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| 1 | Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury显示文摘The outbreak of the 2019-nCoV infection began in December 2019 in Wuhan,Hubei province,and rapidly spread to many provinces in China as well as other countries.Here we report the epidemiological,clinical,laboratory,and radiological characteristics,as well as potential biomarkers for predicting disease severity in 2019-nCoV-infected patients in Shenzhen,China.All 12 cases of the 2019-nCoV-infected patients developed pneumonia and half of them developed acute respiratory distress syndrome (ARDS).The most common laboratory abnormalities were hypoalbuminemia,lymphopenia,decreased percentage of lymphocytes (LYM) and neutrophils (NEU),elevated C-reactive protein (CRP) and lactate dehydrogenase (LDH),and decreased CD8 count.The viral load of 2019-nCoV detected from patient respiratory tracts was positively linked to lung disease severity.ALB,LYM,LYM (%),LDH,NEU (%),and CRP were highly correlated to the acute lung injury.Age,viral load,lung injury score,and blood biochemistry indexes,albumin (ALB),CRP,LDH,LYM (%),LYM,and NEU (%),may be predictors of disease severity.Moreover,the Angiotensin Ⅱlevel in the plasma sample from 2019-nCoV infected patients was markedly elevated and linearly associated to viral load and lung injury.Our results suggest a number of potential diagnosis biomarkers and angiotensin receptor blocker (ARB) drugs for potential repurposing treatment of 2019-nCoV infection. | Yingxia Liu Yang Yang Cong Zhang Fengming Huang Fuxiang Wang Jing Yuan Zhaoqin Wang Jinxiu Li Jianming Li Cheng Feng Zheng Zhang Lifei Wang Ling Peng Li Chen Yuhao Qin Dandan Zhao Shuguang Tan Lu Yin Jun Xu Congzhao Zhou Chengyu Jiang Lei Liu | 2020 | Science China(Life Sciences)2020，63，3： | 157 |
| 2 | Concentration and source identification of polycyclic aromatic hydrocarbons and phthalic acid esters in the surface water of the Yangtze River Delta,China显示文摘The pollution from polycyclic aromatic hydrocarbons(PAHs) and phthalic acid esters(PAEs) in the surface water of the rapidly urbanized Yangtze River Delta region was investigated.Fourteen surface water samples were collected in June 2010.Water samples were liquid-liquid extracted using methylene chloride and analyzed by gas chromatography-mass spectrometry.Concentrations of PAHs and PAEs ranged 12.9-638.1 ng/L and 61-28550 ng/L,respectively.Fluoranthene,naphthalene,pyrene,phenanthrene,di-2ethylhexyl phthalate,and di-n-butyl phthalate were the most abundant compounds in the samples.The water samples were moderately polluted with benzo[a]pyrene according to China's environmental quality standard for surface water.The two highest concentrations of PAHs and PAEs occurred in samples from Taihu Lake,Wuxi City and the western section of Yangchenghu Lake.Potential sources of pollution at S7 were petroleum combustion and the plastics industry,and at Yangchenghu Lake were petroleum combustion and domestic waste.Pollution in samples from the Beijing-Hangzhou Grand Canal originated from diesel engines.There were no obvious sources of pollution for the other water samples.These results can be used as reference levels for future monitoring programs of pollution from PAHs and PAEs. | Lifei Zhang Liang Dong Lijun Ren Shuangxin Shi Li Zhou Ting Zhang Yeru Huang | 2012 | Journal of Environmental Sciences2012，24，2： | 56 |
| 3 | Epigenetic regulation of phosphodiesterase 4d in restrictive cardiomyopathy mice with cTnI mutations显示文摘Epigenetic regulations play an important role in disease development.In this study,we have investigated epigenetic regulations in restrictive cardiomyopathy mice with cTnI 193 His mutation.Our results demonstrated that phosphodiesterase(PDEs)4d was down-regulated in the heart of these mice.Further studies showed that the epigenetic modifications were associated with enhanced acetylation of histone 3 lysine 4 and lysines 9,whereas tri-methylation of histone 3 lysine 4,were decreased in histones