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| 1 | HCV replication in PBMC and its influence on interferon therapy显示文摘AIM: To study hepatic virus C (HCV) RNA and HCV proteinexpression in peripheral blood mononuclear cells (PBMCs)of patients with HCV infection, and explore the relationshipbetween the HCV RNA in the PBMCs and response tointerferon (IFN) therapy.METHODS: Type-specific primers were designed and RT-nested PCR was used to detect the plus- and minus- strandsof HCV RNA in PBMCs of 54 patients with HCV infection;Indirect immunofluorescence assay was applied to identifyHCVNS5 protein expression in PBMCs; 6 month-, 3 MU-IFNregiment was administrated to observe the responses toIFN in 35 chronic hepatitis C patients with different HCVRNA status in PBMCs.RESULTS: HCV plus strand RNA was found in 10 of 19(52.6 %) acute hepatitis C patients and 22 of 35 (62.9 %)chronic hepatitis C patients. HCV minus strand RNA wasdetected in 14 of 35 (40.0 %) chronic hepatitis C patients,but only one patient (5.3 %) with acute HCV infection wasfound to be minus HCV RNA positive. Though no HCV NS5protein expression was found in the examined 10 cases ofacute HCV infection, it was positive in 17 of 20 (85.0 %)chronic hepatitis C patients by indirect immunofluoresenceassay. There are significant differences of positive rate of theminus-strand and HCVNS5 protein between acute and chronichepatitis C groups(u=2.07, P<0.05and u=4.43, P<0.01respectively). The patients with minus-strand HCV RNAshowed a significantly lower 6-month sustained response (SR-6) to IFN compared to those without minus-strand HCVRNAin PBMCs (biologically 14.3 % vs 42.8 %, X2=4.12, P<0.05and virologically 7.1% vs23.9 %, X2=4.24, P<0.05).CONCLUSION: HCV is capable of infecting and replicatingin PBMCs, and HCVNS5 protein was expressed in PBMCs.The patients with minus strand HCV RNA in PBMCs showeda significantly lower 6-month sustained response to IFN,suggesting that minus-strand HCV RNA in PBMCs may beone of the factors influencing response to IFN therapy. | Guo-Zhong Gong Li-Ying Lai Yong-Fang Jiang Yan He Xian-Shi Su Center for Liver Diseases, Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China | 2003 | World Journal of Gastroenterology2003，9，2： | 14 |
| 2 | Dynamic scheduling model of computing resource based on MAS cooperation mechanism显示文摘Allocation of grid resources aims at improving resource utility and grid application performance. Currently, the algorithms proposed for this purpose do not fit well the autonomic, dynamic, distributive and heterogeneous features of the grid environment. According to MAS (multi-agent system) cooperation mechanism and market bidding game rules, a model of allocating allocation of grid resources based on market economy is introduced to reveal the relationship between supply and demand. This model can make good use of the studying and negotiating ability of consumers’ agent and takes full consideration of the consumer’s behavior, thus rendering the application and allocation of resource of the consumers rational and valid. In the meantime, the utility function of consumer is given; the existence and the uniqueness of Nash equilibrium point in the resource allocation game and the Nash equilibrium solution are discussed. A dynamic game algorithm of allocating grid resources is designed. Experimental results demonstrate that this algorithm diminishes effectively the unnecessary latency, improves significantly the smoothness of response time, the ratio of throughput and resource utility, thus rendering the supply and demand of the whole grid resource reasonable and the overall grid load balanceable. | JIANG WeiJin1,2, ZHANG LianMei3 & WANG Pu4 1 School of Computer and Electronic Engineering, Hunan University of Commerce, Changsha 410205, China 2 School of Information Engineering, Xiangtan University, Xiangtan 411000, China 3 Electrical Engineering College, Wuhan University, Wuhan 430072, China 4 School of Commerce, Central South University, Changsha 410083, China | 2009 | Science in China(Series F)2009，52，8： | 11 |
