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| 1 | Trends in Lipids Level and Dyslipidemia among Chinese Adults, 2002-2015显示文摘Objective To investigate the trends of lipid profiles and dyslipidemia among Chinese adults from 2002 to 2015.Methods Data were collected from three nationally representative cross-sectional surveys.Fasting venous blood samples were collected and serum lipids were tested by biochemical analysis and enzymatic determination.Lipid levels and the prevalence of dyslipidemia among adults were analyzed with complex sampling weighting adjustment for age and gender.Results The weighted means of TC, TG, and LDL-c significantly increased linearly from 3.93, 1.12, and 2.12 mmol/L in 2002 to 4.59, 1.41, and 2.78 mmol/L in 2010 and then to 4.63, 1.47, and 2.87 mmol/L in 2015, respectively;by contrast, HDL-c levels decreased significantly from 1.30 mmol/L to 1.26 mmol/L over the same period.Similar trends in mean non-HDL-c and lipid-related ratios were observed.The weighted dyslipidemia prevalence linearly increased;in particular, hypercholesterolemia increased from 1.6% to 5.6% and then to 5.8%, hypertriglyceridemia increased from 5.7% to 13.6% and then to 15.0%, low HDL-c increased from 18.8% to 35.5% and then to 24.9%, and high LDL-c increased from 1.3% to 5.6% and then to 7.2%(P for trend <0.001).Conclusion Dyslipidemia increased among Chinese adults from 2002 to 2015.Development of a comprehensive strategy to decrease lipid levels in this population is urgently required. | SONG Peng Kun MAN Qing Qing LI Hong PANG Shao Jie JIA Shan Shan LI Yu Qian HE Li ZHAO Wen Hua ZHANG Jian | 2019 | Biomedical and Environmental Sciences2019，32，8： | 45 |
| 2 | Garcinol inhibits esophageal cancer metastasis by suppressing the p300 and TGF-β1 signaling pathways显示文摘Metastasis causes the main lethality in esophageal cancer patient.Garcinol,a natural compound extracted from Gambogic genera,is a histone acetyltransferase(HAT)inhibitor that has shown anticancer activities such as cell cycle arrest and apoptosis induction.In this study,we investigated the effects of garcinol on the metastasis of esophageal cancer in vitro and in vivo.We found that garcinol(5-15μM)dose-dependently inhibited the migration and invasion of human esophageal cancer cell lines KYSE150 and KYSE450 in wound healing,transwell migration,and Matrigel invasion assays.Furthermore,garcinol treatment dose-dependently decreased the protein levels of p300/CBP(transcriptional cofactors and HATs)and p-Smad2/3 expression in the nucleus,thus impeding tumor cell proliferation and metastasis.Knockdown of p300 could inhibit cell metastasis,but CBP knockdown did not affect the cell mobility.It has been reported that TGF-β1 stimulated the phosphorylation of Smad2/3,which directly interact with p300/CBP in the nucleus,and upregulating HAT activity of p300.We showed that garcinol treatment dose-dependently suppressed TGF-β1-activated Smad and non-Smad pathway,inhibiting esophageal cancer cell metastasis.In a tail vein injection pulmonary metastasis mouse model,intraperitoneal administration of garcinol(20 mg/kg)or 5-FU(20 mg/kg)significantly decreased the number of lung tumor nodules and the expression levels of Ki-67,p300,and p-Smad2/3 in lung tissues.In conclusion,our study demonstrates that garcinol inhibits esophageal cancer metastasis in vitro and in vivo,which might be related to the suppression of p300 and TGF-β1 signaling pathways,suggesting the therapeutic potential of Garcinol for metastatic tumors. | Jing Wang Man Wu Dan Zheng Hong Zhang Yue Lv Li Zhang Hong-sheng Tan Hua Zhou Yuan-zhi Lao Hong-xi Xu | 2020 | Acta Pharmacologica Sinica2020，41，1： | 12 |
