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| 1 | Current systemic treatment of hepatocellular carcinoma:A review of the literature显示文摘Hepatocellular carcinoma(HCC) is the fifth most common form of human cancer worldwide and the third most common cause of cancer-related deaths. The strategies of various treatments for HCC depend on the stage of tumor,the status of patient's performance and the reserved hepatic function. The Barcelona Clinic Liver Cancer(BCLC) staging system is currently used most for patients with HCC. For example,for patients with BCLC stage 0(very early stage) and stage A(early stage) HCC,the curable treatment modalities,including resection,transplantation and radiofrequency ablation,are taken into consideration. If the patients are in BCLC stage B(intermediate stage) and stage C(advanced stage) HCC,they may need the palliative transarterial chemoembolization and even the target medication of sorafenib. In addition,symptomatic treatment is always recommended for patients with BCLC stage D(end stage) HCC. In this review,we will attempt to summarize the historical perspective and the current developments of systemic therapies in BCLC stage B and C in HCC. | Kai-Wen Chen Tzu-Ming Ou Chin-Wen Hsu Chi-Ting Horng Ching-Chang Lee Yuh-Yuan Tsai Chi-Chang Tsai Yi-Sheng Liou Chen-Chieh Yang Chao-Wen Hsueh Wu-Hsien Kuo | 2015 | World Journal of Hepatology2015，7，10： | 12 |
| 2 | Adsorption behavior of heavy metal ions by carbon nanotubes grown on microsized Al/_2O_3 particles显示文摘Carbon nanotubes (CNTs) were grown on the surface of microsized Al2O3 particles in CH4 atmosphere at 700°C under the catalysis of Fe-Ni nanoparticles. The CNTs on Al2O3 were used for adsorbing Pb2+, Cu2+, and Cd2+ from the solution and the results were compared with active carbon powders, commercial carbon nanotubes, and Al2O3 particles. The as-grown CNTs/Al2O3 have de- monstrated extraordinary absorption capacity with further treatment or oxidation, as well as hydrophilic ability that other CNTs lacked. The adsorption capacity of CNTs on Al2O3 is superior to other adsorbents and the preference order of adsorption on composite Al2O3 is Pb2+>Cu2+>Cd2+. It seemed that the adsorption of those Pb2+, Cu2+, and Cd2+ did not change the surface properties of composite particles. The adsorption behaviors of Pb2+, Cu2+, and Cd2+ by CNTs on Al2O3 match well with the Langmuir isothermal adsorption model and the second order kinetic model. The calculated saturation amount adsorbed by 1 g of CNTs on Al2O3 are 67.11, 26.59, and 8.89 mg/g for Pb2+, Cu2+, and Cd2+ in single adsorption test, respectively. | Shu-Huei Hsieh Jao-Jia Horng | 2007 | Journal of University of Science and Technology Beijing2007，14，1： | 7 |
| 3 | High Levels of Hepatitis B Surface Antigen Increase Risk of Hepatocellular Carcinoma in Patients With Low HBV Load显示文摘 | Tai–Chung Tseng Chun–Jen Liu Hung–Chih Yang Tung–Hung Su Chia–Chi Wang Chi–Ling Chen Stephanie Fang–Tzu Kuo Chen–Hua Liu Pei–Jer Chen Ding–Shinn Chen Jia–Horng Kao | 2012 | Gastroenterology2012，，5： | 6 |
