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| 1 | 亚洲高血压合并左心室肥厚诊治专家共识显示文摘流行病学调查发现,高血压合并左心室肥厚(left ventricular hypertrophy,LVH)的比例很高,由于诊断标准的差异,不同研究LVH的检出率差别也很大。高血压合并LVH显著增加心血管事件的风险,但临床实践中仍关注不足,诊疗欠规范。亚洲高血压合并左心室肥厚诊治专家共识在LVH的诊断流程、治疗策略和患者随访等方面详细地进行了文献回顾和方案推荐,对于规范高血压防治有重要意义。 | 孙宁玲 Jaw-Wen Chen 王继光 谢良地 陈鲁原 牟建军 孙跃民 Chern-En Chiang Cheuk-Man Yu Huay Cheem Tan Razali Omar 霍勇 无 | 2016 | 中华高血压杂志2016，24，7： | 122 |
| 2 | Production of high-quality agarwood in Aquilaria sinensis trees via whole-tree agarwood-induction technology显示文摘我们使用了整个树的 agarwood 感应的技术在 20 个月以内从 Aquilaria sinensis 树生产 agarwood,并且评估了这 agarwood 的质量。结果证明它的特征以质地,化学成分,香精油内容,和乙醇可溶的摘录内容类似于高级野 agarwood 的那些,与远超过繁体中文药 agarwood 的要求的最後的质量,作为在中国药典 2010 显示了。就我们的知识而言,这是第一研究证明高质量的 agarwood 能在整个 A 被生产。经由一种化学上导致的技术的 sinensis 树。 | Xing Li Zhang Yang Yang Liu Jian He Wei Yun Yang Zheng Zhang Jun Qing Huang Huai Qiong Chen Yu Jun Liu | 2012 | Chinese Chemical Letters2012，23，6： | 28 |
| 3 | Peroxisome proliferator-activated receptor-γ is essential in the pathogenesis of gastric carcinoma显示文摘AIM:To investigate whether peroxisome proliferator-activated receptor γ (PPAR-γ) is expressed in human gastric carcinoma and whether PPAR-γ is a potential target for gastric carcinoma therapy.METHODS: PPAR-γ protein in gastric carcinoma was examined by immunohistochemistry. In the gastric carcinoma cell line MGC803, PPAR-γ, survivin, Skp2 and p27 protein and mRNA were examined by Western blotting and real-time reverse transcription-polymerase chain reaction, respectively; proliferation was examined by MTT; apoptosis was examined by chromatin staining with Hoechst 33342 and fluorescence activated cell sorting (FACS). and cell cycle was examined by FACS; the knockdown of PPAR-γ was done by RNA interference.RESULTS: A high level of expression of PPAR-γ was observed in human gastric carcinoma and in a human gastric carcinoma cell line MGC803. The PPAR-γ agonist 15-deoxy-12,14-prostaglandin J2 (15d-PGJ2) inhibited growth, and induced apoptosis and G1/G0 cell cycle arrest in MGC803 cells in a concentration-dependent and time-dependent manner. The effect of 15d-PGJ2 on MGC803 cells was not reversed by the selective and irreversible antagonist GW9662 for PPAR-γ. Furthermore, survivin and Skp2 expression were decreased, whereasp27 expression was enhanced following 15d-PGJ2 treatment in a dose-dependent manner in MGC803 cells. Interestingly, we also found that small interfering RNA for PPAR-γ inhibited growth and induced apoptosis in MGC803 cells. The inhibition of PPAR-γ function may be a potentially important and novel modality for treatment and prevention of gastric carcinoma.CONCLUSION: A PPAR-γ agonist inhibited growth of human gastric carcinoma MGC803 cells by inducing apoptosis and G1/G0 cell cycle arrest with the involvement of survivin, Skp2 and p27 and not via PPAR-γ. | Xiu-Mei Ma Hong Yu Na Huai | 2009 | World Journal of Gastroenterology2009，15，31： | 13 |
| 4 | Ginzburg-Landau Vortex and Mean Curvature Flow with External Force Field显示文摘This paper is devoted to the study of the vortex dynamics of the Cauchy problem for aparabolic Ginzburg-Landau system which simulates inhomogeneous type Ⅱ superconducting materialsand three-dimensional superconducting thin films having variable thickness.We will prove that thevortex of the problem is moved by a codimension k mean curvature flow with external force field.Besides,we will show that the mean curvature flow depends strongly on the external force,havingcompletely different phenomena from the usual mean curvature flow. | Huai Yu JIAN Yan Nan LIU | 2006 | Acta Mathematica Sinica,English Series2006，22，6： | 11 |
