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| 1 | Effect of subsoil tillage depth on nutrient accumulation, root distribution, and grain yield in spring maize显示文摘A four-year field experiment was conducted to investigate the effect of subsoiling depth on root morphology, nitrogen(N), phosphorus(P), and potassium(K) uptake, and grain yield of spring maize. The results indicated that subsoil tillage promoted root development,increased nutrient accumulation, and increased yield. Compared with conventional soil management(CK), root length, root surface area, and root dry weight at 0–80 cm soil depth under subsoil tillage to 30 cm(T1) and subsoil tillage to 50 cm(T2) were significantly increased, especially the proportions of roots in deeper soil. Root length, surface area, and dry weight differed significantly among three treatments in the order of T2 > T1 > CK at the12-leaf and early filling stages. The range of variation of root diameter in different soil layers in T2 treatment was the smallest, suggesting that roots were more likely to grow downwards with deeper subsoil tillage in soil. The accumulation of N, P, and K in subsoil tillage treatment was significantly increased, but the proportions of kernel and straw were different. In a comparison of T1 with T2, the grain accumulated more N and P, while K accumulation in kernel and straw varied in different years. Grain yield and biomass were increased by 12.8% and 14.6% on average in subsoil tillage treatments compared to conventional soil treatment. Although no significant differences between different subsoil tillage depths were observed for nutrient accumulation and grain yield, lodging resistance of plants was significantly improved in subsoil tillage to 50 cm, a characteristic that favors a high and stable yield under extreme environments. | Hongguang Cai Wei Ma Xiuzhi Zhang Jieqing Ping Xiaogong Yan Jianzhao Liu Jingchao Yuan Lichun Wang Jun Ren | 2014 | The Crop Journal2014，2，5： | 42 |
| 2 | Phytoremediation of petroleum polluted soil显示文摘An experimental study of the rhizosphere effect on phytoremediation of petroleum polluted soil was carried out with three species of grasses,namely Pannicum,Eleusine indica(L.)Gaerth,and Tall Fescue.After a period of 150 days,this pot experiment showed that the rhizosphere of these three species accelerated the degradation of petroleum hydrocarbons to different extents.The results showed that the number of microorganisms in the rhizosphere increased by three orders of magnitude.The induction of the plant rhizosphere and the coercion influence of petroleum changed the species and activity of microorganisms.The degradation of petroleum hydrocarbons in the rhizosphere was 3-4 times that in unplanted soil.The dehydrogenase activity in the rhizosphere was 1.61-2.20 times that in unplanted soil, but the catalase activity was 0.90-0.93 times that in unplanted soil,and soil moisture content increased by 5%compared with the unplanted soil. | Wang Jing Zhang Zhongzhi Su Youming He Wei He Feng Song Hongguang | 2008 | Petroleum Science2008，5，2： | 12 |
| 3 | Differences in leaf functional traits between red and green leaves of two evergreen shrubs Photinia×fraseri and Osmanthus fragrans显示文摘Leaf functional traits are adaptations that enable plants to live under different environmental conditions. This study aims to evaluate the differences in leaf functional traits between red and green leaves of two evergreen shrubs Photinia 9 fraseri and Osmanthus fragrans. Specific areas of red leaves are higher than that of green leaves in both species. Thus, the material investment per unit area and per lamina of red leaves is significantly lower than that of green leaves, implying an utmost effort of red leaves to increase light capture and use efficiency because of their low leafchlorophyll concentration. The higher petiole length of green leaves compared with that of red leaves indicates that adult green leaves may have large fractional biomass allocation to support the lamina structures in capturing light with maximum efficiency and obtaining a high growth rate. The high range of the phenotypic plasticity of leaf size, leaf thickness,single-leaf wet and dry weights, and leaf moisture of green leaves may be beneficial in achieving efficient control of water loss and nutrient deprivation. The high range of phenotypic plasticity of leaf chlorophyll concentration of red leaves may be advantageous in increasing resource(especially light) capture and use efficiency because this leaf type is juvenile in the growth stage and has low leaf-chlorophyll concentration. | Congyan Wang Hongguang Xiao Jun Liu Jiawei Zhou | 2017 | Journal of Forestry Research2017，28，3： | 12 |