| 3 | Garciesculenxanthone B induces PINK1-Parkin-mediated mitophagy and prevents ischemia-reperfusion brain injury in mice显示文摘Mitophagy is a selective form of autophagy involving the removal of damaged mitochondria via the autophagy-lysosome pathway.PINK1-Parkin-mediated mitophagy is one of the most important mechanisms in cardiovascular disease,cerebral ischemia-reperfusion(I/R)injury,and neurodegenerative diseases.In this study we conducted an image-based screening in YFP-Parkin HeLa cells to discover new mitophagy regulators from natural xanthone compounds.We found that garciesculenxanthone B(GeB),a new xanthone compound from Garcinia esculenta,induced the formation of YFP-Parkin puncta,a well known mitophagy marker.Furthermore,treatment with GeB dose-dependently promoted the degradation of mitochondrial proteins Tom20,Tim23,and MFN1 in YFP-Parkin HeLa cells and SH-SY5Y cells.We revealed that GeB stabilized PINK1 and triggered Parkin translocation to the impaired mitochondria to induce mitophagy,and these effects were abolished by knockdown of PINK1.Finally,in vivo experiments demonstrated that GeB partially rescued ischemia-reperfusion-induced brain injury in mice.Taken together,our findings demonstrate that the natural compound GeB can promote the PINK1-Parkin-mediated mitophagy pathway,which may be implicated in protection against I/R brain injury. | Man Wu Guang Lu Yuan-zhi Lao Hong Zhang Dan Zheng Zhao-qing Zheng Juan Yi Qian Xiang Li-ming Wang Hong-sheng Tan Hua Zhou Han-ming Shen Hong-xi Xu | 2021 | Acta Pharmacologica Sinica2021，42，2： | 7 |
| 4 | Clinical significance of PCR in Helicobacter pylori DNA detection in human gastric disorders显示文摘ClinicalsignificanceofPCRinHelicobacterpyloriDNAdetectioninhumangastricdisordersXUGuoMing,JIXuHuai,LIZhaoShen,MANXiaoHua... | XU Guo Ming, JI Xu Huai, LI Zhao Shen, MAN Xiao Hua and ZHANG Hong Fu | 1997 | World Journal of Gastroenterology1997，3，2： | 6 |
| 5 | Eosinophil-derived CCL-6 impairs hematopoietic stem cell homeostasis显示文摘嗜曙红血球(曙光女神) 长在层次造血的系统被看作了结束阶段受动器房间。证据的众多的线建议了那个曙光女神是关于各种各样的煽动性或有免疫力的反应的开始,繁殖和规定的多功能的白血球,特别在过敏疾病。最近的研究证明了那个曙光女神也为骨头髓血浆房间的维护和 B 房间的区别被要求。然而,曙光女神是否贡献造血的干细胞(HSC ) 的规定,仍然保持不清楚动态平衡。这里,我们证明曙光女神由在野类型的老鼠损害 HSC 静止和体质能力破坏 HSC 动态平衡后面的 ovalbumin (卵) 挑战并且甚至由引起骨头髓 HSC 在 Cd3-Il-5 转基因的老鼠的失败和疲劳。HSC 的损害维护和功能与导致曙光女神的氧化还原作用不平衡(增加的氧化 phosphorylation 和减少的抗氧化剂层次) 被联系。用集体 spectrometry,更重要地,我们决定 CCL-6 在嗜曙红血球过多下面在高水平被表示。我们证明 CCL-6 为损害 HSC 动态平衡导出曙光女神、负责。有趣地,有特定的抵销抗体的 CCL-6 的阻塞,当在质问卵的老鼠加重嗜曙红血球过多航线发炎时,恢复了 HSC 的体质能力。因此,我们的学习在 HSC 动态平衡揭示 Eos/CCL-6 的意外功能。 | Chao Zhang, Fei Li, Xufei Du, Man Luo, Wen Hua, Wen Li, Zhihua Chen, Songmin Ying, Huahao Shen Weiwei Yi, Hu Wang, Zhenyu Ju Hu Wang, Zhenyu Ju Ping Wu, Chao Peng, Catherine CL Wong James J Lee Songmin Ying Songmin Ying Huahao Shen | 2018 | Cell Research2018，28，3： | 6 |
| 6 | An App knock-in rat model for Alzheimer’s disease exhibiting Aβand tau pathologies,neuronal death and cognitive impairments显示文摘A major obstacle in Alzheimer’s disease(AD)research is the lack of predictive and translatable animal models that reflect disease progression and drug efficacy.Transgenic mice overexpressing amyloid precursor protein(App)gene manifest non-physiological and ectopic expression of APP and its fragments in the brain,which is not observed in AD patients.The App knock-in mice circumvented some of these problems,but they do not exhibit tau pathology and neuronal death.We have generated a rat model,with three familiar App mutations and humanized