| 3 | Hypoxia Induces Transforming Growth Factor-β1 Gene Expression in the Pulmonary Artery of Rats via Hypoxia-inducible Factor-1α显示文摘现在的学习被承担调查组织缺氧的动态表示可诱导的 factor-1a (HTF-1a ) 和在老鼠的 hypoxia-inducedpulmonary 高血压的转变生长 factor-beta1 (TGF-beta1 ) 。意味着在组织缺氧的 7 d 以后显著地增加的肺的动脉的压力(mPAP ) ,这被发现。肺的动脉改变索引和恰好室的肥大在 hypoxia.HIF-1 高山的 14 d 以后变得明显哈染色的 mRNA 在控制,为 3 d 的组织缺氧和为 7 d 的组织缺氧是不太积极的,但是开始在组织缺氧的 14 d 以后显著地提高了,然后仍然是的马厩。在控制的 HIF-1alpha 蛋白质的表示是不太积极的,但是在肺的动脉的大桶集成通信适配器是起来调整的在肺的动脉的墙中的所有 hypoxic rats.TGF-beta1 mRNA 表达式的 intima 在组织缺氧的 14 d 以后显著地被增加,但是没在组织缺氧的 3 或 7 d 以后显示出明显的变化。在肺的大桶集成通信适配器外膜和大桶集成通信适配器媒介, TGF-beta1 蛋白质染色在控制老鼠是不太积极的,但是显著地在组织缺氧的 3 d 以后被提高,到达它在组织缺氧的 7 d 以后的山峰,然后在组织缺氧的 14 和 21 d 以后变弱。西方的弄污显示出层次在组织缺氧的 7 d 以后显著地增加了然后在高 level.TGF-beta1 蛋白质水平留下了的那 HIF-1alpha 蛋白质,到达它是显著地在 3 以后提高了组织缺氧的 d 在组织缺氧的 7 d 以后说,然后在组织缺氧的 14 和 21 d 以后减少。线性关联分析显示出那 HIF-1alpha mRNA , TGF-beta1 mRNA , TGF-beta1 蛋白质断然与 mPAP ,容器 morphometry 和权利被相关室的肥大 index.TGF-beta1 蛋白质( tunicaadventitia )否定地一起与 HIF-1alpha mRNA.Taken 被相关,我们的结果建议在在组织缺氧以后的 HIF-1alpha 和 TGF-beta1 表示的变化起一个重要作用老鼠的 导致inhypoxia 的肺的高血压。 | Yongliang JIANG Aiguo DAI Qifang LI and Ruicheng HU Depoptment of Respiratory Medicine,Hunan Institute of Gerontology,Hunan Province Geriatric Hospital,Changsha 410001,China | 2007 | Acta Biochimica et Biophysica Sinica2007，39，1： | 10 |
| 4 | Treatment of rotaviral gastroenteritis with Qiwei Baizhu powder显示文摘AIM To observe the effects of Qiwei Baizhu Powder ( QWBZP) on rotaviral gastroenteritis in children and in animal models.``METHODS Enrolled patients were divided into two groups, and one group was treated with oral rehydration solution(ORS) and the other treated with oral liquid of QWBZP. Neonate mice were orally infected with 50 μLrotavirus suspension (4 × l0s PFU/mL) and treated with ORS or oral liquid of QWBZP, respectively.``RESULTS Eighty-three cases of rotaviral gastroenteritis treated with QWBZP revealed a better efficacy than that treated with ORS (x2 - 10.8T, P<0.05). The contents of sodium and glucose as well as number of patients with positive human rotavirus antigen in stool in QWBZP group were all less than that in ORS group. In animal models,QWBZP was found effective in treating rotavirus gastroenteritis in neonate NIH mice, as compared with control groups. In QWBZP group, the mortality of infected mice was decreased by 73.3%, the body weight of infected mice was increased, the contents of sodium and glucose as well as number of mice with positive rotavirus antigen in feces were significantly reduced, and the pathological changes such as damage of small intestinal mucosa and villi were also obviously alleviated.``CONCLUSION QWBZP has effects on improving the absorptive function of small intestine, shortening the duration of diarrhea and rotavirus shedding from stool and alleviating the pathological changes of small intestine induced by rotavirus. | Shuang-Teng He~1 Fei-Zhou He~2 Can-Rong Wu~3 Shun-Xiang Li~2 Wei-Xin Liu~4 Yong-Fang Yang~2 Shi-Sheng Jiang~2 Gang He~1 1 Institute of Combined Traditional Chinese and Western Medicine,Xiangya Hospital,Hunan Medical University,Changsha,410008,China2 Hunan Province Academy of Traditional Chinese Medicine,Changsha 410006,China3 Department of Microbiology,Hunan College of Traditional Chinese Medicine,Changsha 410007,China4 Department of Pediatrics,The Second Hospital of Shuangfeng County,Hunan Province,411700,China | 2001 | World Journal of Gastroenterology2001，7，5： | 6 |
| 5 | Vitrectomy for vitreous amyloidosis显示文摘AIM: To study the clinical features of vitreous amyloidosis and the effect of vitrectomy for it.METHODS: We treated 6 eyes (4 Patients) with vitreous amyloidosis from 2008 to 2009,and followed up for 18-30 months after vitrectomy.RESULTS: The visual acuity ranged from counting fingers to 3/50 before surgery and 15/50-40/50 after vitrectomy.No severe complication was observed.CONCLUSION: Vitrectomy is an effective and safe treatment for eyes with vitreous amyloidosis.A long period of follow-up after surgery should be performed. | Jiang You Department of Ophthalmology,the Second Xiangya Hospital of Central South University,Changsha 410011,Hunan Province,China | 2011 | International Journal of Ophthalmology(English edition)2011，4，3： | 5 |
