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| 1 | Euphorbia factor L2 induces apoptosis in A549 cells through the mitochondrial pathway显示文摘Euphorbia factor L2, a lathyrane diterpenoid isolated from caper euphorbia seed(the seeds of Euphorbia lathyris L.), has been traditionally applied to treat cancer. This article focuses on the cytotoxic activity of Euphorbia factor L2 against lung carcinoma A549 cells and the mechanism by which apoptosis is induced. We analyzed the cytotoxicity and related mechanism of Euphorbia factor L2 with an MTT assay, an annexin V-FITC/PI test, a colorimetric assay, and immunoblotting. Euphorbia factor L2 showed potent cytotoxicity to A549 cells. Euphorbia factor L2 led to an increase in reactive oxygen species(ROS) generation,a loss of mitochondrial electrochemical potential, release of cytochrome c, activation of caspase-9 and caspase-3, and cleavage of poly(ADP-ribose) polymerase, suggesting that Euphorbia factor L2 induced apoptosis through a mitochondrial pathway. The cytotoxic activity of Euphorbia factor L2 in A549 cells and the related mechanisms of apoptotic induction provide support for the further investigation of caper euphorbia seeds. | Minting Lin Sili Tang Chao Zhang Hubiao Chen Wenjing Huang Yun Liu Jianye Zhang | 2017 | Acta Pharmaceutica Sinica B2017，7，1： | 14 |
| 2 | Simulation research on a minimum root-mean-square error rotation-fitting algorithm for gravity matching navigation显示文摘Gravity/inertial combination navigation is a leading issue in realizing passive navigation onboard a submarine. A new rotation-fitting gravity matching algorithm, based on the Terrain Contour Matching (TERCOM) algorithm, is proposed in this paper. The algorithm is based on the principle of least mean-square-error criterion, and searches for a certain matched trajectory that runs parallel to a trace indicated by an inertial navigation system on a gravity base map. A rotation is then made clockwise or counterclockwise through a certain angle around the matched trajectory to look for an optimal matched trajectory within a certain angle span range, and through weighted fitting with another eight suboptimal matched trajectories, the endpoint of the fitted trajectory is considered the optimal matched position. In analysis of the algorithm reliability and matching error, the results from simulation indicate that the optimal position can be obtained effectively in real time, and the positioning accuracy improves by 35% and up to 1.05 nautical miles using the proposed algorithm compared with using the widely employed TERCOM and SITAN methods. Current gravity-aided navigation can benefit from implementation of this new algorithm in terms of better reliability and positioning accuracy. | WANG HuBiao WANG Yong FANG Jian CHAI Hua ZHENG Hui | 2012 | Science China Earth Sciences2012，55，1： | 12 |
| 3 | Synthesis, Structure and H+/K+-ATPase Inhibitory Activity of Novel Triazolyl Substituted Tetrahydrobenzofuran Derivatives via One-pot Three-component Click Reaction显示文摘 | Hubiao Fang Lei Jin Nianyu Huang Junzhi Wang Kun Zou Zaigang Luo | 2013 | Chinese Journal of Chemistry2013，31，6： | 6 |
| 4 | Exosomes with low miR-34c-3p expression promote invasion and migration of non-small cell lung cancer by upregulating integrinα2β1显示文摘Exosomes play critical roles in regulating various physiological and pathological processes,including immune stimulation,immune suppression,cardiovascular diseases,and cancers.Recent studies show that exosomes that transport specific microRNAs(miRNAs)are involved in tumor development.However,the molecular mechanism by which tumor invasion and migration are regulated by exosomes from non-small cell lung cancer(NSCLC)is not well understood.Here,we show that exosomes shuttling low levels of miR-34c-3p are involved in NSCLC progression.Our results showed that exosomes derived from NSCLC cells carrying low levels of