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| 1 | Role of the nerve growth factor precursor-neurotrophin receptor p75 and sortilin pathway on apoptosis in the brain of patients with intracerebral hemorrhage显示文摘This study demonstrated that brain areas surrounding the site of hematoma following intracerebral hemorrhage are characterized by significantly increased apoptosis and expression of neurotrophin receptor p75 and sortilin. However, as detected by terminal deoxynucleotidyl transferase dUTP nick end labeling and immunohistochemical staining, there was no significant change in nerve growth factor precursor expression levels. The appearance of neurotrophin receptor p75 expressing cells was positively correlated with cells that were detected by terminal deoxynucleotidyl transferase dUTP nick end labeling. These findings confirm that the nerve growth factor precursor-neurotrophin receptor p75-sortilin heterotrimeric complex-mediated apoptosis pathway may play an important role in cellular apoptosis following intracerebral hemorrhage. | Gang Bao Qi Li Yuliang Han Ning Wang Shiwen Guo Jinning Song Baixiang He Kai Wang | 2011 | Neural Regeneration Research2011，6，22： | 1 |
| 2 | Study on Transformation of Ideas of Environmental Protection Administration and Construction of Ecological Civilization in China显示文摘The transformation process of ideas of environmental protection administration in China was introduced firstly,and then the connotation and construction of ecological civilization were analyzed. | Fu Baorong Yang Tao He Zhe Zuo Shiwen Gu Chunyu Liu Song Zhang Runjie | 2017 | Meteorological and Environmental Research2017，8，3： | 1 |
| 3 | An internal amplification control for quantitative nucleic acid analysis using nanoparticle-based dipstickbiosensors显示文摘 | Huan Huang Li Jin Xian Yang Qinxin Song Bingjie Zou Shiwen Jiang Lizhou Sun Guohua Zhou | 2013 | Biosensors and Bioelectronics2013，，： | 1 |
| 4 | Neural basis of Chinese phonological processing under picture stimulus A functional magnetic resonance imaging study显示文摘Studies concerning phonological processing mainly use written stimuli. Functional magnetic resonance imaging was used to investigate the brain regions related to the phonological processing under the picture stimulus in the rhyme task of Chinese language. Results of the test in 13 healthy college students whose native language is Chinese showed the extensive activation in the frontal lobe, parietal lobe and the occipitotemporal cortex, including the inferior frontal gyrus, middle frontal gyrus, supramarginal gyrus and medial occipitotemporal gyrus under the picture stimuli. Moreover, phonological processing induced activation in the superior temporal gyrus (BA 22) under the picture stimuli, but activation was not found in the middle temporal gyrus. | Junfei Liu | 2011 | Neural Regeneration Research2011，6，11： | 1 |
| 5 | 美国临床病理学会全球实验室检验人员专业认证显示文摘美国临床病理学会(American Society for ClinicalPathology, ASCP)对实验室检验人员的专业认证是由非政府机构或协会承认个人己达到预定资格能力的过程。它帮助确定致力于实验室检验专业,并对本专业知识和经验寻求认可的个人。ASCP认证委员会(Board of Certification,BOC)对准备从事,或继续从事和以医学实验室检验为职业生涯的人才开发、建立并坚持标准和流程。 | joseph brendan baker shiwen song patricia a.tanabe jennifer young 宋世文 | 2016 | 中华临床实验室管理电子杂志2016，4，3： | 1 |