near the PDE4d gene promoter regions.The binding levels of histone transmethylase SMYD1 and histone deacetylase HDAC1 were increased in the gene promoter regions in cTnI193 His transgenic hearts.Using immune-fluorescent labeling we found an evidence of cTnI existence in the nucleus of cardiomyocytes and Western blotting further confirmed that both wild type and mutated cTnI could be detected in the cell nucleus of the hearts.Furthermore,an interaction between cTnI and SMYD1,or cTnI and HDAC1 was observed.Overexpression of the mutated cTnI in cultured cardiomyocytes reduced the expression of PDE4d.Our data suggest that the decrease of PDE4d expression in RCM mice caused by cTnI mutations may be related to epigenetic regulation,i.e.,histone acetylation and methylation,and cTnI might be involved in this procedure via an interaction with HDAC1 and SMAD1 in the hearts. | Weian Zhao Xiaoqi Wu Zhiyuan Wang Bo Pan Lifei Liu Lingjuan Liu Xupei Huang Jie Tian | 2020 | Science China(Life Sciences)2020，63，4： | 4 |
| 4 | Lateral transfer of mRNA and protein by migrasomes modifies the recipient cells显示文摘Dear Editor,Migrasomes are recently discovered vesicular organelles which form on the retraction fibers(RFs)of migrating cells.'Once detached from cells,migrasomes can rupture and release their luminal contents'in a process named migracytosis.Recently,migrasomes have been shown to play an important role in zebrafish organ morphogenesis by releasing chemokine signals to defined regions of the embryo.2 Thus,migracytosis is considered as a major mechanism for migrasomes to carry out their functions.It has been frequently observed that intact migrasomes can be engulfed by surrounding cells,'and this has been proposed as a potential mechanism for lateral transfer of cellular contents between cells.However,it is not clear whether the lateral transfer of cellular contents by migrasomes has functional consequences for the recipient cells. | Mingli Zhu Qin Zou Rongyao Huang Ying Li Xudong Xing Jianhuo Fang Liang Ma Lifei Li Xuerui Yang Li Yu | 2021 | Cell Research2021，31，2： | 3 |
| 5 | Progress in octahedral spherical hohlraum study显示文摘In this paper,we give a review of our theoretical and experimental progress in octahedral spherical hohlraum study.From our theoretical study,the octahedral spherical hohlraums with 6 Laser Entrance Holes(LEHs)of octahedral symmetry have robust high symmetry during the capsule implosion at hohlraum-to-capsule radius ratio larger than 3.7.In addition,the octahedral spherical hohlraums also have potential superiority on low backscattering without supplementary technology.We studied the laser arrangement and constraints of the octahedral spherical hohlraums,and gave a design on the laser arrangement for ignition octahedral hohlraums.As a result,the injection angle of laser beams of 50°-60°was proposed as the optimum candidate range for the octahedral spherical hohlraums.We proposed a novel octahedral spherical hohlraum with cylindrical LEHs and LEH shields,in order to increase the laser coupling efficiency and improve the capsule symmetry and to mitigate the influence of the wall blowoff on laser transport.We studied on the sensitivity of the octahedral spherical hohlraums to random errors and compared the sensitivity among the octahedral spherical hohlraums,the rugby hohlraums and the cylindrical hohlraums,and the results show that the octahedral spherical hohlraums are robust to these random errors while the cylindrical hohlraums are the most sensitive.Up till to now,we have carried out three experiments on the spherical hohlraum with 2 LEHs on Shenguang(SG)laser facilities,including demonstration of improving laser transport by using the cylindrical LEHs in the spherical hohlraums,spherical hohlraum energetics on the SGIII prototype laser facility,and comparisons of laser plasma instabilities between the spherical hohlraums and the cylindrical hohlraums on the SGIII laser facility. | Ke Lan Jie Liu Zhichao Li Xufei Xie Wenyi Huo Yaohua Chen Guoli Ren Chunyang Zheng Dong Yang Sanwei Li Zhiwen Yang Liang Guo Shu Li Mingyu Zhang Xiaoying Han Chuanlei Zhai Lifei Hou Yukun Li Keli Deng Zheng Yuan Xiayu Zhan Feng Wang Guanghui Yuan Haijun Zhang Bobin Jiang Lizhen Huang Wei Zhang Kai Du Runchang Zhao Ping Li Wei Wang Jingqin Su Xuewei Deng Dongxia Hu Wei Zhou Huaiting Jia Yongkun Ding Wanguo Zheng Xiantu He | 2016 | Matter and Radiation at Extremes2016，1，1： | 2 |
