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| 1 | Transplantation of collagen scaffold with autologous bone marrow mononuclear cells promotes functional endometrium reconstruction via downregulating ΔNp63 expression in Asherman's syndrome显示文摘Asherman's syndrome(AS) is a common disease that presents endometrial regeneration disorder. However, little is known about its molecular features of this aregenerative endometrium in AS and how to reconstruct the functioning endometrium for the patients with AS. Here, we report that ΔNp63 is significantly upregulated in residual epithelial cells of the impaired endometrium in AS; the upregulated-ΔNp63 induces endometrial quiescence and alteration of stemness. Importantly, we demonstrate that engrafting high density of autologous bone marrow mononuclear cells(BMNCs) loaded in collagen scaffold onto the uterine lining of patients with AS downregulates ΔNp63 expression, reverses ΔNp63-induced pathological changes, normalizes the stemness alterations and restores endometrial regeneration. Finally, five patients achieved successful pregnancies and live births. Therefore, we conclude that ΔNp63 is a crucial therapeutic target for AS. This novel treatment significantly improves the outcome for the patients with severe AS. | Guangfeng Zhao Yun Cao Xianghong Zhu Xiaoqiu Tang Lijun Ding Haixiang Sun Juan Li Xinan Li Chenyan Dai Tong Ru Hui Zhu Jingjie Lu Caimei Lin Jingmei Wang Guijun Yan Huiyan Wang Lei Wang Yimin Dai Bin Wang Ruotian Li Jianwu Dai Yan Zhou Yali Hu | 2017 | Science China(Life Sciences)2017，60，4： | 39 |
| 2 | Assessment of cognitive dysfunction in traumatic brain injury patients:a review显示文摘Traumatic brain injury(TBI)is one of the major causes of human mortality and morbidity in the world.Brain injury could affect the core of a person’s being–their thinking,memory,personality and behaviour.Electrophysiological markers from the human electroencephalogram and brain imaging provide a rich source of data which helps to elucidate specific processing impairments in TBI patients.To assess the cognitive and social function in traumatic brain injury patients,this review will focus on some of methods for assessing the disabling cognitive and social function deficits induced by TBI.There are many new technologies available to address TBI and recognition related questions.Integration of the various techniques will help to facilitate our comprehending of TBI,cognitive function and social function,and improve treatment and rehabilitation. | Huiyan Sun Chengliang Luo Xiping Chen Luyang Tao | 2017 | Forensic Sciences Research2017，2，4： | 5 |
| 3 | Warburg Effects in Cancer and Normal Proliferating Cells:Two Tales of the Same Name显示文摘It has been observed that both cancer tissue cells and normal proliferating cells(NPCs)have the Warburg effect.Our goal here is to demonstrate that they do this for different reasons.To accomplish this,we have analyzed the transcriptomic data of over 7000 cancer and control tissues of 14 cancer types in TCGA and data of five NPC types in GEO.Our analyses reveal that NPCs accumulate large quantities of ATPs produced by the respiration process before starting the Warburg effect,to raise the intracellular pH from 6.8 to 7.2 and to prepare for cell division energetically.Once cell cycle starts,the cells start to rely on glycolysis for ATP generation followed by ATP hydrolysis and lactic acid release,to maintain the elevated intracellular pH as needed by cell division since together the three processes are pH neutral.The cells go back to the normal respirationbased ATP production once the cell division phase ends.In comparison,cancer cells have reached their intracellular pH at 7.4 from top down as multiple acid-loading transporters are up-regulated and most acid-extruding ones except for lactic acid exporters are repressed.Cancer cells use continuous glycolysis for ATP production as way to acidify the intracellular space since the lactic acid secretion is decoupled from glycolysis-based ATP generation and is pH balanced by increased expressions of acid-loading transporters.Co-expression analyses suggest that lactic acid secretion is regulated by external,non-pH related signals.Overall,our data strongly suggest that the two cell types have the Warburg effect for very different reasons. | Huiyan Sun Liang Chen Sha Cao Yanchun Liang Ying Xu | 2019 | Genomics, Proteomics & Bioinformatics2019，17，3： | 4 |
