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| 1 | Dissecting the molecular pathophysiology of drug-induced liver injury显示文摘Drug-induced liver injury(DILI) has become a major topic in the field of Hepatology and Gastroenterology. DILI can be clinically divided into three phenotypes: hepatocytic, cholestatic and mixed. Although the clinical manifestations of DILI are variable and the pathogenesis complicated, recent insights using improved preclinical models, have allowed a better understanding of the mechanisms that trigger liver damage. In this review, we will discuss the pathophysiological mechanisms underlying DILI. The toxicity of the drug eventually induces hepatocellular damage through multiple molecular pathways, including direct hepatic toxicity and innate and adaptive immune responses. Drugs or their metabolites, such as the common analgesic, acetaminophen, can cause direct hepatic toxicity through accumulation of reactive oxygen species and mitochondrial dysfunction. The innate and adaptive immune responses play also a very important role in the occurrence of idiosyncratic DILI. Furthermore, we examine common forms of hepatocyte death and their association with the activation of specific signaling pathways. | Hui Ye Leonard J Nelson Manuel Gómez del Moral Eduardo Martínez-Naves Francisco Javier Cubero | 2018 | World Journal of Gastroenterology2018，24，13： | 19 |
| 2 | Co-effect of Demand-control-support Model and Effort-reward Imbalance Model on Depression Risk Estimation in Humans: Findings from Henan Province of China显示文摘Objective To investigate the co-effect of Demand-control-support(DCS) model and Effort-reward Imbalance(ERI) model on the risk estimation of depression in humans in comparison with the effects when they are used respectively. Methods A total of 3 632 males and 1 706 females from 13 factories and companies in Henan province were recruited in this cross-sectional study. Perceived job stress was evaluated with the Job Content Questionnaire and Effort-Reward Imbalance Questionnaire(Chinese version). Depressive symptoms were assessed by using the Center for Epidemiological Studies Depression Scale(CES-D). Results DC(demands/job control ratio) and ERI were shown to be independently associated with depressive symptoms. The outcome of low social support and overcommitment were similar. High DC and low social support(SS), high ERI and high overcommitment, and high DC and high ERI posed greater risks of depressive symptoms than each of them did alone.ERI model and SS model seem to be effective in estimating the risk of depressive symptoms if they are used respectively. Conclusion The DC had better performance when it was used in combination with low SS. The effect on physical demands was better than on psychological demands. The combination of DCS and ERI models could improve the risk estimate of depressive symptoms in humans. | YU Shan Fa NAKATA Akinori GU Gui Zhen SWANSON Naomi G ZHOU Wen Hui HE Li Hua WANG Sheng | 2013 | Biomedical and Environmental Sciences2013，26，12： | 8 |
| 3 | Celiac disease serology in patients with different pretest probabilities: Is biopsy avoidable?显示文摘AIM: To establish the diagnostic performance of sev-eral serological tests, individually and in combination, for diagnosing celiac disease (CD) in patients with different pretest probabilities, and to explore potential se- rological algorithms to reduce the necessity for biopsy. METHODS: We prospectively performed duodenal biopsy and serology in 679 adults who had either high risk (n = 161) or low risk (n = 518) for CD. Blood samples were tested using six assays (enzyme-linked immunosorbent assay) that detected antibodies to tissue transglutaminase (tTG) and deamidated gliadin peptide (DGP). RESULTS: CD prevalence was 39.1% in the high-risk population and 3.3% in the low-risk group. In high-risk patients, all individual assays had a high diagnostic efficacy [area under receiving operator characteristic curves (AU ROC): 0.968 to 0.999]. In contrast, assays had a lower diagnostic efficacy (AU ROC: 0.835 to 0.972) in the low-risk group. Using assay combinations, it would be possible to reach or rule out diagnosis of CD without biopsy in 92% of cases in both pretest populations. We observed that the new DGP/tTG Screen assay resulted in a surplus compared to more conventional assays in any clinical situation. CONCLUSION: The DGP/tTG Screen assay could be considered as the best initial test for CD. Combinations of two tests, including a DGP/tTG Screen, might be able to diagnose CD accurately in different clinical scenarios making biopsy avoidable in a high proportion of subjects. | Emilia Sugai María L Moreno Hui J Hwang Ana Cabanne Adriana Crivelli Fabio Nach-man Horacio Vázquez Sonia Niveloni Julio Argonz Roberto Mazure Graciela La Motta María E Caniggia Edgardo Smecuol Néstor Chopita Juan C Gómez Eduardo Maurińo Julio C Bai | 2010 | World Journal of Gastroenterology2010，16，25： | 4 |
