrinic architectures for boosting photodynamic therapy(PDT)have attracted significant attentions recently years due to their great potential for light-mediated generation of reactive oxygen species.However,there is still a gap between the structure design and their PDT performance for biomedical applications.This tutorial review provides a historical overview on(i)the basic concept of PDT for deeply understanding the porphyrin-mediated PDT reactions,(ii)developing strategies for constructing porphyrinic architectures,like nanorings,boxes,metal-organic frameworks(MOFs),covalent-organic frameworks(COFs),vesicles,etc.,where we classified into the following three categories:multiporphyrin arrays,porphyrinic frameworks,and others porphyrin assemblies,(iii)the various application scenarios for clinical cancer therapy and antibacterial infection.Also,the existing challenges and future perspectives on the innovation of porphyrinic architectures for clinical PDT applications are mentioned in the end section.Moreover,the porphyrinic nanomaterials with atomically precise architectures provide an ideal platform for investigating the relationship between structures and PDT outputs,design of personalized“all-in-one”theranostic agents,and the popularization and application in wider biomedical fields. | Yuwei Gao Yan Li Zhengwei Xu Shuangjiang Yu Junqiu Liu Hongcheng Sun | 2024 | Aggregate2024，5，1： | 0 |
| 16 | The Extract Behaviour and Control of ^(99)Tc in Purex Process显示文摘TheExtractBehaviourandControlof~(99)Tcin PurexProcessTianBaosheng;LuoLongjun;ZhangQinfen;LiWeimin;FeiHongcheng;HuHuaizhong;Su... | Tian Baosheng Luo Longjun Zhang Qinfen Li Weimin Fei Hongcheng Hu Huaizhong Sun Yuzhen Yin Huaying Li Ruixue Guo Jianhua | 1996 | 中国原子能科学研究院年报1996，，1： | 0 |
| 17 | Trojan nanobacteria hybridized with prodrug nanocapsules for efficient combined tumor therapy显示文摘Live bacteria-based drug delivery systems have been raised as promising tools for enhancing drug delivery into tumors due to their active tumor targeting and easy surface modifiability.In this work,a“Trojan nanobacteria hybrid”,E.coli@highly integrated nanocapsules(HINCs)hybrid(HINE-Hybrid),was successfully constructed with HINCs of prodrug based on covalent selfassembly and the facultative anaerobic bacterium E.coli MG 1655 for combined chemotherapy,photothermal therapy(PTT),and chemodynamic therapy(CDT).HINCs were constructed by covalent cross-linking of pillar[5]arene derivatives and cisplatin prodrug linker,which can be endocytosed and lysed to release therapeutic agents.Under the near-infrared(NIR)light(at 808 nm)irradiation,the system temperature can be significantly increased by HINCs,which further leads to the highly efficient generation of reactive oxygen species(ROS).In addition,HINE-Hybrid shows significant antitumor effects in in vitro and in vivo studies and also promotes immune cell infiltration and antitumor cytokine expression in the tumor microenvironment(TME).HINEHybrid exerts its anticancer properties efficiently due to selective enrichment and multiplication of E.coli at tumor sites,which is important for the construction of bacterial-assisted antitumor platforms. | Mingsong Zang Yuancheng Ji Xiaoran Ding Zhengwei Xu Jinxing Hou Jianxin Sun Jiayun Xu Shuangjiang Yu Hongcheng Sun Tingting Wang Junqiu Liu | 2023 | Nano Research2023，16，7： | 0 |
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