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| 1 | Emerging ultra-narrow-band cyan-emitting phosphor for white LEDs with enhanced color rendition显示文摘Phosphor-converted white LEDs rely on combining a blue-emitting InGaN chip with yellow and red-emitting luminescent materials.The discovery of cyan-emitting(470-500 nm)phosphors is a challenge to compensate for the spectral gap and produce full-spectrum white light.Na_(0.5)K_(0.5)Li_(3)SiO_(4):Eu^(2+)(NKLSO:Eu^(2+))phosphor was developed with impressive properties,providing cyan emission at 486 nm with a narrow full width at half maximum(FWHM)of only 20.7 nm,and good thermal stability with an integrated emission loss of only 7% at 150℃.The ultra-narrow-band cyan emission results from the high-symmetry cation sites,leading to almost ideal cubic coordination for UCr_(4)C_(4)-type compounds.NKLSO:Eu^(2+) phosphor allows the valley between the blue and yellow emission peaks in the white LED device to be filled,and the color-rendering index can be enhanced from 86 to 95.2,suggesting great applications in full-spectrum white LEDs. | Ming Zhao Hongxu Liao Maxim S.Molokeev Yayun Zhou Qinyuan Zhang Quanlin Liu Zhiguo Xia | 2019 | Light(Science & Applications)2019，8，1： | 21 |
| 2 | Primarily screening and analyzing ESTs differentially expressed in rats' primary liver cancer显示文摘Objective: To screen and analyze key express sequence tags (ESTs) which were differentially displayed in every period of SD rats' primary hepatic carcinoma and reveal the molecular mechanism of carcinogenesis. Methods: Using diethylnitrosamine (DENA) as a cancerigenic agent, animal models with different phases of primary hepatic cancer were constructed in SD rats. Rats were respectively sacrificed at d 14, d 28, d 56, d 77, d 105 and d 112 after the rats received DENA by gavage, then the livers were harvested. One part of the livers was classified according to their pathological changes, while the other was reserved for molecular mechanism studies on hepatocarcinogenesis. The differentially expressed genes were isolated from both normal and morbid tissues by mRNA differential display technique (DDRT-PCR). After the fragments were sequenced, bioinformatics were used to analyze the results. Results: Twelve differentially expressed cDNA fragments were obtained. Nine fragments had the homology with known cDNA clones, especially EST-7 was similar to BN/SsNHsdMCW mitochondrion gene and the identity was 100% which suggested EST-7 may be the part of BN/SsNHsdMCW mitochondrion gene. In contrast, other three fragments (EST-1, EST-3 and EST-5) had extremely low identity to any genes registered in GENBANK databases. Conclusions: BN/SsNHsdMCW mitochondrion gene was expressed in different periods of hepatocarcinogenesis. Moreover, EST-1, EST-3 and EST-5 were suggested to contribute to the development of rat hepatocarcinogenesis, and thus may be candidates of new targets of oncogenes or cancer suppressor genes. | Dandan Liu Lijuan Zhi Mingxia Ma Dan Qiao Meijuan Wang Yawei Wang Baijie Jin Anqi Li Guting Liu Yiqing Zhang Yanyan Song Hongxu Zhang | 2013 | Chinese Journal of Cancer Research2013，25，1： | 9 |
| 3 | Dynamic analysis of heat extraction rate by supercritical carbon dioxide in fractured rock mass based on a thermal-hydraulic-mechanics coupled model显示文摘Heat production from geothermal reservoirs is a typical heat transfer process involving a cold working fluid contacting a hot rock formation.Compared to the thermal-physical characteristics of water,supercritical CO_(2)(scCO_(2))has a higher heat storage capacity over a wide temperature-pressure range and may be favored as a heat transfer fluid.Singularly characteristic of scCO_(2)-based heat extraction is that the hydraulic-thermal properties of the scCO_(2) vary dramatically and dynamically with the spatial pressure gradient during unsteady-state flow along fracture.This highly nonlinear behavior presents a challenge in the accurate estimation of heat extraction efficiency in scCO_(2)-based EGS.In this paper,a thermal-h ydraulic-mechanical(THM)coupled model is developed by