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| 1 | Outline of Uranium Resources Characteristics and Metallogenetic Regularity in China显示文摘Uranium,as one of twenty-six kinds of important minerals in China,is strategic resource and energy mineral,which has been thoroughly investigated in the project of National Potential Evaluation of Uranium Resource.During the implementation of this project,the authors summarized the metallogenic regularity of uranium resource in China systematically,through the researches of geological characteristics of uranium resource,uranium deposits type(genetic and prediction type),temporal and spatial distribution,and metallogenic series.Based on the investigation of present situation and progress in uranium exploration,this paper proposes the uranium deposits in China should be divided into 4 classes,9 types,21 subtypes in genetic,and 50 types in prediction;suggests to divide China into 29 uranium metallogenic belts and 20 uranium prospective area,and constructs 20uranium-polymetallic metallogenic series,through summarizing temporal and spatial distribution characteristics and metallogenic regularity of uranium deposits in China.The above research is beneficial to the comprehensive understanding of regional uranium metallogenic regularity,and will direct the uranium exploration in the future. | CAI Yuqi ZHANG Jindai LI Ziying GUO Qingyin SONG Jiye FAN Honghai LIU Wusheng QI Fucheng ZHANG Minglin | 2015 | Acta Geologica Sinica(English Edition)2015，89，3： | 11 |
| 2 | Twa1/Gid8 is a β-catenin nuclear retention factor in Wnt signaling and colorectal tumorigenesis显示文摘 | Yi Lu Shanshan Xie Wen Zhang Cheng Zhang Cheng Gao Qiang Sun Yuqi Cai Zhangqi Xu Min Xiao Yanjun Xu Xiao Huang Ximei Wu Wei Liu Fudi Wang Yibin Kang Tianhua Zhou | 2017 | Cell Research2017，27，12： | 9 |
| 3 | STING signaling activation inhibits HBV replication and attenuates the severity of liver injury and HBV-induced fibrosis显示文摘The covalently closed circular DNA(cccDNA)of HBV plays a crucial role in viral persistence and is also a risk factor for developing HBV-induced diseases,including liver fibrosis.Stimulator of interferon genes(STING),a master regulator of DNA-mediated innate immune activation,is a potential therapeutic target for viral infection and virus-related diseases.In this study,agonist-induced STING signaling activation in macrophages was revealed to inhibit cccDNA-mediated transcription and HBV replication via epigenetic modification in hepatocytes.Notably,STING activation could efficiently attenuate the severity of liver injury and fibrosis in a chronic recombinant cccDNA(rcccDNA)mouse model,which is a proven suitable research platform for HBV-induced fibrosis.Mechanistically,STING-activated autophagic flux could suppress macrophage inflammasome activation,leading to the amelioration of liver injury and HBV-induced fibrosis.Overall,the activation of STING signaling could inhibit HBV replication through epigenetic suppression of cccDNA and alleviate HBV-induced liver fibrosis through the suppression of macrophage inflammasome activation by activating autophagic flux in a chronic HBV mouse model.This study suggests that targeting the STING signaling pathway may be an important therapeutic strategy to protect against persistent HBV replication and HBV-induced fibrosis. | Yuqi Li Minjing He Ziyu Wang Zhiyun Duan Zhiwei Guo Ziteng Wang Ruijie Gong Tianhao Chu Jiabin Cai Bo Gao | 2022 | Cellular & Molecular Immunology2022，19，1： | 7 |