Aβsequence knocked into the rat App gene.Without altering the levels of full-length APP and other APP fragments,this model exhibits pathologies and disease progression resembling those in human patients:deposit of Aβplaques in relevant brain regions,microglia activation and gliosis,progressive synaptic degeneration and AD-relevant cognitive deficits.Interestingly,we have observed tau pathology,neuronal apoptosis and necroptosis and brain atrophy,phenotypes rarely seen in other APP models.This App knock-in rat model may serve as a useful tool for AD research,identifying new drug targets and biomarkers,and testing therapeutics. | Keliang Pang Richeng Jiang Wei Zhang Zhengyi Yang Lin-Lin Li Makoto Shimozawa Simone Tambaro Johanna Mayer Baogui Zhang Man Li Jiesi Wang Hang Liu Ailing Yang Xi Chen Jiazheng Liu Bengt Winblad Hua Han Tianzi Jiang Weiwen Wang Per Nilsson Wei Guo Bai Lu | 2022 | Cell Research2022，32，2： | 6 |
| 7 | Malnutrition in Relation with Dietary, Geographical, and Socioeconomic Factors among Older Chinese显示文摘Objective Nutrition is closely related to the health of the elderly population. This study aimed to provide a comprehensive picture of the nutrition status of elderly Chinese and its related dietary,geographical, and socioeconomic factors.Methods A total of 13,987 ≥ 60-year-old persons from the 2010–2013 Chinese National Nutrition and Health Survey were included to evaluate various aspects of malnutrition, including underweight,overweight or obesity, and micronutrient inadequacy.Results Overall, the prevalence of obesity, overweight, and underweight was 12.4%, 34.8%, and 5.7%,respectively, with disparities both geographically and socioeconomically. The prevalence of underweight was higher among the older old(≥ 75 years), rural residents and those with low income, with low education status, and residing in undeveloped West areas. More than 75% of the elderly do not meet the Dietary Reference Intakes for vitamins A, B1, B2, and E, folate, calcium, selenium, potassium, biotin,and choline, with the prevalence of inadequate intake increasing with age for most nutrients. At the population level, the mean intakes of numerous food groups did not meet the recommendations by the Chinese Dietary Guideline.Conclusions Obesity epidemic, inadequacy of micronutrient intake, and high prevalence of underweight and anemia in susceptible older people are the major nutrition challenges for the rapidly aging population in China. | ZHANG Jian SONG Peng Kun ZHAO Li Yun SUN Ye YU Kai YIN Jing PANG Shao Jie LIU Zhen MAN Qing Qing HE Li LI Cheng ARIGONI Fabrizio BOSCO Nabil DING Gang Qiang ZHAO Wen Hua | 2021 | Biomedical and Environmental Sciences2021，34，5： | 5 |
| 8 | Association between Fine Particulate Air Pollution and Outpatient Visits for Eczema in Beijing, China: A Time-series Analysis显示文摘Eczema is a very common inflammatory skin disease characterized by patches of erythematous,itchy, cracked, and scaly skin.According to the 2010 Global Burden of Disease Study, the global prevalence of eczema is 3.33% and the leading cause of skin condition-based disability-adjusted life years is eczema[1].The large health burden brought about by eczema suggests high direct medical costs and health care utilization[2].Thus, eczema prevention is of great importance in efforts to eliminate the public health burden of the disease. | WANG Xiao Wen TIAN Yao Hua CAO Ya Ying SONG Jing LI Man WU Yao WANG Meng Ying HUANG Zhe HU Yong Hua | 2019 | Biomedical and Environmental Sciences2019，32，8： | 4 |
