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| 1 | Aerosol and boundary-layer interactions and impact on air quality显示文摘Air quality is concerned with pollutants in both the gas phase and solid or liquid phases. The latter are referred to as aerosols, which are multifaceted agents affecting air quality, weather and climate through many mechanisms. Unlike gas pollutants, aerosols interact strongly with meteorological variables with the strongest interactions taking place in the planetary boundary layer(PBL). The PBL hosting the bulk of aerosols in the lower atmosphere is affected by aerosol radiative effects. Both aerosol scattering and absorption reduce the amount of solar radiation reaching the ground and thus reduce the sensible heat fluxes that drive the diurnal evolution of the PBL. Moreover, aerosols can increase atmospheric stability by inducing a temperature inversion as a result of both scattering and absorption of solar radiation, which suppresses dispersion of pollutants and leads to further increases in aerosol concentration in the lower PBL.Such positive feedback is especially strong during severe pollution events. Knowledge of the PBL is thus crucial for understanding the interactions between air pollution and meteorology. A key question is how the diurnal evolution of the PBL interacts with aerosols, especially in vertical directions, and affects air quality.We review the major advances in aerosol measurements, PBL processes and their interactions with each other through complex feedback mechanisms, and highlight the priorities for future studies. | Zhanqing Li Jianping Guo Aijun Ding Hong Liao Jianjun Liu Yele Sun Tijian Wang Huiwen Xue Hongsheng Zhang Bin Zhu | 2017 | National Science Review2017，4，6： | 37 |
| 2 | Genome of Wild Mandarin and Domestication History of Mandarin显示文摘官员(柠檬 reticulata ) 是世界范围的最重要的柠檬庄稼之一。它的驯服被相信发生在华南,它是四几千年的官员耕作的中心之一。我们在 Nanling 区域附近收集了官员的自然野人口并且在附近栽培了 landraces。我们发现柠檬性的酸水平戏剧性地在栽培官员被减少。理解 ? 官员驯服的基因基础,我们 de novo 装配了野官员的一个草稿染色体并且分析了一套 104 个柠檬染色体。我们发现 Mangshan 官员是一种原始类型并且二个独立驯服事件发生了,分别地导致在北方和南方 Nanling 山的二组栽培官员(MD1 和 MD2 ) 。二个瓶颈和有效人口尺寸的二扩大为栽培官员的 MD1 组被识别。然而,在 MD2 组织 ? 在人口尺寸有长、连续的减少。MD1 和 MD2 官员从栽培 pummelo 种类显示出种间的基因渗入的不同模式。我们在官员的驯服期间在选择下面可能在基因在柠檬酸盐内容的规定包含了的 aconitate hydratase (ACO ) 识别了高分叉的一个区域,它是。这研究为现存野官员人口的地理起源提供具体基因证据并且使驯服和官员的进化历史清楚些。 | Lun Wang Fa He Yue Huang Jiaxian He Shuizhi Yang Jiwu Zeng Chongling Deng Xiaolin Jiang Yiwen Fang Shaohua Wen Rangwei Xu Huiwen Yu Xiaoming Yang Guangyan Zhong Chuanwu Chen Xiang Yan Changfu Zhou Hongyan Zhang Zongzhou Xie Robert M. Larkin Xiuxin Deng Qiang Xu | 2018 | Molecular Plant2018，11，8： | 14 |
| 3 | A seed-specific AP2-domain transcription factor from soybean plays a certain role in regulation of seed ger-mination显示文摘Plant seed development and germination are under strict temporal and spatial regulation, and tran-scription factors play important roles in this regulation. In the present study we identified an EST ex-pressed specifically in the developing soybean seeds. The full length of the gene was obtained through further RACE analysis and the gene was named GmSGR. Sequence analysis revealed that this gene belonged to the AP2/ERF transcription factor family. Its AP2 domain had the highest similarity with that of the A-3 member AtABI4 of DREB subgroup in the AP2/ERF family in Arabidopsis. GmSGR did not exhibit transcriptional activation activity in the yeast assay system. GmSGR was overexpressed in Arabidopsis and the germination rates of the transgenic seeds were significantly higher than that of the wild type seeds under higher concentrations of ABA and glucose respectively. However, the germina-tion rates of the transgenic seeds were lower than that of control under salt stress. The expression of AtEm6 and AtRD29B was higher in the seedlings of the transgenic plants than that in the wild-type seedlings. These results suggest that GmSGR may confer reduced ABA sensitivity and enhanced salt sensitivity to the transgenic seeds through regulating the expression of AtEm6 and AtRD29B genes. | WANG ChunMei, WANG HuiWen, ZHANG JinSong & CHEN ShouYi National Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Bei-jing 100101, China | 2008 | Science China(Life Sciences)2008，51，4： | 11 |