| 4 | Centrosomal protein FOR20 is essential for S-phase progression by recruiting Plkl to centrosomes显示文摘中心体主要被安排微导管动力学并且便于 G1/S 和 G2/M 转变为有效房间周期前进要求。然而,在 S 阶段前进的中心体的角色大部分是未知的。这里,我们报导 FOR20 (20 kDa 的蠢人相关的蛋白质) 的那弄空,保存 centrosomal 蛋白质,禁止 S 阶段前进并且阻止 Plk1 指向(像马球的 kinase 1 ) 到中心体,在 FOR20 与 Plk1 交往的地方。Plk1 的脱离显著地也导致 S 阶段缺点,它被没能本地化到中心体的 Plk1,甚至 kinase 死了的异种,然而并非异种的宫外的表示颠倒。拴住中心体的 Plk1 的外长的表示,然而并非野类型的 Plk1,撤销 FOR20 导致弄空的 S 阶段独立于它的 kinase 活动背叛。因此,这些数据显示到由 FOR20 的中心体的 Plk1 的招募可以充当一个信号准许 S 阶段的有效前进。这代表一迄今在房间周期规定的中心体的 uncharacterized 角色。 | Minhong Shen Yuqi Cai YuehongYang Xiaoyi Yan Xiaoqi Liu Tianhua Zhou | 2013 | Cell Research2013，23，11： | 6 |
| 5 | Uranium Metallogenic Regionalization and Resource Potential in China显示文摘This paper is comprehensively involved in main types of uranium deposits and their general metallogenic characteristics, metallogenic fields, provinces, regions and belts, and uranium resources potential evaluation. Generally speaking, there are favorable conditions and good uranium resources potential for uranium mineralization in China. | LI Ziying ZHANG Jindai JIAN Xiaofei CAI Yuqi GUO Qingyin ZHU Pengfei | 2012 | Acta Geologica Sinica(English Edition)2012，86，3： | 4 |
| 6 | 雷公藤红素通过靶向核受体Nur77促进损伤线粒体自噬而抑制炎症反应显示文摘文章简介线粒体在细胞死亡、自噬、免疫和炎症中起着不可或缺的作用。前期研究发现,孤儿核受体Nur77通过靶向线粒体诱导细胞凋亡。本文报道了Nur77作为具有抗炎作用的雷公藤红素的直接靶点,介导雷公藤红素通过自噬清除损伤线粒体,抑制炎症反应而达到治疗炎症疾病包括肥胖症的功能。 | Mengjie Hu Qiang Luo Gulimiran Alitongbieke Shuyi Chong Chenting Xu Lei Xie Xiaohui Chen Duo Zhang Yuqi Zhou Zhaokai Wang Xiaohong Ye Lijun Cai Fang Zhang Huibin Chen Fuquan Jiang Hui Fang Shanjun Yang Jie Liu Maria T.Diaz-Meco Ying Su Hu Zhou Jorge Moscat Xiangzhi Lin 张晓坤 | 2018 | 科学新闻2018，0，4： | 3 |
| 7 | Inhibition of cytokinesis by overexpression of NudCL that is localized to the centrosome and midbody显示文摘 | Yuqi Cai Yuehong Yang Minhong Shen Tianhua Zhou | 2009 | Cell Research2009，19，11： | 2 |
| 8 | Morphology,Chemistry and U-Pb Geochronology of Zircon Grains in Quartz Monzodiorite from the Sunzhuang Area,Fanshi County,Shanxi Province显示文摘The morphology, REE geochemistry and U-Pb geochronology of zircons from quartz monzodiorite in the Sunzhuang area, Fanshi County, Shanxi Province are presented in this study. The zircon crystals can be classified into four main types as: AB, L, S and P, and 24 subtypes such as AB4, AB5, L5, and S3. The maximum crystallization temperature of zircon was estimated as 850°C, with the minimum of 550°C. The peak temperatures of the zircon crystallization range from 650°C to 700°C. The abundances of Th and U in the zircon grains show large variation with the Th/U values > 0.4. The Th and U values also show a positive correlation in most zircons. The REE abundance of zircon in the quartz monzodiorite ranges from 280.4 ppm to 2143 ppm with an average of 856.4 ppm. The chondrite normalized zircon REE patterns show two types, one is characterized by HREE enrichment and LREE depletion with positive Ce-anomaly and negative Eu-anomaly whereas the other is HREE enriched and LREE depleted with negative Eu-anomaly but without positive Ce-anomaly, and relatively flat patterns. The LA-ICP-MS U-Pb geochronology on the zircons yields a mean age of 133±0.87 Ma. Our data on zircon morphology, composition and U-Pb geochronology reveal that the parent magma of the quartz monzodiorite which was emplaced during late Yanshanian had a mixed crust-mantle source, with crustal components dominating. The magma is inferred to have been water rich and alkaline with initial high oxygen fugacity. Post-magmatic hydrothermal activity occurred under relatively reducing conditions which was conductive for gold precipitation in the Yixingzhai gold deposit. | SONG Jiye LI Shengrong QIN Mingkuan CAI Yuqi LUO Junyan ZHANG Juquan LI Chenglu SANTOSH M. | 2015 | Acta Geologica Sinica(English Edition)2015，89，4： | 2 |