| 9 | Comparison of the oncological,perioperative and functional outcomes of partial nephrectomy versus radical nephrectomy for clinical T1b renal cell carcinoma:A systematic review and metaanalysis of retrospective studies显示文摘Objective:To conduct a meta-analysis assessing the perioperative,functional and oncological outcomes of partial nephrectomy(PN)and radical nephrectomy(RN)for T1b tumours.The primary endpoints were the oncological outcomes.The secondary endpoints were the perioperative and functional outcomes.Methods:A systematic literature review was performed by searching multiple databases through February 2019 to identify eligible comparative studies according to the Preferred Reporting Items for Systematic Review and Meta-analysis statement.Identified reports were assessed according to the Newcastle-Ottawa Scale for nonrandomized controlled trials.Results:Overall,13 retrospective cohort studies were included in the analysis.Patients undergoing PN were younger(weighted mean difference[WMD]3.49 years,95%confidence interval[CI]5.16 to1.82;p<0.0001)and had smaller masses(WMD0.45 cm,95%CI0.59 to0.31;p<0.0001).There were no differences in the oncological outcome,which was demonstrated by progression-free survival(hazard ratio[HR]0.70;pZ0.22),cancerspecific mortality(HR 0.91;pZ0.57)and all-cause mortality(HR 1.01;pZ0.96).The two procedures were similar in estimated blood loss(WMD16.47 mL;pZ0.53)and postoperative complications(risk ratio[RR]1.32;pZ0.10),and PN provided better renal function preservation and was related to a lower likelihood of chronic kidney disease onset(RR 0.38;pZ0.006).Conclusion:PN is an effective treatment for T1b tumours because it offers similar surgical morbidity,equivalent cancer control,and better renal preservation compared to RN. | Yucong Zhang Gongwei Long Haojie Shang Beichen Ding Guoliang Sun Wei Ouyang Man Liu Yuan Chen Heng Li Hua Xu Zhangqun Ye | 2021 | Asian Journal of Urology2021，8，1： | 4 |
| 10 | Expression, purification, and functional characterization of recombinant PTD-SARA显示文摘为蛋白质是的受体激活(SARA ) 的 Smad 锚为在支持发信号的小径的 fibrotic 起一个重要作用的 Smad2/3 的一个有约束力的搭挡由转变生长 factor-1 (TGF-1 ) 开始了。C 终端 SARA 的 665750 aa 包括 Smad 有约束力的领域(SBD ) 。由通过 SBD 的直接相互作用, SARA 禁止 Smad2/3 phosphorylation 并且堵住在 Smad2/3 和 Smad4 之间的相互作用,从而制止纤维变性的过程。在这研究,我们基于 SBD 顺序构造了 SARA 肽 aptamer。recombinant SARA aptamer,与一个蛋白质 transduction 领域(PTD-SARA ) 熔化了,被克隆,从 E 净化了。coli,并且第一次描绘了。编码顺序的全身的 PTD-SARA,与 E 创造了。coli 赞成了 codons,被克隆进 pQE-30 向量,并且 recombinant plasmid 被转变成 M15 紧张。在 Isopropyl -D-1-Thiogalactopyranoside (IPTG ) 以后正式就职和 Ni2+ 亲密关系纯化, recombinant PTD-SARA 被定序的 immunoblotting 和蛋白质 N 终端进一步识别。Epifluorescence 显微镜学表明 recombinant PTD-SARA 比 SARA 更高效地被变成细胞质和原子核。而且, recombinant PTD-SARA 被发现 E-cadherin 和下面调整的水平到起来调整 -SMA 和 phospho-Smad3 的层次更高效地比 SARA (P < 0.05 ) 。我们的工作探索了一个方法获得 recombinant PTD-SARA 蛋白质。recombinant PTD-SARA 熔化蛋白质能进入 HK2 房间(使不朽的近似小管上皮的房间线) 更高效地比 SARA 蛋白质和颠倒被 TGF-1 比 SARA 蛋白质更有效地导致的肾的 epithelial-to-mesenchymal transdifferentiation 过程。Recombinant PDT-SARA 是可能的是肾的纤维变性的临床的预防和处理的一个潜在的候选人。 | Chen Huang Rui Du Peng Zhang Hua Meng Huiwei Jia Yang Song Man Li Yingqi Zhang Shiren Sun | 2011 | Acta Biochimica et Biophysica Sinica2011，43，2： | 4 |