| 4 | Variations in leaf functional traits among plant species grouped by growth and leaf types in Zhenjiang,China显示文摘Leaf functional traits are adaptations that enable plants to live under various environmental conditions. This study aims to determine the differences in leaf functional traits among plants grouped by growth habit, leaf life span,leaf lifestyle, leaf form, and origin. Specific leaf area(SLA) of perennial or evergreen species was lower than that of annual or deciduous species because longer-lived leaves of perennial or evergreen species require more investment in structural integrity and/or defense against disturbances, especially with any resource constraint. SLA of large individuals was lower than that of small individuals. The low SLA in large individuals can improve their response to changing light and water conditions because increasing plant height is advantageous for light competition, but it can also impose a cost in terms of structural support and water transport. Petioles of plants with compound leaves were significantly longer than those of simple leaves because branching is expensive in terms of gaining height. SLA of plants increased with increasing invasiveness accordingly, and SLA of invasive plants was higher than that of their native congeners because invasive plants should invest more biomass on leaf growth rather than leaf structures per unit area to achieve a higher growth rate.Overall, variation in leaf functional traits among different groups may play an adaptive role in the successful survival of plants under diverse environments because leaf functional traits can lead to pronounced effects on leaf function,especially the acquisition and use of light. Plant species with different growth and leaf traits balance resource acquisition and leaf construction to minimize trade-offs and achieve fitness advantages in their natural habitat. | Congyan Wang Jiawei Zhou Hongguang Xiao Jun Liu Lei Wang | 2017 | Journal of Forestry Research2017，28，2： | 10 |
| 5 | Effect of Combined Application of Organic Fertilizer and Chemical Fertilizer in Different Ratios on Growth,Yield and Quality of Fluecured Tobacco显示文摘The effect of different ratio of organic and inorganic fertilizers on the growth and the yield and quality of flue-cured tobacco was studied.Using randomized blocks design,the data of the test materials K326 were analyzed by using variance analysis,significance test and other methods.The release efficiency of organic fertilizer in the soil was slower,and the effect of organic fertilizer on the growth of tobacco plants was worse than that of chemical fertilizers,and under 25% organic fertilizer + 75% chemical fertilizer treatment,the quality of the fluecured tobacco was good.Under the treatment of 50% organic fertilizer + 50% chemical fertilizer,the production of flue-cured tobacco was high and the ratio of first-class tobacco was high.It is suggested that the organic fertilizer application ratio should be 25%-50% in the agricultural production. | Bing LIANG Kun HUANG Yali FU Hongguang LI Chi WANG Xiaotian ZHONG Qinghua LU Chengxiao HU | 2017 | Asian Agricultural Research2017，9，12： | 9 |
| 6 | Insights into the differences in leaf functional traits of heterophyllous Syringa oblata under different light intensities显示文摘Many plants exhibit heterophylly; the spatially and temporally remarkable ontogenetic differences in leaf morphology may play an adaptative role in their success under diverse habitats. Thus, this study aimed to gain insights into differences in leaf functional traits of heterophyllous Syringa oblata Lindl., which has been widely used as an ornamental tree around the world under different light intensities in East China. No significant differences existed in specific leaf area(SLA) between lanceolate- and heart-shaped leaves. Differences in the investment per unit of light capture surface area deployed between lanceolate- and heart-shaped leaves may be not obvious. This may be attributing to the fact that single leaf wet and dry weight of heart-shaped leaves were significantly higher than those of lanceolate leaves but leaf length and leaf thickness of heart-shaped leaves were significantly lower than those of lanceolate leaves. The SLA of shade trees was significantly higher than that of sun trees. The investment per unit of light capture surface of shade trees was lower than that of sun trees, making it possible to increase light capture and use efficiency in low-light