considering deformation of the fractured reservoir,non-Darcy flow and the varying thermal-physical properties of scCO_(2).The proposed model is validated by matching the modeling temperature distribution with published data.The results show that during continuous injection of scCO_(2),the fracture first widens and then narrows,ultimately reopening over the long term.The sequential fracture deformation behaviors are in response to the combined impacts of mechanical compression and thermally-induced deformation.By controlling the injection parameters of the scCO_(2),it is found that the heat extraction rate is positively correlated to its pore pressure or mass flow rate.The heat extraction rate can be significantly enhanced,when the inlet temperature of scCO_(2) is below its critical temperature.As a result,the heat increment recovered per unit mass of scCO_(2) decreases as the hot rock is gradually cooled.Meanwhile,the heat increment recovered per unit mass of scCO_(2) decreases by increasing the inlet temperature of scCO_(2) or its mass flow rate,but increases as the outlet pressure rises.Furthermore,multi-linear regression indicates that controlling the inlet temperature of the scCO_(2) can significantly improve the thermodynamic efficiency of heat extraction. | Chunguang Wang Xingkai Shi Wei Zhang Derek Elsworth Guanglei Cui Shuqing Liu Hongxu Wang Weiqiang Song Songtao Hu Peng Zheng | 2022 | International Journal of Mining Science and Technology2022，32，2： | 3 |
| 4 | Green Space System Planning in Shuangcheng City and Creation of the City's Characteristics显示文摘Characteristic urban construction has already become a trend of modern social development,in this context,components of characteristic urban green spaces,and ways of demonstrating features of urban green space system were analyzed.Shuangcheng City in Heilongjiang Province was taken for example to analyze planning objectives and principles of characteristic urban green space system.Moreover,the green space layout of 'A Hundred Years Old Castle,A Hundred of Enterprises and A Hundred of Gardens' was introduced.It was proposed that green space system planning suited to the development features and ecological conditions of the city should be developed from the perspective of greater regional environment,historical and cultural deposits,urban development pattern and lifestyle of the locals,so as to create urban green space system with regional features. | LI Hongxu DONG Yuxin LIU Huimin | 2012 | Journal of Landscape Research2012，4，9： | 2 |
| 5 | BPGM: A Big Graph Mining Tool显示文摘The design and implementation of a scalable parallel mining system target for big graph analysis has proven to be challenging. In this study, we propose a parallel data mining system for analyzing big graph data generated on a Bulk Synchronous Parallel(BSP) computing model named BSP-based Parallel Graph Mining(BPGM). This system has four sets of parallel graph mining algorithms programmed in the BSP parallel model and a well-designed workflow engine optimized for cloud computing to invoke these algorithms. Experimental results show that the graph mining algorithm components in BPGM are efficient and have better performance than big cloud-based parallel data miner and BC-BSP. | Yang Liu Bin Wu Hongxu Wang Pengjiang Ma | 2014 | Tsinghua Science and Technology2014，19，1： | 2 |
| 6 | The prognostic value of programmed cell death ligand 1expression in non-Hodgkin lymphoma:a meta-analysis显示文摘Objective: Although the prognostic value of programmed cell death-ligand 1(PD-L1) expression in non-Hodgkin lymphoma(NHL) has been evaluated in many studies, the results remain controversial. To investigate the prognostic role of PD-L1 expression and the association between PD-L1 expression and clinicopathological features of NHL, we performed a meta-analysis.Methods: The Pub Med, EMBASE, and Cochrane Library databases were searched up to November 30, 2017. The hazard ratio(HR), 95% confidence interval(CI), and odds ratios(OR) with 95% CIs were combined to evaluate the association of PD-L1 expression with overall survival(OS) and