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| 1 | Optimal central venous pressure during partial hepatectomy for hepatocellular carcinoma显示文摘BACKGROUND:Low central venous pressure(CVP) affects hemodynamic stability and tissue perfusion.This prospective study aimed to evaluate the optimal CVP during partial hepatectomy for hepatocellular carcinoma(HCC).METHODS:Ninety-seven patients who underwent partial hepatectomy for HCC had their CVP controlled at a level of 0 to 5 mmHg during hepatic parenchymal transection.The systolic blood pressure(SBP) was maintained,if possible,at 90 mmHg or higher.Hepatitis B surface antigen was positive in 90 patients(92.8%) and cirrhosis in 84 patients(86.6%).Pringle maneuver was used routinely in these patients with clamp/unclamp cycles of 15/5 minutes.The average clamp time was 21.4±8.0 minutes.These patients were divided into 5 groups based on the CVP:group A:0-1 mmHg;B:1.1-2 mmHg;C:2.1-3 mmHg;D:3.1-4 mmHg and E:4.1-5 mmHg.The blood loss per transection area during hepatic parenchymal transection and the arterial blood gas before and after liver transection were analyzed.RESULTS:With active fluid load,a constant SBP ≥90 mmHg which was considered as optimal was maintained in 18.6% in group A(95% CI:10.8%-26.3%);39.2% in group B(95% CI:29.5%-48.9%);72.2% in group C(95% CI:63.2%-81.1%);89.7% in group D(95% CI:83.6%-95.7%);and 100% in group E(95% CI:100%-100%).The blood loss per transection area during hepatic parenchymal transection decreased with a decrease in CVP.Compared to groups D and E,blood loss in groups A,B and C was significantly less(analysis of variance test,P<0.05).Compared with the baseline,the blood oxygenation decreased significantly when the CVP was reduced.Base excess and HCO 3-in groups A and B were significantly decreased compared with those in groups C,D and E(P<0.05).CONCLUSION:In consideration of blood loss,SBP,base excess and HCO 3-,a CVP of 2.1-3 mmHg was optimal in patients undergoing partial hepatectomy for HCC. | Cheng-Xin Lin Ya Guo Wan Yee Lau Guang-Ying Zhang Yi-Ting Huang Wen-Zheng He Eric CH Lai | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，5： | 19 |
| 2 | Tumor size as a prognostic factor in patients with advanced gastric cancer in the lower third of the stomach显示文摘AIM: To explore the impact of tumor size on outcomes in patients with advanced gastric cancer in the lower third of the stomach. METHODS: We retrospectively analyzed the clinical records of 430 patients with advanced gastric cancer in the lower third of the stomach who underwent distal subtotal gastrectomy and D2 lymphadenectomy in our hospital from January 1998 to June 2004. Receiver-operating characteristic (ROC) curve analysis was used to determine the appropriate cutoff value for tumor size, which was measured as maximum tumor diameter. Based on this cutoff value, patients were divided into two groups: those with large-sized tumors (LSTs) and those with small-sized tumors (SSTs). The correlations between other clinicopathologic factors and tumor size were investigated, and the 5-year overall survival (OS) rate was compared between the two groups. Potential prognostic factors were evaluated by univariate KaplanMeier survival analysis and multivariate Cox's propor-tional hazard model analysis. The 5-year OS rates in the two groups were compared according to pT stage and pN stage. RESULTS: The 5-year OS rate in the 430 patients with advanced gastric cancer in the lower third of the stomach was 53.7%. The mean ± SD tumor size was 4.9 ± 1.9 cm, and the median tumor size was 5.0 cm. ROC analysis indicated that the sensitivity and specificity results for the appropriate tumor size cutoff value of 4.8 