environments. The phenotypic plasticity of most leaf functional traits of lanceolate leaves was higher than those of heart-shaped leaves because the former is the juvenile and the latter is the adult leaf shape during the process of phylogenetic development of S. oblate. The higher range of phenotypic plasticity of leaf thickness and leaf moisture for sun trees may be beneficial to obtain a more efficient control of water loss and nutrient deprivation in highlight environments, and the lower range of phenotypic plasticity of single leaf wet and dry weight, and SLA for shade trees may gain an advantage to increase resource(especially light) capture and use efficiency in low-light environments. In brief, the successfully ecological strategy of plants is to find an optimal mode for the trade-off between various functional traits to obtain more living resources and achieve more fitness advantage as much as possible in the multivariate environment. | Hongguang Xiao Congyan Wang Jun Liu Lei Wang Daolin Du | 2015 | Journal of Forestry Research2015，26，3： | 8 |
| 7 | Determination of Heterotic Groups and Heterosis Analysis of Yield Performance in indica Rice显示文摘To compare the heterosis levels among various groups of parental lines used extensively in China, identify foundational heterotic groups in parental pools and understand the relationship between genetic distance and heterosis performance, 16 parental lines with extensive genetic variation were selected from various sub-groups, and 39 hybrid combinations were generated and evaluated in Fujian and Hainan Provinces of China. The main results were as follows:(1) The 16 parental lines can be grouped into 7 sub-groups consisting of 1 maintainer sub-group and 6 restorer sub-groups;(2) Mean grain yield of the restorer lines was higher than that of the maintainer lines, and mean yield of parental lines was higher than that of the hybrid combinations;(3) The two best heterotic patterns were II-32A × G5 and II-32A × G6, moreover, the order of restorer sub-groups according to grain yield, from the highest to lowest, was G7, G6, G5, G4, G3 and G2; High specific combining ability values were observed for combinations of II-32A × G5, II-32A × G6 and Tianfeng A × G7;(4) Hybrid combinations derived from II-32A crossed with 13 restorer lines had higher yield trait values(mid-parent heterosis, better-parent heterosis, standard heterosis over check and specific combining ability) than any other combinations;(5) Genetic distance was positively correlated with panicle number, grain length and length-to-width ratio(P < 0.05) and negatively correlated with grain width, grain yield, seed-setting rate, as well as mid-parent heterosis, standard heterosis over check, and specific combining ability for grain yield(P < 0.01). These heterotic groups and patterns and their argonomic traits will provide useful information for future hybrid rice breeding programs. | WANG Yingheng CAI Qiuhua XIE Hongguang WU Fangxi LIAN Ling HE Wei CHEN Liping XIE Hua'an ZHANG Jianfu | 2018 | Rice science2018，25，5： | 8 |
| 8 | Crystalloid and colloid preload for maintaining cardiac output in elderly patients undergoing total hip replacement under spinal anesthesia显示文摘The aim of the present study was to compare the effects of colloid and crystalloid preload on cardiac output (CO) and incidence of hypotension in elderly patients under spinal anesthesia (SA). A randomized, double-blinded study was conducted including 47 elderly patients undergoing scheduled total hip replacement (THR), who were randomized to three groups: the control group (C group, n = 15), crystalloid (RS group, n =16) and colloid group (HES group, n = 16). An intravenous preload of 8 mL/kg of either lactated Ringer's solution in the RS group or 6% hydroxyethyl starch in the HES group was infused within 20 min before SA induction, while no intravenous preload was given in the C group. There was a trend of decrease in CO and systolic blood pressure after SA with time in the C group. In the RS and HES groups, CO increased significantly after fluid preloading as compared with baseline (P < 0.01). Thereafter, CO remained higher than baseline until 30 min after SA in the HES group. The change of systolic blood pressure was similar to CO, but no significant difference from baseline was observed in each group. Hypotension occurred in 3 patients in the C group and one each in the RS and HES group, respec-tively (P = 0.362). Intravascular volume preload with colloid is more effective than crystalloid solution in main-taining CO, which may be improved the hemodynamic stability in elderly patients during SA. | Rufeng Xie Lizhong Wang Hongguang Bao | 2011 | The Journal of Biomedical Research2011，25，3： | 6 |