| 4 | Tumor necrosis factor-α-induced protein 1 and immunity to hepatitis B virus显示文摘AIM: To compare the gene expression profile in a pair of HBV-infected twins.METHODS: The gene expression profile was compared in a pair of HBV-infected twins.RESULTS: The twins displayed different disease outcomes. One acquired natural immunity against HBV,whereas the other became a chronic HBV carrier. Eightyeight and forty-six genes were found to be up- or downregulated in their PBMCs, respectively. Tumor necrosis factor-alpha-induced protein 1 (TNF-αIP1) that expressed at a higher level in the HBV-immune twins was identified and four pairs of siblings with HBV immunity by RTPCR. However, upon HBV core antigen stimulation,TNF-αIP1 was downregulated in PBMCs from subjects with immunity, whereas it was slightly upregulated in HBV carriers. Bioinformatics analysis revealed a K+channel tetramerization domain in TNF-αIP1 that shares a significant homology with some human, mouse, and C elegan proteins.CONCLUSION: TNF-αIP1 may play a role in the innate immunity against HBV. | Marie C Lin Nikki P Lee Ning Zheng Pai-Hao Yang Oscar G Wong Hsiang-Fu Kung Chee-Kin Hui John M Luk George Ka-Kit Lau | 2005 | World Journal of Gastroenterology2005，11，48： | 3 |
| 5 | 缺血性脑卒中后的中期血压变异性与临床结局的关系显示文摘本研究旨在探讨急性脑卒中患者发病7d内的中期血压变异性(blood pressure variability,BPV)与预后的关系。方法:本研究纳入873例急性缺血性脑卒中患者。通过计算发病7d内的收缩压和舒张压的变异系数来评价中期BPV。 | Wang Y Wang J Meng P Liu N Ji N Zhang G Xu B Zhou X Sun Y Xu Y Hui R He M 陈云 叶鹏 | 2018 | 中华高血压杂志2018，26，5： | 2 |
| 6 | Insulin resistance is associated with chronic hepatitis C and virus infection fibrosis progression显示文摘 | Jason M Hui Archana Sud Geoffrey C Farrell Priyanka Bandara Karen Byth James G Kench Geoffrey W McCaughan Jacob George | 2003 | Gastroenterology2003，，6： | 2 |
| 7 | Enhanced Offset Averaging Technique for Flash ADC Design显示文摘This paper presents a new combined AC/DC-coupled output averaging technique for input amplifier design of flash analog-to-digital converters (ADC). The new offset averaging design technique takes full advantage of traditional DC-coupled resistance averaging and AC-coupled capacitance averaging techniques to minimize offset-induced ADC nonlinearities. Circuit analysis allows selection of optimum resistance and capacitance averaging factors to achieve maximum offset reduction in ADC designs. The new averaging method is verified in designing a 4 bit 1 Gs/s flash ADC that is implemented in foundry 0.13 μm CMOS technology. | Siqiang FAN He TANG Hui ZHAO Xin WANG Albert WANG Bin ZHAO Gary G ZHANG | 2011 | Tsinghua Science and Technology2011，16，3： | 2 |
| 8 | Preva- lence and Molecular haracterization of Tetracycline Re- sistance in Enterococcus Isolates from Food 显示文摘 | HUYS G HAENE K D COLLARD J M | 2004 | Appl Environ Microbiol2004，70，3： | 1 |
| 9 | Preparation of ultrathin free-standing porous metal films显示文摘 | XU Hui Werner A G | 2005 | Small2005，1，： | 1 |
| 10 | Das Winkelmass: Theoretische tl berlegungen zum optimalen Standardwinkel显示文摘 | Hui G Y Gadow K | 2002 | Allgemeine Forst und Jagdzei- tung2002，173，9： | 1 |
| 11 | Oxidation state of gold and arsenic in gold-hearing arsenian pyrites 显示文摘 | Simon G Huang Hui Penner J E | 1999 | American Mineralogist1999，84，： | 1 |
| 12 | Molecular characterization of tet (M) genes in Lactobacillus isolates from different types of fermented dry sausage显示文摘 | GEVERS D DANIELSEN M HUYS G | 2003 | Applied and Environmental Microbiology2003，69，2： | 1 |
| 13 | Evaluating tree species diversity based on neighborhood relationships显示文摘 | HUI G Y ZHAO X H ZHAO Z H | 2011 | Forest Science2011，57，： | 1 |
| 14 | Incidence of antibiotic resistance and virulence determinants among Enterococcus italicus isolates from dairy products显示文摘 | MAIETTI L BONVINI B HUYS G | 2007 | Syst Appl Microbiol2007，30，6： | 1 |
| 15 | Two-dimensional traffic flow problems in inhomogeneous lattices显示文摘 | Gu G Q Chung K H Hui P M | 1995 | Physica A1995，217，34： | 1 |
| 16 | The R0-type fuzzy logic metric space and an algorithm for solving fuzzy modus ponens显示文摘 | Wang G J Hui X J Song J S | | (to appear)0，，： | 1 |
| 17 | Market access of biosimilars: not only a cost issue显示文摘 | Simoens S Verbeken G Huys I | 2011 | Oncologie2011，13，5： | 1 |
| 18 | Study of grass carp (Ctenopharyngo~lon idellus )quality predictive model based on electronic nose 显示文摘 | Hui G Wang L Mo Y Zhang L | 2012 | Sensors and Actuators B: Chemical2012，35，2： | 1 |
| 19 | A double-blind, crossover assessment of the sedative and analgesic effects of in- tranasal dexmedetomidine显示文摘 | YUEN V M IRWIN M G HUI T W | 2007 | Anesthesia and Analgesia2007，105，2： | 1 |
| 20 | Photonic-crystal slow-light enhancement of nonlinear phase sensitivity显示文摘 | 1 SOLJACIC M JOHNSON S G FAN Shan hui | 2002 | Opt Soc Am B2002，19，9： | 1 |
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