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| 1 | Synergistic immunoreaction of acupuncture-like dissolving microneedles containing thymopentin at acupoints in immune-suppressed rats显示文摘Dissolving microneedles carried drug molecules can effectively penetrate the stratum corneum of skin to improve the transdermal drug delivery. The traditional Chinese medicine acupuncture is based on the needle stimulation at a specific location(acupoint) to generate and transmit biochemical and physiological signals which alter the pathophysiological state of patients. However, the pain associated with conventional acupuncture needles and the requirement of highly trained professionals limit the development of acupuncture in non-Asian countries. The purpose of this study is to investigate whether the dissolving microneedles can be utilized as a self-administered painless replacement for acupuncture and locally released drug molecules can achieve expected therapeutic outcomes. Immunosuppressive rats were treated with acupuncture at Zusanli(ST36) acupoint using microneedles containing thymopentin.The immune functions and psychological mood of the immunosuppressed animals were examined. The proliferation of splenocytes was examined by CCK-8 assay. CD4 and CD8 expression patterns in spleen cells were detected by flow cytometry. The current study showed that use of either microneedles containing thymopentin or conventional acupuncture both resulted in immune cell proliferation, which was confirmed by flow cytometry. Furthermore, either conventional acupuncture or microneedles were able to effectively mitigate the anxiety caused by immune-suppression when applied on the ST36. | Qian Zhang Chuncao Xu Shiqi Lin Huanbin Zhou Gangtao Yao Hu Liu Lili Wang Xin Pan Guilan Quan Chuanbin Wu | 2018 | Acta Pharmaceutica Sinica B2018，8，3： | 9 |
| 2 | An investigation into the three-dimensional cloud structure over East Asia from the CALIPSO-GOCCP Data显示文摘The spatial distribution of clouds and their seasonal variations, and the three-dimensional(3D) cloud structures over East Asia have been analyzed with the CALIPSO-GOCCP data during the period from 2007 to 2012. The results show that there is a large cloud fraction greater than 0.7 over southern China, and the largest cloud fraction appears in southwest China. Besides, a large cloud fraction occurs over the southeast of the Tibetan Plateau. The total and high cloud fractions show notable variations with seasons, while the middle and low cloud fractions vary a little. As for cloud vertical structure, significant differences of the cloud vertical distributions are observed between over land and ocean. Cloud fractions and the height of the maximum cloud fractions decline gradually with the increasing latitude, except for the vertical-latitude profiles over the Tibetan Plateau regions. The longitude-vertical cross sections show similar patterns from the longitude 70° E to 140° E, except the profiles with large cloud fractions over the Tibetan Plateau. From the horizontal distribution patterns and vertical structures of the clouds over East Asia, it is concluded that the huge terrain of the Tibetan Plateau has significant impacts on the cloud formation over the Tibetan Plateau region and the areas to the east. At last, the clouds from the CALIPSO-GOCCP observations are compared to those from the ERA-Interim reanalysis data. The results indicate that the ERA-Interim reanalysis data provide reasonable spatial distribution patterns and the vertical structures in terms of the total cloud fraction over East Asia. However, the total cloud fraction was underestimated about 20% by the ERA-Interim reanalysis data over most parts of East Asia, especially over the neighboring areas east of the Tibetan Plateau. Additionally, the ERA-interim reanalysis data overestimate the cloud fractions at each level in the vertical direction. | YIN JinFang WANG DongHai XU HuanBin ZHAI GuoQing | 2015 | Science China Earth Sciences2015，58，12： | 4 |
| 3 | Bone marrow and the control of immunity显示文摘Bone marrow is thought to be a primary hematopoietic organ. However, accumulated evidences demonstrate that active function and trafficking of immune cells, including regulatory T cells, conventional T cells, B cells, dendritic cells, natural killer T (NKT) cells, neutrophils, myeloid-derived suppressor cells and mesenchymal stem cells, are observed in the bone marrow. Furthermore, bone marrow is a predetermined metastatic location for multiple human tumors. In this review, we discuss the immune network in the bone marrow. We suggest that bone marrow is an immune regulatory organ capable of fine tuning immunity and may be a potential therapeutic target for immunotherapy and immune vaccination. | Ende Zhao Huanbin Xu Lin Wang Ilona Kryczek Ke Wu Yu Hu Guobin Wang Weiping Zou | 2012 | Cellular & Molecular Immunology2012，9，1： | 3 |
| 4 | Key Issues in Developing Numerical Models for Artificial Weather Modification显示文摘The scientific foundation of artificial weather modification is meso-and small-scale dynamics and cloud–precipitation microphysics. Artificial weather modification requires the realistic coupling of weather patterns, dynamical processes, and microphysical processes. Now that numerical models with weather dynamical characteristics have been widely applied to artificial weather modification, several key points that should not be neglected when developing numerical models for artificial weather modification are proposed in this paper, including the dynamical equations,model resolution, cloud–precipitation microphysical processes, numerical computation method, and initial and boundary conditions. Based on several examples, approaches are offered to deal with the problems that exist in these areas. | Huanbin XU Jinfang YIN | 2017 | Journal of Meteorological Research2017，31，6： | 1 |