| 9 | Characteristics of fat metabolism in skeletal muscle of rats after hypobaric hypoxic acclimation显示文摘Objective: To investigate the characteristics of fat metabolism in rat skeletal muscle after hypobaric hypoxia acclimation. Methods: Sprague-Dawley rats were divided into 3 groups randomly: control group (H0), hypoxic 5-day group (H5), and hypoxic 15-day group (H15). Animals of H5 and 15 groups were exposed to hypobaric hypoxia chamber simulating 5 000 m high altitude for 5 d or 15 d respectively, 23 h per day. H0 group stayed outside of chamber. The level of fatty acid oxidation and uptake, and glucose oxidation were examined, and the level of non-esterified fatty acids (NEFA), ATP and phosphocreatine (PCr) were also assayed in rat skeletal muscles. Results: The contents of ATP and PCr in H5 group were lower than those in H0 and H15 groups (P<0.05), while there was no significant difference between H0 and H15. Compared with H0, the blood NEFA level in all hypoxia groups was increased significantly (P<0.05). The muscle NEFA level in H15 group was greatly higher than that in H0 and H5 groups. The rates of fatty acid oxidation and uptake in H15 group were significantly higher than those in H0 and H5 groups (P<0.05), and the rate of glucose oxidation in all hypoxia groups was significantly decreased than that in H0 group (P<0.05). Conclusion: It is concluded that the enhanced fat oxidation may be one of the mechanisms in the maintenance of energy homeostasis after hypobaric hypoxic acclimation. | Mao Sunzhong Gao Yuqi Chen Jian Liu Fuyi Gao Wenxiang Huang Jian Liao Weigong Cai Mingchun | 2008 | Journal of Medical Colleges of PLA(China)2008，23，5： | 2 |
| 10 | Modulating the function of ABCB1: in vitro and in vivo characterization of sitravatinib, a tyrosine kinase inhibitor显示文摘Background:Overexpression of ATP-binding cassette(ABC)transporter is a major contributor to multidrug resistance(MDR),in which cancer cells acquire resistance to a wide spectrum of chemotherapeutic drugs.In this work,we evaluated the sensitizing effect of sitravatinib,a broad-spectrum tyrosine kinase inhibitor(TKI),on ATP-binding cassette subfamily B member 1(ABCB1)-and ATP-binding cassette subfamily C member 10(ABCC10)-mediated MDR.Methods:MTT assay was conducted to examine cytotoxicity and evaluate the sensitizing effect of sitravatinib at non-toxic concentrations.Tritium-labeled paclitaxel transportation,Western blotting,immunofluorescence analysis,and ATPase assay were carried out to elucidate the mechanism of sitravatinib-induced chemosensitization.The in vitro findings were translated into preclinical evaluation with the establishment of xenograft models.Results:Sitravatinib considerably reversed MDR mediated by ABCB1 and partially antagonized ABCC10-mediated MDR.Our in silico docking simulation analysis indicated that sitravatinib strongly and stably bound to the transmembrane domain of ABCB1 human-mouse chimeric model.Furthermore,sitravatinib inhibited hydrolysis of ATP and synchronously decreased the efflux function of ABCB1.Thus,sitravatinib could considerably enhance the intracellular concentration of anticancer drugs.Interestingly,no significant alterations of both expression level and localization of ABCB1 were observed.More importantly,sitravatinib could remarkably restore the antitumor activity of vincristine in ABCB1-mediated xenograft model without observable toxic effect.Conclusions:The findings in this study suggest that the combination of sitrvatinib and substrate antineoplastic drugs of ABCB1 could attenuate the MDR mediated by the overexpression of ABCB1. | Yuqi Yang Ning Ji Chao-Yun Cai Jing-Quan Wang Zi-Ning Lei Qiu-Xu Teng Zhuo-Xun Wu Qingbin Cui Yihang Pan Zhe-Sheng Chen | 2020 | Cancer Communications2020，40，7： | 2 |