| 6 | Homogeneous label-free fluorescent assay of small molecule-protein interactions using protein binding-inhibited transcription nanomachine显示文摘Quantitative analysis of interactions between small molecules and proteins is a central challenge in chemical genetics, molecular diagnostics and drug developments. Here, we developed a RNA transcription nanomachine by assembling T7 RNA polymerase on a small molecule-labeled DNA heteroduplex. The nanomachine, of which the RNA transcription activity can be quantitatively inhibited by protein binding, showed a great potential for small molecule-protein interaction assay. This finding enabled us to develop a novel homogeneous label-free strategy for assays of interactions between small molecules and their protein receptors. Three small molecule compounds and their protein receptors have been used to demonstrate the developed strategy. The results revealed that the protein-small molecule interaction assay strategy shows dynamic responses in the concentration range from 0.5 to 64 nM with a detection limit of 0.2 nM. Due to its label-free, homogeneous, and fluorescence-based detection format, besides its desirable sensitivity this technique could be greatly robust, cost-efficient and readily automated, implying that the developed small molecule-protein interaction assay strategy might create a new methodology for developing intrinsically robust, sensitive and selective platforms for homogeneous protein detection. | ZHOU DianMing, WU YiDan, LIU Pei, BAI HaoTian, TANG LiJuan, YU RuQin & JIANG JianHui State Key Laboratory of Chemo/Bio-Sensing and Chemometrics College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China | 2011 | Science China Chemistry2011，54，8： | 4 |
| 7 | Aspects of recent developments in analytical chemometrics显示文摘Some aspects of recent developments in analytical chemometrics are discussed, in par- ticular the developments viewed from the angle of the research efforts undertaken in authors’ labora- tories. The topics concerned include resolution of high-order chemical data, morphological theory and methodology for chemical signal processing, multivariate calibration and chemical pattern recognition for solving complex chemical problems, and resolution of two-way chemical data from hyphenated chromatographic instruments. | LIANG Yizeng1,2, WU Hailong1, SHEN Guoli1, JIANG Jianhui1, LIANG Sheng2 & YU Ruqin1 1. State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China 2. Research Center of Modernization of Traditional Chinese Medicines, Central South University, Changsha 410081, China | 2006 | Science China Chemistry2006，49，3： | 3 |
| 8 | Utilization of nuclear magnetic resonance (NMR) in the determination of water status on rice seeds | JIANG Xiaocheng, Dept of Biology, Hunan Normal Univ. Changsha 410081 YANG Xiaoquan. Dept of Food Sci and Tech, Southern China Univ of Tech, Guangzhou 510610 FU Jiarui, Dept of Biol, Zhongshan Univ, Guangzhou 510275, China | 1997 | Chinese Rice Research Newsletter1997，5，1： | 1 |
| 9 | POSITIVE SOLUTIONS OF HIGHER DIMENSIONAL DISCRETE BOUNDARY VALUE PROBLEM显示文摘By means of the critical point theory, we prove the existence of positive solutions for a higher dimensional discrete boundary value problem. Our results generalize one of Agarwal in [2]. | Jiang Liqun Zhou Zhan ( Dept. of Math, and Computer Science, Jishou University, Jishou 416000 Dept. of Applied Math., Hunan University, Changsha 410082 Dept. of Applied Math., Guangzhou University, Guangzhou 510006) | 2006 | Annals of Differential Equations2006，22，3： | 1 |
