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| 1 | A novel population of expanded human CD3^+CD56^+ cells derived from T cells with potent in vivo antitumor activity in mice with severe combined immunodeficiency显示文摘 | Hualu P Negrin PS | 1994 | J Immunol1994，153，4： | 1 |
| 2 | Revision of convection and vertical diffusion schemes in the NCEP global forecast system显示文摘 | HAN JONGIL PAN HUALU | 2011 | Mon Wea Rev2011，26，4： | 1 |
| 3 | Sensitivity of hurricane intensity forecast to convective momentum transport parameterization显示文摘 | HAN JONGIL PAN HUALU | 2006 | Mon Wea Rev2006，134，2： | 1 |
| 4 | The NCEP Climate Forecast System Reanalysis显示文摘 | Saha S Moorthi S Pan Hualu | 2010 | Bulletin of the American Meteorological Society2010，91，8： | 1 |
| 5 | Numerical simulation of the Somali Jet显示文摘 | Klishnamurti T N Molinari J Pan Hualu | 1976 | J Atmos Sci1976，33，12： | 1 |
| 6 | Association of RFC1 ASOG and MTHFR C677T polymorphisms with Alzheimer' s disease 显示文摘 | XiuHua B HuaLu Z ZhenXin Z | 2009 | Neurobiol Aging2009，30，10： | 1 |
| 7 | Effects td immunosuppressants on platlet-derived growth factor-A chain mRNA expression and coronary arteriosclerosis in rat cardiac allograft显示文摘 | Hachida M Zhang XL Hualu | 1999 | Jpn Circ J1999，63，： | 1 |
| 8 | pH-activatable oxidative stress amplifying dissolving microneedles for combined chemo-photodynamic therapy of melanoma显示文摘Photodynamic therapy(PDT)-mediated oxidation treatment is extremely attractive for skin melanoma ablation,but the strong hydrophobicity and poor tumor selectivity of photosensitizers,as well as the oxygen-consuming properties of PDT,leading to unsatisfactory therapeutic outcomes.Herein,a tumor acidic microenvironment activatable dissolving microneedle(DHA@HPFe-MN)was developed to realize controlled drug release and excellent chemo-photodynamic therapy of melanoma via oxidative stress amplification.The versatile DHA@HPFe-MN was fabricated by crosslinking a self-synthesized protoporphyrin(PpIX)-ADH-hyaluronic acid(HA)conjugate HA-ADH-PpIX with“iron reservoir”PA-Fe 3+complex in the needle tip via acylhydrazone bond formation,and dihydroartemisinin(DHA)was concurrently loaded in the hydrogel network.HA-ADH-PpIX with improved water solubility averted undesired aggregation of PpIX to ensure enhanced PDT effect.DHA@HPFe-MN with sharp needle tip,efficient drug loading and excellent mechanical strength could efficiently inserted into skin and reach the melanoma sites,where the acidic pH triggered the degradation of microneedles,enabling Fe-activated and DHA-mediated oxidation treatment,as evidenced by abundant reactive oxygen species(ROS)generation.Moreover,under light irradiation,a combined chemo-photodynamic therapeutic effect was achieved with amplified ROS generation.Importantly,the Fe-catalyzed ROS production of DHA was oxygen-independent,which work in synergy with the oxygen-dependent PDT to effectively destroy tumor cells.This versatile microneedles with excellent biosafety and biodegradability can be customized as a promising localized drug delivery system for combined chemo-photodynamic therapy of melanoma. | Yanjuan Huang Hualu Lai Jingwen Jiang Xiaoyu Xu Zishan Zeng Lingling Ren Qiuxing Liu Meixu Chen Tao Zhang Xin Ding Chunshun Zhao Shengmiao Cui | 2022 | Asian Journal of Pharmaceutical Sciences2022，17，5： | 1 |
| 9 | A Highly Efficient System for Automatic Face Region Detection in MPEG Video显示文摘 | Hualu Wang Shih-Fu Chang | 1997 | IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS FOR VIDEO TECHNOLOGY1997，7，4： | 1 |