| 11 | Characteristics of Uranium Mineralization in Red Clastic Formations in the Southwestern Margin of the Ordos Basin显示文摘In the southwestern margin of the Ordos Basin,uranium mineralization is primarily hosted by predominantly oxidative red clastic formations in the Lower Cretaceous.The main target layers for uranium exploration are the Madongshan and Liwaxia formations of the Liupanshan Group,followed by the Jingchuan Formation of the Zhidan Group.The host rocks(medium-fine feldspar quartz sandstone),which are bleached to a light grayish white color,contain a minor organic matter component and pyrite.Uranium mineralization changes from surficial infiltration or phreatic oxidation in the upper part to interlayer oxidation in the lower part.Uranium ore bodies are mostly lenticular or tabular in shape,locally shaped like crescent rolls.Individual ore bodies are typically small and shallow.Uranium predominantly manifests as pitchblende and coffinite.Coffinite is usually short and columnar or granular in habit,whereas pitchblende occurs as an irregular colloidal covering on the surface or in fissures of ferric oxide,silicate,clay or carbonate.Secondary uranium minerals are torbernite,uranophane,and uranopilite.Minerals associated with uranium are mainly pyrite,chalcopyrite and,to a minor extent,arsenopyrite and fluorite.The associated elements are Mo,V,Se,Co,Ni,and Mn,the host sandstone being high in Cu and Ba.Overall,the red clastic formations in the southwestern margin of the Ordos Basin are characterized by’five multiples but one low’which means multiple target layers,multiple stages of mineralization,multiple ore body shapes,multiple kinds of uranium minerals,multiple associated elements,but low organic matter.This implies an overall complex uranium metallogenic environment and mineralization process.It is recommended that future uranium exploration should take into consideration regional metallogenic conditions and mineralization features,with target layers in the wide-smooth synclinal slope being focused on.Most uranium deposits are small to medium in size,and the main type of uranium mineralization can vary by target layer. | ZHANG Zilong HE Feng YI Longsheng FAN Honghai CAI Yuqi LIU Hongxu LIU Xinyang CHEN Hongbin JIA Cui YANG Mengjia | 2020 | Acta Geologica Sinica(English Edition)2020，94，5： | 1 |
| 12 | Foxm1 Expression in Prostate Epithelial Cells Is Essential for Prostate Carcinogenesis显示文摘 | Yuqi Cai David Balli Vladimir Ustiyan Logan Fulford Andrea Hiller Vinko Misetic Yufang Zhang Andrew M. Paluch Susan E. Waltz Susan Kasper Tanya V. Kalin | 2013 | Journal of Biological Chemistry2013，，31： | 1 |
| 13 | Molecular wakes for ultrashort laser pulses显示文摘The molecular wake-assisted interaction between two collinear femotosecond laser pulses is investigated in air,which leads to the generation of a controllable 1.8 mJ super-continuum pulse with an elongated self-guided channel due to the cross-phase modulation of the impulsively aligned diatomic molecules in air. For two parallel launched femtosecond laser pulses with a certain spatial separation,controllable attraction and repulsion of the pulses are observed due to the counter-balance among molecular wakes,Kerr and plasma effects,where the molecular wakes show a longer interaction distance than the others to control the propagation of the intense ultrashort laser pulses. | CAI Hua,WU Jian,LU PeiFen,TONG YuQi,YANG Xuan,BAI XueShi,LI Hao,PAN HaiFeng & ZENG HePing State Key Laboratory of Precision Spectroscopy,East China Normal University,Shanghai 200062,China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，6： | 1 |