clinicopathological features. Review manager 5.3 and STATA 12.0 were used in this meta-analysis.Results: A total of 2,005 patients across nine studies were enrolled in our meta-analysis, and the pooled results showed that high PD-L1 expression was associated with a poor prognosis(HR=2.04, 95% CI: 1.18–3.54, P=0.01). In the subgroup analysis according to histology types, pooled results demonstrated that an increased PD-L1 expression was an unfavorable prognostic factor for diffuse large B-cell lymphoma(HR=1.92, 95% CI: 1.06–3.48, P=0.03) but not for natural killer/T-cell lymphoma(HR=2.41, 95%CI: 0.47–12.22, P=0.29). Pooled ORs indicated that PD-L1 expression was higher in NHL with international prognostic indices of≥3. However, PD-L1 expression had no correlation with gender, age, disease stage, lactate dehydrogenase level, B symptoms, and germinal center B-cell-like lymphoma.Conclusions: High PD-L1 expression was a poor prognostic biomarker in patients with NHL. Because of our limited sample size,high-quality studies with larger sample sizes are needed to validate our results. | Shu Zha Minghui Zhang Yu Zhang Hongxue Meng Yan Wang Yupeng Liu Jing Jing Lan Huang Mengqi Sun Yue Zhang Qingyuan Zhang | 2018 | Cancer Biology & Medicine2018，15，3： | 2 |
| 7 | Mineralogy,Fluid Inclusion and H-O-C-S Stable Isotopes of Mengqiguer Uranium Deposit in the Southern Yili Basin,Xinjiang:Implication for Ore Formation显示文摘The Mengqiguer deposit in the southern Yili basin Ili Basin is a large interlayer-oxidation-zone type uranium deposit.In this paper,we applied multiple methods including microscopic observation,scanning electron microscope and electronic probe,to analyze the systematical alteration characteristics of the ore-bearing sandstone layer.Fluid inclusion and stable isotope studies on the ore-bearing sandstone have also been carried out to discuss the internal relations between fluid activities,epigenetic alteration and the uranium mineralization.Major epigenetic alteration include clay alteration,carbonatization and pyritization,of which biogenetic pyritization is most closely related to the uranium mineralization.This suggests the existence of microorganism during the uranium mineralization process.The mineralization fluids of low temperature,medium density but varied salinities are suggested to be derived from multi-source,including the meteoric water and organic acidic vapor components from coal-bearing strata.Uranium mineralization,grain-dispersed kaolinite,limonite,colloidal pyrite,and the carbonate cements associated with sulfate-reducing bacteria were formed by meteoric water and vermicular-shaped kaolinite,autologous pyrite,and the carbonate cementation associated with the dehydroxylation of organic matter was formed by organic acidic.Based on these results,we consider that the uranium mineralization and epigenetic alteration both resulted from the reciprocity of organic–inorganic fluid and fluid–rock during the formation of the interlayer oxidation zone. | DING Bo LIU Hongxu ZHANG Chuang LIU Hongjun LI Ping ZHANG Bin | 2020 | Acta Geologica Sinica(English Edition)2020，94，5： | 2 |
| 8 | Injectable melatonin-loaded carboxymethyl chitosan(CMCS)-based hydrogel accelerates wound healing by reducing inflammation and promoting angiogenesis and collagen deposition显示文摘Carboxymethyl chitosan(CMCS)-based hydrogels have antibacterial activity,and have shown the abilities of preventing wound infection,promoting cell proliferation,accelerating collagen deposition,and stimulating hyaluronic acid formation during wound healing.As a hormone produced by the pineal gland in humans and animals,melatonin promotes skin wound healing by regulating the release of inflammatory mediators and accelerating the proliferation and migration of cells,angiogenesis,and collagen deposition.However,the combined effects of CMCS and melatonin on wound healing remain unclear.Injectable CMCS-based hydrogels containing melatonin were prepared,and their healing effects were evaluated using a full-thickness cutaneous wound model in rats.Compared with the control