| 10 | A highly efficient system for automatic face region detection in MPEG video 显示文摘 | Wang Hualu Chang Shih-Fu | 1997 | IEEE Transactions on Circuits and Systems for Video Technology1997，7，4： | 1 |
| 11 | Effects of low-intensity microwave radiation on Yribolium eastaneum physiological and biochemical charae-teristics and survival 显示文摘 | LU Hualu ZHOU Jichen XIONG Shanbai | 2010 | Insect Physiol2010，56，9： | 1 |
| 12 | A highly efficient system for automatic face region detection in MPEG video 显示文摘 | WANG Hualu CHANG Shinfu | 1997 | IEEE Trans CSVT1997，7，4： | 1 |
| 13 | Survey of Compressed-domain Features Used in Audio-visual Indexing and Analysis显示文摘 | Wang Hualu Divakaran A Vetro A | | 0，，02： | 1 |
| 14 | A Highly Efficient System for Automatic Face Region Detection in MPEG Video 显示文摘 | Wang Hualu Chang Shih-Fu | 1997 | IEEE Transactions on Circuits and Systems for Video Technology1997，7，4： | 1 |
| 15 | Survey of compressed-domain features used in audio-visual indexing and analysis 显示文摘 | WANG Hualu DIVAKARAN A | 2003 | Elsevier Science2003，14，3： | 1 |
| 16 | Nonlocal boundary layer vertical diffusion in a medium-range显示文摘 | HONG Songyou Pan Hualu | 1996 | Monthly weather review1996，124，： | 1 |
| 17 | Aroma-active compounds of Beijing roast duck显示文摘 | CHEN Genjun SONG Hualu MA Changwei | 2009 | Flavour and Fragrance Journal2009，24，4： | 1 |
| 18 | Biological Characterization and Whole Genome Sequencing of a Genotype VII Newcastle Disease Virus Strain显示文摘[Objective] The aim of this paper was to study the genotype, pathogenicity and nucleotide difference between Newcastle disease virus(NDV) isolates and traditional NDV vaccine strain(La Sota). [Method] A suspected NDV strain was isolated from a chicken farm. The isolate was preliminarily determined by HA and HI tests. A pair of primers was designed based on the partial sequence of NDV F gene published in GenBank(accession No. JF950510.1). F gene was amplified by RT-PCR, cloned and sequenced. The sequencing result was compared with the F gene sequences published in GenBank, and the phylogenetic tree was constructed to analyze the genotypes. The pathogenicity of the virus was determined by mean death time(MDT) of chicken embryos, intracerebral pathogenicity index(ICPI) of one-day-old chicks and intravenous pathogenicity index(IVPI) of six-week-old chickens, respectively. Based on the NDV genome sequence published in GenBank(accession No. JF950510.1), nine pairs of primers were designed to amplify the genome sequence of the isolate, and its structure was analyzed. [Result] The length of F gene was about 500 bp, and a NDV strain of genotype VII was isolated. The MDT, ICPI and IVPI were 52.8 h, 1.675 and 2.46, respectively, indicating the isolate was a virulent strain. The whole genome sequence analysis results showed that the full genome length of the isolate was 15 192 bp, which had 6 more nu-cleotides than that of La Sota strain, and the homology between the two strains was 82.8%. [Conclusion] A virulent NDV strain of genotype Ⅶ was isolated, with low homology to La Sota strain in nucleotide sequence. | Sun Hualu Li Xiqing Bi Yunying Yu Zekun Li Sifei Liu Yang Li Mingyi Cui Xianlan | 2018 | Animal Husbandry and Feed Science2018，10，5： | 0 |
| 19 | On the Arithmetic of Endomorphism Ring End (Zp×Zpm)显示文摘 | LIU Xiusheng LIU Hualu HU Peng | 2018 | Wuhan University Journal of Natural Sciences2018，23，4： | 0 |
| 20 | 适应技术创新形势要求 做好建设项目前期工作显示文摘 | Hualu Engineering Science & Technology Co.Ltd. | 2004 | 化工设计2004，14，4： | 0 |
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