| 4 | Isolation and characterization of Sporobolomyces sp. LF1 capable of degrading chlorimuron-ethyl显示文摘A yeast strain which was capable of degrading sulfonylurea herbicide chlorimuron-ethyl named as LF1 was isolated from a chlorimuron-ethyl contaminated soil near the warehouse of the factory producing chlorimuron-ethyl in Shenyang City,Northeast China. The strain was identified as Sporobolomyces sp.,based on its morphological and physiological characteristics and the phylogenetic analysis of 18S rRNA gene sequence.So far,this is the only yeast strain of Sporobolomyces sp.which is able to degrade chlorimuron-ethyl.Incubation tests showed that when the initial concentration of chlorimuron-ethyl in culture was 5 mg/L,LF1 could degrade more than 77%of the herbicide after incubation for 4 d at 30°C.The possible mechanism of chlorimuron-ethyl degradation by LF1 could be the acidic hydrolysis caused by the acids from the metabolism of the yeast strain.Further study should be conducted to examine the pathways of chlorimuron-ethyl degradation by LF1 and to approach the feasibility of using LF1 to degrade the chlorimuron-ethyl in soil system. | ZHANG Xiaoli ZHANG Huiwen LI Xu SU Zhencheng WANG Jingjing ZHANG Chenggang | 2009 | Journal of Environmental Sciences2009，21，9： | 10 |
| 5 | High-speed image reconstruction for optically sectioned,super-resolution structured illumination microscopy显示文摘Super-resolution structured illumination microscopy(SR-SIM)is an outstanding method for visualizing the subcellular dynamics in living cells.To date,by using elaborately designed systems and algorithms,SR-SIM can achieve rapid,optically sectioned,SR observation with hundreds to thousands of time points.However,real-time observation is still out of reach for most SIM setups as conventional algorithms for image reconstruction involve a heavy computing burden.To address this limitation,an accelerated reconstruction algorithm was developed by implementing a simplified workflow for SR-SIM,termed joint space and frequency reconstruction.This algorithm results in an 80-fold improvement in reconstruction speed relative to the widely used Wiener-SIM.Critically,the increased processing speed does not come at the expense of spatial resolution or sectioning capability,as demonstrated by live imaging of microtubule dynamics and mitochondrial tubulation. | Zhaojun Wang Tianyu Zhao Huiwen Hao Yanan Cai Kun Feng Xue Yun Yansheng Liang Shaowei Wang Yujie Sun Piero RBianco Kwangsung Oh Ming Lei | 2022 | Advanced Photonics2022，4，2： | 9 |
| 6 | Adaptive neuro fuzzy inference system for classification of water quality status显示文摘An adaptive neuro fuzzy inference system was used for classifying water quality status of river.It applied several physical and inorganic chemical indicators including dissolved oxygen,chemical oxygen demand,and ammonia-nitrogen.A data set (nine weeks,total 845 observations) was collected from 100 monitoring stations in all major river basins in China and used for training and validating the model.Up to 89.59% of the data could be correctly classified using this model.Such performance was more competitive when compared with artificial neural networks.It is applicable in evaluation and classification of water quality status. | Han Yan,Zhihong Zou,Huiwen Wang School of Economics and Management,Beihang University,Beijing 100191,China | 2010 | Journal of Environmental Sciences2010，22，12： | 9 |
