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| 1 | Effects of glucagon-like peptide-1 receptor agonists on non-alcoholic fatty liver disease and inflammation显示文摘Glucagon-like peptide1(GLP-1)is secreted from Langerhans cells in response to oral nutrient intake.Glucagon-like peptide-1 receptor agonists(GLP-1RAs)are a new class of incretin-based anti-diabetic drugs.They function to stimulate insulin secretion while suppressing glucagon secretion.GLP-1-based therapies are now well established in the management of type 2 diabetes mellitus(T2DM),and recent literature has suggested potential applications of these drugs in the treatment of obesity and for protection against cardiovascular and neurological diseases.As we know,along with change in lifestyles,the prevalence of non-alcoholic fatty liver disease(NAFLD)in China is rising more than that of viral hepatitis and alcoholic fatty liver disease,and NAFLD has become the most common chronic liver disease in recent years.Recent studies further suggest that GLP-1RAs can reduce transaminase levels to improve NAFLD by improving blood lipid levels,cutting down the fatcontent to promote fat redistribution,directly decreasing fatty degeneration of the liver,reducing the degree of liver fibrosis and improving inflammation.This review shows the NAFLD-associated effects of GLP-1RAs in animal models and in patients with T2DM or obesity who are participants in clinical trials. | Xing-Chun Wang Aaron M Gusdon Huan Liu Shen Qu | 2014 | World Journal of Gastroenterology2014，20，40： | 23 |
| 2 | P2RX7 sensitizes Mac-1/ICAM-1-dependent leukocyte- endothelial adhesion and promotes neurovascular injury during septic encephalopathy显示文摘 | Huan Wang Ling-Juan Hong Ji-Yun Huang Quan Jiang Rong-Rong Tao Chao Tan Nan-Nan Lu Cheng-Kun Wang Muhammad M Ahmed Ying-Mei Lu Zhi-Rong Liu Wei-Xing Shi En-Yin Lai Christopher S Wilcox Feng Han | 2015 | Cell Research2015，25，6： | 16 |
| 3 | Cytoplasmic dynein:a key player in neurodegenerative and neurodevelopmental diseases显示文摘Cytoplasmic dynein is the most important molecular motor driving the movement of a wide range of cargoes towards the minus ends of microtubules.As a molecular motor protein,dynein performs a variety of basic cellular functions including organelle transport and centrosome assembly.In the nervous system,dynein has been demonstrated to be responsible for axonal retrograde transport.Many studies have revealed direct or indirect evidence of dynein in neurodegenerative diseases such as amyotrophic lateral sclerosis,Charcot-Marie-Tooth disease,Alzheimer’s disease,Parkinson’s disease and Huntington’s disease.Among them,a number of mutant proteins involved in various neurodegenerative diseases interact with dynein.Axonal transport disruption is presented as a common feature occurring in neurodegenerative diseases.Dynein heavy chain mutant mice also show features of neurodegenerative diseases.Moreover,defects of dynein-dependent processes such as autophagy or clearance of aggregation-prone proteins are found in most of these diseases.Lines of evidence have also shown that dynein is associated with neurodevelopmental diseases.In this review,we focus on dynein involvement in different neurological diseases and discuss potential underlying mechanisms. | CHEN Xiang-Jun XU Huan COOPER Helen M LIU Yaobo | 2014 | Science China(Life Sciences)2014，57，4： | 8 |
| 4 | Acute pancreatitis in aging animals:Loss of pancreatitis-associated protein protection?显示文摘AIM:To investigate the effect of age on severity of acute pancreatitis(AP) using biochemical markers,histology and expression of the protective pancreatitisassociated proteins(PAPs).METHODS:AP was induced via intraductal injection of 4% sodium taurocholate in young and old rats.Sera and pancreata were assayed at 24 h for the parameters listed above;we also employed a novel molecular technique to assess bacterial infiltration using polymerase chain reaction to measure bacterial genomic ribosomal RNA.RESULTS:At 24 h after induction of AP,the pancreata of older animals had less edema(mean ± SE histologic score of young vs old:3.11 ± 0.16 vs 2.50 ±-0.11,P < 0.05),decreased local inflammatory response(histologic score of stromal infiltrate:3.11 ± 0.27 vs 2.00 ± 0.17,P < 0.05) and increased bacterial infiltration(174% ± 52% increase from sham vs 377% ± 4%,P < 0.05).A decreased expression of PAP1 and PAP2 was demonstrated by Western blotting analysis and immunohistochemical staining.There were no differences in serum amylase and lipase activity,or tissue myeloperoxidase or monocyte chemotactic protein-1 levels.However,in the most-aged group,serum C-reactive protein levels were higher(young vs old:0.249 ± 0.04 mg/dL vs 2.45 ± 0.68 mg/dL,P < 0.05).CONCLUSION:In older animals,there is depressed PAP expression related to a blunted inflammatory response in AP which is associated with worsened bacterial infiltration and higher C-reactive protein level;this may explain the more aggressive clinical course. | Sophia Fu Albert Stanek Cathy M Mueller Nefertti A Brown Chongmin Huan Martin H Bluth Michael E Zenilman | 2012 | World Journal of Gastroenterology2012，18，26： | 5 |
