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| 1 | Probabilistic analysis of embankment slope stability in frozen ground regions based on random finite element method显示文摘Prediction on the coupled thermal-hydraulic fields of embankment and cutting slopes is essential to the assessment on evolution of melting zone and natural permafrost table, which is usually a key factor for permafrost embankment design in frozen ground regions. The prediction may be further complicated due to the inherent uncertainties of material properties. Hence, stochastic analyses should be conducted. Firstly, Karhunen-Loeve expansion is applied to attain the random fields for hydraulic and thermal conductions. Next, the mixed-form modified Richards equation for mass transfer(i.e., mass equation) and the heat transport equation for heat transient flow in a variably saturated frozen soil are combined into one equation with temperature unknown. Furthermore, the finite element formulation for the coupled thermal-hydraulic fields is derived. Based on the random fields, the stochastic finite element analyses on stability of embankment are carried out. Numerical results show that stochastic analyses of embankment stability may provide a more rational picture for the distribution of factors of safety(FOS), which is definitely useful for embankment design in frozen ground regions. | Xi Chen JianKun Liu Nan Xie HuiJing Sun | 2015 | Research in Cold and Arid Regions2015，7，4： | 3 |
| 2 | Generating Giant Membrane Vesicles from Live Cells with Preserved Cellular Properties显示文摘Biomimetic giant membrane vesicles,with size and lipid compositions comparable to cells,have been recognized as an attractive experimental alternative to living systems.Due to the similarity of their membrane structure to that of body cells,cell-derived giant plasma membrane vesicles have been used as a membrane model for studying lipid/protein behavior of plasma membranes.However,further application of biomimetic giant membrane vesicles has been hampered by the side-efects of chemical vesiculants and the utilization of osmotic bufer.We herein develop a facile strategy to derive giant membrane vesicles(GMVs)from mammalian cells in biofriendly medium with high yields.Tese GMVs preserve membrane properties and adaptability for surface modifcation and encapsulation of exogenous molecules,which would facilitate their potential biological applications.Moreover,by loading GMVs with therapeutic drugs,GMVs could be employed for drug transport to tumor cells,which represents another step forward in the biomedical application of giant membrane vesicles.Tis study highlights biocompatible GMVs with biomimicking membrane surface properties and adaptability as an ideal platform for drug delivery strategies with potential clinical applications. | Qiaoling Liu Cheng Bi Jiangling Li Xuejiao Liu Ruizi Peng Cheng Jin Yang Sun Yifan Lyu Hui Liu Huijing Wang Can Luo Weihong Tan | 2019 | Research2019，，1： | 2 |
| 3 | Chaos control and synchronization of a modified chaotic system显示文摘 | SUN Huijing CAO Hongjun | 2008 | Chaos Solitons and Fractals2008，37，5： | 1 |
| 4 | Chaos Control and Synchronization of a Modified Chaotic System显示文摘 | Sun Huijing Cao Hongjun | 2008 | Chaos Solitons and Fractals2008，37，5： | 1 |
| 5 | Brainmask:an ultrasoft and moist microelectrocorticography electrode for accurate positioning and long-lasting recordings显示文摘Bacterial cellulose(BC),a natural biomaterial synthesized by bacteria,has a unique structure of a cellulose nanofiberweaved three-dimensional reticulated network.BC films can be ultrasoft with sufficient mechanical strength,strong water absorption and moisture retention and have been widely used in facial masks.These films have the potential to be applied to implantable neural interfaces due to their conformality and moisture,which are two critical issues for traditional polymer or silicone electrodes.In this work,we propose a micro-electrocorticography(micro-ECoG)electrode named“Brainmask”,which comprises a BC film as the substrate and separated multichannel parylene-C microelectrodes bonded on the top surface.Brainmask can not only guarantee the precise position of microelectrode sites attached to any nonplanar epidural surface but also improve the long-lasting signal quality during acute implantation with an exposed cranial window for at least one hour,as well as the in vivo recording validated for one week.This novel ultrasoft and moist device stands as a next-generation neural interface regardless of complex surface or time of duration. | Bowen Ji Fanqi Sun Jiecheng Guo Yuhao Zhou Xiaoli You Ye Fan Longchun Wang Mengfei Xu Wen Zeng Jingquan Liu Minghao Wang Huijing Hu Honglong Chang | 2023 | Microsystems & Nanoengineering2023，9，5： | 0 |