| 6 | Improved strength and ductility of AZ31B Mg alloy sheets processed by accumulated extrusion bonding with artificial cooling显示文摘In this study,accumulated extrusion bonding(AEB)process with application of artificial water cooling was successfully performed to fabricate fined-grains AZ31B Mg alloy sheets at 150℃,200℃ and 250℃.The resultant microstructure and mechanical properties are systematically investigated.It reveals that the processing temperature has an important effect on the microstructural evolution during extrusion.During AEB process at 150℃ and 200℃,{10-12}tensile twinning was activated at early stage of extrusion,and subsequently continuous dynamic recrystallization(CDRX)occurred and dominated the further deformation.However,for the sample extruded at 250℃,hardly any twins can be observed,and new fined dynamic recrystallized grains were found along grain boundaries.Artificial cooling was utilized to reduce the rate of grain growth out of the extrusion die,resulting the grains significantly refined from 11μm to 2.5μm.Local high dislocation density region was also observed in the microstructure of sample processed at 150℃ in artificial cooling condition,and the degree decreased with the processing temperature increase.The results summarized from tensile tests indicated that due to the grain refinement the strength and ductility was significantly enhanced(YS of 186 MPa vs.145 MPa,UTS of 391 MPa vs.336 MPa and FE of 31.5%vs.24.5%compared with the as-received sample).Subsequently,annealing treatment at different temperatures was applied to eliminate the high dislocation density.The sample annealed at 200℃ exhibited the best comprehensive mechanical property with YS of 179 MPa,UTS of 390 MPa and FE of 33.0%.As the annealing temperature increasing,the dislocation density was reduced by static recrystallization(SRX)and grain growth,leading to a decreased strength and ductility. | Tingzhuang Han Jingfeng Zou Guangsheng Huang Lifeng Ma Chaojie Che Weitao Jia Lifei Wang Fusheng Pan | 2021 | Journal of Magnesium and Alloys2021，9，5： | 2 |
| 7 | Corrigendum to“First demonstration of improving laser propagation inside the spherical hohlraums by using the cylindrical laser entrance hole”[Matter Radiation Extremes 1(1)(2016)2-7]显示文摘Corrigendum Text:On page 2 of this letter,there is a misprint in the unit.The unit of the geometrical dimension of the spherical hohlraums on this page should always be“mm”rather than“mm”,i.e.in the second paragraph,“…with 800 J per beam at 0.35 mm…”should be“…with 800 J per beam at 0.35 mm…”,“The slit of 400 mm width is parallel…”should be“The slit of 400 mm width is parallel…”,“The laser focal diameter is about 500 mm…”should be“The laser focal diameter is about 500 mm…”;in the third paragraph,“…we take 850 mm as the radius…”should be“…we take 850 mm as the radius…”,“The LEH radius R_(L) is 400 mm…”should be“The LEH radius R_(L) is 400 mm…”,“…the radius of the cylindrical LEH outer ring is taken as 1.5 R_(L)=600 mm”should be“…the radius of the cylindrical LEH outer ring is taken as 1.5 R_(L)=600 mm”.This mistake does not affect any of the main results of the original letter. | Wenyi Huo Zhichao Li Dong Yang Ke Lan Jie Liu Guoli Ren Sanwei Li Zhiwen Yang Liang Guo Lifei Hou Xuefei Xie Yukun Li Keli Deng Zheng Yuan Xiayu Zhan Guanghui Yuan Haijun Zhang Baibin Jiang Lizhen Huang Kai Du Runchang Zhao Ping Li Wei Wang Jingqin Su Yongkun Ding Xiantu He Weiyan Zhang | 2016 | Matter and Radiation at Extremes2016，1，2： | 1 |