| 14 | On the generation and propagation of internal solitary waves in the southern Andaman Sea:A numerical study显示文摘Numerous internal solitary waves(ISWs)have been observed in the southern Andaman Sea.In this study,the twodimensional Massachusetts Institute of Technology general circulation model is applied to investigate the dynamics of ISWs and explore the effects of the bottom topography and tidal forcing on the generation and propagation of ISWs in the southern Andaman Sea.The results show that the large-amplitude depression ISWs are mainly generated via the oscillating tidal flow over the sill of the Great Channel,and the generation of ISWs is subject to the lee wave regime.The Dreadnought Bank cannot generate ISWs itself;however,it can enhance the amplitudes of eastward-propagating ISWs generated from sill A,owing to constructive interference of internal tide generation between the sill of the Great Channel and the Dreadnought Bank.The eastward-propagating ISWs generated by the eastern shallow sill near the continental shelf can propagate to the shelf,where they evolve into elevation waves because of the shallow water.Sensitivity runs show that both the semidiurnal and diurnal tides over the sill of the Great Channel can generate ISWs in this area.However,the ISWs generated by diurnal tides are much weaker than those generated by semidiurnal tides.Mixed tidal forcing has no significant effect on the generation of ISWs. | Shuqun CAI Yuqi WU Jiexin XU Zhiwu CHEN Jieshuo XIE Yinghui HE | 2021 | Science China Earth Sciences2021，64，10： | 1 |
| 15 | Geological and Geochemical Characteristics of the Zhiluo Formation in the Bayinqinggeli Uranium Deposit, Northern Ordos Basin: Significance for Uranium Mineralization显示文摘The Bayinqinggeli deposit in the northern Ordos Basin, northwestern of China, is a recently discovered sandstone-type uranium deposit. The uranium(U) orebodies are generally hosted in the lower member of the Jurassic Zhiluo Formation(Fm.), and are primarily tabular or irregular in shape. In the study area, 23 sandstone samples were collected from the Zhiluo Fm. and analyzed for major, trace, and rare earth elements(REEs). The geochemical characteristics of these sandstones are used to evaluate the factors controlling U mineralization. The source rocks of the Zhiluo Fm. sandstones are mainly volcanic and felsic magmatic rocks formed in continental arc and active continentalmarginal arc environments, and they provided the material required for the mineralization. The index of compositional variability ranges from 1.02 to 3.29(average1.38), indicating that the Zhiluo Fm. sandstones are immature and composed of first-cycle sediments. The corrected chemical index of alteration averages 56, suggesting that the source rocks underwent weak chemical weathering. The ore host rocks are loose, providing favorable conditions for epigenetic oxidation and U precipitation and enrichment. Ferrous iron in minerals such as chlorite, biotite, ilmenite, and pyrite might have played a role either in adsorbing or reducing the uranium. | CAI Yuqi HAN Meizhi ZHANG Chuang YI Chao LI Xiaocui ZHANG Yan WANG Gui LI Huaming | 2021 | Acta Geologica Sinica(English Edition)2021，95，6： | 0 |
| 16 | Seasonal and spatial variations of kinematic parameters of internal solitary waves in the Andaman Sea显示文摘The horizontally variable density stratification and background currents are taken into the variable-coefficent extended Korteweg-de Vries(evKdV)theory to obtain the geographical and seasonal distribution of kinematic parameters of internal solitary waves in the Andaman Sea(AS).The kinematic parameters include phase speed,dispersion parameter,quadratic and cubic nonlinear parameters.It shows that the phase speed and dispersion parameter are mainly determined by the topographic feature and have limited seasonal variation.The maximum phase speed is 2.6 m/s,which occurs in the cool season(November)in the middle of the AS,while the phase speed in the cool season is slightly larger than those in other seasons,up to 11.4%larger than that in the rainy season(July)in the southern AS.The dispersion parameter in the cool season can be 22.3%larger than that in the hot season.The nonlinear