cm were 80.0% and 68.2%, respectively (AUC=0.795, 95%CI: 0.751-0.839, P=0.000). Using this cutoff value, 222 patients (51.6%) had LSTs (tumor size ≥ 4.8 cm) and 208 (48.4%) had SSTs (tumor size<4.8 cm). Tumor size was significantly correlated with histological type (P=0.039), Borrmann type (P=0.000), depth of tumor invasion (P=0.000), lymph node metastasis (P=0.000), tumor-nodes metastasis stage (P=0.000), mean number of metastatic lymph nodes (P=0.000) and metastatic lymph node ratio (P=0.000). Patients with LSTs had a significantly lower 5-year OS rate than those with SSTs (37.1% vs 63.3%, P=0.000). Univariate analysis showed that depth of tumor invasion (c 2=69.581, P=0.000), lymph node metastasis (c 2=138.815, P=0.000), tumor size (c 2=78.184, P=0.000) and metastatic lymph node ratio (c 2=139.034, P=0.000) were significantly associated with 5-year OS rate. Multivariate analysis revealed that depth of tumor invasion (P=0.000), lymph node metastasis (P=0.019) and tumor size (P=0.000) were independent prognostic factors. Gastric cancers were divided into 12 subgroups: pT2N0; pT2N1; pT2N2; pT2N3; pT3N0; pT3N1; pT3N2; pT3N3; pT4aN0; pT4aN1; pT4aN2; and pT4aN3. In patients with pT2-3N3 stage tumors and patients with pT4a stage tumors, 5-year OS rates were significantly lower for LSTs than for SSTs (P<0.05 each), but there were no significant differences in the 5-year OS rates in LST and SST patients with pT23N0-2 stage tumors (P > 0.05). CONCLUSION: Using a tumor size cutoff value of 4.8cm, tumor size is a prognostic factor in patients with pN3 stage or pT4a stage advanced gastric cancer located in the lower third of the stomach. | Hong-Mei Wang, Chang-Ming Huang, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Jun Lu, Department of Gastric Surgery, Affiliated Union Hospital of Fujian Medical University, Fuzhou 350001, Fujian Province, China Author contributions: Wang HM and Huang CM conceived of the study, analyzed the data, and drafted the manuscript Zheng CH, Li P and Xie JW helped revise the manuscript critically for important intellectual content Wang JB, Lin JX and Lu J helped collect data and design the study and all authors read and approved the final manuscript. | 2012 | World Journal of Gastroenterology2012，18，38： | 15 |
| 3 | TT viral infection through blood transfusion:retrospective investigation on patients in a prospective study of post-transfusion hepatitis显示文摘AIM To investigate the role of bloodtransfusion in TT viral infection(TTV).METHODS We retrospectively studied serumsamples from 192 transfusion recipients whounderwent cardiovascular surgery and bloodtransfusion between July 1991 and June 1992.Allpatients had a follow-up every other week for atleast 6 months after transfusion.Eightyrecipients received blood before screeningdonors for hepatitis C antibody(anti-HCV),and112 recipients received screened blood.Recipients with alanine aminotransferase level>2.5 times the upper normal limit were testedfor serological markers for viral hepatitis A,B,C,G,Epstein-Barr virus and cytomegalovirus.TTV infection was defined by the positivity forserum TTV DNA using the polymerase chainreaction method.RESULTS Eleven and three patients,whoreceived anti-HCV unscreened and screened'blood,respectively,had serum ALT levels>90 IU/L.Five patients(HCV and TTV:1;HCV,HGV,and TTV:1;TTV:2;and CMV and TTV:1)were positive for TTV DNA,and four of them hadsero-conversion of TTV DNA.CONCLUSION TTV can be transmitted viablood transfusion.Two recipients infected byTTV alone may be associated with the hepatitis.However,whether TTV was the causal agentremains unsettled,and further studies arenecessary to define the role of TTV infection inchronic hepatitis. | Yang SS Wu CH Chen TH Huang YY Huang CS | 2000 | World Journal of Gastroenterology2000，6，1： | 8 |