| 8 | Comparison of the kinetics of lipopeptide production by bacillus amyloliquefaciens xz-173 in solid-state fermentation under isothermal and non-isothermal conditions 显示文摘 | Zhu Zhen Sun Lifei Huang Xiaolei | 2013 | World Journal of Microbiology and Biotechnology2013，12，： | 1 |
| 9 | Evolution of springback and neutral layer of AZ31B magnesium alloy V-bending under warm forming conditions显示文摘 | Lifei Wang Guangsheng Huang Hua Zhang Yanxia Wang Liang Yin | 2013 | Journal of Materials Processing Tech2013，，6： | 1 |
| 10 | Evolution of neutral layer and microstructure of AZ31B magnesium alloy sheet during bending显示文摘 | Guangsheng Huang Lifei Wang Hua Zhang Yanxia Wang Zhaoyang Shi Fusheng Pan | 2013 | Materials Letters2013，，： | 1 |
| 11 | Concentrations and possible sources of polychlorinated biphenyls in the surface water of the Yangtze River Delta, China显示文摘 | Lifei Zhang Shuangxin Shi Liang Dong Ting Zhang Li Zhou Yeru Huang | 2011 | Chemosphere2011，，3： | 1 |
| 12 | Organochlorine pesticides contamination in surface soils from two pesticide factories in Southeast China显示文摘 | Lifei Zhang Liang Dong Shuangxin Shi Li Zhou Ting Zhang Yeru Huang | 2009 | Chemosphere2009，，5： | 1 |
| 13 | Evolution ofspringback and neutral layer of AZ31B magnesium alloyV-bending under warm forming conditions 显示文摘 | Wang Lifei Huang Guangsheng Zhang Hua | 2013 | Journal of Mate-rials Processing Technology2013，213，： | 1 |
| 14 | Passive air sampling of organochlorine pesticides and polychlorinated biphenyls in the Yangtze River Delta, China: Concentrations, distributions, and cancer risk assessment显示文摘 | Lifei Zhang Liang Dong Wenlong Yang Li Zhou Shuangxin Shi Xiulan Zhang Shan Niu Lingling Li Zhongxiang Wu Yeru Huang | 2013 | Environmental Pollution2013，，： | 1 |
| 15 | Influence of warm pre-stretching on microstructure and properties of AZ31 magnesium alloy显示文摘 | Hua Zhang Guangsheng Huang Jinhan Li Lifei Wang Hans J?rgen Roven | 2013 | Journal of Alloys and Compounds2013，，： | 1 |
| 16 | Evolution ofspringback and neutral layer of AZ31B magnesium alloy V~bendingunder warm forming conditions 显示文摘 | Wang Lifei Huang Guangsheng Zhang Hua | 2013 | Journal ofMaterials Process-ing Technology2013，213，： | 1 |
| 17 | The Brassicaceae-specific secreted peptides,STMPs,function in plant growth and pathogen defense显示文摘Low molecular weight secreted peptides have recently been shown to affect multiple aspects of plant growth,development,and defense responses.Here,we performed stepwise BLAST filtering to identify unannotated peptides from the Arabidopsis thaliana protein database and uncovered a novel secreted peptide family,secreted transmembrane peptides(STMPs).These low molecular weight peptides,which consist of an N-terminal signal peptide and a transmembrane domain,were primarily localized to extracellular compartments but were also detected in the endomembrane system of the secretory pathway,including the endoplasmic reticulum and Golgi.Comprehensive bioinformatics analysis identified 10 STMP family members that are specific to the Brassicaceae family.Brassicaceae plants showed dramatically inhibited root growth uponexposure to chemically synthesized STMP1 and STMP2.Arabidopsis overexpressing STMP1,2,4,6,or 10 exhibited severely arrested growth,suggesting that STMPs are involved in regulating plant growth and development.In addition,in vitro bioassays demonstrated that STMP1,STMP2,and STMP10 have antibacterial effects against Pseudomonas syringae pv.tomato DC3000,Ralstonia solanacearum,Bacillus subtilis,and Agrobacterium tumefaciens,demonstrating that STMPs are antimicrobial peptides.These findings suggest that STMP family members play important roles in various developmental events and pathogen defense responses in Brassicaceae plants. | Zipeng Yu Yang Xu Lifei Zhu Lei Zhang Lin Liu Di Zhang Dandan Li Changai Wu Jinguang Huang Guodong Yang Kang Yan Shizhong Zhang Chengchao Zheng | 2020 | Journal of Integrative Plant Biology2020，62，4： | 1 |