| 4 | The role of MAPK and FAS death receptor pathways in testicular germ cell apoptosis induced by lead显示文摘现在的学习的目的是调查在阴囊的细菌房间的导致铅的 apoptosis 涉及 MAPK 的信号小径和船边交货的死亡信号受体小径的基因表示。首先,房间生存能力被 MTT 试金决定。第二,使用单个房间胶化电气泳动测试(彗星试金) 和染色技术, apoptotic 率和阴囊的细菌房间的房间 apoptosis 本地化的 TUNEL 在分别地与 0.15% , 0.3% ,和 0.6% 铅一起对待的老鼠被测量。第三, K 地岬, c-fos,船边交货,和活跃 caspase-3 蛋白质的 immunolocalization 被 immunohistochemistry 决定。最后,在 K 地岬, c-fos,船边交货,和活跃 caspase-3 的翻译层次的变化被西方的污点分析进一步检测。我们的结果证明铅能显著地以一种剂量依赖者方式导致阴囊的细菌房间 apoptosis (P < 0.01 ) 。机制是仔细与在 apoptotic 细菌房间的 K 地岬, c-fos,船边交货,和活跃 caspase-3 的增加的表情有关。在结论, K-ras/c-fos 和 Fas/caspase-3 死亡发信号受体小径在老鼠涉及阴囊的细菌房间的导致铅的 apoptosis。 | Shuying Dong Duoping Liang Na An Li Jia Yujuan Shan Chao Chen Kuo Sun Fei Niu Huiyan Li Songbin Fu | 2009 | Acta Biochimica et Biophysica Sinica2009，41，9： | 4 |
| 5 | Fenton reactions drive nucleotide and ATP syntheses in cancer显示文摘我们在场 14 癌症的织物 transcriptomic 数据的计算研究打字到地址:什么可以驾驶癌症房间分割?我们到由 Fenton 反应的细胞内部的 pH 的那坚持的混乱的分析点可能在癌症开发的根。明确地,我们统计上证明了 Fenton 反应发生在癌症 cytosol,越过所有 14 癌症的线粒体打字,基于经由 Michaelis-Menten 方程综合的癌症组织基因表示数据。另外,我们证明了在疾病房间的 cytosol 的(i) Fenton 反应将连续地房间由产生网质子通过综合的联合使 pH 稳定,对哪个作出回应增加他们的 pH 对哪个 glycolytic ATP 并且由核苷酸综合体消费他们,它可以驱使房间分割连续地综合的核苷酸根除;并且(ii ) 在线粒体的 Fenton 反应与最终来自 H 2 O 2, 大部分从有免疫力的房间发源。一个模型被开发连接这些到癌症开发,在一些变化可以被选择以 Fenton 反应支配的率便于房间分割的地方。 | Huiyan Sun Chi Zhang Sha Cao Tao Sheng Ning Dong Ying Xu | 2018 | Journal of Molecular Cell Biology2018，10，5： | 2 |
| 6 | Angiopoietin-1 and Vascular Endothelial Growth Factor Regulation of Leukocyte Adhesion to Endothelial Cells: Role of Nuclear Receptor-77显示文摘 | Hodan Ismail Mahroo Mofarrahi Raquel Echavarria Sharon Harel Eric Verdin Hyung W. Lim Zheng-Gen Jin Jianxin Sun Huiyan Zeng Sabah N.A. Hussain | 2012 | Arteriosclerosis Thrombosis and Vascular Biology2012，，7： | 1 |
| 7 | Determination of clenbuterol from pork samples using surface molecularly imprinted polymers as the selective sorbents for microextraction in packed syringe显示文摘 | Wei Du Chunmei Lei Siruo Zhang Gang Bai Huiyan Zhou Min Sun Qiang Fu Chun Chang | 2013 | Journal of Pharmaceutical and Biomedical Analysis2013，，： | 1 |
| 8 | Rapid puff?cation of polysaccharides using novel radial ?ow ion-exchange by response surface methodology from Ganoderma lucidum 显示文摘 | JIANG Huiyan SUN Peilong HE Jinzhe | 2012 | Food and Bioproducts Process- ing2012，90，1： | 1 |
| 9 | Effect of autologous bone marrow stem cells-scaffold transplantation on the ongoing pregnancy rate in intrauterine adhesion women:a randomized,controlled trial显示文摘Intrauterine adhesion is a major cause of female reproductive disorders.Although we and others uncontrolled pilot studies showed that treatment with autologous bone marrow stem cells made a few patients with severe intrauterine adhesion obtain live birth,no large sample randomized controlled studies on this therapeutic strategy in such patients have been reported so far.To verify if the therapy of autologous bone marrow stem cells-scaffold is superior to traditional treatment in moderate to severe intrauterine adhesion patients in increasing their ongoing pregnancy rate,we conducted this randomized controlled clinical trial.Totally 195 participants with moderate to severe intrauterine adhesion were screened and 152 of them were randomly assigned in a 1:1 ratio to either group with autologous bone marrow stem cells-scaffold plus Foley balloon catheter or group with only Foley balloon