miR-34c-3p could be transported into the cytoplasm of NSCLC cells and accelerate NSCLC invasion and migration by upregulating integrinα2β1.A luciferase assay revealed that integrinα2β1 was the direct target of miR-34c-3p,and overexpression of integrinα2β1 could promote the invasion and migration of NSCLC cells.The analysis of exosomes derived from clinical serum samples indicated that the expression of miR-34c-3p was significantly downregulated in exosomes from NSCLC patients compared with that of normal controls.A549-derived exosomes promoted NSCLC cells lung metastases in vivo.Exosomes shuttling low levels of miR-34c-3p were associated with the progression of NSCLC in vitro and in vivo.Our data demonstrate that exosomes shuttling low levels of miR-34c-3p can accelerate the invasion and migration of NSCLC by upregulating integrinα2β1.MiR-34c-3p can be a diagnostic and prognostic marker for NSCLC.High expression of integrinα2β1 is positively related to the migration and metastasis of NSCLC cells. | Wenjing Huang Yanyan Yan Yun Liu Minting Lin Jinxiang Ma Wei Zhang Jianwei Dai Jiajun Li Qiaoru Guo Hubiao Chen Bolat Makabel Hong Liu Chaoyue Su Hong Bi Jianye Zhang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 5 | Tissue-based metabolite profiling and qualitative comparison of two species of Achyranthes roots by use of UHPLC-QTOF MS and laser micro-dissection显示文摘Achyranthes bidentata and Achyranthes aspera are saponin and steroid rich medicinal plants, used extensively for therapeutic treatments in Traditional Chinese Medicine(TCM) and Ayurveda. A. bidentata is reported to be one of the rare and extensively exploited medicinal plant species that face the issue of being endangered.Finding qualitative substitute with identical phyto-constituents contributing to similar composition and pharmacological benefits will help in reducing the burden of exploitation of the natural habitats of such plants.In the present study, a comparative metabolite analysis of the whole drug and specific tissues isolated by laser micro-dissection(LMD) was carried out for both the selected species, by use of ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry(UHPLC-QTOF MS). The results of the study indicate that the cortex and the medullary ray tissues are rich in their content of steroidal and saponin constituents such as(25 S)-inokosterone-20,22-acetonide, ginsenoside Ro, bidentatoside II and achyranthoside B.Metabolite profiling of the whole tissues of both the species indicates presence of identical constituents. Thus,it is inferred that A. bidentata and A. aspera can be used as qualitative substitutes for each other. | Yogini Jaiswal Zhitao Liang Alan Ho Hubiao Chen Leonard Williams Zhongzhen Zhao | 2018 | Journal of Pharmaceutical Analysis2018，8，1： | 5 |
| 6 | Chemical profiling and histochemical analysis of Bupleurum marginatum roots from different growing areas of Hubei province显示文摘Bupleuri Radix has been widely used in traditional Chinese medicine.In the current herbal market,the species Bupleurum marginatum Wall.ex DC.is the main source of Bupleuri Radix.Although Bupleuri Radix from the roots of B.marginatum grown wild in the North West of Hubei province has higher quality compared with those from other regions according to the previous investigations,the exhaustive exploitation driven by increasing demand has drastically reduced the wild resource.As a result,germplasm evaluation and quality resource exploration are important for the sustainable utilization and cultivation of B.marginatum.A preliminary study indicated differences in the tissue structure of B.marginatum grown in different areas of North Western Hubei province.In the current study,various tissues of the roots of B.marginatum grown in different areas of North Western Hubei were subjected to laser microdissection and analyzed by microscopy and ultra-high performance liquid chromatography quadrupole time-of-flight mass spectrometry(UHPLC–Q-TOF-MS).The results show that wild plants from Maqiao Town,Baokang County contain the most saikosaponins distributed mainly in cork,cortex and phloem.This study provides key chemical information for evaluating the quality of B.marginatum roots. | Zhitao Liang Jian Zhang Guangyi Yang Hubiao Chen Zhongzhen Zhao | 2013 | Acta Pharmaceutica Sinica B2013，3，3： | 4 |
