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| 1 | High strength and high conductivity Cu alloys: A review显示文摘High strength and high conductivity(HSHC) Cu alloys are widely used in many fields,such as high-speed electric railway contact wires and integrated circuit lead frames. Pure Cu is well known to have excellent electrical conductivity but rather low strength. The main concern of HSHC Cu alloys is how to strengthen the alloy efficiently. However,when the Cu alloys are strengthened by a certain method,their electrical conductivity will inevitably decrease to a certain extent. This review introduces the strengthening methods of HSHC Cu alloys. Then the research progress of some typical HSHC Cu alloys such as Cu-Cr-Zr,Cu-Ni-Si,Cu-Ag,Cu-Mg is reviewed according to different alloy systems. Finally,the development trend of HSHC Cu alloys is forecasted. It is pointed out that precipitation and micro-alloying are effective ways to improve the performance of HSHC Cu alloys. At the same time,the production of HSHC Cu alloys also needs to comply with the large-scale,low-cost development trend of industrialization in the future. | YANG HuiYa MA ZiChao LEI ChenHui MENG Liang FANG YouTong LIU JiaBin WANG HongTao | 2020 | Science China(Technological Sciences)2020，63，12： | 7 |
| 2 | Comprehensive characterization of CRC with germline mutations reveals a distinct somatic mutational landscape and elevated cancer risk in the Chinese population显示文摘Objective:Hereditary colorectal cancer(CRC)accounts for approximately 5%–10%of all CRC cases.The full profile of CRC-related germline mutations and the corresponding somatic mutational profile have not been fully determined in the Chinese population.Methods:We performed the first population study investigating the germline mutation status in more than 1,000(n=1,923)Chinese patients with CRC and examined their relationship with the somatic mutational landscape.Germline alterations were examined with a 58-gene next-generation sequencing panel,and somatic alterations were examined with a 605-gene panel.Results:A total of 92 pathogenic(P)mutations were identified in 85 patients,and 81 likely pathogenic(LP)germline mutations were identified in 62 patients,accounting for 7.6%(147/1,923)of all patients.MSH2 and APC was the most mutated gene in the Lynch syndrome and non-Lynch syndrome groups,respectively.Patients with P/LP mutations had a significantly higher ratio of microsatellite instability,highly deficient mismatch repair,family history of CRC,and lower age.The somatic mutational landscape revealed a significantly higher mutational frequency in the P group and a trend toward higher copy number variations in the non-P group.The Lynch syndrome group had a significantly higher mutational frequency and tumor mutational burden than the nonLynch syndrome group.Clustering analysis revealed that the Notch signaling pathway was uniquely clustered in the Lynch syndrome group,and the MAPK and cAMP signaling pathways were uniquely clustered in the non-Lynch syndrome group.Population risk analysis indicated that the overall odds ratio was 11.13(95%CI:8.289–15.44)for the P group and 20.68(95%CI:12.89–33.18)for the LP group.Conclusions:Distinct features were revealed in Chinese patients with CRC with germline mutations.The Notch signaling pathway was uniquely clustered in the Lynch syndrome group,and the MAPK and cAMP signaling pathways were uniquely clustered in the non-Lynch syndrome group.Patients with P/LP germline mutations exhibited higher CRC risk. | Jianfei Yao Yunhuan Zhen Jing Fan Yuan Gong Yumeng Ye Shaohua Guo Hongyi Liu Xiaoyun Li Guosheng Li Pan Yang Xiaohui Wang Danni Liu Tanxiao Huang Huiya Cao Peisu Suo Yuemin Li Jingbo Yu Lele Song | 2022 | Cancer Biology & Medicine2022，19，5： | 1 |