| 11 | Association between Selenium in Soil and Diabetes in Chinese Residents Aged 35–74 Years:Results from the 2010 National Survey of Chronic Diseases and Behavioral Risk Factors Surveillance显示文摘Objective To explore the association between soil selenium levels and the risk of diabetes in Chinese adults aged 35–74 years.Methods Data for this study were derived from the China Chronic Diseases and Behavioral Risk Factors Surveillance 2010 survey.Selenium concentrations in soil were obtained from the Atlas of Soil Environmental Background Values in China.A two-level binary logistic regression model was used to determine the association between soil selenium concentrations and the risk of diabetes,with participants nested within districts/counties.Results A total of 69,332 participants aged 35–74 years,from 158 districts/counties were included in the analysis.Concentrations of selenium in soil varied greatly across the 158 districts/counties,with a median concentration of 0.219 mg/kg(IQR:0.185–0.248).The results showed that both Quartile 1(0.119–0.185 mg/kg)and Quartile 4(0.249–0.344 mg/kg)groups were positively associated with diabetes compared to a soil selenium concentration of 0.186–0.219 mg/kg(Quartile 2),crude odds ratios(ORs)(95%CI)were 1.227(1.003–1.502)and 1.280(1.048–1.563).The P values were 0.045 and 0.013,for Quartile 1 and Quartile 4 groups,respectively.After adjusting for all confounding factors of interest,the Quartile 1 group became non-significant,and the Quartile 4 group had an adjusted OR(95%CI)of 1.203(1.018–1.421)relative to the reference group(Quartile 2),the P values was 0.030.No significant results were seen for the Quartile 3 group(0.220–0.248 mg/kg)compared to the reference group.Conclusion Excessive selenium concentrations in soil could increase the risk of diabetes among Chinese adults aged 35–74 years. | WANG Qi Qi YU Shi Cheng XU Cheng Dong LIU Jian Jun LI Yuan Qiu ZHANG Man Hui LONG Xiao Juan LIU Yun Ning BI Yu Fang ZHAO Wen Hua YAO Hong Yan | 2020 | Biomedical and Environmental Sciences2020，33，4： | 3 |
| 12 | Abnormal spontaneous brain activity in patients with non-arteritic anterior ischemic optic neuropathy detected using functional magnetic resonance imaging显示文摘To the Editor: Non-arteritic anterior ischemic optic neuropathy (NAION), characterized by a sudden onset of unilateral painless visual loss and a swollen optic disc, is the most common form of acute optic neuropathy in patients over 50 years of age.[1] The pathogenesis of NAION remains unclear, but most histopathological studies support the concept of vasculopathic occlusion in the region of the short posterior ciliary arteries.[2] Functional magnetic resonance imaging (fMRI) is one of the most widely used non-invasive techniques for measuring brain function over time in vivo. To the best of our knowledge, only one study has investigated the effects of stimulating the affected eye in the extra-visual areas in NAION in humans.[3]However, this previous study only examined task-state fMRI, and lacked a measure of resting-state fMRI (rs-fMRI). Thus, it remains unclear whether regional spontaneous brain changes are limited to the visual system. | Peng-De Guo Peng-Bo Zhao Han Lv Feng-Yuan Man Yan Su Jing Zhao Ming Liu Yun-Xiang Chen Yan Wang Hai-Qin Hua Ling-Ling Cai Jian Zhou | 2019 | Chinese Medical Journal2019，，6： | 3 |
| 13 | Prevalence of Undernutrition and Related Dietary Factors among People Aged 75 Years or Older in China during 2010-2012显示文摘Objective Undernutrition is highly prevalent among older people. The aim of this study was to estimate the prevalence of undernutrition in elderly Chinese residents and explore the relationship between undernutrition and dietary factors. Methods Data were collected from 2,552 elderly people aged 75 years and over from the Chinese Nutrition and Health Surveillance during 2010-2012 using questionnaires, anthropometric measurement, and individual consecutive 3-day 24-hour dietary records. Results The present study showed that 10.5% of participants