| 4 | Emerging radiotherapy technologies and trends in nasopharyngeal cancer显示文摘AbTechnology has always driven advances in radiotherapy treatment.In this review,we describe the main technological advances in radiotherapy over the past decades for the treatment of nasopharyngeal cancer(NPC)and highlight some of the pressing issues and challenges that remain.We aim to identify emerging trends in radiation medicine.These include advances in personalized medicine and advanced imaging modalities,standardization of planning and delineation,assessment of treatment response and adaptive re-planning,impact of particle therapy,and role of artificial intelligence or automation in clinical care.In conclusion,we expect significant improvement in the therapeutic ratio of radiotherapy treatment for NPC over the next decade. | Michelle Tseng Francis Ho Yiat Horng Leong Lea ChoungWong Ivan WK Tham Timothy Cheo Anne WM Lee | 2020 | Cancer Communications2020，40，9： | 5 |
| 5 | Serum Hepatitis B Surface Antigen Levels Predict Surface Antigen Loss in Hepatitis B e Antigen Seroconverters显示文摘 | Tai–Chung Tseng Chun–Jen Liu Tung–Hung Su Chia–Chi Wang Chi–Ling Chen Pei–Jer Chen Ding–Shinn Chen Jia–Horng Kao | 2011 | Gastroenterology2011，，2： | 4 |
| 6 | A genetic algorithm with adaptive mutations and family competition for training neural networks显示文摘 | YANG Jinn-moon HORNG Jomg-tzong KAO Cheng-yan | 2000 | International J of Neural Systems2000，10，5： | 4 |
| 7 | Peginterferon Alfa-2a Plus Ribavirin for the Treatment of Dual Chronic Infection With Hepatitis B and C Viruses显示文摘 | Chun–Jen Liu Wan–Long Chuang Chuan–Mo Lee Ming–Lung Yu Sheng–Nan Lu Shun–Sheng Wu Li–Ying Liao Chi–Ling Chen Hsing–Tao Kuo You–Chen Chao Shui–Yi Tung Sien–Sing Yang Jia–Horng Kao Chen–Hua Liu Wei–Wen Su Chih–Lin Lin Yung–Ming Jeng Pei–Jer Chen Ding–Shinn | 2009 | Gastroenterology2009，，2： | 3 |
| 8 | Highly flexible supercapacitors with manganese oxide nanosheet/carbon cloth electrode显示文摘 | Ying-Chu Chen Yu-Kuei Hsu Yan-Gu Lin Yu-Kai Lin Ying-Ying Horng Li-Chyong Chen Kuei-Hsien Chen | 2011 | Electrochimica Acta2011，，20： | 3 |
| 9 | Asialo GM1-positive liver-resident CD8 T cells that express CD44 and LFA-1 are essential for immune clearance of hepatitis B virus显示文摘Persistent hepatitis B virus(HBV)infection results in chronic liver diseases that may progress to chronic hepatitis,liver cirrhosis,and subsequent hepatocellular carcinoma.Previous studies demonstrated that adaptive immunity,in particular CD8 T cells,is critical in HBV elimination.Recent studies have revealed a distinct tissue-localized T cell lineage,tissue-resident memory(TRM)cells,that is crucial for protective immunity in peripheral tissues.In this study,we showed that treatment with an anti-asialo GM1(ASGM1)antibody(Ab),which depletes NK cells,led to impairment of HBV clearance in a mouse animal model.Unexpectedly,the ability to clear HBV was not significantly impaired in NFIL3 KO mice,which are deficient in NK cells,implying that other non-NK ASGM1-positive immune cells mediate HBV clearance.We isolated intrahepatic ASGM1-positive cells from NFIL3 KO mice and analyzed the immune phenotype of these cells.Our results demonstrated a distinct population of CD44+LFA-1hi CD8 T cells that were the major intrahepatic ASGM1-positive immune cells in NFIL3 KO mice.Importantly,transcriptome analysis revealed that these ASGM1-positive CD8 T cells had distinct gene profiles and shared a similar core gene signature with TRM cells.In addition to both transcriptional and phenotypic liver residency characteristics,ASGM1-positive CD8 T cells were able to home to and be retained in the liver after adoptive transfer.Taken together,our study results indicate that these ASGM1-positive liver-resident CD8 T cells are the major effector immune cells mediating anti-HBV immunity. | Chi-Chang Sung Jau-Hau Horng Shih-Hong Siao I-Tsu Chyuan Hwei-Fang Tsai Pei-Jer Chen Ping-Ning Hsu | 2021 | Cellular & Molecular Immunology2021，18，7： | 3 |