and the hydrogel with no melatonin groups,the melatonin-loaded hydrogel significantly increased the percentage of wound closure,promoted the proliferation of granulation tissue and re-epithelialization,and accelerated collagen deposition.Additionally,the melatonin-loaded hydrogel promoted angiogenesis and vascular endothelial growth factor receptor protein expression and increased the expression of cyclooxygenase-2 and inducible nitric oxide synthase.The melatonin-loaded hydrogel also markedly increased the expression of collagen III,α-smooth muscle actin,and transforming growth factor-β1 proteins and reduced collagen I expression.These results suggest that the melatonin-loaded hydrogel promoted granulation tissue formation and accelerated wound healing by reducing inflammation and promoting angiogenesis and collagen deposition. | Kai Chen Changci Tong Jinge Yang Peifang Cong Ying Liu Xiuyun Shi Xu Liu Jun Zhang Rufei Zou Keshen Xiao Yuyang Ni Lei Xu Mingxiao Hou Hongxu Jin Yunen Liu | 2021 | Journal of Materials Science & Technology2021，，4： | 2 |
| 9 | Rapid, cost-effective DNA quantification via a visuallydetectable aggregation of superparamagnetic silicamagnetite nanoparticles显示文摘 | Qian Liu Jingyi Li Hongxue Liu Ibrahim Tora Matthew S. Ide Jiwei Lu Robert J. Davis David L. Green James P. Landers | 2014 | Nano Research2014，7，5： | 2 |
| 10 | Endovascular stent-grafts for acute and chronic type B aortic dissection: comparison of clinical outcomes显示文摘Objective To evaluate the early and mid-term results of endovascular repair for acute and chronic type B aortic dissection, and to compare the clinical outcomes between the 2 groups. Methods From May 2002 to December 2006, 50 patients with type B aortic dissection were treated by endovascular stent-graft. There were 23 patients in the acute aortic dissection (AAD) group and 27 patients in the chronic aortic dissection (CAD) group. All patients were followed up from 1 to 54 months (average, 17±16 months).The immediate and follow-up clinical outcomes were documented and compared between the 2 groups. Results Placement of endovascular stent-grafts across the primary entry tears was technically successful in all 50 patients. Compared to the CAD group, the AAD group had a higher percentage of pleural effusion (17.4% vs. 0%, P=0.04) and visceral /leg ischemia (26.1% vs 3.7%, P=0.04). Procedure related complications, including endoleak and post-implantation syndrome, occurred more frequently in the AAD group than in the CAD group (21.7% vs 3.7% and 30.4% vs 11.1%, respectively; P=0.08 and P=0.04). Kaplan–Meier analysis showed no difference in the survival rate at 4 years between the 2 groups (86.4% vs 92.3%, P=0.42 by log-rank test). However, the event-free survival rate was higher in patients with chronic dissection than in patients with acute aortic dissection(96.2% vs 73.9%; P=0.02 by log-rank test). Conclu- sions Endovascular repair with stent-graft was safe and effective for the treatment of both acute and chronic type B aortic dissection. However, both immediate and long term major complications occurred more frequently in patients with acute dissection than in those with chronic dissection. | Quanming Jing Yaling Han Xiaozheng Wang Jie Deng Bo Luan Hongxu Jin Xiaojiang Liu Fei Li Ying Liu | 2007 | Journal of Geriatric Cardiology2007，4，2： | 2 |
| 11 | Characteristics of Uranium Mineralization in Red Clastic Formations in the Southwestern Margin of the Ordos Basin显示文摘In the southwestern margin of the Ordos Basin,uranium mineralization is primarily hosted by predominantly oxidative red clastic formations in the Lower Cretaceous.The main target layers for uranium exploration are the Madongshan and Liwaxia formations of the Liupanshan Group,followed by the Jingchuan Formation of the Zhidan Group.The host rocks(medium-fine feldspar quartz sandstone),which are bleached to a light grayish white color,contain a minor organic matter component and pyrite.Uranium mineralization changes from surficial infiltration or phreatic oxidation in the upper part to interlayer oxidation in the lower part.Uranium