| 6 | Structure, function, and mechanism of the TNFAIP8 (TIPE) family of proteins in cancer and inflammation显示文摘The multiple roles of the tumor necrosis factor(TNF)-α-inducible protein 8(TNFAIP8),also named TIPE family of proteins have been shown in tumor and inflammation progression and regulation of cellular autophagy and apoptosis.In this review,we found that the TIPE family showed highly homologous sequences and conserved functional domains,such as the death effector domain(DED)-like domain but displayed different roles and mechanisms in different biological activities.For example,while TIPE is primarily associated with tumor progression and antitumor drug resistance,TIPE1 suppresses tumor progression in most instances.TIPE2 has multiple roles in tumor progression regulation,and antitumor drug resistance.Moreover,TIPE2 was also involved in inflammatory response regulation,tumor typing,and staging.A few studies reported that TIPE3 was engaged in tumor development by activating the phosphatidylinositol-3-kinase(PI3K)/protein kinase B(AKT)signaling pathway.The structure,function,and mechanism of the TIPE family in cancer and inflammation have been summarized in this review.This might serve as a reference for further research on the TIPE family and shed new light on the crosstalk among antitumor responses,inflammation,and immunology. | ZIPENG LIN CHUXI TANG LE KANG GUANXI LAI SHIWEN LIU YIXIANG WU HUIQUN TIAN SONG LIU | 2023 | BIOCELL2023，47，10： | 0 |
| 7 | Magnesium promotes vascularization and osseointegration in diabetic states显示文摘Diabetes has long been considered a risk factor in implant therapy and impaired wound healing in soft and hard oral tissues.Magnesium has been proved to promote bone healing under normal conditions.Here,we elucidate the mechanism by which Mg~(2+)promotes angiogenesis and osseointegration in diabetic status.We generated a diabetic mice model and demonstrated thealveolar bone healing was compromised,with significantly decreased angiogenesis.We then developed Mg-coating implants with hydrothermal synthesis.These implants successfully improved the vascularization and osseointegration in diabetic status.Mechanically,Mg~(2+)promoted the degradation of Kelch-like ECH-associated protein 1 (Keap1) and the nucleation of nuclear factor erythroid 2-related factor 2 (Nrf2) by up-regulating the expression of sestrin 2 (SESN2) in endothelial cells,thus reducing theelevated levels of oxidative stress in mitochondria and relieving endothelial cell dysfunction under hyperglycemia.Altogether,our data suggested that Mg~(2+)promoted angiogenesis and osseointegration in diabetic mice by regulating endothelial mitochondria metabolism. | Linfeng Liu Feiyu Wang Wei Song Danting Zhang Weimin Lin Qi Yin Qian Wang Hanwen Li Quan Yuan Shiwen Zhang | 2024 | International Journal of Oral Science2024，16，1： | 0 |
| 8 | Effect of ivabradine on hyperpolarization activated cation current in canine pulmonary vein sleeve cardiomyocytes with atrial fibrillation显示文摘Objective To study the effect of ivabradine on hyperpolarization activated cation current in canine pulmonary vein(PY) sleeve cardiomyocytes with atrial fibrillation.Methods Dissociation of PVs yielded single cardiomyocytes from a Landengorff column without or with pacemaker activity from long-term rapidly atrial pacing (RAP) canines.If current was measured with the whole-cell patch-clamp technique.Results Compared with the control group,the rapidly atrial pacing canine PV cardiomyocytes had spontaneous diastolic depolarization and had larger If densities.Ivabradine (Iva,1 μM),a selective inhibitor of the If current,markedly reduced If currents in the RAP from -2.66±0.4 pA/pF to -1.58±0.1 pA/pF at the test potential of-120 mV (P<0.01,n=12).Inhibition effect of Iva of If current showed concentration-dependent range from 0.1 to 10.0μM,with IC50 of 2.2 μ M ( 1.8-2.9 μM,95% CL).Furthermore,V1/ of steady-state activated curve was shifted from -84.3±4.9 mV to -106.9±3.4 mV and k value of steady-state activated curve was changed from 12.1+2.6 mV to 9.9±3.4 mV by the application of.1.0 μM Iva ( P<0.01,n=12).Conclusions Our study revealed that Ivarbadine may significantly decrease If of rapidly atrial pacing pulmonary vein sleeve ceUs with atrial fibdllation.(J Geriatr Cardiol 2008;5:39-42) | Yang Li Yan Huang Zongbin Li Hao Wang Jianguo Song Yuqi Liu Lei Gao Shiwen Wang | 2008 | Journal of Geriatric Cardiology2008，5，1： | 0 |