| 6 | SYNTHESIS OF NANOPOROUS SILICA WITH INTERIOR COMPOSITE CELLS WITH SYNTHETIC BLOCK COPOLYPEPTIDE AS TEMPLATE显示文摘Nanoporous silica with unusual interior composite cells was synthesized with synthetic block copolypeptide Phe20-b-PBLG50 as template for the first time. Anilino-methyl triethoxy silane (AMTS) was used as an intermedium to interact with block co-polypeptide Phe20-b-PBLG50 through π-π interaction between the phenyl groups of block copolypeptide and those of AMTS. Meanwhile, AMTS co-condenses together with tetraethoxylsilane (TEOS) after hy-drolysis. The structure of composite vesicles due to the self-assembly of block copolypeptide in the or-ganic solvent was immobilized and transcribed by the formation of silica. The formation of nanopores could be ascribed to the secondary structure of block co-polypeptide and small molecular amine. Our results provide a new avenue to synthesize porous oxide materials with novel interior structures templated by the copolypeptide self-assembly under ambient con-ditions. | LIU Yuping ZHOU Huijing SHEN Zhurui LI Liying ZHOU Xingdi SUN Pingchuan YUAN Zhongyong CHEN Tiehong LI Baohui DING Datong | 2006 | Chinese Science Bulletin2006，51，4： | 0 |
| 7 | Docking Study and Three-Dimensional Quantitative Structure- Activity Relationship (3D-QSAR) Analyses and Novel Molecular Design of a Series of 4-Aminoquinazolines as Inhibitors of Aurora B Kinase显示文摘曙光蛋白质为 anticancer 治疗是主要有丝分裂的事件和吸引人的目标的批评管理者。3D-QSAR 研究在 40 4-aminoquinazolines 混合物的数据集上基于分子的停靠被执行。CoMSIA 模型比 CoMFA 模型生产了显著地更好的结果,与 q2=0.652 和 r2=0.991。轮廓分析为禁止曙光 B 为 4-aminoquinazolines 关于结构的要求提供有用信息。支架跳跃方法被用来基于训练和测试集合混合物的最大的普通基础产生新结构。ADMET 性质,有约束力的亲密关系和新设计混合物的禁止的活动分别地被预言。最后, 16 混合物为曙光 B kinase 作为新奇禁止者被识别。 | Sun, Haopeng Zhu, Jia Chen, Yadong Sun, Yuan Zhi, Huijing Li, Hao You, Qidong | 2011 | Chinese Journal of Chemistry2011，29，9： | 0 |
| 8 | 3 - 32 Effects of Swift Heavy Ions Irradiation on Graphene and Thin Graphite Films显示文摘 | Zeng Jian Liu Jie Yao Huij un Zhai Pengfei Sun Youmei HouMingdong | 2012 | IMP & HIRFL Annual Report2012，，1： | 0 |
| 9 | Full-profile pharmacokinetics, anticancer activity and toxicity of an extended release trivalent PEGylated irinotecan prodrug显示文摘Irinotecan is an anticancer topoisomerase I inhibitor that acts as a prodrug of the active metabolite,SN-38.Unfortunately,the limited utility of irinotecan is attributed to its pH-dependent stability,short half-life and dose-limiting toxicity.To address this problem,a novel trivalent PEGylated prodrug(PEG-[Irinotecan]3)has been synthesized and its full-profile pharmacokinetics,antitumor activity and toxicity compared with those of irinotecan.The results show that after intravenous administration to rats,PEG-[Irinotecan]3 undergoes stepwise loss of irinotecan to form PEG-[Irinotecan]3-x(x=1,2)and PEG-[linker]during which time the released irinotecan undergoes conversion to SN-38.As compared with conventional irinotecan,PEG-[Irinotecan]3 displays extended release of irinotecan and efficient formation of SN-38 with significantly improved AUC and half-life.In a colorectal cancer-bearing model in nude mice,the tumor concentrations of irinotecan and SN-38 produced by PEG-[Irinotecan]3 were respectively 86.2 and 2293 times higher at 48 h than produced by irinotecan.In summary,PEG-[Irinotecan]3 displays superior pharmacokinetic characteristics and antitumor activity with lower toxicity than irinotecan.This supports the view that PEG-[Irinotecan]3 is a superior anticancer drug to irinotecan and it has entered the phaseⅡtrial stage. | Shiwen Song Dong Sun Hong Wang Jinliang Wang Huijing Yan Xuan Zhao John Paul Fawcett Xin Xu Deqi Cai Jingkai Gu | 2023 | Acta Pharmaceutica Sinica B2023，13，8： | 0 |
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