| 18 | M^(2)LC-Net: A Multi-Modal Multi-Disease Long-Tailed Classification Network for Real Clinical Scenes显示文摘Leveraging deep learning-based techniques to classify diseases has attracted extensive research interest in recent years.Nevertheless,most of the current studies only consider single-modal medical images,and the number of ophthalmic diseases that can be classified is relatively small.Moreover,imbalanced data distribution of different ophthalmic diseases is not taken into consideration,which limits the application of deep learning techniques in realistic clinical scenes.In this paper,we propose a Multimodal Multi-disease Long-tailed Classification Network(M^(2)LC-Net)in response to the challenges mentioned above.M^(2)LC-Net leverages ResNet18-CBAM to extract features from fundus images and Optical Coherence Tomography(OCT)images,respectively,and conduct feature fusion to classify 11 common ophthalmic diseases.Moreover,Class Activation Mapping(CAM)is employed to visualize each mode to improve interpretability of M^(2)LC-Net.We conduct comprehensive experiments on realistic dataset collected from a Grade III Level A ophthalmology hospital in China,including 34,396 images of 11 disease labels.Experimental results demonstrate effectiveness of our proposed model M^(2)LC-Net.Compared with the stateof-the-art,various performance metrics have been improved significantly.Specifically,Cohen’s kappa coefficient κ has been improved by 3.21%,which is a remarkable improvement. | Zhonghong Ou Wenjun Chai Lifei Wang Ruru Zhang Jiawen He Meina Song Lifei Yuan Shengjuan Zhang Yanhui Wang Huan Li Xin Jia Rujian Huang | 2021 | China Communications2021，18，9： | 0 |
| 19 | Research on Chemical Prevention and Control against Stem Base Rot of Sweet Potato显示文摘[Objective]The paper was to effectively control stem base rot of sweet potato.[Method]Chemical prevention and control test against stem base rot of sweet potato were conducted for consecutive three years from 2016 to 2018.[Result]The use of carbendazim or carbendazim+mancozeb,and carbendazim+embamycin had significant control effect on stem base rot of sweet potato.However,the applied concentration should be higher than the recommended concentration.Especially the concentration of 50%carbendazim WP should be no more than 300 times,and the prevention and control effect of 100 times dilution would be better.[Conclusion]The types and concentrations of prevention and control agents are determined in the test,which will provide certain basis for chemical prevention and control against stem base rot of sweet potato. | Liu Yenan Liu Weiming He Xianbiao Huang Lifei | 2021 | Plant Diseases and Pests2021，12，1： | 0 |
| 20 | Purification and anti-inflammatory effect of selenium-containing protein fraction from selenium-enriched Spirulina platensis显示文摘Spirulina platensis is an excellent carrier of Se,and thus widely used in medical fields and as well as in the food industry.However,there is little information about the characteristics and bioactivity of selenium-containing S.platensis proteins(Se-SP).In this study,Se-SP with different molecular weights were isolated from selenium-enriched S.platensis,and the bioactivities(such as antioxidant and anti-inflammatory activities)of Se-SP were investigated.Se-SP3(with a molecular weight range of 20-48 kDa)showed better free radical scavenging ability(ABTS)than the other Se-SPs.In addition,Se-SP3 suppressed inflammatory cytokines,in which decreased by 74% interleukin 6(IL-6),42.28% tumor necrosis factor-α(TNF-α),69.07% content of malondialdehyde(MDA),40.45% interleukin-1β(IL-1β)relative to the LPS group.Moreover,Se-SP3 decreased the nitric oxide(NO)production by 64.84% compared with the LPS group and increased the activities of superoxide dismutase(SOD)and glutathione peroxidase(GSH-Px),indicating that Se-SP3 has excellent antioxidant and anti-inflammatory activities,and could be used as a functional food ingredient or natural medicine. | Pingyingzi Jiang Jinhao Meng Lifei Zhang Li Huang Lulu Wei Yunxia Bai Xiaoling Liu Shubo Li | 2022 | Food Bioscience2022，45，1： | 0 |
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