| 7 | Ectopic expression of soybean GmKNT1 in Arabidopsis results in altered leaf morphology and flower identity显示文摘Plant morphology is specified by leaves and flowers, and the shoot apical meristem (SAM) defines the architecture of plant leaves and flowers. Here, we reported the characterization of a soybean KNOX gene GmKNT1, which was highly homologous to Arabidopsis STM. The GmKNT1 was strongly expressed in roots, flowers and developing seeds. Its expression could be induced by IAA, ABA and JA, but inhibited by GA or cytokinin. Staining of the transgenic plants overexpressing GmKNT1-GUS fusion protein revealed that the GmKNT1 was mainly expressed at lobe region, SAM of young leaves, sepal and carpel, not in seed and mature leaves. Scanning electron micros-copy (SEM) disclosed multiple changes in morphology of the epidermal cells and stigma. The transgenic Arabidopsis plants overexpress-ing the GmKNT1 showed small and lobed leaves, shortened internodes and small clustered inflorescence. The lobed leaves might result from the function of the meristems located at the boundary of the leaf. Compared with wild type plants, transgenic plants had higher ex-pression of the SAM-related genes including the CUP, WUS, CUC1, KNAT2 and KNAT6. These results indicated that the GmKNT1 could affect multiple aspects of plant growth and development by regulation of downstream genes expression. | Jun Liu Da Ha Zongming Xie Chunmei Wang Huiwen Wang Wanke Zhang Jinsong Zhang Shouyi Chen | 2008 | Journal of Genetics and Genomics2008，35，7： | 8 |
| 8 | 15-deoxy-△12,14-prostaglandin J2 ameliorates endotoxin-induced acute lung injury in rats显示文摘 | Geng Zhilong Zhu Wankun Wang Huiwen Chen Ye Liang Juan Liu Dong | 2014 | Chinese Medical Journal2014，，5： | 7 |
| 9 | Spatiotemporal evolution of carbon sequestration of limestone weathering in China显示文摘Carbonate carbon sequestration(CS) can aid in solving the problem of terrestrial residual carbon sinks and imbalances in the global carbon budget. Thus, complete understanding of the magnitude, spatiotemporal distribution, and evolution of this sequestration is highly desirable. On the basis of random forest regression and maximal potential dissolution model for carbonate, we estimated the CS of typical carbonate weathering in China from 2000 to 2014, that is, the sequestration of limestone weathering, using long-term ecologic, meteorological, hydrological raster data, and monitored data from 44 watersheds in China and surrounding regions. We extended our analyses by systematically exploring the spatiotemporal pattern and evolution trend of the flux and total sequestration. High levels of ionic activity coefficients of Ca^(2+) and HCO_3^- in limestone regions were observed to be mainly distributed in Northern and Northwestern China with a clear gradient from northwest to southeast. With a contrary spatial pattern, the annual average CS flux(CSF) of limestone weathering in China was estimated to be 4.28 t C km^(-2) yr^(-1), with high values mainly in the karst zones in Southeastern China. The mean CSF in different latitudes showed that Southern China(south of 28.14°N) was the region with the largest interannual fluctuation of flux and CSF increases as latitude decreases. The mean CSF in subtropical and tropical(TR) regions was the maximum of all major climate types, and for the frigid(F), mid-temperate(MTE), warm temperate(WTE), and temperate(TE) major climates; the CSF in the desert(D)subdivided climate was the minimum of these climates. By contrast, the values in grassland(G) and broad-leaved forest subdivided climate were the maximum. The pixel-based trend analysis indicated that the CSF of limestone weathering in China was slightly increasing in the period 2000–2014 with a rate of 0.036 t C km^(-2) yr^(-1). Furthermore, the annual total CS was estimated to be 7.07 Tg carbon per year(Tg C yr^(-1)) with high levels in 2002, 2008, and 2010, and the minimum appeared in 2011 with a slightly increasing trend of the total CS being observed with a rate of 0.06 Tg C yr^(-1). Tibet Autonomous Region was the administrative division with the largest total CS of limestone weathering(1.20 Tg C yr^(-1)) in China, and karst zones in Southeastern China had the largest total CS(4.95 Tg C yr^(-1)) which accounts for 70.01% of that in the three divided karst regions. On the basis of the diversity of rock chemical weathering carbon cycle mechanisms of different carbonate rock types, we estimated that the total CS of carbonate weathering in China may reach 11.37 