| 7 | High Precision Vertical Deflection Over China Marginal Sea and Global Sea Derived from Multi-Satellite Altimeter显示文摘根据重力场模型(EIGEN_CG01C ) ,和多高度表数据,在 2 ′
× 2 ′
的垂直 gridded 的改进偏转在在 5 ′
× 5 ′
的中国边缘海和 gridded由最不使用沿着轨道的加权的方法在全球海是坚定的摆平,并且精确性比 1.2 ″
好在中国边缘海。至于 vertical 的偏转的质量,它为高分辨率和精确性的重力场遇见挑战。它证明与在海的舷侧重力测量学相比,严肃异例的精确性由反的 Vening-Meinesz 与 vertical 的海洋的偏转计算了公式是 7.75 m · s −2 。 | WANG Hubiao WANG Yong LU Yang | 2008 | Geo-Spatial Information Science2008，11，4： | 2 |
| 8 | A critical review on the bio-removal of hazardous heavy metals from contaminated soils: Issues, progress, eco-environmental concerns and opportunities显示文摘 | Gang Wu Hubiao Kang Xiaoyang Zhang Hongbo Shao Liye Chu Chengjiang Ruan | 2009 | Journal of Hazardous Materials2009，，1： | 2 |
| 9 | Analysis of phenolic com- pounds in Rhubarbs using liquid chromatography coupled with electrospray ionization mass spectrometry显示文摘 | Min Ye Jian Han Hubiao Chen | 2007 | J Am Soc Mass Spectrom2007，18，： | 1 |
| 10 | Comparison of rawand processed Radix Polygoni Multiflori ( Heshouwu) by high per-formance liquid chromatography and mass spectrometry 显示文摘 | Liang Zhi tao Chen Hubiao Yu Zhiling | 2010 | ChinMed2010，5，： | 1 |
| 11 | Analysis of phenolic compounds in Rhubarbs using liquid chromatography coupled with electrospray ionization mass spectrometry 显示文摘 | Ye Min Han Jian Chen Hubiao | 2007 | J Am Soc Mass Spectrom2007，18，： | 1 |
| 12 | Analysis of phenolic compounds in Rhubarbs using liquid chromatography coupled with electrospray ionization mass spectrometry显示文摘 | Min Ye Jian Han Hubiao Chen | 2007 | J Am Soc Mass Spectrom2007，18，： | 1 |
| 13 | A critical review on the bio-removal of hazardous heavy metals from contaminated soils : Issues, progress, eco-environmental concerns and opportunities显示文摘 | Wu Gang Kang Hubiao Zhang Xiaoyang | 2010 | Journal of Hazardous Materials2010，174，13： | 1 |
| 14 | Analysis of phenolic compounds in Rhubarbs using liquid chromatography coupled with electrospray ioni- zation mass spectrometry显示文摘 | YeMin Han Jian Chen Hubiao | 2007 | J Am Soc Mass Spectrom2007，18，： | 1 |
| 15 | A critical review on the bio-re-moval of hazardous heavy metals from contaminated soils : Issues,progress, eco -environmental concerns and opportunities显示文摘 | Gang W Hubiao K Xiaoyang Z | 2010 | Journal ofHazardous Materials2010，174，： | 1 |
| 16 | Determination of Diterpenoids and Flavonoids in Lsodon Rubescens by LC-ESI-MS-MS 显示文摘 | Han Jian Ye Min Chen Hubiao | 2005 | Chromatographia2005，62，34： | 1 |
| 17 | Graphene oxide nanosheet: an emerging star material for novel separation membranes 显示文摘 | Hubiao Huang Yulong Ying Xinsheng Peng | 2014 | Journal of Materials Chemistry A2014，34，： | 1 |
| 18 | Mining and utilization of salinity tolerant legumes in tropical coastal agroecosystems: An overview显示文摘Coastal saline soils are increasing year by year caused by climate change and human activities.Most of the coastal saline soils are idle due to their high salinity level and few crops can grow normally.Salinity tolerant legumes are naturally tolerant to salt,which can ecologically cover the coastal saline soil,enhance soil fertility by symbiotic nitrogen fixation and increase the smallholder farmers’benefits in terms of forage,green manure,food or medicine.However,few reports are available for the systematic evaluation of salinity tolerant legumes.This review summarizes and evaluates currently available salinity tolerant legume species that could potentially be used and discusses their potential for integration