| 5 | CRISPR/Sc^(++)-mediated genome editing in rice显示文摘Streptococcus canis Cas9(ScCas9)is an RNAguided endonuclease with NNG protospacer adjacent motif(PAM)specificity whose genomeediting activity in rice is locus-dependent.Here we investigated the performance of a ScCas9 variant named Sc^(++)at different NNG PAM sites in the rice genome;Sc^(++)harbors a T1227K mutation and the substitution of a positively charged loop(residues 367-376).Sc^(++)nuclease achieved broader genome editing compared to the original ScCas9,and its nickase improved targeted base editing in transgenic rice plants.Using the high-efficiency adenine base editor rBE73b,we generated many new OsGS1 alleles suitable for screening of rice germplasm for potential herbicide resistance in the future.The CRISPR/Sc^(++)system expands the genomeediting toolkit for rice. | Guigen Ma Yongjie Kuang Zhenwan Lu Xueqi Li Ziyan Xu Bin Ren Xueping Zhou Huanbin Zhou | 2021 | Journal of Integrative Plant Biology2021，63，9： | 0 |
| 6 | A Modified Double-Moment Bulk Microphysics Scheme Geared toward the East Asian Monsoon Region显示文摘Representation of cloud microphysical processes is one of the key aspects of numerical models.An improved double-moment bulk cloud microphysics scheme(named IMY)was created based on the standard Milbrandt-Yau(MY)scheme in the Weather Research and Forecasting(WRF)model for the East Asian monsoon region(EAMR).In the IMY scheme,the shape parameters of raindrops,snow particles,and cloud droplet size distributions are variables instead of fixed constants.Specifically,the shape parameters of raindrop and snow size distributions are diagnosed from their respective shape-slope relationships.The shape parameter for the cloud droplet size distribution depends on the total cloud droplet number concentration.In addition,a series of minor improvements involving detailed cloud processes have also been incorporated.The improved scheme was coupled into the WRF model and tested on two heavy rainfall cases over the EAMR.The IMY scheme is shown to reproduce the overall spatial distribution of rainfall and its temporal evolution,evidenced by comparing the modeled results with surface gauge observations.The simulations also successfully capture the cloud features by using satellite and ground-based radar observations as a reference.The IMY has yielded simulation results on the case studies that were comparable,and in ways superior to MY,indicating that the improved scheme shows promise.Although the simulations demonstrated a positive performance evaluation for the IMY scheme,continued experiments are required to further validate the scheme with different weather events. | Jinfang YIN Donghai WANG Guoqing ZHAI Hong WANG Huanbin XU Chongjian LIU | 2022 | Advances in Atmospheric Sciences2022，39，9： | 0 |
| 7 | ASAP3 regulates microvilli structure in parietal cells and presents intervention target for gastric acidity显示文摘Gastric acidity-associated disorders such as peptic ulcer and reflux diseases are widespread,and the reported resistance and side effects of currently used medicines suggest an urgent requirement for alternative therapeutic approaches.Here we demonstrate a critical role of ASAP3 in regulating the microvilli structure of parietal cells in vivo,and reveal the feasibility of controlling gastric acidity by targeting ASAP3.Conditional knockout of ASAP3 in mice caused elongation and stacking of microvilli in parietal cells,and substantially decreased gastric acid secretion.These were associated with active assembly of F-actin caused by a higher level of GTP-bound Arf6 GTPase.Consistently,a small molecular compound QS11 inhibited ASAP3 function and significantly reduced gastric acidity in vivo.Of note,the expression of ASAP3 was positively correlated with gastric acid secretion in 90 human cases,and high expression of ASAP3 was associated with reflux disease and peptic ulcer.These results reveal for the first time that ASAP3 regulates the microvilli structures in parietal cells.Our data also suggest ASAP3 as a feasible and drugable therapeutic target for gastric acidity-associated diseases. | Jin Qian Yueyuan Li Han Yao Haiying Tian Huanbin Wang Luoyan Ai Yuanhong Xie Yujie Bao Lunxi Liang Ye Hu Yao Zhang Jilin Wang Chushu Li Jiayin Tang Yingxuan Chen Jie Xu Jing-Yuan Fang | 2017 | Signal Transduction and Targeted Therapy2017，2，1： | 0 |
| 8 | Three novel alleles of OsGS1 developed by base-editing-mediated artificial evolution confer glufosinate tolerance in rice显示文摘Only few glufosinate-tolerant genes,such as phosphinothricin acetyltransferase(PAT)and bialaphos resistance(bar)identified from Streptomyces,are currently available for developing genetically modified rice in agricultural application.Following the rapid development of genome editing technology,generation of novel glufosinate-tolerant gene resources through artificial evolution of endogenous genes is more promising and highly desirable in rice molecular breeding program.In this study,the endogenous Glutamine synthetase1(OsGS1)was artificially evolved by base-editing-mediated gene evolution(BEMGE)in rice cells to create novel alleles conferring glufosinate tolerance in rice germplasms.Two novel glufosinate-tolerant OsGS1 alleles(OsGS1-AVPS and OsGS1-+AF)and one reported tolerant allele(OsGS1-SGTA)were successfully identified from approximately 4200 independent hygromycin-tolerant calli.Germination assays and spray tests revealed that these three OsGS1 alleles confer glufosinate tolerance in rice.Furthermore,OsGS1-AVPS and OsGS1-SGTA were quickly deployed into the elite rice cultivar Nangeng 46 through precise base editing.Overall,our results demonstrate the feasibility of developing glufosinate-tolerant rice by editing an endogenous rice gene in molecular breeding programs. | Bin Ren Yongjie Kuang Ziyan Xu Xuemei Wu Dawei Zhang Fang Yan Xiangju Li Xueping Zhou Guirong Wang Huanbin Zhou | 2023 | The Crop Journal2023，11，2： | 0 |
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