| 9 | Dark matter direct search sensitivity of the PandaX-4T experiment显示文摘The Panda X-4T experiment, a 4-ton scale dark matter direct detection experiment, is being planned at the China Jinping Underground Laboratory. In this paper we present a simulation study of the expected background in this experiment. In a 2.8-ton fiducial mass and the signal region between 1-10 keV electron equivalent energy, the total electron recoil background is found to be 4.9 × 10^(-5) kg^(-1) d^(-1) keV^(-1). The nuclear recoil background in the same region is 2.8 × 10^(-7) kg^(-1) d^(-1) keV^(-1). With an exposure of 5.6 ton-years, the sensitivity of Panda X-4 T could reach a minimum spin-independent dark matter-nucleon cross section of 6 × 10^(-48) cm^2 at a dark matter mass of 40 Ge V/c^2. | HongGuang Zhang Abdusalam Abdukerim Wei Chen Xun Chen YunHua Chen XiangYi Cui BinBin Dong DeQing Fang ChangBo Fu Karl Giboni Franco Giuliani LinHui Gu XuYuan Guo ZhiFan Guo Ke Han ChangDa He ShengMing He Di Huang XingTao Huang Zhou Huang Peng Ji XiangDong Ji YongLin Ju ShaoLi Li Yao Li Heng Lin HuaXuan Liu JiangLai Liu YuGang Ma YaJun Mao KaiXiang Ni JinHua Ning XiangXiang Ren Fang Shi AnDi Tan AnQing Wang Cheng Wang HongWei Wang Meng Wang QiuHong Wang SiGuang Wang XiuLi Wang XuMing Wang Zhou Wang MengMeng Wu ShiYong Wu JingKai Xia MengJiao Xiao PengWei Xie BinBin Yan JiJun Yang Yong Yang ChunXu Yu JuMin Yuan JianFeng Yue Dan Zhang Tao Zhang Li Zhao QiBin Zheng JiFang Zhou Ning Zhou XiaoPeng Zhou | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，3： | 6 |
| 10 | Nitrous oxide emissions from different land use patterns in a typical karst region, Southwest China显示文摘Fluxes of nitrous oxide (N2O) from different land use patterns (matured forest, secondary forest, grassland and cropland) in a subtropical karst region of Guizhou Province, Southwest China, were measured for one year with a closed static chamber technique and by gas chromatography. The results showed that soil under different land uses was a source of atmospheric N2O. The cropland was a source with relatively high N2O as compared to forest and grassland, but no significant differences were observed. N2O emissions from soils varied with land use change and fertilizer application. There were two peaks of N2O flux occurred following the combination of two obvious precipitation and fertilizer events in the cultivated land. Converting from the matured forest to secondary forest tended to increase annual emissions of N2O (from 1.40 to 1.65 kg N ha -1 a -1 ), while changing land use from secondary forest to scattered grassland tended to decrease annual emissions of N2O slightly (from 1.65 to 1.45 kg N ha -1 a -1 ). Our range of cumulative annual N2O emission across different land uses (1.40-1.91 kg N ha -1 a -1 ) in a karst region is in general agreement with previously published data in a non-karst region. However, in the maize field, N2O emission factor (EF) was 0.34% for fertilizer application, which is about 71.2% lower than the IPCC default value. It is suggested that current IPCC (Intergovernmental Panel on Climate Change) EF methodology could overestimate N2O emission from the karstic cropland. Anyway, the N2O emission from cropland in the karst region would contribute significantly to the global N2O budget, so reducing fertilization frequency during the crop growing season could lead to a decrease in N2O emission in the whole year. | CHENG Jianzhong LEE Xinqing ZHOU Zhihong WANG Bing XING Ying CHENG Hongguang | 2013 | Chinese Journal Of Geochemistry2013，32，2： | 5 |
| 11 | Constraint Force Analysis of Metamorphic Joints Based on the Augmented Assur Groups显示文摘In order to obtain a simple way for the force analysis of metamorphic mechanisms, the systematic method to unify the force analysis approach of metamorphic mechanisms as that of conventional planar mechanisms is proposed. A force analysis method of metamorphic mechanisms is developed by transforming the augmented Assur groups into Assur groups, so that the force analysis problem of metamorphic mechanisms is converted into the force analysis problems of conventional planar mechanisms. The constraint force change rules and values of metamorphic joints are obtained by the proposed method, and the constraint force analysis equations of revolute metamorphic joints in augmented Assur group RRRR and prismatic metamorphic joints in augmented Assur group RRPR are deduced. The constraint force analysis is illustrated by the constrained spring force design of paper folding metamorphic mechanism, and its metamorphic working process is controlled by the spring force and geometric constraints of metamorphic joints. The results of spring force show that developped design method and approach are feasible and practical. By transforming augmented Assur groups into Assur groups, a new method for the constraint force analysis of metamorphic joints is proposed firstly to provide the basis for dynamic analysis of metamorphic mechanism. | LI Shujun WANG Hongguang YANG Qiang | 2015 | Chinese Journal of Mechanical Engineering2015，28，4： | 5 |