catheter(control group)from February 2016 to January 2020.The per-protocol analysis included 140 participants:72 in bone marrow stem cells-scaffold group and 68 in control group.The ongoing pregnancy occurred in 45/72(62.5%)participants in the bone marrow stem cells-scaffold group which was significantly higher than that in the control group(28/68,41.2%)(RR=1.52,95%CI 1.08–2.12,P=0.012).The situation was similar in live birth rate(bone marrow stem cells-scaffold group 56.9%(41/72)vs.control group 38.2%(26/68),RR=1.49,95%CI 1.04–2.14,P=0.027).Compared with control group,participants in bone marrow stem cells-scaffold group showed more menstrual blood volume in the 3rd and 6th cycles and maximal endometrial thickness in the 6th cycle after hysteroscopic adhesiolysis.The incidence of mild placenta accrete was increased in bone marrow stem cells-scaffold group and no severe adverse effects were observed.In conclusion,transplantation of bone marrow stem cells-scaffold into uterine cavities of the participants with moderate to severe intrauterine adhesion increased their ongoing pregnancy and live birth rates,and this therapy was relatively safe. | Hui Zhu Taishun Li Peizhen Xu Lijun Ding Xianghong Zhu Bin Wang Xiaoqiu Tang Juan Li Pengfeng Zhu Huiyan Wang Chenyan Dai Haixiang Sun Jianwu Dai Yali Hu | 2024 | Science China(Life Sciences)2024，67，1： | 0 |
| 10 | Gene regulatory network inference based on causal discovery integrating with graph neural network显示文摘Gene regulatory network (GRN) inference from gene expression data is asignificant approach to understanding aspects of the biological system.Compared with generalized correlation-based methods, causality-inspiredones seem more rational to infer regulatory relationships. We proposeGRINCD, a novel GRN inference framework empowered by graph representationlearning and causal asymmetric learning, considering both linearand non-linear regulatory relationships. First, high-quality representation ofeach gene is generated using graph neural network. Then, we apply theadditive noise model to predict the causal regulation of each regulator-targetpair. Additionally, we design two channels and finally assemble them forrobust prediction. Through comprehensive comparisons of our frameworkwith state-of-the-art methods based on different principles on numerousdatasets of diverse types and scales, the experimental results show that ourframework achieves superior or comparable performance under variousevaluation metrics. Our work provides a new clue for constructing GRNs,and our proposed framework GRINCD also shows potential in identifyingkey factors affecting cancerdevelopment. | Ke Feng Hongyang Jiang Chaoyi Yin Huiyan Sun | 2023 | Quantitative Biology2023，11，4： | 0 |
| 11 | Electrolyte Strategies Toward Optimizing Zn Anode for Zinc-Ion Batteries显示文摘Zinc-ion batteries(ZIBs)with low cost and high safety have become potential candidates for large-scale energy storage.However,the knotty Zn anode issues such as dendritic growth,hydrogen evolution reaction(HER)and corrosion and passivation are still unavoidable,which greatly limits the wide applications of ZIBs.The states and additives of electrolytes are closely related to these problems.However,there is a lack of systematic understanding and discussion about the intrinsic connection between the states and additives of electrolyte and Zn anode issues.In this review,the basic principles of dendritic growth,HER and corrosion and passivation are fi rstly introduced,and then,electrolyte optimization strategies with the corresponding electrochemical properties are systematically summarized.In particular,the action mechanism of electrolyte additives and the electrolyte states for Zn anode optimization is analyzed in detail.Finally,some unique views on the improvement of electrolyte for Zn anode optimization are put forward,which is expected to provide a certain professional reference for designing high-performance ZIBs. | Zenglong Xu Huiyan Xu Jinfeng Sun Jieqiang Wang Degang Zhao Bingqiang Cao Xiutong Wang Shuhua Yang | 2023 | Transactions of Tianjin University2023，29，6： | 0 |
