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| 1 | Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress显示文摘癌症房间以他们的能力著名给新陈代谢的小径换新电线在各种各样的压力条件下面支持幸存和增长。尽管在肝生产了,酉同类身体没在正常的成年的肝房间被消费。我们这里发现酉同类分解代谢或 ketolysis 在 hepatocellular 被重新激活在营养剥夺条件下面的癌(HCC ) 房间。机械学地, 3-oxoacid CoA-transferase 1 (OXCT1 ) ,其表情在正常的成年的肝纸巾被压制的限制率的 ketolytic 酶,被浆液重新导致被触发饥饿的 mTORC2-AKT-SP1 在 HCC 房间发信号。而且,我们观察到在 HCC 的那提高的 ketolysis 为 AMPK 激活的压抑是批评的并且保护 HCC 房间免受过多的 autophagy 的伤害,从而提高肿瘤生长。重要地,临床的 HCC 样品的分析表明那增加的 OXCT1 表情预言更高耐心的死亡。一起拿,我们这里揭开剥夺营养的 HCC 房间为精力由采用酉同类身体的新奇新陈代谢的改编供应和癌症前进。 | De Huang Tingting Li Lin Wang Long Zhang Ronghui Yan Kui Li Songge Xing Gongwei Wu Lan Hu Weidong Jia Sheng-Cai Lin Chi V Dang Libing Song Ping Gao Huafeng Zhang | 2016 | Cell Research2016，26，10： | 27 |
| 2 | Convergence Analysis of a Block-by-Block Method for Fractional Differential Equations显示文摘The block-by-block method,proposed by Linz for a kind of Volterra integral equations with nonsingular kernels,and extended by Kumar and Agrawal to a class of initial value problems of fractional differential equations(FDEs)with Caputo derivatives,is an efficient and stable scheme.We analytically prove and numerically verify that this method is convergent with order at least 3 for any fractional order indexα>0. | Jianfei Huang Yifa Tang Luis Vázquez | 2012 | Numerical Mathematics(Theory,Methods and Applications)2012，5，2： | 11 |
| 3 | Meta-analysis of single strain probiotics for the eradication of Helicobacter pylori and prevention of adverse events显示文摘AIM:To assess the efficacy and safety of single strain probiotics for the:(1) eradication of Helicobacter pylori(H.pylori);(2) prevention of adverse events;and(3) prevention of antibiotic-associated diarrhea associated with eradication therapy.METHODS:We searched Pub Med(1960-2014),EMBASE(1974-2014),Cochrane Database of Systematic Reviews(1990-2014),and ISI Web of Science(2000-2014).Additionally,we conducted a grey literature search including contact with National Institutes of Health Clinical Trials Registry,abstracts from annual infectious disease and gastroenterology meetings,experts in the field and correspondence with authors.Randomized controlled trials of H.pylori positive adults or children treated with eradication therapy and assessing the adjunctive therapy with a single strain of probiotics were included.The primary outcomes were the rates of eradication of H.pylori and frequency of patients with adverse events or antibiotic-associated diarrhea.Outcomes were pooled using fixed or random-effects models to calculate the relative risk and corresponding 95%CI and weighted on study size.To explore possible explanations for heterogeneity,a priori subgroup analyses were conducted on daily probiotic dose,study population,and quality of the study.The overall quality of the evidence for each probiotic strain was assessed using the GRADE criteria.RESULTS:A total of 25 randomized controlled trials(28 treatment arms,with a total of 3769 participants) assessed one of six single probiotic strains as adjunctive treatments to standard eradication therapy.Only one probiotic strain significantly improved H.pylori eradication rates:Saccharomyces boulardii(S.boulardii) CNCM I-745 [pooled relative risks(p RR) = 1.11,95%CI:1.07-1.16].Only one probiotic strain(S.boulardii CNCM I-745) significantly prevented any adverse events(p RR = 0.42,95%CI:0.28-0.62).Both S.boulardii CNCM I-745 and Lactobacillus rhamnosus GG significantlyreduced