| 12 | Practical Structural Design Approach of Multiconfiguration Planar Single‑Loop Metamorphic Mechanism with a Single Actuator显示文摘As a type of multiconfiguration mechanism that can operate in an under-actuated state,metamorphic mechanisms were proposed more than two decades ago and attracted significant interest.Studies on structural synthesis of metamorphic mechanisms tend to focus more on metamorphic techniques and the structural synthesis of source mechanisms for metamorphic mechanisms.By designing different constraint architectures of metamorphic joints,multistructures can be obtained from the same source metamorphic mechanism.To determine the constraint architectures of metamorphic joints and their different assembly combinations,a kinematic status matrix and a corresponding constraint status matrix are constructed based on the metamorphic cyclogram of a source mechanism.According to the equivalent resistance gradient model and the constraint status matrix,an equivalent resistance matrix for the metamorphic joints is proposed.A structural synthesis matrix of the metamorphic mechanism is then obtained from the equivalent resistance matrix by deducing the constraint form vectors of the metamorphic joints.Furthermore,a kinematic diagram synthesis of the source metamorphic mechanism of a planar single-loop metamorphic mechanism is proposed,which is based on only the 14 one-or zero-degrees-of-freedom linkage groups.The entire structural design method of a metamorphic mechanism is based on the structural synthesis matrix and is presented as a systematic process.Finally,the proposed structural design approach is illustrated by two examples to verify its feasibility and practicality.This study provides an effective method for designing a practical multi-mobility and multiconfiguration planar single-loop metamorphic mechanism with a single actuator. | Qiang Yang Guangbo Hao Shujun Li Hongguang Wang Haiyang Li | 2020 | Chinese Journal of Mechanical Engineering2020，33，5： | 5 |
| 13 | Experimental study on dynamic load magnification factor for ballastless track-subgrade of high-speed railway显示文摘The magnitude of dynamic load produced by high-speed trains depends on many factors,of which train speed is the most critical one.However,it is quite difficult to determine the effect of train speed on dynamic load using the theoretical methods due to the complexity of the interaction between vehicle and track-subgrade.Thus large-scale model test has gradually become an important approach for studying dynamic responses of ballastless track-subgrade of high-speed railway.In this study,a full-scale model of ballastless track-subgrade was constructed in accordance with the design and construction standards for Shanghai-Nanjing intercity high-speed railway line firstly.Then,the dynamic strain of slab and the dynamic earth pressure of subgrade were measured by conducting single wheel axle excitation test.In addition,the relationship between the dynamic load magnification factor(DLF) and the train speed was obtained.Finally,the DLF of track-subgrade under different train speeds was proposed,similar to that given by German Railway Standard. | Renpeng Chen Xing Zhao Zuozhou Wang Hongguang Jiang Xuecheng Bian | 2013 | Journal of Rock Mechanics and Geotechnical Engineering2013，5，4： | 5 |