| 5 | Real-time Fluorescence PCR Method for Detection of Burkholderia glumae from Rice显示文摘Burkholderia glumae causing seedling rot and grain rot of rice was listed as a plant quarantine disease of China in 2007. It's quite necessary to set up effective detection methods for the pathogen to manage further dispersal of this disease.The present study combined the real-time PCR method with classical PCR to increase the detecting efficiency,and to develop an accurate,rapid and sensitive method to detect the pathogen in the seed quarantine for effective management of the disease.The results showed that all the tested strains of B.glumae produced about 139 bp specific fragments by the real-time PCR and the general PCR methods,while others showed negative PCR result.The bacteria could be detected at the concentrations of 1×104CFU/mL by general PCR method and at the concentrations below 100 CFU/mL by real-time fluorescence PCR method.B.glumae could be detected when the inoculated and healthy seeds were mixed with a proportion of 1:100. | FANG Yuan XU Li-hui TIAN Wen-xiao HUAI Yan YU Shan-hong LOU Miao-miao XIE Guan-lin | 2009 | Rice science2009，16，2： | 5 |
| 6 | Towards a paradigm for open and free sharing of scientific data on global change science in China显示文摘Despite great progress in data sharing that has been made in China in recent decades,cultural,policy,and technological challenges have prevented Chinese researchers from maximizing the availability of their data to the global change science community.To achieve full and open exchange and sharing of scientific data,Chinese research funding agencies need to recognize that preserva-tion of,and access to,digital data are central to their mission,and must support these tasks accord-ingly.The Chinese government also needs to develop better mechanisms,incentives,and rewards,while scientists need to change their behavior and culture to recognize the need to maximize the usefulness of their data to society as well as to other researchers.The Chinese research communi-ty and individual researchers should think globally and act personally to promote a paradigm of open,free,and timely data sharing,and to increase the effectiveness of knowledge development. | Changhui Peng Xinzhang Song Hong Jiang Qiuan Zhu Huai Chen Jing MChen Peng Gong Chang Jie Wenhua Xiang Guirui Yu Xiaolu Zhou | 2016 | Ecosystem Health and Sustainability2016，2，5： | 4 |
| 7 | Systems pharmacology dissection of action mechanisms for herbs in osteoporosis treatment显示文摘Objective:Osteoporosis has become the biggest cause of non-fatal health issue.Currently,the limitations of traditional anti-osteoporosis drugs such as long-term ill-effects and drug resistance,have raised concerns toward complementary and alternative therapies,particularly herbal medicines and their natural active compounds.Thus,this study aimed to provide an integrative analysis of active chemicals,drug targets and interacting pathways of the herbs for osteoporosis treatment.Methods:Here,we introduced a systematic pharmacology model,combining the absorption,distribution,metabolism,and excretion(ADME)screening model,drug targeting and network pharmacology,to probe into the therapeutic mechanisms of herbs in osteoporosis.Results:We obtained 86 natural compounds with favorable pharmacokinetic profiles and their 58 targets from seven osteoporosis-related herbs.Network analysis revealed that they probably synergistically work through multiple mechanisms,such as suppressing inflammatory response,maintaining bone metabolism or improving organism immunity,to benefit patients with