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| 1 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 2 | Half-wavelength power transmis- sion lines显示文摘 | Hubert G J Gent M R | 1965 | IEEE Trans on Power Apparatus and Sys- tems1965，84，10： | 1 |
| 3 | CART peptides as modulators of dopamine and psychostimula nts and interactions with the mesolimbic dopaminergic system 显示文摘 | Hubert G W Jones D C Moffett M C Rogge G Kuhar M J | 2008 | Biochem Pharmacol2008，75，： | 1 |
| 4 | A Robust Measure of Skew-ness显示文摘 | Brys G Hubert M Struyf A | 2004 | Journal of Computational and Graphical Statistics2004，13，4： | 1 |
| 5 | Corrosion risk associated with microbial souring control using nitrate or nitrite 显示文摘 | Hubert C Nemati M Jenneman G E | 2005 | Appl Microbiol Biotechnol2005，68，： | 1 |
| 6 | Quantitation of viral load using real - time amplification techniques显示文摘 | Hubert G M Niesters | | 0，，： | 1 |
| 7 | On the high speed capacity of bearingless drives 显示文摘 | HUBERT M WOLFGANG G WOLFGANG A | 2014 | IEEE Transactions on Industrial Electronics2014，，61： | 1 |
| 8 | 白细胞端粒长度缩短较动脉粥样硬化的临床表现提前出现:血液和肌肉模型显示文摘白细胞端粒长度与动脉粥样硬化性心血管病(atherosclerotic cardiovascular disease,ASCVD)相关。目前还不清楚这种关系是否源于出生时天生较短的白细胞端粒长度(leukocy tetelomere length,LTL)和(或)之后较快的LTL消耗。LTL代表高增殖性造血系统中的端粒长度,而骨骼肌中的端粒长度(muscle tetelomere length,MTL)代表最低限度复制的组织。 | Benetos A Toupance S Gautier S Labat C Kimura M Rossi PM Settembre N Hubert J Frimat L Bertrand B Boufi M Flecher X Sadoul N Eschwege P Kessler ML Tzanetakou IP Doulamis IP Konstantopoulos PS Tzani AI Korou LM Gkogkos A Perreas KG Menenakos E Samanidis G Vasiloglou-Gkanis M Kark JD Malikov S Verhulst S Aviv A 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，1： | 1 |
| 9 | Surgical treatment of acute and chronic anterior and posterior cruciate ligament and medial-side injuries of the knee 显示文摘 | Hubert M G Stannard J P | 2011 | Sports Med Arthrosc2011，19，2： | 1 |
| 10 | Containment of biogenic sulfide production in continuous up-flow packed-bed bioreactors with nitrate or nitrite 显示文摘 | Hubert C Nemati M Jenneman G | 2003 | Biotechnology Progress2003，19，2： | 1 |
| 11 | Fate of POPs(DDX, HCHs, PCBs) in upper soil layers of pine forests显示文摘 | Wenzel KD Manz M Hubert A Schii/irmann G | 2002 | Science of the Total Environment2002，286，123： | 1 |
| 12 | Generalized procedures for evaluating spatial autocorrela- tion显示文摘 | HUBERT L J GOLLEDGE R G CONSTANZO C M | 1981 | Geographical Analysis1981，，12： | 1 |
| 13 | Mesenehymal stem cells injection in degenerated intervertebral disc: cell leakage may induce osteophyte formation 显示文摘 | Vadala G Sowa G Hubert M | 2012 | J Tissue Eng Regen Med2012，6，5： | 1 |
| 14 | SEU prediction from SET modeling using multi-node collection in bulk transistors and SRAMs down to the 65 nm technology node显示文摘 | Artola L Hubert G Warren K M | 2011 | IEEE Trans on Nuclear Science2011，58，3： | 1 |
| 15 | Corrosion risk associat- ed with microbial souring control using nitrate or nitrite显示文摘 | Hubert C Nemati M Jenneman G | 2005 | Ap- plied Microbiol Biotechnology2005，68，2： | 1 |
| 16 | High extraction efficiency for POPs in real contaminated soil samples using accelerated solvent extraction 显示文摘 | Hubert A Wenzel K D Manz M Weissflog L Engewald W Schuurmann G | 2000 | Analyitical Chemistry2000，72，6： | 1 |
| 17 | Fate of POPs (DDX, HCHs, PCBs) in upper soil layers of pine forests显示文摘 | K.-D Wenzel M Manz A Hubert G Schüürmann | 2002 | Science of the Total Environment2002，，1： | 1 |
| 18 | Phase and amplitude-based clustering for functional data显示文摘 | L Slaets G Claeskens M Hubert | 2012 | Computational Statistics & Data Analysis2012，56，7： | 1 |
| 19 | Efficacy of keratinocyte growth factor-2 in dextran sulfate sodium-induced murine colitis显示文摘 | Miceli R Hubert M Santiago G | 1999 | J Pharmacol Exp Ther1999，290，1： | 1 |
| 20 | Mesenchymal stem cells injection in degenerated intervertebral disc:cell leakage may induce osteophyte formation 显示文摘 | Vadala G Sowa G Hubert M | 2012 | J Tissue Eng Regen Med2012，6，5： | 1 |
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