| 14 | 800 Gbit/s transmission over 1 km single-mode fiber using a four-channel silicon photonic transmitter显示文摘We demonstrate the optical transmission of an 800 Gbit/s(4×200 Gbit/s)pulse amplitude modulation-4(PAM-4)signal and a 480 Gbit/s(4×120 Gbit/s)on–off-keying(OOK)signal by using a high-bandwidth(BW)silicon photonic(SiP)transmitter with the aid of digital signal processing(DSP).In this transmitter,a four-channel SiP modulator chip is co-packaged with a four-channel driver chip,with a measured 3 dB BW of 40 GHz.DSP is applied in both the transmitter and receiver sides for pre-/post-compensation and bit error rate(BER)calculation.Back-to-back(B2B)BERs of the PAM-4 signal and OOK signal are first measured for each channel of the transmitter with respect to a variety of data rates.Similar BER performance of four channels shows good uniformity of the transmitter between different channels.The BER penalty of the PAM-4 and OOK signals for 500 m and 1 km standard single-mode fiber(SSMF)transmission is then experimentally tested by using one channel of the transmitter.For a 200 Gbit/s PAM-4 signal,the BER is below the hard-decision forward error correction(HD-FEC)threshold for B2B and below the soft-decision FEC(SD-FEC)threshold after 1 km transmission.For a 120 Gbit/s OOK signal,the BER is below SD-FEC threshold for B2B.After 500 m and 1 km transmission,the data rate of the OOK signal shrinks to 119 Gbit/s and 118 Gbit/s with the SD-FEC threshold,respectively.Finally,the 800 Gbit/s PAM-4 signal with 1 km transmission is achieved with the BER of all four channels below the SD-FEC threshold. | Hongguang Zhang Miaofeng Li Yuguang Zhang Di Zhang Qiwen Liao Jian He Shenglei Hu Bo Zhang Lei Wang Xi Xiao Nan Qi Shaohua Yu | 2020 | Photonics Research2020，8，11： | 5 |
| 15 | Lichtenstein inguinal hernia repairs with porcine small intestine submucosa: a 5- year follow-up. a prospective randomized controlled study显示文摘Porcine small intestine submucosa(SIS)biologic patch has been used in inguinal hernia repair.However,there are lttle data available to assess the long-term effect after repair.This study aimed to explore the long-term effect of SIS patch in open inguinal hernia repair.Sevent-six patients with unilateral inguinal hernia were treated with Lichtenstein tension-free hernia repair using SIS patch(Beijing Datsing Bio-Tech Co,Ltd.)and Surgisis patch(COOK,USA)in Tianjn Union Medical Center and China-Japan Friendship Hospital.In the trial,the long-term efficacy of the treatment group and the control group were compared.A total of 66 patients in both groups received long-term follow-up(>5years)after surgery,with a followup rate of 86.8%.During the follow-up period,there was one case of recurrence,one case of chronic pain in the control group.There was no statistically significant difference(P>0.05)in terms of recurrence,chronic pain,foreign body sensation and infection between the two groups of patients.After long-term observations,it has been found that the porcine small intestinal submucosa(SIS)biological patch is safe and effective for inguinal hernia Lichtenstein repair,and has a low recurrence rate and complication rate. | Baoshan Li Xin Zhang Yi Man Jiadong Xie Wei Hu Huang Huang Yinlong Wang Hongguang Ma | 2021 | Regenerative Biomaterials2021，8，1： | 5 |
| 16 | Bimodular effects of D614G mutation on the spike glycoprotein of SARS-CoV-2 enhance protein processing,membrane fusion,and viral infectivity显示文摘Dear Editor,By the end of June 2020,the pandemic of coronavirus diseases 2019(COVID-19)had resulted in more than 10 million individuals,all over the world,being infected with the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).1 The high contagiousness of SARS-CoV-2 virus was largely attributed to the relatively unique sequence composition in its spike(S)glycoprotein,which is in charge of the host entry by interacting with its cellular receptor angiotensin-converting enzyme 2(ACE2).2,3 The S glycoprotein can be processed into an N terminal S1 fragment that is responsible for receptor binding,and a C terminal S2 fragment that functions to promote membrane fusion.4 SARS-CoV-2 is a type of single-stranded positive-sense ribonucleic acid(RNA)virus,and an increasing number of mutations were identified across the SARS-CoV-2 genome,including the region encoding S glycoprotein.Nevertheless,the functional implications of these mutations remain largely unknown,we here reported the mutation analysis of S gene and a functional exploration of the dominant D614G mutation. | Xiaoyi Jiang Zhengrong Zhang Chenxi Wang Hongguang Ren Lihua Gao Haoran Peng Zubiao Niu He Ren Hongyan Huang Qiang Sun | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 17 | Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model显示文摘Chaperone-mediated autophagy(CMA)is a lysosome-dependent selective degradation pathway implicated in the pathogenesis of cancer and neurodegenerative diseases.However,the mechanisms that regulate CMA are not fully understood.Here,using unbiased drug screening approaches,we discover Metformin,a drug that is commonly the first medication prescribed for type 2 diabetes,can induce CMA.We delineate the mechanism of CMA induction by Metformin to be via activation of TAK1-IKKα/β