into smallholder mixed coastal systems of the Asia-Pacific region.Fourty four salinity tolerant legumes were summarized,six of them showed a high level of salinity tolerance,17 of them showed a moderate level of salinity tolerance and 21 of them showed potential salinity tolerance but need to be further studied.Many gaps such as combined tolerance evaluation,nitrogen fixation efficiency,animal feeding experiments and salinity tolerant rhizobia screening/inoculants exist.Case studies demonstrate legumes could be used to reclaim coastal saline soils,but commitment and support from government and public services are necessary to address both seed system and extension needs,through the provision of adequate incentives,policies and development efforts. | Yiming Liu Mary Atieno Juan Andres Cardoso Hubiao Yang Bin Xu Rongshu Dong Linling Yan Chunqiong Huang Hengfu Huan Daogeng Yu Sabine Douxchamps Guodao Liu | 2022 | Grass Research2022，2，1： | 0 |
| 19 | Study on Saccharification of Saccharum spontaneum L. by Sulphuric Acid Hydrolysis显示文摘In order to improve the saccharification rate by acid hydrolysis in the technique for production of ethanol from biomass,in this study,Saccharum spontaneum L. was used as the experimental material to investigate the rules and technological conditions for two-step acid-hydrolysis saccharification by single factor experiment and orthogonal experiment. According to the results,concentrated sulfuric acid hydrolysis was the first step,with the liquid-solid ratio of 42∶ 1,sulfuric acid concentration of 70%,hydrolysis time of 20 min,and hydrolysis temperature of 55 ℃; dilute sulphuric acid hydrolysis was the second step,with the liquidsolid ratio of 115∶ 1,sulfuric acid concentration of 5. 5%,hydrolysis time of 155 min,and hydrolysis temperature of 100 ℃. In two-step acid hydrolysis process,the yield of reducing sugar was 48. 78%. The results indicated that two-step acid-hydrolysis saccharification required mild conditions,simple operation and low cost,and led to high reducing sugar yield,exhibiting a broad application prospect. | Jianle LIU Changjun BAI Linling YAN Qinglin JIA Yu ZHANG Hubiao YANG | 2014 | Agricultural Biotechnology2014，3，6： | 0 |
| 20 | Nutritional Value Evaluation of Saccharum spontaneum L. Germplasm Resources显示文摘The contents of dry matter, crude fat, crude protein, neutral detergent fiber, acid detergent fiber, crude ash, Ca and P in 43 Saccharum spontaneum L.germplasms during the vegetative period were determined. Among them, the crude protein, crude fat, neutral detergent fiber, acid detergent fiber, P and Ca contents were treated as the judging indicators. The nutritional value evaluation was carried out with the analytic hierarchy process(AHP). The results showed A49(Guangxi)had the highest nutritional value. Its dry matter, crude protein, crude fat, crude ash,neutral detergent fiber, acid detergent fiber, Ca and P contents were 32.35%,7.20%, 4.06%, 8.07%, 75.81%, 50.72%, 0.23% and 0.16% respectively. While A3(Guangdong) had the lowest nutritional value. Its dry matter, crude protein, crude fat, crude ash, neutral detergent fiber, acid detergent fiber, Ca and P contents were32.24%, 4.62%, 0.51%, 6.38%, 46.40%, 40.02%, 0.15% and 0.09% respectively.The crude protein content differed significantly among different germplasms. A48 had the highest crude protein content(9.11%), and A14 had the lowest crude protein content(3.72%). Based on the evaluation results, the 43 Saccharum spontaneum L.germplasms were divided into 3 groups: high-nutritional value type, moderate-nutritional value type and low-nutritional value type. We hoped to provide a theoretical reference for the application of Saccharum spontaneum L. as a forage grass. | Jianle LIU Changjun BAI Linling YAN Shimeng CHEN Yu ZHANG Hubiao YANG | 2014 | Agricultural Science & Technology2014，15，11： | 0 |
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