Tg C yr^(-1)(the sink was approximately 5.02 t C km^(-2) yr^(-1)),which amounts to 16.20% of the total biomass CS in China, furthermore, the CSF of carbonate weathering in China can reach6.54 t C km^(-2) yr^(-1) if excluding the interference of the negative runoff. This finding indicates that CS of carbonate weathering is an indispensable part of China's terrestrial carbon sink system. The research pattern of this study was important for further improving the accuracy of the estimation for the global carbonate weathering carbon sink. | Huiwen LI Shijie WANG Xiaoyong BAI Yue CAO Luhua WU | 2019 | Science China Earth Sciences2019，62，6： | 7 |
| 10 | Review of Chinese atmospheric science research over the past 70 years: Synoptic meteorology显示文摘Synoptic meteorology is a branch of meteorology that uses synoptic weather observations and charts for the diagnosis,study,and forecasting of weather.Weather refers to the specific state of the atmosphere near the Earth’s surface during a short period of time.The spatial distribution of meteorological elements in the atmosphere can be represented by a variety of transient weather phenomena,which are caused by weather systems of different spatial and temporal scales.Weather is closely related to people’s life,and its development and evolution have always been the focus of atmospheric scientific research and operation.The development of synoptic meteorology is closely related to the development of observation systems,dynamical theories and numerical models.In China,observation networks have been built since the early 1950 s.Up to now,a comprehensive meteorological observation systembased on ground,air and space has been established.In particular,the development of a new generation of dense radar networks,the development of the Fengyun satellite series and the implementation of a series of large field experiments have brought our understanding of weather from large-scale environment to thermal dynamics,cloud microphysical structure and evolution characteristics of meso and micro-scale weather systems.The development of observation has also promoted the development of theory,numerical model and simulation.In the early days,China mainly used foreign numerical models.Lately,China has developed numerical model systems with independent intellectual property rights.Based on the results of high-resolution numerical simulations,in-depth understanding of the initiation and evolution mechanism and predictability of weather at different scales has been obtained.Synoptic meteorology has gradually changed from an initially independent development to a multidisciplinary approach,and the interaction between weather and the change of climate and environment has become a hot and frontier topic in atmospheric science.This paper reviews the important scientific and technological achievements made in China over the past 70 years in the fields of synoptic meteorology based on the literatures in China and abroad,from six aspects respectively including atmospheric dynamics,synoptic-scale weather,typhoon and tropical weather,severe convective weather,numerical weather prediction and data assimilation,weather and climate,atmospheric physics and atmospheric environment. | Zhiyong MENG Fuqing ZHANG Dehai LUO Zhemin TAN Juan FANG Jianhua SUN Xueshun SHEN Yunji ZHANG Shuguang WANG Wei HAN Kun ZHAO Lei ZHU Yongyun HU Huiwen XUE Yaping MA Lijuan ZHANG Ji NIE Ruilin ZHOU Sa LI Hongjun LIU Yuning ZHU | 2019 | Science China Earth Sciences2019，62，12： | 7 |