| 12 | Research on Reimbursement Management of Innovative Drugs Abroad and Its Enlightenment to China显示文摘Objective To analyze the reimbursement policies of innovative drugs in some developed countries,and to provide reference for future reimbursement management in China.Methods Literature research method was used to study the policies related to the reimbursement management of innovative drugs in Germany,France and Japan,and their successful experience was summarized.Results and Conclusion China should establish an open and transparent value evaluation standard to improve the medical insurance reimbursement management of innovative drugs.Besides,the value of innovative drugs should be taken as an important basis for reimbursement decisions,and an independent third-party value evaluation agency must be established. | Yu Hanshuang Huang Xianqin Wang Huiyan Sun Lihua | 2024 | Asian Journal of Social Pharmacy2024，19，1： | 0 |
| 13 | Energy-Efficient Deployment of Water Quality Sensor Networks显示文摘Water quality sensor networks are promising tools for the exploration of oceans.Some key areas need to be monitored effectively.Water quality sensors are deployed randomly or uniformly,however,and understanding how to deploy sensor nodes reasonably and realize effective monitoring of key areas on the basis of monitoring the whole area is an urgent problem to be solved.Additionally,energy is limited in water quality sensor networks.When moving sensor nodes,we should extend the life cycle of the sensor networks as much as possible.In this study,sensor nodes in non-key monitored areas are moved to key areas.First,we used the concentric circle method to determine the mobile sensor nodes and the target locations.Then,we determined the relationship between the mobile sensor nodes and the target locations according to the energy matrix.Finally,we calculated the shortest moving path according to the Floyd algorithm,which realizes the redeployment of the key monitored area.The simulation results showed that,compared with the method of direct movement,the proposed method can effectively reduce the energy consumption and save the network adjustment time based on the effective coverage of key areas. | Qian Sun Zhiping Shen Jinglin Liang Xiaoyi Wang Jiping Xu Li Wang Huiyan Zhang Jiabin Yu Ning Cao Ruichao Wang | 2021 | Computers, Materials & Continua2021，，9： | 0 |
| 14 | Network Invulnerability Enhancement Algorithm Based on WSN Closeness Centrality显示文摘Wireless Sensor Network(WSN)is an important part of the Internet of Things(IoT),which are used for information exchange and communication between smart objects.In practical applications,WSN lifecycle can be influenced by the unbalanced distribution of node centrality and excessive energy consumption,etc.In order to overcome these problems,a heterogeneous wireless sensor network model with small world characteristics is constructed to balance the centrality and enhance the invulnerability of the network.Also,a new WSN centrality measurement method and a new invulnerability measurement model are proposed based on the WSN data transmission characteristics.Simulation results show that the life cycle and data transmission volume of the network can be improved with a lower network construction cost,and the invulnerability of the network is effectively enhanced. | Qian Sun Fengbo Yang Xiaoyi Wang Jing Li Jiping Xu Huiyan Zhang Li Wang Jiabin Yu Xiao Peng Ruichao Wang | 2022 | Computers, Materials & Continua2022，，11： | 0 |
