2篇
您的检索式：作者名="Hongkuan Yang"
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| 1 | Correlation of ARNTL2 with Immune Infiltration and Its Role as a Potential Prognostic Biomarker in Lung Adenocarcinoma显示文摘Background:ARNTL2 is a core component of the circadian clock genes and plays regulatory roles in the cell cycle and immune infiltration,but its mechanism in lung cancer(LC)remains unclear.Objective:To investigate the clinical and therapeutic value of ARNTL2 in LC.Methods:The Oncomine and Cancer Cell Line Encyclopedia(CCLE)databases were adopted for assessing the ARNTL2 expression,after which the Kaplan-Meier plotter and Gene Expression Profiling Interactive Analysis 2(GEPIA2)databases were used to assess the correlation of ARNTL2 with prognosis.The univariate and multi-variate Cox regression analyses were utilized to identify independent prognostic factors.Also,we explored how ARNTL2 expression is related to immune infiltration,and immunomodulators in non-small lung cancer(NSCLC)using the Tumor Immune Estimation Resource(TIMER)database,TISIDB database and Gene Set Enrichment Analysis(GSEA).Finally,coexpression of ARNTL2 and PD-L1 in lung adenocarcinoma(LUAD)was verified via immunofluorescence staining and COXPRESdb v7 database.Results:Our study demonstrated a remarkable upregulated expression of ARNTL2 in multiple cell lines and can-cers,including NSCLC.Prognostic analysis displayed a remarkable correlation between high ARNTL2 expression and unfavorable overall survival(OS)and first progressive(FP)survival among patients ailing from LUAD,and ARNTL2 was an independent predictor of prognosis for LUAD patients.GSEA analysis showed that overexpres-sion of ARNTL2 was significantly linked with cell cycle and immunity.Furthermore,we reported a correlation of ARNTL2 expression with immunomodulators and lymphocytes.Immunofluorescence staining revealed that ARNTL2 and PD-L1 were elevated relative to normal tissue for LUAD,and colocalization of them was observed.Conclusion:Elevated ARNTL2 expression in LUAD revealed the prognostic values and its prospective role as a target for cell cycle and immune therapy. | Junjie Pan Hongkuan Yang Lihong Zhu Yafang Lou | 2021 | Clinical Complementary Medicine and Pharmacology2021，1，1： | 0 |
| 2 | Residue Analysis of 55% MCPA·ametryn·diuron WP显示文摘The digestion regularity of MCPA,ametryn and diuron which were the active ingredients of 55% MCPA·ametryn·diuron WP in sugarcane leaves and soil of sugarcane plantation collected from Changsha of Hunan Province and Haikou of Hainan Province in 2009 and 2010were studied in the paper,and the results showed that these three agents had rapid digestion. The final residue test showed that both MCPA and ametryn had not been detected in the study; the average residues of diuron in the soil collected from Hunan Province in 2009 and 2010 were 0. 018 and 0. 015 mg / kg,respectively which were slightly larger than the critical value of 0. 013mg / kg; diuron had no been detected in other treatments. | Yang Lang Liang Xueqiang Huang Lifei Wang Weilan Xu Hongkuan Wu Hongguo Huang Jing | 2014 | Plant Diseases and Pests2014，5，1： | 0 |
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