| 11 | Whole-genome sequencing to detect mutations associated with resistance to insecticides and Bt proteins in Spodoptera frugiperda显示文摘The fall armyworm(FAW),Spodoptera frugiperda,is a major pest native to the Americas that has recently invaded the Old World.Point mutations in the target-site proteins acetylcholinesterase-1(ace-1),voltage-gated sodium channel(VGSC)and ryanodine receptor(RyR)have been identified in S.frugiperda as major resistance mechanisms to organophosphate,pyrethroid and diamide insecticides respectively.Mutations in the adenosine triphosphate-binding cassette transporter C2 gene(ABCC2)have also been identified to confer resistance to Cry IF protein.In this study,we applied a whole-genome sequencing(WGS)approach to identify point mutations in the target-site genes in 150 FAW individuals collected from China,Malawi,Uganda and Brazil.This approach revealed three amino acid substitutions(A201S,G227A and F290V)of S.frugiperda ace-1,which are known to be associated with organophosphate resistance.The Brazilian population had all three ace-1 point mutations and the 227A allele(mean frequency=0.54)was the most common.Populations from China,Malawi and Uganda harbored two of the three ace-1 point mutations(A201S and F290V)with the 290V allele(0.47-0.58)as the dominant allele.Point mutations in VGSC(T929I,L932F and L1014F)and RyR(I4790M and G4946E)were not detected in any of the 150 individuals.A novel 12-bp insertion mutation in exon 15 of the ABCC2 gene was identified in some of the Brazilian individuals but absent in the invasive populations.Our results not only demonstrate robustness of the WGS-based genomic approach for detection of resistance mutations,but also provide insights for improvement of resistance management tactics in S.frugiperda. | Fang Guan Jianpeng Zhang Huiwen Shen Xingliang Wang Amanda Padovan Tom K.Walsh Wee Tek Tay Karl H.J.Gordon William James Cecilia Czepak Michael Hilary Otim Donald Kachigamba Yidong Wu | 2021 | Insect Science2021，28，3： | 6 |
| 12 | PLS1回归对多变量信息的综合与筛选作用分析显示文摘王惠文,PLS1回归对多变量信息的综合与筛选作用分析,数理统计与管理,1998,17(4),46~49。本文讨论了PLS1回归对多变量系统中的信息进行综合与筛选的工作策略。通过例证分析指出,PLS1回归方法可以有效地提取对系统解释性最强的综合变量,排除重叠信息或无解释意义的信息干扰。 | Wang Huiwen(School of Management,Beijing University of Aeronautics and Astronaudics) | 1998 | 数理统计与管理1998，17，4： | 4 |
| 13 | LINEAR REGRESSION OF INTERVAL-VALUED DATA BASED ON COMPLETE INFORMATION IN HYPERCUBES显示文摘最近的年在珍视间隔的数据分析见证增加的兴趣。作为核心话题之一,线性回归吸引特别注意。它试图由适合一个线性方程到珍视间隔的观察为在至少一个解释变量和一个反应变量之间的关系建模。尽管有象厘米,在文学建议的 CRM 和 CCRM 那样的著名方法,进一步的学习仍然被需要造能在珍视间隔的观察捕获完全的信息的一个回归模型。到这个目的,在这份报纸,我们为线性回归建模建议新奇完全的信息方法(计算机输入缩微胶卷) 。由把 hypercubes 划分成增进知识的格子数据,计算机输入缩微胶卷定义珍视间隔的变量的内部产品,并且转变当模特儿进一些内部产品的计算的回归。合成、真实世界的数据设置的两个的实验在为珍视间隔的数据建模,并且避免厘米和 CRM 介绍的数学松散表明计算机输入缩微胶卷的优点。 | Huiwen WANG Rong GUAN Junjie WU | 2012 | Journal of Systems Science and Systems Engineering2012，21，4： | 3 |
| 14 | GCN2 deficiency protects mice from denervation-induced skeletal muscle atrophy via inhibiting FoxO3a nuclear translocation显示文摘 | Yuting Guo Huiwen Wang Yinglong Tang Yue Wang Mengqi Zhang Zhiguang Yang Eric Nyirimigabo Bin Wei Zhongbing Lu Guangju Ji | 2018 | Protein & Cell2018，9，11： | 3 |
| 15 | Environmental Conditions of Barchan Dune and Barchan Chain-A Case Study from the Hexi Desert Area of Gansu显示文摘[Objective] The paper was to discuss why the top of tall barchan dunes and barchan chains widespread in single prevailing wind area had not been leveled by wind erosion. [Method] Based on the preliminary survey of distribution status,the morphological characteristics and environmental conditions of barchan dunes and barchan chains in Hexi desert area of Gansu were investigated in details. The significance of difference between samples and significance of correlation between indicators were examined via variance test. [Result] Barchan dunes and barchan chains in Hexi desert area of Gansu distributed at the leeward direction of desert fringe,generally in patch distribution. The distribution area was gravelly beach or cohesive gravel beach,with broader dune slack; winds in distribution area of barchan dunes and barchan chains blew obviously from one direction,while winds at other directions were light or occasionally strong but with low frequency;the barchan dune in the desert fringe of Hexi desert area of Gansu was relatively tall,while barchan chain was even more taller and larger. Coincidence or separation of the dune peak and the sand ridge might be related to distribution frequency of dominant prevailing wind or wind at opposite direction and the observation seasons.[Conclusion]Studying top stability of barchan dune has an important academic value in revealing blowing sand movement rule at desert fringe,invasion of sand flow,and expansion of desert. | Chang Zhaofeng Wang Qiangqiang Zhang Jianhui Xi Junqiang Wang Qi Zhang Dekui Tang Jinnian Zhang Huiwen | 2015 | Animal Husbandry and Feed Science2015，7，6： | 2 |