ore bodies are mostly lenticular or tabular in shape,locally shaped like crescent rolls.Individual ore bodies are typically small and shallow.Uranium predominantly manifests as pitchblende and coffinite.Coffinite is usually short and columnar or granular in habit,whereas pitchblende occurs as an irregular colloidal covering on the surface or in fissures of ferric oxide,silicate,clay or carbonate.Secondary uranium minerals are torbernite,uranophane,and uranopilite.Minerals associated with uranium are mainly pyrite,chalcopyrite and,to a minor extent,arsenopyrite and fluorite.The associated elements are Mo,V,Se,Co,Ni,and Mn,the host sandstone being high in Cu and Ba.Overall,the red clastic formations in the southwestern margin of the Ordos Basin are characterized by’five multiples but one low’which means multiple target layers,multiple stages of mineralization,multiple ore body shapes,multiple kinds of uranium minerals,multiple associated elements,but low organic matter.This implies an overall complex uranium metallogenic environment and mineralization process.It is recommended that future uranium exploration should take into consideration regional metallogenic conditions and mineralization features,with target layers in the wide-smooth synclinal slope being focused on.Most uranium deposits are small to medium in size,and the main type of uranium mineralization can vary by target layer. | ZHANG Zilong HE Feng YI Longsheng FAN Honghai CAI Yuqi LIU Hongxu LIU Xinyang CHEN Hongbin JIA Cui YANG Mengjia | 2020 | Acta Geologica Sinica(English Edition)2020，94，5： | 1 |
| 12 | Study on the influencing factors to reduce the recovery time of superconducting tapes and coils for the DC superconducting fault current limiter applications显示文摘Superconducting fault current limiters(SFCLs)are important in improving the stability of electrical power systems.However,the existing resistive-type DC SFCL has a long re-covery time,which cannot meet the requirements of power system auto-reclosure.Thus,it is necessary to investigate the methods of reducing recovery time of SFCLs.In the simulations on superconducting tapes,there is a lack of investigation about the effects of design factors of superconducting tapes and coils such as material,thickness,coil radius,coil winding method on recovery characteristics.The objective of this study is to obtain the effects of material and geometric properties of superconducting tapes and coils on recovery characteristics and obtain methods to reduce the recovery time.The recovery times under different conducting currents are also compared by simulations and exper-iments to verify simulation accuracy.The maximum error is below 40%and most of the cases have an error below 10%.Besides,by increasing tape thickness,the recovery time can be reduced by 22%.Tape materials and coil winding methods can be designed ac-cording to the auto-reclosure and current-limiting requirements of the power systems.The research provided directions for the design of superconducting tape and super-conducting coil for resistive-type DC SFCLs. | Bin Xiang Wenqing Wang Hongxu Li Lei Gao Zhiyuan Liu Yingsan Geng Jianhua Wang Youping Tu | 2022 | High Voltage2022，7，3： | 1 |
| 13 | Video-assisted thoracoscopic surgery versus open lobectomy for stageI lung cancer: A meta-analysis of long-term outcomes显示文摘 | Zhengjun Li Hongxu Liu Le Li | 2012 | Experimental and Therapeutic Medicine2012，，5： | 1 |
| 14 | Engineering the morphology and electronic structure of atomic cobalt-nitrogen-carbon catalyst with highly accessible active sites for enhanced oxygen reduction显示文摘The stabilization of non-precious metals as isolated active sites with high loading density over nitrogendoped carbon materials is essential for realizing the industrial application of single atom catalysts.However,achieving high loading of single cobalt active sites with greatly enhanced oxygen reduction reaction(ORR)activity and stability remains challenging.Here,an efficient approach was described to create a single atom cobalt electrocatalyst(Co SAs/NC)which possesses enhanced mesoporosity