| 4 | Effect of Qinling granule in treatment of 102 patients with chronic hepatitis B显示文摘EfectofQinlinggranuleintreatmentof102patientswithchronichepatitisBHUANGZhengMing1,YANGXinBo1,CAOWenBin1,ZHOUYiJun2andLULi... | HUANG Zheng Ming 1, YANG Xin Bo 1, CAO Wen Bin 1, ZHOU Yi Jun 2 and LU Li Yan 2 1Department of Pharmacology, Chinese PLA Beijing Medical School, Beijing 100071, China 2Chinese PLA 184 Hospital, Yingtan 350000, Jiangxi Province, Ch | 1998 | World Journal of Gastroenterology1998，4，1： | 7 |
| 5 | RATIONAL GENERAL SOLUTIONS OF HIGHER ORDER ALGEBRAIC ODES显示文摘This paper generalizes the method of Ngo and Winkler(2010,2011)for finding rational general solutions of a first order non-autonomous algebraic ordinary differential equation(AODE)to the case of a higher order AODE,provided a proper parametrization of its solution hypersurface.The authors reduce the problem of finding the rational general solution of a higher order AODE to finding the rational general solution of an associated system.The rational general solutions of the original AODE and its associated system are in computable 1-1 correspondence.The authors give necessary and sufficient conditions for the associated system to have a rational solution based on proper reparametrization of invariant algebraic space curves.The authors also relate invariant space curves to first integrals and characterize rationally solvable systems by rational first integrals. | HUANG Yanli NG L X Chu WINKLER Franz | 2013 | Journal of Systems Science & Complexity2013，26，2： | 3 |
| 6 | Design and Simulation of Flow Field for Bone Tissue Engineering Sca old Based on Triply Periodic Minimal Surface显示文摘A novel method was proposed to design the structure of a bone tissue engineering scafold based on triply periodic minimal surface.In this method,reverse engineering software was used to reconstruct the surface from point cloud data.This method overcomes the limitations of commercially available software packages that prevent them from generating models with complex surfaces used for bone tissue engineering scafolds.Additionally,the fluid feld of the scafolds was simulated through a numerical method based on fnite volume and the cell proliferation performance was evaluated via an in vitro experiment.The cell proliferation and the mass flow evaluated in a bioreactor further verifed the flow feld simulated using computational fluid dynamics.The result of this study illustrates that the pressure value drops rapidly from 0.103 Pa to 0.011 Pa in the y-axis direction and the mass flow is unevenly distributed in the outlets.The mass flow in the side outlets is observed to be approximately 24.3 times higher thanthe bottom.Importantly,although the mean value of wall shear stress is signifcantly more than 0.05 Pa,there is stil a large area with a suitable shear stress below 0.05 Pa where most cells can proliferate well.The result shows that th inlet velocity 0.0075 m/s is suitable for cell proliferation in the scafold.This study provides an insight into the design analysis,and in vitro experiment of a bone tissue engineering scafold. | Zhen Wang Chuanzhen Huang Jun Wang Peng Wang Shisheng Bi Ch Asad Abbas | 2019 | Chinese Journal of Mechanical Engineering2019，32，2： | 2 |
