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| 1 | Mannose metabolism normalizes gut homeostasis by blocking the TNF-α-mediated proinflammatory circuit显示文摘Mannose is a naturally occurring sugar widely consumed in the daily diet;however,mechanistic insights into how mannose metabolism affects intestinal inflammation remain lacking.Herein,we reported that mannose supplementation ameliorated colitis development and promoted colitis recovery.Macrophage-secreted inflammatory cytokines,particularly TNF-α,induced pathological endoplasmic reticulum stress(ERS)in intestinal epithelial cells(IECs),which was prevented by mannose via normalization of protein N-glycosylation.By preserving epithelial integrity,mannose reduced the inflammatory activation of colonic macrophages.On the other hand,mannose directly suppressed macrophage TNF-αproduction translationally by reducing the glyceraldehyde 3-phosphate level,thus promoting GAPDH binding to TNF-αmRNA.Additionally,we found dysregulated mannose metabolism in the colonic mucosa of patients with inflammatory bowel disease.Finally,we revealed that activating PMM2 activity with epalrestat,a clinically approved drug for the treatment of diabetic neuropathy,elicited further sensitization to the therapeutic effect of mannose.Therefore,mannose metabolism prevents TNF-α-mediated pathogenic crosstalk between IECs and intestinal macrophages,thereby normalizing aberrant immunometabolism in the gut. | Peng Xiao Ziwei Hu Jiaheng Lang Tianyuan Pan Randall Tyler Mertens Huilun Zhang Ke Guo Manlu Shen Hongqiang Cheng Xue Zhang Qian Cao Yuehai Ke | 2023 | Cellular & Molecular Immunology2023，20，2： | 2 |
| 2 | Specific biotests to assess eco-toxicity of biodegradable polymer materials in soil显示文摘Eco-toxicity investigation of polymer materials was considered extremely necessary for their potential menace,which was widely use as mulching materials in agricultural.In this study,polyethylene(PE),polystyrene(PS)and synthetic biomaterials-Ecoflex and cellulose were applying into soil cultivated with two potential indicator plants species:oat(A v ena sati v a)and red radish(Raphanus sativum).Variety of chemical,biochemical parameters and enzyme activity in soil were proved as effective approach to evaluate polymers phytotoxicity in plant-soil mesocosm.The F-value of biomass,pH,heavy metal and electoral conductivity of Raphanus behaved significant different from T0.Significant analysis results indicated biodegradation was fast in PE than PS,besides,heavy metals were dramatically decrease in the end implied the plant absorption may help decrease heavy metal toxicity.The increase value at T2 of Dehydrogenase activity(0.84 higher than average value for Avena&0.91 higher for Raphanus),Metabolic Index(3.12 higher than average value for Avena&3.81 higher for Raphanus)means during soil enzyme activity was promoted by biodegradation for its heterotrophic organisms’energy transportation was stimulated.Statistics analysis was carried on Biplot PC1(24.2%of the total variance),PC2(23.2%of the total variance),versus PC3(22.8%of the total variance),which indicated phosphatase activity and metabolic index was significant correlated,and high correlation of ammonium and protease activity.Furthermore,the effects were more evident in Raphanus treatments than in Avena,suggesting the higher sensitivity of Raphanus to polymers treatment,which indicate biodegradation of polymers in Raphanus treatment has produced intermediate phytotoxic compounds. | Haiyan Chen Fei Wang Huilun Chen HongDa Fang Weiying Feng Yuan Wei FanFan Wang HaiLei Su YiDong Mi Min Zhou XinRu Li Serena Doni Andrea Corti | 2021 | Journal of Environmental Sciences2021，33，7： | 2 |
| 3 | Tocopherol speciation as first screening for the assessment of extra virgin olive oil quality by reversed-phase high-performance liquid chromatography/fluorescence detector显示文摘 | CHEN Huilun MARCO A CARLO F | 2011 | Food Chemistry2011，125，： | 1 |
| 4 | Quali- tative and Quantitative Analysis of Wood Samples by Fourier Transform Infrared Spectroscopy and Multivari- ate Analysis 显示文摘 | Huilun Chen Carlo Ferrari Marco Angiuli | 2010 | Carbohydrate Polymers2010，，82： | 1 |
| 5 | Tocopherol speciation as first screening for the assessment of extra virgin olive oil quality by reversed-phase high-perform- ance liquid chromatography/fluorescence detector 显示文摘 | Chen Huilun Angiuli M Ferrari C | 2011 | Food Chemistry2011，125，4： | 1 |
| 6 | Toxic Effect of Inorganic Arsenite [As(III)] on Metabolic Activity of Bacillus subtilis by Combined Methods显示文摘 | Yanjiao Chen Jun Yao Fei Wang Yong Zhou Huilun Chen Nan Gai Haiyan Chen Ke Chen Thomas Maskow Brunello Ceccanti Polonca Trebse Gyula Zaray | 2008 | Current Microbiology2008，，3： | 1 |
| 7 | The universal formula computing the position of subaperture spot image for Shack-Hartmann wavefront sensor 显示文摘 | Huilun LIN Chunhong WANG Wenhan JIANG | 2004 | SPIE2004，5639，： | 1 |
| 8 | Effect of silver nano-fluid on pulsating heat pipe thermal performance 显示文摘 | Lin Yusing Kang Shungwen Chen Huilun | 2008 | Applied Thermal Engineering2008，28，： | 1 |
| 9 | Tocopherol speciation as first screening for the assessment of extra virgin olive oil quality by reversed-phase high-performance liquid chromatography/fluorescence detector显示文摘 | Huilun Chen Marco Angiuli Carlo Ferrari Elpidio Tombari Giuseppe Salvetti Emilia Bramanti | 2010 | Food Chemistry2010，，4： | 1 |
| 10 | Isolation and characterization of a novel phenanthrene (PHE) degrading strain Psuedomonas sp. USTB-RU from petroleum contaminated soil显示文摘 | Kanaji Masakorala Jun Yao Minmin Cai Radhika Chandankere Haiyan Yuan Huilun Chen | 2013 | Journal of Hazardous Materials2013，，： | 1 |
| 11 | Qualitative and quantitative analysis of wood samples by Fourier transform infrared spectroscopy and multivariate analysis显示文摘 | Huilun Chen Carlo Ferrari Marco Angiuli etal | 2010 | Carbohydrate Polymers2010，82，： | 1 |
| 12 | Investigation of the acute toxic effect of chlorpyrifos on Pseudomonas putida in a sterilized soil environment monitored by microcalorimetry 显示文摘 | CHEN Huilun YAO Jun WANG Fei | 2010 | Archives of Environmental Contamination Toxicology2010，58，： | 1 |
| 13 | Evaluation of solvmat tolerance of microorganisms by microcalorimetry 显示文摘 | CHEN Huilun YAO Jun WANG Lin | 2009 | Chemosphere2009，74，： | 1 |
| 14 | Oxidative decomposition of atrazine in water in the presence of hydrogen peroxide using an innovative microwave photochemical reactor显示文摘 | Huilun Chen Emilia Bramanti Iginio Longo Massimo Onor Carlo Ferrari | 2010 | Journal of Hazardous Materials2010，，2： | 1 |
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