osteoporosis.Furthermore,experimental results showed that all the five compounds(calycosin,asperosaponin VI,hederagenin,betulinic acid and luteolin)enhanced osteoblast proliferation and differentiation in vitro,which corroborated the validity of this system pharmacology approach.Notably,gentisin and aureusidin among the identified compounds were first predicted to be associated with osteoporosis.Conclusion:Herbs and their natural compounds,being characterized as the classical combination therapies,might be engaged in multiple mechanisms to coordinately improve the osteoporosis symptoms.This work may contribute to offer novel strategies and clues for the therapy and drug discovery of osteoporosis and other complex diseases. | Ying Huai Wen-juan Zhang Wei Wang Kai Dang Shan-feng Jiang Dan-ming Li Meng Li Qiang Hao Zhi-ping Miao Yu Li Ai-rong Qian | 2021 | Chinese Herbal Medicines2021，13，3： | 3 |
| 8 | Synthesis of O-glycosylα-aryl nitrones显示文摘伪 - 芳基 nitrone 是 nitrones 的最有用的类型之一并且广泛地在最近的年里被探索了。然而,糖一半以前没被介绍进这些分子。我们这里在苯经由代替 N 的 hydroxylamine 和芳基醛 glycosides 的冷凝作用介绍了伪 - 芳基 nitrone O-glycosides 的有效合成。 | Ying Fu Huai Yuan Zhang Yan Hua Liu Xue Feng Li Dan Feng Huang Yu Lai Hu | 2010 | Chinese Chemical Letters2010，21，9： | 3 |
| 9 | 3D MHD simulation of the double-gradient instability of the magnetotail current sheet显示文摘Flapping motion of the current sheet(CS) is an important physical process in the Earth's magnetotail. The magnetic doublegradient model, which includes both the instability and wave modes, offers a reasonable explanation for the exciting and propagation of the flapping wave. In this paper, we apply an advanced numerical magnetohydrodynamic(MHD) scheme(conservation element and solution element(CESE)-MHD) to simulate the magnetic double-gradient instability in an idealized current sheet that mimics the magnetotail configuration. We initialize the simulations with a numerically relaxed magnetotail equilibrium, in which the normal component of the magnetic field has a tailward gradient. It is confirmed in our simulation that the instability develops in the current layer. The growth rate of the instability yielded from the simulation is very close to the prediction of theory, with a relative deviation of only ten percent. The results demonstrate that the CESE-MHD scheme is very powerful in numerical study of the double-gradient mechanism of the CS flapping mode, and can be used for further investigations of the flapping motion in more realistic CS configurations. | DUAN AiYing ZHANG Huai LU Hao Yu | 2018 | Science China(Technological Sciences)2018，61，9： | 3 |
| 10 | Facile synthesis and characterization of novel thermo-chromism cholesteryl-containing hydrogen-bonded liquid crystals显示文摘新奇包含 cholesteryl 的二个系列结合 H 的液体晶体被准备通过灵巧在展出一个单音的回归线 cholesteric 阶段,和 4-alkoxy-benzoic 酸或 4-alkoxy 的 cholesteryl isonicotinate (质子领受人) 之间自己组装苯乙烯的酸(质子施主) 。长度能贡献的 conjugate 长度以及终端的增加提高分子的相互作用,这被发现并且显著地因此影响了结合 H 的 LC 的热行为。导致的中央的 cholesteric 思考系列遗传因子的建筑群与颜色位于可见区域可协调的 thermo 敏感,它能被用于显示申请。 | Wan Li He Tao Liu Zhou Yang Dong Yu Zhao Wei Huang Hui Cao Guo Jie Wang Huai Yang | 2009 | Chinese Chemical Letters2009，20，11： | 3 |