| 7 | At the crossroad of conception and infection: initiatives for immunoglobulin-based contraceptive R & D显示文摘Better understanding of the immunological inechanisms implying the insemination and the infertility of some menand women is needed and crucial to the developnlent of an effective imlntmocona'aceptive method. To provide goodprotection against conception or infection, and avoid any possible and unexpected complications which immunocontra-cepfive 'vaccine' my arise of, it seems the right time for scientists to create a virtually new thinking for this extremelyurgent and important issue. This conceptual article describes our original thoughts of the future development of im-munocontracepdves, preferably, based on immunoglobulins rather than vaccines, against human sperm specific antigensand seminal plasma immtmosuppressive factors. Its general correctness, advantages and feasibility for fertility regula-tion and prevention of infection are discussed. | Nian-Qing LU Yi-Fei WANG Yu-Feng HUANG Xing-Hai WANG Jiangsu Family Planning Research Institute, Nanjing 210029, China Department of Reproductive Health and Research, WHO, 20 Avenue Appia, CH 1211 Geneva, Switzerland Nanjing General Hospital, Nanjing 210002, China | 1999 | Asian Journal of Andrology1999，1，3： | 2 |
| 8 | The Crosstalk of mTOR/S6K1 and Hedgehog Pathways显示文摘 | Yan Wang Qingqing Ding Chia-Jui Yen Weiya Xia Julie G. Izzo Jing-Yu Lang Chia-Wei Li Jennifer L. Hsu Stephanie A. Miller Xuemei Wang Dung-Fang Lee Jung-Mao Hsu Longfei Huo Adam M. LaBaff Dongping Liu Tzu-Hsuan Huang Chien-Chen Lai Fuu-Jen Tsai Wei-Chao Ch | 2012 | Cancer Cell2012，，3： | 2 |
| 9 | Behavioral stress modifies hippocampal synaptic plasticity through corticosterone-induced sustained extracellular signal-regulated Kinase/mitogen-activated protein Kinase activation显示文摘 | Yang CH Huang CC Hsu KS | 2004 | J Neurosci2004，24，11： | 1 |
| 10 | Genetic variation in open reading frame 5 gene of porcine reproductive and respiratory syndrome virus in Taiwan显示文摘 | Wang Ch Lee F Huang T Sh | 2008 | Vet Microbiol2008，131，34： | 1 |
| 11 | Ultrasound stimulates NF-kappaB activation and iNOS expression via the Ras/Raf/ MEK/ERK signaling pathway in cultured preosteoblasts 显示文摘 | Hou CH Lin J Huang SC | 2009 | J Cell Physiol2009，220，1： | 1 |
| 12 | Topotecan in the treatment of rcplased small cell lung cancer patients with poor pcrfommnce status 显示文摘 | Treat J Huang CH Lane SiR | 2004 | Oncolgist2004，9，： | 1 |
| 13 | Effects of tamsulosin on lower uri-nary tract symptoms due to double-J stent:a prospective study显示文摘 | Wang CJ Huang SW Chang CH | 2009 | U-rol Int2009，83，1： | 1 |
| 14 | Structure activity studies on group C meningococcal polysaccharide-protein conjugate vaccines: effect of O-acetylation on the nature of the protective epitope显示文摘 | Michon F Huang CH Farley EK | 2000 | Dev Biol2000，103，： | 1 |
| 15 | QTc dispersion as a prognostic factor in intracerebral hemorrhage 显示文摘 | Huang CH Chen WJ Chang WT | 2004 | Am J Emerg Med2004，22，3： | 1 |
| 16 | Anterior approach for postero- medial tibial plateau fractures 显示文摘 | Hsieh CH Huang hT Liu PC | 2010 | Kaohsiung J Med Sci2010，26，3： | 1 |
| 17 | Oestrogen-induced epithelial-mesenchymal transition of endometrial epithelial cells contributes to the development of adenomyosis显示文摘 | Chen YJ Li HY Huang CH | 2010 | J Pathol2010，222，3： | 1 |
| 18 | Pegylated interferon - e2a with or without low -dose ribavirin for treatment -naive patients with hepatitis C virus genotype 1 receiving hemodial- ysis: a randomized trial 显示文摘 | LIU CH HUANG CF LIU C J | 2013 | Ann Intern Med2013，159，： | 1 |
| 19 | RegRNA: an in- tegrated web server for identifying regulatory RNA motifs and elements 显示文摘 | Huang HY Chien CH Jen KH | 2006 | Nucleic Acids Res2006，34，： | 1 |
| 20 | A compound heterozygote in the NADH -Cytochrome b5 reduetase gene from a chinese patient with hereditery methaemoglobinaemia type I 显示文摘 | Wu YS Wang Y Huang CH | 2000 | Int J Hematol2000，72，1： | 1 |
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