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| 1 | Expression of pin1 and ki67 in cervical cancer and their significance显示文摘 | Li Hongyu Shen Hongling Xu Qian Deng Dongrui Wang Shixuan Lu Yunping Ma Ding | 2006 | Journal of Huazhong University of Science and Technology [Medical Sciences]2006，，： | 1 |
| 2 | Cancer targeting Gene-Viro-Therapy specific for liver cancer by α-fetoproteincontrolled oncolytic adenovirus expression of SOCS3 and IL-24显示文摘为癌症治疗的基因治疗和 virotherapy 的联合收到了靠近的注意并且在癌症 biotherapy 的地里成为了一个趋势。称为指向 Gene-Viro-Therapy (CTGVT ) 或基因的癌症的策略武装了 Oncolytic 病毒的治疗(GAOVT ) 被建议了,在哪个 antitumor 基因被插入到 oncolytic 病毒的向量。在我们的以前的学习,有为正常房间和严格的肝的提高的安全的双调整 oncolytic 侵入人体气管粘膜的病菌指向癌症的能力,指明的 AdenAFPE1AE1B (55 )( 简短 AdenAFPD55 ) ,成功地被构造。在水流,工作, interleukin-24 (IL-24 ) 和表明 3 的 cytokine (SOCS3 ) 的 suppressor 基因被包装进 AdenAFPD55。新构造, AdenAFPD55-(IL-24 ) 和 AdenAFPD55-(SOCS3 ) ,在 hepatoma 房间的显示出的改进 tumoricidal 活动与 oncolytic 相比排队病毒的向量 AdenAFPD55。AdenAFPD55-(IL-24 ) 和 AdenAFPD55-(SOCS3 ) 的合作管理在 vitro 并且在一个裸体老鼠异种皮移植模特儿独自比 AdenAFPD55-(IL-24 ) 或 AdenAFPD55-(SOCS3 ) 显示出好一些的 antitumor 效果。而且,我们的结果也在 HuH-7 房间由 AdenAFPD55-(SOCS3 ) 感染显示出 Jak/Stat3 小径的那封锁能下面调整一些 anti-apoptosis 蛋白质例如 XIAP, Bcl-xL,和 survivin,它可能敏化房间到导致的 AdenAFPD55-(IL-24 ) apoptosis。这些结果显示 AdenAFPD55-(IL-24 ) 的那个合作管理, AdenAFPD55-(SOCS3 ) 可以为肝癌症的治疗作为一个候选人服务治疗学的途径。 | Xin Cao Ruicheng Wei Xinran Liu Yan Zeng Hongling Huang Miao Ding Kangjian Zhang Xin-Yuan Liu | 2011 | Acta Biochimica et Biophysica Sinica2011，43，10： | 1 |
| 3 | Transcriptome and metabolome analysis reveal that oral secretions from Helicoverpa armigera and Spodoptera litura influence wound-induced host response in cotton显示文摘Cotton(Gossypium hirsutum)is an important fiber crop worldwide.Insect attack causes cotton yield and quality losses.However,little is known about the mechanism of cotton response to insect attack.We simulated insect feeding by applying insect oral secretions(OS)to wounds,and combined transcriptome and metabolome analysis to investigate how OS from two major pest species(Helicoverpa armigera and Spodoptera litura)affect cotton defense responses.We found that respectively 12,668 and 13,379 genes were differentially expressed in comparison with wounding alone.On addition of OS,the jasmonic acid signaling pathway was rapidly and strongly induced,whereas genes involved in salicylic acid biosynthesis were downregulated.On constructing a coexpression gene network,we identified a hub gene encoding a leucine-rich repeat receptor kinase that may play an important role in early signal recognition and transduction.OS from the two insect species altered the abundance of flavonoid-related compounds in different patterns.Gossypol remained in lower concentration after OS application than after wounding alone,suggesting a suppressive effect of OS on cotton defense response.This study illustrated transcriptional and metabolic changes of cotton in responding to OS from two chewing insect species,identified potential key response genes,and revealed evidence for OS inhibition of wounding-induced cotton defense response. | Huan Si Hongling Liu Yiwen Sun Zhongping Xu Sijia Liang Bo Li Xiao Ding Jianying Li Qiongqiong Wang Lin Sun Xianlong Zhang Shuangxia Jin | 2020 | The Crop Journal2020，8，6： | 1 |
| 4 | Fungal diversity and mycotoxins identification of mouldy rapeseed in China显示文摘Investigation on fungal populations and mycotoxins of mouldy rapeseed was conducted in this paper. A total of 578 rapeseed samples were collected from 11 Chinese provinces in 2015, and 141 samples were contaminted by mycete. Mouldy rapeseed samples with exceeding specified standard were found in all areas. The highest percentages of samples were from Hunan, Jiangxi and Hubei provinces with above standard rate of 31.91%, 24.54% and 20.45% respectively. Mycete in 29 severely mouldy samples were isolatedand determined by using dilution method. Eighty-three dominant isolates were found,among which fungal strain number