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| 1 | Resveratrol induces AMPK and mTOR signaling inhibition-mediated autophagy and apoptosis in multiple myeloma cells显示文摘Resveratrol,a natural compound extracted from the skins of grapes,berries,or other fruits,has been shown to have anti-tumor effects against multiple myeloma(MM)via promoting apoptosis and inhibiting cell viability.In addition to apoptosis,autophagy also plays a significant role in anti-tumor effects.However,whether autophagy is involved in anti-MM activity of resveratrol remains unclear.In this study,human MM cell lines U266,RPMI-8226,and NCI-H929 were treated with resveratrol.Cell Counting Kit-8 assay and colony formation assay were used to measure cell viability.Western blot analysis was used to detect apoptosis-and autophagy-associated proteins.3-Methyladenine(3-MA)was applied to inhibit autophagy.Results showed that resveratrol inhibited cell viability and colony formation via promoting apoptosis and autophagy in MM cell lines U266,RPMI-8226,and NCI-H929.Resveratrol promoted apoptosis-related proteins,Caspase-3 activating poly-ADP-ribose polymerase and Caspase-3 cleavage,and decreased the protein level of Survivin in a dose-dependent manner.Additionally,resveratrol upregulated the levels of LC3 and Beclin1 in a dose-dependent way,indicating that autophagy might be implicated in anti-MM effect of resveratrol.Furthermore,3-MA relieved the cytotoxicity of resveratrol by blocking the autophagic flux.Resveratrol increased the phosphorylation of adenosine monophosphate(AMP)-activated protein kinase and decreased the phosphorylation of mammalian target of rapamycin(mTOR)and its downstream substrates p70S6K and 4EBP1 in a dose-dependent manner,leading to autophagy.Therefore,our results suggest that resveratrol exerts anti-MM effects through apoptosis and autophagy,which can be used as a new therapeutic strategy for MM in clinic. | Ruye Ma Dandan Yu Yu Peng Hongfei Yi Yingcong Wang Taofang Cheng Bingqing Shi Guang Yang Weiming Lai Xiaosong Wu Ye Lu Jumei Shi | 2021 | Acta Biochimica et Biophysica Sinica2021，53，6： | 7 |
| 2 | Antiangiogenic effects of oxymatrine on pancreatic cancer by inhibitionof the NF-κB-mediated VEGF signaling pathway显示文摘 | Hui Chen Jianhong Zhang Jiang Luo Fuji Lai Zhaohong Wang Hongfei Tong Dian Lu Heqi Bu Riyuan Zhang Shengzhang Lin | 2013 | Oncology Reports2013，，2： | 1 |
| 3 | Geochemical Characteristics and Gas-to-Gas Correlation of Two Leakage-type Gas Hydrate Accumulations in the Western Qiongdongnan Basin, South China Sea显示文摘In recent years,a series of highly saturated leakage-type gas hydrates have been discovered in the western Qiongdongnan Basin(QDNB),South China Sea.Based on the molecular compositional and isotopic characteristics of the gas samples relevant to the gas hydrates collected from the two leakage-type gas hydrate accumulations in the GMGS5 and GMGS6 drilling zones,a detailed geochemical gas-to-gas correlation was conducted in this study,in order to further understand the geochemical characteristics and possible hydrocarbon sources of these gas hydrates.The natural gas relevant to the gas hydrates in the GMGS5 block is characterized by wet gas(67.96%<%C_(1)<98.58%,C_(1)/C_(1+)<0.9)and significant molecular and carbon isotope fractionation within the depth profile,whereas the gas samples from the GMGS6 block exhibit the characteristics of dry gas(99.25%<%C_(1)<99.81%,C_(1)/C_(1+)>0.9)and lack molecular and carbon isotope fractionation.Approximately 40%‒60%of the methane within the gas hydrate is of microbial origin,while the C^(2+)gas components are typical coal-type gas that are derived from thermogenic source rocks or deeply-buried natural gas fields.In addition,typical in situ primary microbial methane(−80.6‰<δ^(13)C-C_(1)<−67.7‰)was discovered in well W b,which was applied to estimate the contribution of the microbial gas to the gas hydrates.The gas-to-gas correlation results show that the hydrate gases within the two leakage-type gas hydrate accumulations in the GMGS5 and GMGS6 blocks are geochemically different,suggesting that they may have been derived from different source kitchens.Our results further indicate that the deeply-buried thermogenic gas significantly contributed to the shallowly-buried gas hydrates in the western QDNB and multiple effective thermogenic source kitchens provided the hydrocarbon gas in the gas hydrate accumulations. | LAI Hongfei QIU Haijun LIANG Jinqiang KUANG Zenggui FANG Yunxin REN Jinfeng LU Jing’an | 2022 | Acta Geologica Sinica(English Edition)2022，96，2： | 1 |
| 4 | Sedimentary characteristics and genetic mechanism of the giant ancient pockmarks in the Qiongdongnan Basin,northern South China Sea显示文摘In the late Miocene,giant ancient pockmarks,which are fairly rare globally,developed in the Qiongdongnan Basin.In this paper,to determine the sedimentary characteristics and genetic mechanism of these giant ancient pockmarks in the Yinggehai Formation of the Qiongdongnan Basin,based on high-resolution 3D seismic data and multiattribute fusion technologies,we analyzed the planar distribution and seismic facies of the ancient pockmarks and compared the characteristics of the ancient pockmarks with those of channels,craters,and hydrate pits.Moreover,we also discussed the implications of the fluid escape system and paleo-bottom current activity in the ancient pockmark development area and analyzed the influence of the ancient pockmarks on the paleoclimate in this region.Finally,an evolutionary model was proposed for the giant ancient pockmarks.This model shows that the giant ancient pockmarks in the southern Qiongdongnan Basin were affected by both deep fluid escape and lateral transformation of paleobottom currents.In addition,the giant ancient pockmarks contributed to the atmospheric CO_(2)concentration in the late Miocene and played a great role in the contemporary evaluation of deepwater petroleum exploration. | Pengfei Xiong Cong Cheng Zenggui Kuang Jinfeng Ren Jinqiang Liang Hongfei Lai Zigui Chen Jiang Lu Xiaoyu Fang Tao Jiang | 2023 | Acta Oceanologica Sinica2023，42，2： | 0 |
| 5 | Nd, Sr and O Isotopic Study on Spilite-Keratophyre in Xiqiu,,Zhejiang Province, China显示文摘Nd, Sr and O isotopic study on the spilite-keratophyre sequence in Xiqiu shows that its ∈Nd values are inthe range of 4.02-5.26, and its ∈Sr values, +1.4-2.6. According to the points of these data in the ∈Nd-T,∈Sr-T and ∈Nd-∈Sr diagrams, the spilite-keratophyre is interpreted as being slightly contaminated by crustalmaterials. Its δ18O values are 3.9-5.0‰. The depletion of 18O in the rocks resulted from the influence ofseawater hydrothermal alteration during or soon after the rock formation. Based on the isotopic characteristicsand available geochemical data, it is believed that the spilite-keratophyre was formed in the well-developedisland-arc environment during the Late Proterozoic subduction of the palaeo-Pacific plate beneath thesoutheastern margin of the Yangtze massif. | Shen Weizhou Zhang Bangtong Ling Hongfei Lai Mingyian Yang Jiedong Tao Xiancong Department of Earth Sciences, Nanjing University, Nanjing, Jiangsu Modern Analysis Centre, Nanjing University, Nanjing, Jiangsu | 1992 | Acta Geologica Sinica(English Edition)1992，66，2： | 0 |
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