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| 1 | Superior in vitro anticancer effect of biomimetic paclitaxel and triptolide co-delivery system in gastric cancer显示文摘As a well-known anticancer drug,paclitaxel(PTX),a first-line chemotherapeutic agent,remains unsatisfactory for gastric cancer therapy.It is reported that triptolide(TPL)could enhance the anti-gastric cancer effect of PTX.Considering the poor solubility of both drugs,we developed a red blood cell membrane-biomimetic nanosystem,an emerging tool in drug delivery,to co-load paclitaxel and triptolide(red blood cell membrane coated PTX and TPL co-loaded poly(lactic-co-glycolic acid)[PLGA]nanoparticles,RP(P/T)).The successful preparation was confirmed in terms of particle size,morphology,and surface markers assays.This biomimetic system could prolong circulation and escape immune surveillance.And these properties were verified by stability,in vitro drug release,and cellular uptake assays.Moreover,the MTT and colony formation assays demonstrated the superior anti-proliferation effect of the RP(P/T)to free drugs.The enhanced antitumor effects of RP(P/T)on migration and invasion were also evaluated by wound-healing and transwell assays.Overall,the bionic co-delivery nanoplatform with improved efficacy in vitro is a promising therapy for gastric cancer. | Siwan Wang Hui Jiang Jia Wang Haisi Wu Ting Wu Mengnan Ni Qianqian Zhao You Ji Ziting Zhang Chunming Tang Huae Xu | 2021 | The Journal of Biomedical Research2021，35，4： | 5 |
| 2 | Study on docetaxel-loaded nanoparticles with high antitumor efficacy against malignant melanoma显示文摘Docetaxel (文档) 对许多稳固的肿瘤举办非凡的活动。然而,文档的临床的功效由于它的差的溶解度被限制,低选择分发,在 vivo 的快消除,等等。在现在的学习,文档被合并到基于我们的以前的工作准备的 nanoparticles 的核心壳结构。获得的装载 docetaxel 的 nanoparticles (DOCNP ) 与各种各样的生物物理的方法论被描绘,并且它对恶意的黑瘤的 antitumor 功效在 vitro 并且在 vivo 被评估。我们的结果显示文档能与高封装效率被合并到 nanoparticles (>90%) 。合并文档能以一种持续方式被免除 DOCNP。在 vitro cytotoxicity,研究显示 DOCNP 能有效地杀死 B16 房间并且显示出剂量依赖者和时间依赖者功效。而且, intratumoral 管理表明 DOCNP 比免费文档有显著地更高的 antitumor 效果和更低的毒性到正常房间和纸巾。这些结果建议 DOCNP 可以是在为恶意的黑瘤的治疗的一个有希望的药交货系统。 | Donghui Zheng Xiaolin Li Huae Xu Xiaowei Lu Yong Hu Weixin Fan | 2009 | Acta Biochimica et Biophysica Sinica2009，41，7： | 4 |
| 3 | Curcumin delivery by methoxy polyethylene glycol-poly(caprolactone) nanoparticles inhibits the growth of C6 glioma cells显示文摘 | Junfei Shao Donghui Zheng Zhifeng Jiang Huae Xu Yong Hu Xiaolin Li Xiaowei Lu | 2011 | Acta Biochimica et Biophysica Sinica2011，43，4： | 2 |
| 4 | Harmine induces apoptosis and inhibits tumor cell proliferation, migration and invasion through down-regulation of cyclooxygenase-2 expression in gastric cancer显示文摘 | Hao Zhang Kun Sun Jing Ding Huae Xu Lingjun Zhu Kai Zhang Xiaolin Li Weihao Sun | 2013 | Phytomedicine2013，，： | 1 |
| 5 | Ferroptosis-induced anticancer effect of resveratrol with a biomimetic nano-delivery system in colorectal cancer treatment显示文摘Ferroptosis is a novel form of programmed cell death impelled by iron-dependent lipid peroxidation,which may be a potential strategy for cancer therapy.Here we demonstrated for the first time that Resveratrol(RSV),a traditional Chinese medicine(TCM)chemical monomer,could effectually inhibit the growth of colon cancer cells through the ROS-dependent ferroptosis pathway.Mechanistically,RSV evoked the increase of reactive oxygen species and lipid peroxidation in colorectal cancer cells,and eventually lead to ferroptosis.Furthermore,RSV could promote ferroptosis by downregulating the expression of the channel protein solute carrier family 7 member 11(SLC7A11)and glutathione peroxidase 4(GPX4).To improve the delivery efficiency of RSV,a biomimetic nanocarrier was developed by coating RSV-loaded poly(ε-caprolactone)-poly(ethylene glycol)(PCL-PEG)nanoparticles with erythrocyte membrane(RSV-NPs@RBCm).The RSV-NPs@RBCm provide the possibility to escape macrophage phagocytosis and have a long circulation effect.In addition,when coupled with a tumor-penetrating peptide iRGD,which could trigger enhanced tissue penetration tumor-specifically,the delivery of RSV-NPs@RBCm into tumors would be significantly improved results from the in vivo study demonstrated an excellent treatment efficacy for CRC.Altogether,our study highlighted the therapeutic potential of RSV as a ferroptosis-inducing anticancer agent and when loaded into a biomimetic nanoplatform,it might pave the way for the application of RSV loaded nanosystems for colorectal cancer treatment. | Ziting Zhang You Ji Nan Hu Qinqi Yu Xinrui Zhang Jie Li Fenglei Wu Huae Xu Qiyun Tang Xiaolin Li | 2022 | Asian Journal of Pharmaceutical Sciences2022，17，5： | 0 |
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