| 15 | Optimal Deployment of Heterogeneous Nodes to Enhance Network Invulnerability显示文摘Wireless sensor networks(WSN)can be used in many fields.In wireless sensor networks,sensor nodes transmit data in multi hop mode.The large number of hops required by data transmission will lead to unbalanced energy consumption and large data transmission delay of the whole network,which greatly affects the invulnerability of the network.Therefore,an optimal deployment of heterogeneous nodes(ODHN)algorithm is proposed to enhance the invulnerability of the wireless sensor networks.The algorithm combines the advantages of DEEC(design of distributed energy efficient clustering)clustering algorithm and BAS(beetle antenna search)optimization algorithm to find the globally optimal deployment locations of heterogeneous nodes.Then,establish a shortcut to communicate with sink nodes through heterogeneous nodes.Besides,considering the practical deployment operation,we set the threshold of the mobile location of heterogeneous nodes,which greatly simplifies the deployment difficulty.Simulation results show that compared with traditional routing protocols,the proposed algorithm can make the network load more evenly,and effectively improve energy-utilization and the fault tolerance of the whole network,which can greatly improve the invulnerability of the wireless sensor networks. | Qian Sun Fengbo Yang Xiaoyi Wang Jiping Xu Huiyan Zhang Li Wang Jiabin Yu Xiao Peng Ruichao Wang | 2022 | Computers, Materials & Continua2022，，11： | 0 |
| 16 | Suppression of cell pyroptosis by omeprazole through PDE4-mediated autophagy in gastric epithelial cells显示文摘Helicobacter pylori is a risk factor for the development of peptic ulcers with autophagy dysfunction.Omeprazole was widely known as the first-line regimen for H.pylori-associated gastritis.Objectives:The objective of this work was to assess the role of omeprazole on cell pyroptosis and autophagy.Methods:The clinical samples were collected.Quantitative polymerase chain reaction,western blotting,enzyme linked immunosorbent assay,and immunofluorescence(IF)analysis were conducted to reveal the mechanism of omeprazole on cell pyroptosis and autophagy.Results:The results revealed that omeprazole could decrease cell pyroptosis,which was attributed to the downregulation of cleaved caspase-1 expression,resulting in the inhibition of gasdermin E and interleukin-18/1βmaturation and secretion as well as the resolution of inflammation.Mechanistically,omeprazole treatment led to drastic downregulation of mammalian target of rapamycin(mTOR)activity was observed in BGC823 cells,leading to enhanced autophagy characterized by increased LC3II expression,which further reduced cell pyroptosis.This omeprazole-mediated phenomenon was enhanced after phosphodiesterase-4(PDE4)inhibitor dipyridamole(DIP)treatment.In addition,activation of mTOR by MHY1485 could rescue the suppression of cell pyroptosis induced by omeprazole.Most importantly,IF analysis suggested that phosphorylation of mTOR and PDE4 activity and caspase-1 were enhanced in H.pylori-infected gastric mucosa.Conclusion:These findings indicate that omeprazole suppresses cell pyroptosis through PDE4-mediated autophagy in gastric epithelial cells,and DIP enhanced the omeprazole-mediated inhibition of cell pyroptosis,implying that DIP is an alternative combined therapy strategy in improving the treatment of patients with H.pylori infection. | LIPING YE HUIYAN SUN XINHUA LIANG WENXU PAN LI XIANG WENJUN DU LANLAN GENG WANFU XU SITANG GONG | 2023 | BIOCELL2023，47，12： | 0 |
| 17 | Foreign Experience and Enlightenment of Reimbursement Management of Multi-indication Drugs显示文摘Objective To provide reference for China’s medical insurance reimbursement plan of multi-indication drugs.Methods By referring to relevant foreign literature,the implementation process and conditions of different reimbursement management modes of multi-indication drugs were analyzed to provide suggestions for reimbursement of multi-indication drugs in China.Results and Conclusion It is suggested to further explore the suitable conditions and select the corresponding mode in China.Payment standards should be set according to value pricing and budget impact analysis.Besides,data collection and analysis mechanism must be improved.Lastly,reward and punishment mechanism can be adopted to improve management efficiency. | Wang Huiyan Yu Hanshuang Sun Lihua | 2023 | Asian Journal of Social Pharmacy2023，18，4： | 0 |