| 3 | In-situ construction of a thermodynamically stabilized interface on the surface of single crystalline Ni-rich cathode materials via a onestep molten-salt route显示文摘Nickel rich LiNi_(x)Co_(y)Mn_(1−x−y)O_(2)cathode materials have been studied extensively to increase the energy density of lithium-ion batteries(LIBs)due to their advantages of high capacity and low cost.However,the anisotropic crystal expansion and contraction inside the secondary particles would cause detrimental micro-cracks and severe parasitic reactions at the electrode/electrolyte interface during cycling,which severely decreases the stability of crystalline structure and cathodeelectrolyte interphase and ultimately affects the calendar life of batteries.Herein,a thermodynamically stabilized interface is constructed on the surface of single-crystalline Ni-rich cathode materials(SC811@RS)via a facile molten-salt route to suppress the generation of microcracks and interfacial parasitic side reactions simultaneously.Density functional theory calculations show that the formation energy of interface layer(−1.958 eV)is more negative than that of bulk layered structure(−1.421 eV).Such a thermodynamically stable protective layer can not only prevent the direct contact between highly reactive LiNi_(x)Co_(y)Mn_(1−x−y)O_(2)and electrolyte,but also mitigate deformation of structure caused by stress thus strengthening the mechanical properties.Raman spectra further confirm the excellent structural reversibility and reaction homogeneity of SC811@RS at particle,electrode,time scales.Consequently,SC811@RS cathode material delivers significantly improved cycling stability(high capacity retention of 92%after 200 cycles at 0.5 C)compared with polycrystalline LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)(82%). | Huiya Yang Xiangbang Kong Jiyang Li Pengpeng Dai Jing Zeng Yang Yang Jinbao Zhao | 2023 | Nano Research2023，16，5： | 0 |
| 4 | Progress in research on nanoprecipitates in high-strength conductive copper alloys: a review显示文摘High-strength conductive Cu alloys play an essential role in high-speed railways,5G networks,and power transmission.The compound precipitates of alloying elements such as Cr,Zr,Fe,and Si in Cu alloys significantly regulate the microstructure and properties of these alloys.They can ensure that the alloys have high strength without damaging conductivity seriously,which is usually a difficult problem in the development of Cu alloys.This paper systematically expounds on the microstructure and concerned factors of compound precipitates in high-strength conductive Cu alloys such as Cu-Cr-Zr,Cu-Zr,Cu-Ni-Si,and Cu-Fe-P.In particular,factors affecting the precipitates are summarized from the perspectives of composition and process to guide the regulation of properties.Some new,promising,high-performance Cu alloys,including Cu-Co-Si,Cu-Co-Ti,and Cu-Fe-Ti,are described.Finally,we look at the research prospects for precipitation-strengthened Cu alloys. | Jian YU Feng ZHAO Huiya YANG Jiabin LIU Jien MA Youtong FANG | 2023 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2023，24，3： | 0 |
| 5 | Experimental and numerical investigation into the non-explosive excavation of tunnels显示文摘The use of explosives is restricted on some important holidays,and the handling of unexploded charge is very dangerous.Therefore,an innovative non-explosive technology called instantaneous expansion(IE)was developed for tunneling.IE,whose components are derived from solid wastes such as coal gangue and straw conduces to realizing the reuse of waste.Moreover,its cost is lower than explosives.Blind guns of IE are easy to treat with water.The IE tunneling method is classified into two categories,i.e.IE with a single fracture(IESF)and IE with multiple fractures(IEMF),which are used to form the tunnel crosssection directionally cross-section and to fragment the rocks inside the cross-section,respectively.In this study,the principle of IE tunneling was elaborated first.Then,tunneling experiments and numerical simulations were performed on IE,conventional blasting(CB)and shaped charge blasting(SCB)in comparison.The experimental and numerical results show that IE achieved the best performance of directional rock breaking and corresponded to the most minor excavation-induced damage zone of the surrounding rock.Besides,the tunnel cross-section created by IE was flat and smooth.Comparing IE with CB and SCB,the over/under-excavation area decreased by 64%and 17%,and the excavation-induced damage zone fell by 26%and 11%,respectively.The range of the loose circle is reduced,which is conducive to improving the long-term stability of the roadway.The research provides a safe and economical tunneling method with excellent application prospects. | Quan Zhang Zhigang Tao Chun Yang Shan Guo Manchao He Chongyuan Zhang Huiya Niu Chao Wang Shen Wang | 2022 | Journal of Rock Mechanics and Geotechnical Engineering2022，14，6： | 0 |
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