| 11 | Nonvolatile memristor based on heterostructure of 2D room-temperature ferroelectric α-In2Se3 and WSe2显示文摘Two-dimensional(2D) ferroelectricity is considered to have significant potential for information storage in the future. Semiconducting ferroelectrics that are stable at room temperature afford many possibilities for the assembly of various high-performance heterostructures and fabricating multifuntional devices.Herein, we report the synthesis of a stable van der Waals(vd W) single-crystal semiconductor α-In2 Se3.Piezoresponse force microscopy(PFM) measurements demonstrated the out-of-plane ferroelectricity in ~15 layers α-In2 Se3 at room temperature. Both ferroelectric domains with opposite polarization and the tested amplitude and phase curve proved that this semiconductor exhibits hysteresis behavior during polarization.In the α-In2Se3/WSe2 vertical heterostructure device, the switchable diode effect and nonvolatile memory phenomenon showed a high on/off ratio and a small switching voltage. The distinct resistance switches were further analyzed by band alignment of the heterostructure under different polarizations by first principle calculations. Nonvolatile memory based on vd W ferroelectric heterostructure could provide a novel platform for developing 2 D room-temperature ferroelectrics in information storage. | Huai YANG Mengqi XIAO Yu CUI Longfei PAN Kai ZHAO Zhongming WEI | 2019 | Science China(Information Sciences)2019，62，12： | 3 |
| 12 | Ten‐Day Quadruple Therapy Comprising Proton‐Pump Inhibitor, Bismuth, Tetracycline, and Levofloxacin Achieves a High Eradication Rate for H elicobacter pylori Infection after Failure of Sequential Therapy显示文摘 | Ping‐I Hsu Wen‐Chi Chen Feng‐Woei Tsay Chih‐An Shih Sung‐Shuo Kao Huay‐Min Wang Hsien‐Chung Yu Kwok‐Hung Lai Hui‐Hwa Tseng Nan‐Jing Peng Angela Chen Chao‐Hung Kuo Deng‐Chyang Wu | 2014 | Helicobacter2014，，1： | 3 |
| 13 | Synthesis and characterization of non-symmetrical liquid crystals containing a cholesteryl ester moiety显示文摘在这篇论文,一系列 chiral 作为 chiral 实体和联本基由 cholesteryl 酉旨一半组成的非对称的液体晶体(nBA-chol ) 有不同终端烷基链的芳香的核心被综合了并且为他们的液体调查了水晶的性质。在阶段转变温度上并且在 chiral 液体晶体的温度依赖者沥青长度上的终端烷基链的甲又单位的数字的效果被学习了。长终端烷基链趋于展出近晶的 A 中央阶段。chiral 液体晶体的 cholesteric 中央阶段的沥青长度与增加温度并且与分别地在终端烷基链增加甲又单位的数字减少。 | Duo Wei Zhang Wei Huang Guo Hui Pan Wan Li He Yu Bo Cao Jin Bao Guo Hui Cao Huai Yang | 2009 | Chinese Chemical Letters2009，20，5： | 3 |
| 14 | Analysis of large-scale UAV images using a multi-scale hierarchical representation显示文摘Unmanned aerial vehicle(UAV)-based imaging systems have many superiorities compared with other platforms,such as high flexibility and low cost in collecting images,providing wide application prospects.However,the acquisition of the UAV-based image commonly results in very high resolution and very large-scale images,which poses great challenges for subsequent applications.Therefore,an efficient representation of large-scale UAV images is necessary for the extraction of the required information in a reasonable time.In this work,we proposed a multi-scale hierarchical representation,i.e.binary partition tree,for analyzing large-scale UAV images.More precisely,we first obtained an initial partition of images by an oversegmentation algorithm,i.e.the simple linear iterative clustering.Next,we merged the similar superpixels to build an object-based hierarchical structure by fully considering the spectral and spatial information of the superpixels and their topological relationships.Moreover,objects of interest and optimal segmentation were obtained using object-based analysis methods with the hierarchical structure.Experimental results on processing the post-seismic UAV images of the 2013 Ya’an earthquake and the mosaic of images in the South-west of Munich demonstrate the effectiveness and efficiency of our proposed method. | Huai Yu Jinwang Wang Yu Bai Wen Yang Gui-Song Xia | 2018 | Geo-Spatial Information Science2018，21，1： | 3 |
| 15 | Efficacy of transient elastography in screening for large esophageal varices in patients with suspicious or proven liver cirrhosis显示文摘 | Huay‐Min WANG Gin‐Ho LO Wen‐Chi CHEN Ping‐I HSU Hsien‐Chung YU Chiun‐Ku LIN Hoi‐Hung CHAN Wei‐Lun TSAI Feng‐Woei TSAY Tsan‐Ping LIU E‐Ming WANG Kwok‐Hung LAI | 2012 | Journal of Digestive Diseases2012，，8： | 2 |