and specific surface area that greatly favor the mass transportation and exposure of accessible active sites.The electronic structure of the catalyst by the strong metal-support interaction has been elucidated through experimental characterizations and theoretical calculations.Due to dramatically enhanced mass transport and electron transfer endowed by morphology and electronic structure engineering,Co SAs/NC exhibits remarkable ORR performance with excellent activity(onset and half-wave potentials of 1.04 V(RHE)and 0.90 V(RHE),Tafel slope of 69.8 mV dec^(-1)and J_(k) of 18.8 mA cm^(-2)at 0.85 V)and stability(7 mV activity decay after 10,000 cycles).In additio n,the catalyst demonstrates great promise as an alternative to traditional Pt/C catalyst in zinc-air batteries while maintaining high performance in terms of high specific capacity of(796.1 mAh/g_(Zn)),power density(175.4 mW/cm^(2)),and long-term cycling stability(140 h).This study presents a facile approach to design SACs with highly accessible active sites for electrochemical transformations. | Zhijun Li Leipeng Leng Siqi Ji Mingyang Zhang Hongxue Liu Jincheng Gao Jiangwei Zhang J.Hugh Horton Qian Xu Junfa Zhu | 2022 | Journal of Energy Chemistry2022，31，10： | 1 |
| 15 | Low Transmission Overhead for Polar Coding Physical-Layer Encryption显示文摘In this paper, for physical-layer security(PLS), a novel scheme of polar coding encryption is introduced in the wiretap channel(WTC) model. To decrease transmission overhead of the shared secret information and enhance the security performance against an attacker, we have employed the two following encryption technologies: Firstly, randomization of output bits is not dependent on the traditional randomized bit-channels but they are directly flipped through the random bit sequence. Secondly, for employing Advanced Encryption Standard(AES), we utilize the secret seed to extend an initial secret key of AES cryptosystem, which it appears a good avalanche performance. Result analyses demonstrate that the proposed scheme is strongly resistant against conventional attacks. | Hongxu Jin Rongke Liu Chenyu Zhang | 2019 | China Communications2019，16，2： | 1 |
| 16 | One-step co-doping of ZnO and Zn^(2+)in osteoinductive calcium phosphate ceramics with synergistic antibacterial activity for regenerative repair of infected bone defect显示文摘How to endow bone grafts with long-term antibacterial activity and good bone regenerative ability to achieve the regenerative repair of infected bone defects has been the focus of the clinical treatment of osteomyelitis.The present study introduced a novel one-step route to realizing the co-doping of zinc oxide(ZnO)and zinc ion(Zn^(2+))in biphasic calcium phosphate(BCP)ceramics to utilize their synergistic antibacterial.Compared with the conventional BCP ceramics(BCP-Ca),the ZnO/Zn^(2+)co-doping ones(BCP-Zn)possessed strong antibacterial ability on E.coli and S.aureus as well as stimulated the osteogenic differentiation of bone marrow mesenchymal stem cells(BMSCs)effectively.The synergistic antibacterial mechanism of ZnO and Zn^(2+)was also investigated.BCP-Zn showed excellent osteoinductivity and angiogenesis at three months postoperatively in the canine intramuscular implantation model.Moreover,BCP-Zn exhibited excellent anti-infective ability and bone regenerative repair compared to BCP-Ca and control groups in the infected bone defect model of rat femur.Collectively,these findings suggest that the simultaneous introduction of ZnO/Zn^(2+)could have immense potential to expand the application of osteoinductive BCP ceramics in the regenerative repair of infected bone defects. | Tinghan He Hongxu Chen Puxin Liu Hao Shi Xiujuan Xu Cong Feng Yuyi Wang Xiangfeng Li Ning Lei Yumei Xiao Xiangdong Zhu Jianguo Xu Xingdong Zhang | 2023 | Journal of Materials Science & Technology2023，，32： | 1 |
| 17 | BPGM:A big graph mining tool显示文摘 | Liu Yang Wu Bin Wang Hongxu | 2014 | Journal of Tsinghua University:Science and Technology2014，19，1： | 1 |