parameters have significant seasonal variation,and they can even change their signs at the continental slope in the north of the AS,from season to season.Meanwhile,the algebraic solitons dominate in the AS with minimum amplitudes(aal)ranging from 0.1 m to 102 m,and the maximum aal occurs in the cool season in the southern AS.The effect of the background flow on the parameters is also studied.The background flow has a great influence on the nonlinear parameters,e.g.,the value of cubic nonlinear parameter can be reduced by 1/3 when the background flow is not considered. | Yuqi Wu Jieshuo Xie Jiexin Xu Zhiwu Chen Yinghui He Shuqun Cai | 2022 | Acta Oceanologica Sinica2022，41，4： | 0 |
| 17 | β-Cyclodextrin derived full-spectrum fluorescent carbon dots: The formation process investigation and biological applications显示文摘Carbon dots(CDs), a new building unit, have been revolutionizing the fields of biomedicine, bioimaging, and optoelectronics with their excellent physical, chemical, and biological properties. However, the difficulty of preparing excitation-dependent full-spectrum fluorescent CDs has seriously hindered their further research in fluorescence emission mechanisms and biomedicine. Here, we report full-spectrum fluorescent CDs that exhibit controlled emission changes from purple(380 nm) to red(613 nm) at room temperature by changing the excitation wavelength, and the excitation dependence was closely related to the regulation of sp2 and sp3 hybrid carbon structures by β-cyclodextrin-related groups. In addition,by regulating the content of β-cyclodextrin, the optimal quantum yields of full-spectrum fluorescent CDs were 8.97%, 8.35%, 7.90%, 9.69% and 17.4% at the excitation wavelengths of 340, 350, 390, 410 and 540 nm,respectively. Due to their excellent biocompatibility and color tunability, full-spectrum fluorescent CDs emitted bright and steady purple, blue, green, yellow, and red fluorescence in MCF-7 cells. Moreover, we optimized the imaging conditions of CDs and mitochondrial-specific dyes;and realized the mitochondrialtargeted co-localization imaging of purple, blue and green fluorescence. After that, we also explored the effect of full-spectrum fluorescent CDs in vivo fluorescence imaging through the intratumorally, subcutaneously, and caudal vein, and found that full-spectrum fluorescent CDs had good fluorescence imaging ability in vivo. | Peide Zhu Wenjing Li Yuqi Zhang Qiang Sun Yi Lin Ailin Qiu Xinyi Chen Yujin Zhou Guangfu Wu Yifan Li Zhiqiang Yu Quan Xu Dixian Luo Lulu Cai | 2023 | Chinese Chemical Letters2023，34，10： | 0 |
| 18 | A Parallel Domain Decomposition Algorithm for Simulating Blood Flow with Incompressible Navier-Stokes Equations with Resistive Boundary Condition显示文摘We introduce and study a parallel domain decomposition algorithm for the simulation of blood flow in compliant arteries using a fully-coupled system of nonlinear partial differential equations consisting of a linear elasticity equation and the incompressible Navier-Stokes equations with a resistive outflow boundary condition.The system is discretized with a finite element method on unstructured moving meshes and solved by a Newton-Krylov algorithm preconditioned with an overlapping restricted additive Schwarz method.The resistive outflow boundary condition plays an interesting role in the accuracy of the blood flow simulation and we provide a numerical comparison of its accuracy with the standard pressure type boundary condition.We also discuss the parallel performance of the implicit domain decomposition method for solving the fully coupled nonlinear system on a supercomputer with a few hundred processors. | Yuqi Wu Xiao-Chuan Cai | 2012 | Communications in Computational Physics2012，11，4： | 0 |
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