| 9 | A cloud optical and microphysical property product for the advanced geosynchronous radiation imager onboard China's Fengyun-4 satellites: The first version显示文摘风云四号作为中国新一代静止气象卫星,提供了高时空分辨率的监测产品。本文介绍风云四号搭载的先进地球同步轨道辐射成像仪AGRI的云光学和微物理特性产品.该产品包含了基于双光谱通道反演的云光学厚度和云粒子有效半径产品,以及基于机器学习的云识别和云相态产品。与时空匹配的主动卫星观测结果对比显示,该产品的云识别和云相态的准确率分别在95%和85%;该产品提供的云光学厚度和云有效粒径与经典的MODIS产品的相关系数达到0.76和0.63.团队将持续优化和更新该云光学和微物理特性定量产品,服务风云四号卫星定量应用。 | Chao Liu Yuxing Song Ganning Zhou Shiwen Teng Bo Li Na Xu Feng Lu Peng Zhang | 2023 | Atmospheric and Oceanic Science Letters2023，16，3： | 0 |
| 10 | Full-profile pharmacokinetics, anticancer activity and toxicity of an extended release trivalent PEGylated irinotecan prodrug显示文摘Irinotecan is an anticancer topoisomerase I inhibitor that acts as a prodrug of the active metabolite,SN-38.Unfortunately,the limited utility of irinotecan is attributed to its pH-dependent stability,short half-life and dose-limiting toxicity.To address this problem,a novel trivalent PEGylated prodrug(PEG-[Irinotecan]3)has been synthesized and its full-profile pharmacokinetics,antitumor activity and toxicity compared with those of irinotecan.The results show that after intravenous administration to rats,PEG-[Irinotecan]3 undergoes stepwise loss of irinotecan to form PEG-[Irinotecan]3-x(x=1,2)and PEG-[linker]during which time the released irinotecan undergoes conversion to SN-38.As compared with conventional irinotecan,PEG-[Irinotecan]3 displays extended release of irinotecan and efficient formation of SN-38 with significantly improved AUC and half-life.In a colorectal cancer-bearing model in nude mice,the tumor concentrations of irinotecan and SN-38 produced by PEG-[Irinotecan]3 were respectively 86.2 and 2293 times higher at 48 h than produced by irinotecan.In summary,PEG-[Irinotecan]3 displays superior pharmacokinetic characteristics and antitumor activity with lower toxicity than irinotecan.This supports the view that PEG-[Irinotecan]3 is a superior anticancer drug to irinotecan and it has entered the phaseⅡtrial stage. | Shiwen Song Dong Sun Hong Wang Jinliang Wang Huijing Yan Xuan Zhao John Paul Fawcett Xin Xu Deqi Cai Jingkai Gu | 2023 | Acta Pharmaceutica Sinica B2023，13，8： | 0 |
| 11 | Promising therapeutic approaches of utrophin replacing dystrophin in the treatment of Duchenne muscular dystrophy显示文摘Duchenne muscular dystrophy(DMD)is a serious genetic neuromuscular rare disease that is prevalent and caused by the mutation/deletion of the X-linked DMD gene that encodes dystrophin.Utrophin is a dystrophin homologous protein on human chromosome 6.Dystrophin and utrophin are highly homologous.They can recruit many dystrophin-glycoprotein complex(DGC)-related proteins and co-localize at the sarcolemma in the early stage of human embryonic development.Moreover,utrophin is overexpressed naturally at the mature myofiber sarcolemma in DMD patients.Therefore,utrophin is considered the most promising homologous protein to replace dystrophin.This review summarizes various modulating drugs and gene therapy approaches for utrophin replacement.As a universal method to treat DMD disease,utrophin has a promising therapeutic prospect and deserves further investigation. | Ruo Wu Yafeng Song Shiwen Wu Yongchang Chen | 2022 | Fundamental Research2022，2，6： | 0 |
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