| 18 | Synthesis and structure-insecticidal activity relationship of novel phenylpyrazole carboxylic acid derivatives containing fluorine moiety显示文摘A series of novel phenylpyrazole carboxylic acid derivatives containing fluorine moiety,i.e.,diamides 11,simple aryl-bearing amides 12 and acylthioureas 14 were successfully synthesized based on the key fluo ro-containing phe nylpyrazole acid intermediate.The new compounds were identified and confirmed by melting point,1H NMR,13C NMR and elemental analysis or HRMS.The bioassay results indicated that some of the compounds possessed excellent insecticidal activities towards oriental armyworm,diamondback moth and corn borer at low concentrations.For examples,compounds 11a,11e-g and 14b exhibited remarkable larvicidal activities with LC50 values of 0.13-0.39 mg/L and 0.0002-0.0014 mg/L against oriental armyworm and diamondback moth,respectively,were comparable with those of the control chlorantraniliprole.Particularly,lie were found superior to chlorantraniliprole in oriental armyworm tests(LC50:0.23 mg/L vs.0.26 mg/L);11a,lie,11f and 14c in diamondback moth tests with LC50 values of 0.0002 mg/L,0.0002 mg/L,0.0008 mg/L and 0.0005 mg/L,respectively,we re more effective than that of chlorantraniliprole.In addition,12 a also showed a promising insecticidal potential and development/optimization advantage.Compounds 11a,lle-g,12a,14b and 14c could be considered as possible new leading structures for further study.The SAR investigation indicated that the compounds with fluorine motif(e.g.,-F,-CF2H,-CF3)held apparently favorable insecticidal potentials,which provided useful guidance for further design/development of new phenylpyrazole-containing agrochemicals. | Baolei Wang Hongxue Wang Hang Liu Lixia Xiong Na Yang Yan Zhang Zhengming Li | 2020 | Chinese Chemical Letters2020，31，3： | 1 |
| 19 | Binding of Tetracycline and Chlortetracycline to the Enzyme Trypsin:Spectroscopic and Molecular Modeling Investigations显示文摘 | CHI Zhenxing LIU Rutao YANG Hongxu | 2011 | PLOS One2011，6，28： | 1 |
| 20 | Acupoint application therapies for essential hypertension:a systematic review and Meta-analysis显示文摘OBJECTIVE:To evaluate the efficacy and safety of acupoint application therapies(AA)for hypertension.METHODS:We searched Pub Med,EMBASE,the Cochrane Center Controlled Trials Register,Chinese National Knowledge Infrastructure,Chinese Scientific Journal Database,and Wanfang Med Online Database from their inceptions to October 7,2019.No language restriction was applied.We included randomized clinical trials testing AA against Western Medicine,AA versus placebo,AA combined with Western Medicine versus Western Medicine.Study selection,data extraction,quality assessment,and data analyses were conducted according to the Cochrane standards.RESULTS:Totally 41 trials with 3772 participants were included.The methodological quality of the included trials was evaluated as generally low.AA plus Western Medicine significantly lowered systolic blood pressure(BP)[weighted mean difference(WMD):-10.36,95%confidence intervals(CI):-12.62,-8.10;P<0.00001],diastolic BP(WMD:-5.71,95%CI:-7.30,-4.13;P<0.00001),and total effect[risk ratio(RR):1.23,95%CI:1.15,1.32;P<0.00001].The BP-lowering effect of AA was significantly higher than that of placebo[systolic BP(SBP):-8.05,95%CI:-8.67,-7.43;P<0.00001;diastolic BP(DBP):-6.66,95%CI:-7.31,-6.01,P<0.00001].The total effect also improved significantly from baseline with AA than placebo(RR:10.85,95%CI:4.71,24.98;P<0.00001).Traditional Chinese Medicine symptoms score were significantly reduced by AA compared with Western Medicine(WMD:-1.75,95%CI:-2.52,-0.99;P<0.00001),10 trials reported adverse events,indicating that the safety of SSYX Capsule is still uncertain.CONCLUSIONS:Application therapies may be considered a safe and beneficial for the treatment of hypertension and can reduce BP and improve the total effect.Further well-designed trials are needed to support our conclusions. | LIU Wei XIONG Xingjiang QIAO Lumin CHEN Yuyi LI Yixuan SU Xing CHU Fuyong LIU Hongxu | 2022 | Journal of Traditional Chinese Medicine2022，42，2： | 1 |
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