had undernutrition. The prevalence was higher among the population living in rural areas, those living in the South region, those who smoked, and those with low income levels. Most participants failed to meet the Chinese Dietary Reference Intakes for energy(66.1%) and protein(72.1%). When comparing quartiles of food intake, high rice consumption [odds ratio(OR) = 2.44, 95% confidence interval(CI): 1.35-4.40)], animal oil intake(OR = 1.60, 95% CI: 1.18-2.17), and high fat intake from animal sources(OR = 1.56, 95% CI: 1.06-2.31) were positively associated with underweight whereas high wheat consumption(OR = 0.44, 95% CI: 0.26-0.74), a proper proportion(24%-32%) of energy intake from fat(OR = 0.54, 95% CI: 0.35-0.83), and high fat intake from plant sources(OR = 0.67, 95% CI: 0.46-0.99) were inversely related.Conclusion The prevalence of undernutrition was high among elderly Chinese people, especially in rural areas. Dietary factors, such as high consumption of rice, were associated with undernutrition. | LIU Zhen PANG Shao Jie MAN Qing Qing WANG Jing Zhong ZHAO Wen Hua ZHANG Jian | 2018 | Biomedical and Environmental Sciences2018，31，6： | 3 |
| 14 | Gastric emptying and plasma levels of gastrointestinal hormones in patients with peptic ulcer显示文摘GastricemptyingandplasmalevelsofgastrointestinalhormonesinpatientswithpepticulcerCHENJian,LIJunMan,LIXueHui,HAOHongShengan... | CHEN Jian, LI JunMan, LI XueHui, HAO HongSheng and FU ShuHuaDepartment of Gastroenterology, the Affiliated Hospital of Shandong Medical University, Jinan 250012, Shandong Province, China | 1997 | World Journal of Gastroenterology1997，3，4： | 3 |
| 15 | Synthesis of Isoquinoline-1, 3-Dicarboxylic Acid显示文摘Two new compounds, isoquinoline-1, 3-dicarboxyaldehyde and (IDA) were synthesizedvia 6 or 7 steps starting from benzaldehyde, or prepared via 4 steps starting from allylbenzene. | Xian Hong YINI Man Ya YANG Hua Hong SHI Lian Quan GU(Chemistry Department, Zhongshan University. Guangzhou 510275)(Chemistry Department, Guangxin University for Nationalities, Nanning 530006) | 1999 | Chinese Chemical Letters1999，10，11： | 2 |
| 16 | Delineating spatiotemporal and hierarchical development of human fetal innate lymphoid cells显示文摘Whereas the critical roles of innate lymphoid cells(ILCs)in adult are increasingly appreciated,their developmental hierarchy in early human fetus remains largely elusive.In this study,we sorted human hematopoietic stem/progenitor cells,lymphoid progenitors,putative ILC progenitor/precursors and mature ILCs in the fetal hematopoietic,lymphoid and non-lymphoid tissues,from 8 to 12 post-conception weeks,for single-cell RNA-sequencing,followed by computational analysis and functional validation at bulk and single-cell levels.We delineated the early phase of ILC lineage commitment from hematopoietic stem/progenitor cells,which mainly occurred in fetal liver and intestine.We further unveiled interleukin-3 receptor as a surface marker for the lymphoid progenitors in fetal liver with T,B,ILC and myeloid potentials,while IL-3RA–lymphoid progenitors were predominantly B-lineage committed.Notably,we determined the heterogeneity and tissue distribution of each ILC subpopulation,revealing the proliferating characteristics shared by the precursors of each ILC subtype.Additionally,a novel unconventional ILC2 subpopulation(CRTH2–CCR9+ILC2)was identified in fetal thymus.Taken together,our study illuminates the precise cellular and molecular features underlying the stepwise formation of human fetal ILC hierarchy with remarkable spatiotemporal heterogeneity. | Chen Liu Yandong Gong Han Zhang Hua Yang Yang Zeng Zhilei Bian Qian Xin Zhijie Bai Man Zhang Jian He Jing Yan Jie Zhou Zongcheng Li Yanli Ni Aiqing Wen Yu Lan Hongbo Hu Bing Liu | 2021 | Cell Research2021，31，10： | 2 |