| 5 | Distributed sparse bundle adjustment algorithm based on three-dimensional point partition and asynchronous communication显示文摘Sparse bundle adjustment(SBA) is a key but time-and memory-consuming step in three-dimensional(3 D) reconstruction. In this paper, we propose a 3 D point-based distributed SBA algorithm(DSBA) to improve the speed and scalability of SBA. The algorithm uses an asynchronously distributed sparse bundle adjustment(A-DSBA)to overlap data communication with equation computation. Compared with the synchronous DSBA mechanism(SDSBA), A-DSBA reduces the running time by 46%. The experimental results on several 3 D reconstruction datasets reveal that our distributed algorithm running on eight nodes is up to five times faster than that of the stand-alone parallel SBA. Furthermore, the speedup of the proposed algorithm(running on eight nodes with 48 cores) is up to41 times that of the serial SBA(running on a single node). | Xiao-long SHEN Yong DOU Steven MILLS David M EYERS Huan FENG Zhiyi HUANG | 2018 | Frontiers of Information Technology & Electronic Engineering2018，19，7： | 4 |
| 6 | Sonochemical Synthesis of Highly Luminescent Zinc Oxide Nanoparticles Doped with Magnesium(II)显示文摘 | Huan‐Ming Xiong Dmitry G. Shchukin Helmuth M?hwald Yang Xu Yong‐Yao Xia | 2009 | Angew. Chem. Int. Ed2009，，15： | 2 |
| 7 | Transgene expres- sion is associated with copy number and cytomegalov-irus promoter methylation in transgenic pigs显示文摘 | KONG Q WU M HUAN Y | 2009 | PLoS One2009，4，8： | 1 |
| 8 | Reversing established sepsis with an- tagonists of endogenous high - mobility group box 1 显示文摘 | Huan Y Ochani M Li J | 2004 | Proc Natl Acad Sci US A2004，101，1： | 1 |
| 9 | Extraction of Coal below 350 ℃ in a Flowing Non-polar Solvent 显示文摘 | Miura K Shimada M Mae K Huan H | 2001 | Fuel2001，80，11： | 1 |
| 10 | Effect of metal additions on sulfate reduction activity in wastewaters显示文摘 | Oliver J Hao Li Huan and 1in M Chen | 1994 | Toxicological and Environmental chemistry1994，46，： | 1 |
| 11 | Co2P: A facile solid state synthesis and its applications in alkalinerechargeable batteries 显示文摘 | PENG W X JIAO L F HUAN Q N LI L YANG J Q ZHAO Q Q WANG Q H DU H M L|U G SI Y C WANG Y J YUAN H T | 2012 | J Alloys Compd2012，511，： | 1 |
| 12 | Conjugation with a-linolenic acid improves cancer cell uptake and cytotoxicity of doxorubicin显示文摘 | Huan M Zhou S Y Teng Z H | 2009 | Bioorg Med Chem Lett2009，19，9： | 1 |
| 13 | Effect of metal additions on sulfate reduction activity in wastewaters 显示文摘 | Oliver J Jao Li Huan Jin M Chen | 1994 | Toxicological and Environmental chemistry1994，46，： | 1 |
| 14 | Studies to investigate the pharmacokinetic interactions between ranolazine and Ketoconazole,Diltiazem,or Simvastatin during combined administration in healthy subjects显示文摘 | Jerling M Huan BL Leung K | 2005 | J Clin Pharmacol2005，45，4： | 1 |
| 15 | Changes in flavor compounds of dry-cured Chinese Jinhua ham during processing显示文摘 | HUAN Y J ZHOU G H ZHAO G M | 2005 | Meat Science2005，71，2： | 1 |
| 16 | Deposition of doxorubicin in rats following administration of three newly synthesized doxorubicin conjugates 显示文摘 | Huan M Tian S Cui H | 2013 | Biomed Res Int2013，2013，92： | 1 |
| 17 | Co-expression of several molecular mechanisms of multidurg resistance and their significance for paclitaxcl cytotoxicity in human AML HL-60 cells显示文摘 | HUAN G Y IBR ADO A M REED JC | 1997 | Leukemia1997，11，2： | 1 |
| 18 | Hypoxia-inducible factor induces local thyroid hormone inactivation during hypoxic-ischemic disease in rats显示文摘 | Simonides Warner S Mulcahey Michelle A Redout Everaldo M Muller Alice Zuidwijk Marian J Visser Theo J Wassen Frank W J S Crescenzi Alessandra da-Silva Wagner S Harney John Engel Felix B Obregon Maria-Jesús Larsen P Reed Bianco Antonio C Huan | 2008 | Journal of Clinical Investigation2008，，3： | 1 |
| 19 | Adhesion and friction mechanisms of polymer-on-polymer显示文摘 | MAEDA N CHEN Nian Huan TIRRELL M | 2002 | Sci- ence2002，297，5580： | 1 |
| 20 | Myeloid cell-specific ser- ine palmitoyltransferase subunit 2 haploinsufficiency reduces mu- rine atherosclerosis显示文摘 | Chakraborty M Lou C Huan C | 2013 | J Clin Invest2013，123，4： | 1 |
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