| 10 | Basal core promoter mutations of hepatitis B virus increase the risk of hepatocellular carcinoma in hepatitis B carriers显示文摘 | Jia–Horng Kao Pei–Jer Chen Ming–Yang Lai Ding–Shinn Chen | 2003 | Gastroenterology2003，，2： | 3 |
| 11 | High Prevalence and Mapping of Pre-S Deletion in Hepatitis B Virus Carriers With Progressive Liver Diseases显示文摘 | Bing–Fang Chen Chun–Jen Liu Guey–Mei Jow Pei–Jer Chen Jia–Horng Kao Ding–Shinn Chen | 2006 | Gastroenterology2006，，4： | 2 |
| 12 | Radiation-induced liver disease after three-dimensional conformal radiotherapy for patients with hepatocellular carcinoma: dosimetric analysis and implication显示文摘 | Jason Chia-Hsien Cheng Jian-Kuen Wu Chao-Ming Huang Hua-Shan Liu David Y. Huang Skye Hongiun Cheng Stella Y. Tsai James Jer-Min Jian Yu-Mong Lin Tsun-I Cheng Cheng-Fang Horng Andrew T. Huang | 2002 | International Journal of Radiation Oncology, Biology, Physics2002，，： | 2 |
| 13 | Induction of differentiation in rat C6 glioma cells with Saikosaponins 显示文摘 | Tsai Y J Chen I L Horng L Y | 2002 | Phytother Res2002，16，2： | 2 |
| 14 | Risk stratification for hepatitis B virus related hepatocellular carcinoma显示文摘 | Chih‐Lin Lin Jia‐Horng Kao | 2012 | J Gastroenterol Hepatol2012，，1： | 2 |
| 15 | Growth and etching characteristics of gallium oxide thin films by pulsed laser deposition显示文摘 | Sin-Liang Ou Dong-Sing Wuu Yu-Chuan Fu Shu-Ping Liu Ray-Hua Horng Lei Liu Zhe-Chuan Feng | 2012 | 2012 (2-3)2012，，2： | 2 |
| 16 | Serum hepatitis B surface antigen levels help predict disease progression in patients with low hepatitis B virus loads显示文摘 | Tai‐Chung Tseng Chun‐Jen Liu Hung‐Chih Yang Tung‐Hung Su Chia‐Chi Wang Chi‐Ling Chen Cheng‐An Hsu Stephanie Fang‐Tzu Kuo Chen‐Hua Liu Pei‐Jer Chen Ding‐Shinn Chen Jia‐Horng Kao | 2012 | Hepatology2012，，： | 2 |
| 17 | Diffusion Tensor Imaging (DTI) of the Kidney at 3 Tesla–Feasibility, Protocol Evaluation and Comparison to 1.5 Tesla显示文摘 | Mike Notohamiprodjo Olaf Dietrich Wihelm Horger Annie Horng Andreas D. Helck Karin A. Herrmann Maximilian F. Reiser Christian Glaser | 2010 | Investigative Radiology2010，，： | 2 |
| 18 | Development of an improved PCR-ICT hybrid assay for direct detection of Legionellae and Le- gionella pneumophila from cooling tower water specimens显示文摘 | Horng YT Soo PC Shen BJ | 2006 | Water Res2006，40，： | 1 |
| 19 | Comparison of electromagnetic shielding effectiveness properties of diverse conductive textiles via various measurement techniques 显示文摘 | CHENA Hsin Chuan LEE Kuei Chi LIN Jia Horng | 2007 | Journal of Materials Processing Technology2007，，192193： | 1 |
| 20 | A new algorithm for 5-band Toeplitz matrix inversion with application to GCV smoothing spline computation显示文摘 | Jyh J Horng S | 1999 | Statistic & Probability Lett1999，45，： | 1 |
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