| 17 | Associations of muscle mass,strength,and quality with all-cause mortality in China:a population-based cohort study显示文摘Background It remains unclear about the association of muscle mass,strength,and quality with death in the general Chinese population of diverse economical and geographical backgrounds.The present study aimed to comprehensively examine such associations across different regions in China.Methods Based on the China Kadoorie Biobank study,the present study included 23,290 participants who were aged 38 to 88 years and had no prevalent cardiovascular diseases or cancer.Muscle mass and grip strength were measured using calibrated instruments.Arm muscle quality was defined as the ratio of grip strength to arm muscle mass.Low muscle mass,grip strength,and arm muscle quality were defined as the sex-specific lowest quintiles of muscle mass index,grip strength,and arm muscle quality,respectively.Cox proportional hazards models yielded hazard ratios(HRs)and 95%confidence intervals(CIs)for risks of all-cause mortality in relation to muscle mass,strength,and quality.Results During a median follow-up of 3.98 years,739 participants died.The HR(95%CI)of all-cause mortality risk was 1.28(1.08–1.51)for low appendicular muscle mass index,1.38(1.16–1.62)for low total muscle mass index,1.68(1.41–2.00)for low grip strength,and 1.41(1.20–1.66)for low arm muscle quality in models adjusted for sociodemographic characteristics,lifestyle factors,and medical histories.Conclusion Low muscle mass,grip strength,and arm muscle quality are all associated with short-term increased risks of mortality,indicating the importance of maintaining normal muscle mass,strength,and quality for general Chinese adults. | Man Wu Yuxia Wei Jun Lv Yu Guo Pei Pei Jiachen Li Huaidong Du Ling Yang Yiping Chen Xiaohui Sun Hua Zhang Junshi Chen Zhengming Chen Canqing Yu Liming Li 无 | 2022 | Chinese Medical Journal2022，，11： | 2 |
| 18 | On the loss mechanisms of radiation belt electron dropouts during the 12 September 2014 geomagnetic storm显示文摘Radiation belt electron dropouts indicate electron flux decay to the background level during geomagnetic storms,which is commonly attributed to the effects of wave-induced pitch angle scattering and magnetopause shadowing.To investigate the loss mechanisms of radiation belt electron dropouts triggered by a solar wind dynamic pressure pulse event on 12 September 2014,we comprehensively analyzed the particle and wave measurements from Van Allen Probes.The dropout event was divided into three periods:before the storm,the initial phase of the storm,and the main phase of the storm.The electron pitch angle distributions(PADs)and electron flux dropouts during the initial and main phases of this storm were investigated,and the evolution of the radial profile of electron phase space density(PSD)and the(μ,K)dependence of electron PSD dropouts(whereμ,K,and L^*are the three adiabatic invariants)were analyzed.The energy-independent decay of electrons at L>4.5 was accompanied by butterfly PADs,suggesting that the magnetopause shadowing process may be the major loss mechanism during the initial phase of the storm at L>4.5.The features of electron dropouts and 90°-peaked PADs were observed only for>1 MeV electrons at L<4,indicating that the wave-induced scattering effect may dominate the electron loss processes at the lower