| 18 | Molecular movements of trehalose inside a single network enabling a rapidly-recoverable tough hydrogel显示文摘It remains a challenge to achieve rapidly recoverable hydrogels by molecular hydrogen-bonding interaction because of its slow inter-action kinetics.This work for the first time reports a trehalose(Tre)-based molecular movement mechanism inside a single network of polyacrylamide(PAM)that accelerates the kinetics of hydrogenbonding interaction,and thereby endows the hydrogel with high toughness and rapid shape and mechanical recoverability.The resultant PAM@Tre hydrogel is capable of full shape recovery after 10,000 loading/unloading cycles at a strain of 500%.Even after being stretched at a strain of 2500%,it can recover to its original shape within 10 seconds.Moreover,the molecular movement of trehalose also endows the PAM@Tre hydrogel with fracture energy and toughness as high as~9000 J m^(-2) and~1600 kJ m^(-3),respec-tively,leading to strong resistance to both static and dynamic piercing.The PAM@Tre hydrogel is thus believed to have enormous potentials in protection devices,bionic skin,soft actuator,and stretchable electronics. | Xiaowen Huang Jimin Fu Huiyan Tan Yan Miu Mengda Xu Qiuhua Zhao Yujie Xie Shengtong Sun Haimin Yao Lidong Zhang | 2022 | International Journal of Smart and Nano Materials2022，13，4： | 0 |
| 19 | Metabolic reprogramming in cancer: the bridge that connects intracellular stresses and cancer behaviors显示文摘Cancer heterogeneity and cancer hallmarks are two characteristics o￡most likely,all cancers.The former refers to cancer genomes having diverse changes with little in common at the individual alteration level across different cancer types and different cells in the same tumor[1];and the latter denotes that all cancers share some complex abnormal behaviors,such as sustained cell proliferation,angiogenesis and metastasis[2]. | Yi Zhou Huiyan Sun Ying Xu | 2020 | National Science Review2020，7，8： | 0 |
| 20 | DNA methylation markers in the diagnosis and prognosis of common leukemias显示文摘The ability to identify a specific type of leukemia using minimally invasive biopsies holds great promise to improve the diagnosis,treatment selection,and prognosis prediction of patients.Using genome-wide methylation profiling and machine learning methods,we investigated the utility of CpG methylation status to differentiate blood from patients with acute lymphocytic leukemia(ALL)or acute myelogenous leukemia(AML)from normal blood.We established a CpG methylation panel that can distinguish ALL and AML blood from normal blood as well as ALL blood from AML blood with high sensitivity and specificity.We then developed a methylation-based survival classifier with 23 CpGs for ALL and 20 CpGs for AML that could successfully divide patients into high-risk and low-risk groups,with significant differences in clinical outcome in each leukemia type.Together,these findings demonstrate that methylation profiles can be highly sensitive and specific in the accurate diagnosis of ALL and AML,with implications for the prediction of prognosis and treatment selection. | Hua Jiang Zhiying Ou Yingyi He Meixing Yu Shaoqing Wu Gen Li Jie Zhu Ru Zhang Jiayi Wang Lianghong Zheng Xiaohong Zhang Wenge Hao Liya He Xiaoqiong Gu Qingli Quan Edward Zhang Huiyan Luo Wei Wei Zhihuan Li Guangxi Zang Charlotte Zhang Tina Poon Daniel Zhang Ian Ziyar Run-ze Zhang Oulan Li Linhai Cheng Taylor Shimizu Xinping Cui Jian-kang Zhu Xin Sun Kang Zhang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
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