antibiotic-associated diarrhea(p RR = 0.47,95%CI:0.37-0.60 and p RR = 0.29,95%CI:0.17-0.48,respectively) associated with H.pylori eradication therapy.Meta-regression of sub-groups did not detect significant differences by dose,adult vs pediatric,symptom status,or study quality,but did find significant differences by the strain of probiotic.Potential mild publication bias was found for antibiotic-associated diarrhea,but not for eradication or adverse event outcomes.Analysis of the study quality illuminated areas for improvement in future studies(use of placebos,study size calculations,attrition reasons and discussion of limitations and generalizability).CONCLUSION:The pooled evidence suggests that the adjunctive use of a few probiotic strains may improve H.pylori eradication rates and prevent the development of adverse events and antibiotic-associated diarrhea in those treated with standard eradication therapies.The type of probiotic strain was the most important factor in predicting efficacy. | Lynne V McFarland Peter Malfertheiner Ying Huang Lin Wang | 2015 | World Journal of Meta-Analysis2015，3，2： | 6 |
| 4 | 金刚石中的冰-Ⅶ相包裹体:来自地球深部地幔的含水流体证据显示文摘水在地球内部不同圈层的存在形态、分布、含量以及全球水循环一直以来都是固体地球科学研究的前沿热点问题之一。冰-Ⅶ相作为水的一种高压相,目前已经被国际矿物学会认定为一种新矿物。 | Tschauner O Huang S Greenberg E Prakapenka V B Rossman G R Shen A H Zhang D Newville M Lanzirotti A Tait K 张宝华 | 2018 | 矿物岩石地球化学通报2018，37，6： | 4 |
| 5 | Chronic kidney disease after nephrectomy in patients with renal cortical tumours: a retrospective cohort study显示文摘 | William C Huang Andrew S Levey Angel M Serio Mark Snyder Andrew J Vickers Ganesh V Raj Peter T Scardino Paul Russo | 2006 | Lancet Oncology2006，，9： | 4 |
| 6 | 2021 Chinese consensus on the diagnosis and management of primary immune thrombocytopenia in pregnancy显示文摘Immune thrombocytopenia(ITP)is an acquired disease characterized by isolated thrombocytopenia,which is one of the most common causes of thrombocytopenia during pregnancy.Women with ITP who have severe thrombocytopenia are at an increased risk for life-threatening obstetric complications.Therefore,we established this consensus statement on the diagnosis and management of ITP during pregnancy(detailed information is available in the Supplementary File,http://gffzz16e312a87a7141a5hxv5qpnqbupob6wu0.ffgz.tsg.suse.edu.cn/A978). | Zhang Xiaohui Chen Fangping Chen Xiequn Cheng Yunfeng Fang Meiyun Feng Jianming Fu Haixia Gao Hong Han Yue He Aili Hou Ming Hu Yu Huang Ruibin Huang Wenrong Jing Zhicheng Kong Peiyan Liang Aibin Liang Meiying Liu Daihong Liu Junling Liu Lin Liu Xiaowei Ma Liangming Mei Heng Ni Heyu Niu Ting Peng Jun Qiao Jianlin Ren Jinhai Song Yongping Tang Liang V Tong Tong Wang Shaoyuan Wang Xin Wang Zhao Wei Hui Wu Depei Wu Guangsheng Xu Caigang Xu Xue Xu Yajing Yang Linhua Yang Renchi Yang Tonghua Yin Chenghong Yu Li Zhang Guangsen Zhang Lei Zhang Liansheng Zhang Xi Zhao Weili Zhao Yongqiang Zhou Daobin Zhou Hu Zhou Zeping Zhu Tienan Wang Jianliu Huang Xiaojun | 2022 | Chinese Medical Journal2022，，8： | 2 |