L-shell during the main phase of the storm.Evaluations of the(μ,K)dependence of electron PSD drops and calculations of the minimum electron resonant energies of H+-band electromagnetic ion cyclotron(EMIC)waves support the scenario that the observed PSD drop peaks around L^*=3.9 may be caused mainly by the scattering of EMIC waves,whereas the drop peaks around L^*=4.6 may result from a combination of EMIC wave scattering and outward radial diffusion. | Xin Ma Zheng Xiang BinBin Ni Song Fu Xing Cao Man Hua DeYu Guo YingJie Guo XuDong Gu ZeYuan Liu Qi Zhu | 2020 | Earth and Planetary Physics2020，4，6： | 2 |
| 19 | Multiple olfactory pathways contribute to the lure process of Caenorhabditis elegans by pathogenic bacteria显示文摘Chemosensation is indispensable for the survival of Caenorhabditis elegans to discriminate food and pathogenic bacteria in their living environment. Food-like odors emitted by the pathogen Bacillus nematocida B16 for trapping its hosts and an olfactory signaling pathway responsible to sense the attractant 2-heptanone were identified in our previous study. Here, we further explore how the worms recognize the attractive molecules indole and 2-ethyl hexanol, which have different chemical properties and modest nematode-luring ability. We show that the chemotaxis toward indole and 2-ethyl hexanol requires the G protein-coupled receptors encoded by str-193 on AWC and str-7 on AWA. In a further genetic screen for downstream effectors in olfactory signaling cascades, the Gα subunit GSA-1, guanylyl cyclase ODR-1 and DAF-11 and the c GMP-gated channel TAX-2/TAX-4 were found to be necessary for indole sensation, whereas the TRPV channels OSM-9/OCR-2 and the PLC pathway activated by GPA-6 are responsible for the detection of 2-ethyl hexanol. Altogether, our current work further clarifies the distinct olfactory signaling pathways through which C. elegans senses different chemicals and is lured by B. nematocida B16, improving our comprehensive understanding of the mechanisms by which bacterial pathogens effectively infect their hosts. | Man Zhu Yao Chen Ninghui Zhao Hua Bai Keqin Zhang Xiaowei Huang | 2021 | Science China(Life Sciences)2021，64，8： | 2 |
| 20 | Growth of AgBr/Ag_(3)PO_(4) Heterojunction on Chitosan Fibers for Degrading Organic Pollutants显示文摘Using Fiber as the based material for photocatalyst particles is favorable for their recovery,thereby avoiding the photocatalyst particles cause secondary pollution to water environment.In this work,the AgBr and Ag_(3)PO_(4) photocatalyst particles were loaded onto the surface of chitosan fiber(CF)via chelation and in situ anion-exchange method.The photocatalytic results illustrated that the AgBr/Ag_(3)PO_(4)/CF composites displayed the best photocatalytic performance when the mass ratio of Ag_(3)PO_(4) and AgBr onto the CF was approximately 1:0.15,their degradation rate can reach 98.1%for the methyl orange(MO)solution,this value far exceeded those of pure CF,AgBr/CF composites,and Ag_(3)PO_(4)/CF composites.Besides,the AgBr/Ag_(3)PO_(4)/CF composites also shown excellent durability,after the fifth cycle,they still maintained a decolorization rate of 86.4%for the MO solution,while the Ag_(3)PO_(4)/CF composites maintained a decolorization rate of only 70.7%.Based on these results,we consider that the AgBr/Ag_(3)PO_(4)/CF composites have high practical interest in environmental remediation. | Si-wei Xiong Yan Yu Pei Wang Man Liu Shao-hua Chen Xian-ze Yin Luo-xin Wang Hua Wang | 2020 | Advanced Fiber Materials2020，2，5： | 2 |
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