ranged from 1 to 8. Aspergillus flavus, Penicillium steckii and Penicillium citrinum were dominant myco-populations identified by morphological and molecular biological methods. Rapeseed from the Southern provinces including Jiangxi,Hunan and Guangxi were contaminated by more isolates. Mycotoxins content were evaluated by LC–MS/MS. AFB1, BEA and FB1 were the top 3 prevalent mycotoxins. BEA and FB1 contaminations in rapeseed were relatively low. This investigation provid support for protecting public health and ensuring consumption security of rapeseed. | Linxia Wu Haiyan Zhou Tingting Zhu Hongling Yang Xueli Dong Lin Chen Yizhen Bai Nanri Yin Xiaoxia Ding Peiwu Li | 2017 | Oil Crop Science2017，2，1： | 0 |
| 5 | Characteristics of TP53 germline variants and their correlations with Li-Fraumeni syndrome or Li-Fraumeni-like syndrome in Chinese tumor patients显示文摘Li-Fraumeni syndrome(LFS),a rare autosomal-dominant inheritance condition,is associated with a family cancer history as well as pathogenic/likely-pathogenic TP53 germline variants(P/LP TP53 GV).The current clinical methods for detecting LFS are limited.Here,we retrospectively investigate P/LP TP53 GV among Chinese cancer patients by next-generation sequencing and evaluate its relationship with a family cancer history.A total of 270 out of 19,226 cancer patients have TP53 GV,including 53 patients with P/LP TP53 GV.Patients with P/LP TP53 GV are mainly found in male with glioma,lung cancer or sarcoma.The median age of diagnosis for P/LP TP53 GV patients is significantly lower than that of non-P/LP TP53 GV patients(31-years vs.53-years;P<0.01).One LFS patient and 3 Li-Fraumeni-like syndrome(LFL)patients are among the 26 followed-up P/LP TP53 GV patients.Among 25 types of P/LP TP53 GV,the highest variant frequencies occurred at codon 175 and 248.p.M237 I,p.R158 H,p.C238 Y and p.C275 R,are firstly identified among the Chinese LFS/LFL patients.This study reports the(P/LP)TP53 GV characteristics of Chinese pan-cancer patients.These findings suggest analyzing the P/LP TP53 GV in cancer patients is an effective strategy for identifying cancer predisposition syndrome. | Panwen Tian Xiaoyan Zhang Sheng Yang Yu Fang Hongling Yuan Wei Li Honglin Zhu Fangping Zhao Jinlei Ding Yunshu Zhu Sizhen Wang Guochen Sun Hongbin Ni Tonghui Ma Ting Lei | 2022 | Journal of Genetics and Genomics2022，49，7： | 0 |
| 6 | Staurosporine targets the Hippo pathway to inhibit cell growth显示文摘 | Xueyan Ma Peixue Li Peihao Chen Jinhui Li Hongling Huang Chao Wang Wenjing Li Jianping Ding Yun Zhao Fa-Xing Yu Xiangbing Qi Lei Zhang | 2018 | Journal of Molecular Cell Biology2018，10，3： | 0 |
| 7 | Paleo-polyploidization in Lycophytes显示文摘Lycophytes and seed plants constitute the typical vascular plants.Lycophytes have been thought to have no paleo-polyploidization although the event is known to be critical for the fast expansion of seed plants.Here,genomic analyses including the homologous gene dot plot analysis detected multiple paleo-polyploidization events,with one occurring approximately 13–15 million years ago(MYA)and another about 125–142 MYA,during the evolution of the genome of Selaginella moellendorffii,a model lycophyte.In addition,comparative analysis of reconstructed ancestral genomes of lycophytes and angiosperms suggested that lycophytes were affected by more paleopolyploidization events than seed plants.Results from the present genomic analyses indicate that paleo-polyploidization has contributed to the successful establishment of both lineages—lycophytes and seed plants—of vascular plants. | Jinpeng Wang Jigao Yu Pengchuan Sun Chao Li Xiaoming Song Tianyu Lei Yuxian Li Jiaqing Yuan Sangrong Sun Hongling Ding Xueqian Duan Shaoqi Shen Yanshuang Shen Jing Li Fanbo Meng Yangqin Xie Jianyu Wang Yue Hou Jin Zhang Xianchun Zhang Xiu-Qing Li Andrew HPaterson Xiyin Wang | 2020 | Genomics, Proteomics & Bioinformatics2020，18，3： | 0 |
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