| 16 | Zircon Ce^4+/Ce^3+ ratios and ages for Yulong ore-bearing por- phyries in eastern Tibet显示文摘 | Liang Huaying Campbell I H Allen C Sun Weidong Liu Congqiang Yu Hengxiang Xie Yingwen Zhang Yuqiang | 2006 | Miner Deposita2006，41，2： | 1 |
| 17 | The substantial hospitalization burden of influenza in central China:surveillance for severe,acute respiratory infection,and influenza viruses,2010-2012显示文摘 | Yu H Huang J Huai Y | 2014 | Influenza Other Respir Viruses2014，8，1： | 1 |
| 18 | Construction of cDNA library, nucleotide sequence and analysis of entire genome of classical swine fever virus strain Shimen显示文摘According to the previously published CSFV sequences, 18 pairs of primers have been designed and synthesized, which cover the entire genome of CSFV strain Shimen. Each cDNA fragment has been amplified by RT-PCR from the anticoagulant blood of strain Shimen infected pig. The PCR products have been cloned respectively and sequenced. Results show that the cDNA library of strain Shimen and its nucleotide sequence have been obtained. The genomic RNA of strain Shimen is 12 298 nucleotides in length, containing a 5’ and a 3’ noncoding region 373 and 231 nt long respectively. The center of genome is a single large open reading frame of 11 697 nt which encodes a polyprotein of 3 898 amino acids. The entire sequence of strain Shimen has also been compared with that of other CSFV strains. | Qianhua Huang Chuyu Zhang Jiafu Wang Liezhen Fu Ning Wang Yan Zhu Jisen Huai Pengwei Zhang Jianshi Yu Hui Xu | 2000 | Chinese Science Bulletin2000，45，4： | 1 |
| 19 | Molecular genetic analysis of phosphomannomutase genes in Triticum monococcum显示文摘In higher plants, phosphomannomutase(PMM) is essential for synthesizing the antioxidant ascorbic acid through the Smirnoff–Wheeler pathway. Previously, we characterized six PMM genes(Ta PMM-A1, A2, B1, B2, D1 and D2) in common wheat(Triticum aestivum, AABBDD).Here, we report a molecular genetic analysis of PMM genes in Triticum monococcum(AmAm), a diploid wheat species whose Amgenome is closely related to the A genome of common wheat. Two distinct PMM genes, Tm PMM-1 and Tm PMM-2, were found in T. monococcum. The coding region of Tm PMM-1 was intact and highly conserved. In contrast, two main Tm PMM-2 alleles were identified, with Tm PMM-2a possessing an intact coding sequence and Tm PMM-2b being a pseudogene. The transcript level of Tm PMM-2a was much higher than that of Tm PMM-2b, and a bacterially expressed Tm PMM-2a recombinant protein displayed relatively high PMM activity. In general, the total transcript level of PMM was substantially higher in accessions carrying Tm PMM-1 and Tm PMM-2a than those harboring Tm PMM-1 and Tm PMM-2b. However, total PMM protein and activity levels did not differ drastically between the two genotypes. This work provides new information on PMM genes in T. monococcum and expands our understanding on Triticeae PMM genes, which may aid further functional and applied studies of PMM in crop plants. | Chunmei Yu Xinyan Liu Qian Zhang Xinyu He Wan Huai Baohua Wang Yunying Cao Rong Zhou | 2015 | The Crop Journal2015，3，1： | 1 |
| 20 | Methane emissions from rice paddies natural wetlands, lakes in China: synthesis new estimate显示文摘 | Huai Chen Qiu’an Zhu Changhui Peng Ning Wu Yanfen Wang Xiuqin Fang Hong Jiang Wenhua Xiang Jie Chang Xiangwen Deng Guirui Yu | 2012 | Glob Change Biol2012，，1： | 1 |
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