signaling that leads to phosphorylation of Ser85 of the key mediator of CMA,Hsc70,and its activation.Notably,we find that amyloid-beta precursor protein(APP)is a CMA substrate and that it binds to Hsc70 in an IKKα/β-dependent manner.The inhibition of CMA-mediated degradation of APP enhances its cytotoxicity.Importantly,we find that in the APP/PS1 mouse model of Alzheimer's disease(AD),activation of CMA by Hsc70 overexpression or Metformin potently reduces the accumulated brain Aβplaque levels and reverses the molecular and behavioral AD phenotypes.Our study elucidates a novel mechanism of CMA regulation via Metformin-TAK1-IKKα/β-Hsc70 signaling and suggests Metformin as a new activator of CMA for diseases,such as AD,where such therapeutic intervention could be beneficial. | Xiaoyan Xu Yaqin Sun Xufeng Cen Bing Shan Qingwei Zhao Tingxue Xie Zhe Wang Tingjun Hou Yu Xue Mengmeng Zhang Di Peng Qiming Sun Cong Yi Ayaz Najafov Hongguang Xia | 2021 | Protein & Cell2021，12，10： | 5 |
| 18 | A comparison of unilateral and bilateral pedicle screw fixation combined with transforaminal lumbar interbody fusion for lumbar degenerative diseases显示文摘 | Yang Xiaoming Wang Hong Zhao Quanlai Xu Hongguang Liu Ping Jin Yuelong | 2014 | Chinese Medical Journal2014，，20： | 5 |
| 19 | Clinical significance of HBME-1,Galectin-3,and CK19 expression and the status of BRAF mutation in papillary thyroid carcinoma显示文摘Objective The aim of this study was to explore the clinical significance of the expression of proteins human bone marrow endothelial cell markers(HBME-1), Galectin-3, and cytokeratin19(CK19), as well as the status of v-raf murine sarcoma viral oncogene homolog B1(BRAF) mutation in papillary thyroid carcinoma(PTC). Methods Immunohistochemical staining was performed in 82 specimens each of PTC and papillary benign lesions to detect the expression of HBME-1, Galectin-3, and CK19. Polymerase chain reaction(PCR) and gene sequencing were performed on 60 specimens each of PTC and papillary benign lesions to detect the status of BRAF mutation. Results The positive expression ratios of HBME-1, Galectin-3, and CK19 in PTC were 98.8%, 97.6% and 100% respectively, which were significantly higher than the expressions in papillary benign lesions(P < 0.05). No significant relationship was observed between the expression of these makers and the clinicopathological features of PTC. The sensitivity of co-expression of HBME-1 and CK19 or HBME-1 and Galectin-3 as diagnostic criteria of PTC was 99.9%, with a specificity of 95.4%. BRAF mutation was detected in 40 of 60 PTC(66.7%) specimens. There was a statistical difference in BRAF mutations between PTC and papillary benign lesions(P < 0.05); there were no associations between BRAF mutation and the clinicopathological features of PTC. Conclusion Combined immunohistochemical staining of HBME-1, Galectin-3, and CK19 can further improve the sensitivity and specificity of differential diagnosis of PTC. BRAF mutation is a significant genetic event, which may have diagnostic value for PTC. | Li Zheng Min Zhao Xiangyang Hu Jin Huang Ling Ang Hongguang Hu Qiang Zou Jin Wang Mingqiang Liu Yang Zhao | 2016 | Oncology and Translational Medicine2016，2，4： | 4 |
| 20 | Monte-Carlo simulation of pinhole collimator of a small field of view gamma camera for small animal imaging显示文摘Needs in scintimammography applications,especially for small animal cardiac imaging,lead to develop a small field of view,high spatial resolution gamma camera with a pinhole collimator.However the ideal pinhole collimator must keep a compromise between spatial resolution and sensitivity.In order to design a pinhole collimator with an optimized sensitivity and spatial resolution,the spatial resolution and the geometric sensitivity response as a function of the source to collimator distance has been obtained by means of Monte-Carlo simulation for a small field of view gamma camera with a pinhole collimator of various-hole diameters.The results show that the camera with pinhole of 1 mm,1.5 mm and 2 mm diameter has respectively spatial resolution of 1.5 mm,2.25 mm and 3 mm and geometric sensitivity of 0.016%,0.022%and 0.036%,while the source to collimator distance is 3 cm.We chose the pinhole collimator with hole diameter size of 1.2 mm for our the gamma camera designed based on the trade-off between sensitivity and resolution. | ZHU Jie MA Wenyan ZHU Yufeng MA Hongguang WU Yuelei HU Huasi ZHANG Boping HUO Yonggang LIU Silu JIAN Bin WANG Zhaomin | 2009 | Nuclear Science and Techniques2009，20，1： | 4 |
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