| 7 | Preparation of stable micropatterns of gold on cell-adhesion-resistant hydrogels assisted by a hetero-bifunctional macromonomer linker显示文摘Surface patterning is very useful in biomaterial studies, yet it is not easy to prepare a micropattern with cell-adhesion contrast that is stable in a wet environment. Recently, a platform technique of transfer photolithography was invented to fabricate stable metal microarrays on the surface of a cell-adhesion resistant and mechanically biomimetic poly(ethylene glycol) hydrogel; the linker is the key chemical in such a transfer strategy. This article reports the design and synthesis of a hetero-bifunctional macromonomer linker with a thiol group at one end and an acryloyl group at the other end. The bifunctional linker was characterized by GPC and 1H NMR, and the average number of thiol groups in the bifunctional linker was detected by Ellman's reagent. The regent stability under wet conditions was also confirmed by the model reactants. The resultant micropatterned surfaces are meaningful for future studies of cell behaviors on mechanically biomimetic matrixes. | SUN JianGuo GRAETER Stefan V TANG Jian HUANG JingHuan LIU Peng LAI YuXiao YU Lin MAJER Günter SPATZ Joachim P DING JianDong | 2014 | Science China Chemistry2014，57，4： | 2 |
| 8 | Cavitation instabilities in elastic-plasticsolids 显示文摘 | Huang Y Hutchinson J W Tvergaard V | 1991 | Mech Phys Solids1991，39，： | 2 |
| 9 | Cavitation instabilities in a power hardening elastic-plastic solids 显示文摘 | Tvergaard V Huang Y Hutchinson J W | 1992 | EurJ Mech A/Solids1992，11，： | 2 |
| 10 | A petri net based safety analysis of workflow authorization models显示文摘 | Atluri V Huang W K | 2000 | Journal of Computer Security2000，8，2： | 1 |
| 11 | Genomic structure, chromosomal localization and expression profile of a novel melanoma differentiation associated (mda-7) gene with cancer specific growth suppressing and apoptosis inducing properties显示文摘 | Huang E Y Madireddi M T Gopalkrishnan R V | 2001 | Oncogene2001，20，： | 1 |
| 12 | Optical coherence tomography (OCT) abnormalities in rhodopsin mutant transgenic swine with retinal degeneration显示文摘 | Cideciyan A V Aleman T S | 2000 | Exp Eye Res2000，70，2： | 1 |
| 13 | An analysis of manufacturerretailer supply chain coordination in cooperative advertising 显示文摘 | Huang Z Li S X Mahajan V | 2002 | Decision Sciences2002，33，3： | 1 |
| 14 | Spatio-temporal tracking of myocardial deformations with a 4D B-spline model from tagged MRI显示文摘 | Huang JT Abendschein D Davila-Roman V | 1999 | IEEE Trans Med Imaging1999，18，10： | 1 |
| 15 | Visual interpretation of hand gestures for human-computer interaction: a review显示文摘 | Pavlovic V I Sharma R Huang H S | 1997 | IEEE Transactions on Pattern Analysis and Machine Learning1997，19，7： | 1 |
| 16 | Visual Interpretation ofHand Gestures for Human-computer Interaction:A Review显示文摘 | Pavlovic V I Sharma R Huang T S | 1997 | IEEE Transactions on Pattern Analysis and MachineIntelligence1997，19，7： | 1 |
| 17 | Permeability and consolidation of normally consolidated soils显示文摘 | SAMARASINGHE A M HUANG Y H DRNEVICH V P | 1982 | Journal of Geoteehnieal Engineering ASCE1982，108，6： | 1 |
| 18 | Angiotensin Ⅱ up-regulates angiotensin I -conver-ting enzyme (ACE), but down-regulates ACE2 via the AT1-ERK/p38 MAP kinase pathway 显示文摘 | Koka V Huang XR Chung AC Wang W Truong LD Lan HY | 2008 | Am J Pathol2008，172，5： | 1 |
| 19 | Reconstruction of through-and-through cheek defects involving the oral commissure,using chimeric flaps from the thigh lateral femoral circumflex system显示文摘 | Huang WC Chen HC Jain V | 2002 | Plast Reconstr Surg2002，109，： | 1 |
| 20 | A unified scheme of some nonhomogenous poisson process models for software reliability estimation显示文摘 | HUANG C v LYU M R KUO S | 2003 | IEEE Transactions on Software Engineering2003，29，3： | 1 |
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