| 16 | Postharvest BTH treatment induced disease resistance and enhanced reactive oxygen species metabolism in muskmelon (Cucumis melo L.) fruit显示文摘 | Yalin Ren Yunfei Wang Yang Bi Yonghong Ge Yi Wang Cunfei Fan Daqiang Li Huiwen Deng | 2012 | European Food Research and Technology2012，，6： | 2 |
| 17 | A Review of Blockchain Layered Architecture and Technology Application Research显示文摘The development of blockchain is at a nascent stage.Current research on blockchain mainly focuses on a single technology,failing to reflect the correlation between the integrated technologies due to a lack of application in the real world.In this paper,according to the function classification,we divide blockchain technology into five layers:the data layer,the network layer,the consensus layer,the contract layer,and the application layer.For each layer,we elaborate on its technical principles and the latest research status.We also provide empirical cases of blockchain application.This paper summarizes the general functional modules of the blockchain to support the rapid implementation of blockchain applications.In the end,we investigate the challenges faced by blockchain technology and present the research prospects. | WANG Changjing JIANG Huiwen ZENG Jingshan YU Min HUANG Qing ZUO Zhengkang | 2021 | Wuhan University Journal of Natural Sciences2021，26，5： | 2 |
| 18 | Sieve M-estimator for a semi-functional linear model显示文摘We propose sieve M-estimator for a semi-functional linear model in which the scalar response is explained by a linear operator of functional predictor and smooth functions of some real-valued random variables.Spline estimators of the functional coefficient and the smooth functions are considered,and by selecting appropriate knot numbers the optimal convergence rate and the asymptotic normality can be obtained under some mild conditions.Some simulation results and a real data example are presented to illustrate the performance of our estimation method. | HUANG LeLe WANG HuiWen CUI HengJian WANG SiYang | 2015 | Science China Mathematics2015，58，11： | 2 |
| 19 | Cytokine nanosponges suppressing overactive macrophages and dampening systematic cytokine storm for the treatment of hemophagocytic lymphohistiocytosis显示文摘Hemophagocytic lymphohistiocytosis(HLH)is a highly fatal condition with the positive feedback loop between continued immune cell activation and cytokine storm as the core mechanism to mediate multiple organ dysfunction.Inspired by macrophage membranes harbor the receptors with special high affinity for proin-flammation cytokines,lipopolysaccharide(LPS)-stimulated macrophage membrane-coated nanoparticles(LMNP)were developed to show strong sponge ability to both IFN-γand IL-6 and suppressed overactivation of macrophages by inhibiting JAK/STAT signaling pathway both in vitro and in vivo.Besides,LMNP also efficiently alleviated HLH-related symptoms including cytopenia,hepatosplenomegaly and hepatorenal dysfunction and save the life of mouse models.Furthermore,its sponge effect also worked well for five human HLH samples in vitro.Altogether,it’s firstly demonstrated that biocompatible LMNP could dampen HLH with high potential for clinical transformation,which also provided alternative insights for the treatment of other cytokine storm-mediated pathologic conditions such as COVID-19 infection and cytokine releasing syndrome during CAR-T therapy. | Honglan Wang Huiwen Liu Jia Li Chunying Liu Hui Chen Junying Li Chunyan Sun Tao Guo Zhiqing Pang Bo Zhang Yu Hu | 2023 | Bioactive Materials2023，，3： | 1 |
| 20 | Prepration of Magnefic Lipsomes Encapsulating Fibrinplytic Enzymes of Earthworm显示文摘 | Jing Tianyu Wang Huiwen Zhao Xiaoyu | 1999 | Journal of Hebeuniversity1999，19，4： | 1 |
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