| 10 | Changes of Plasma tPA and PAI Activities in Patients with Diabetic Retinopathy显示文摘Purpose:To investigate the relationship between the diabetic retinopathy (DR) and the activity of plasma tissue plasminogen activator (tPA) and plasminogen activator inhibitor (PAI).Methods :tPA and PAI activities were measured by chromatogenous substrate assay in plasma samples obtained from patients with and without diabetic retinopathy (n = 42). Retinopathy was determined by stereoscopic color fundus photographs graded according to a modification of Chinese National Fundus Disease Academic Meeting. And 21 sex-age matched normal people were as controls. This study was in a masked fashion.Results:①tPA activity was lower and PAI activity was higher in all of diabetic patients than those in controls (P<0. 001); ②tPA activity was lower and PAI activity was higher in proliferative DR (PDR) subgroup than those in non-DR (NDR) and background-DR (BDR) subgroups (P<0.01,respectively); ③there was no significant difference between BDR and NDR subgroups (P>0. 05); and ④the results also suggested that the | Du Zhenya, Jiang Deyong, Tan Jiaquan, Nie Aiguang, Tang ChaozhenDepartment of Ophthalmology, First Affiliated Hospital, Hunan Medical University Changsha 410008, ChinaDepartment of Ophthalmology, 2nd Affiliated Hospital, Hunan Medical University Changsha 410000,China | 1997 | 眼科学报1997，13，1： | 1 |
| 11 | Multi-componential metal intercalated graphite hybrids synthesized by co-intercalation polymerization towards highefficient microwave absorptions显示文摘Magnetic expanded graphite(EG)hybrids were synthesized by co-intercalation polymerization of aniline together with transition metal ions.Experimental results show that metal ions(Fe,Co,Ni,Cu)and even their mixtures can co-intercalate into graphite interlayers with flexibly controllable ratios and contents.Among these co-intercalation compounds,Fe/Ni-intercalated graphite with a predesigned mole ratio of 1:3 transforms into NiFe_(2)O_(4)/FeNi_(3)@EG during the annealing process.The synthesized magnetic EG hybrids present multiband microwave absorption in C and X bands due to improved impedance match as well as significantly enhanced interfacial polarization relaxation induced by multi-componential metals.The reflection values of−39.1 dB at 6.95 GHz and−25.7 dB at 9.4 GHz are achieved with an ultra-low loading of 5 wt.%.This work provides a flexible approach for tuning the components and structures of magnetic EG hybrids,which may contribute to the development of microwave absorption materials with superior performances. | Junhua Su Qinbo Ma Longkun Que Hunan Jiang Xiaoling Xu Yong Wang Yifan Guo Zuowan Zhou | 2023 | Nano Research2023，16，5： | 0 |
| 12 | Analysis of a piezoelectric screw dislocation inside an elliptical inhomogeneity with confocal rigid line in piezoelectric material显示文摘This paper deals with the electro-elastic coupling interaction between a piezoelectric screw dislocation which is located inside the elliptical inhomogeneity and an electrically conductive confocal rigid line under remote anti-plane shear stresses and in-plane electrical loads in piezoelectric composite material. The analytical-functions of the complex potentials, stress fields and the image force acting on the piezoelectric screw dislocation are obtained based on the principle of conformal mapping, the method of series expansion, the technical of analytic continuation and the analysis of singularity of complex potentials. The rigid line and the piezoelectric material property combinations upon the image force and the equilibrium position of the dislocation are discussed in detail by the numerical computation. | Chunzhi Jiang,1,2,3, ) Chao Xie,1,2 Youwen Liu,1,2 and Xin Zeng1,2 1)State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body, Hunan University, Changsha 410082, China 2)College of Mechanical and Vehicle Engineering, Hunan University, Changsha 410082, China 3)Department of Physics and Electronic Information Engineering, Xiangnan University, Chenzhou 423000, China | 2011 | Theoretical & Applied Mechanics Letters2011，1，6： | 0 |
| 13 | An Aggregation Composition Compensation Method Based on Paired Net显示文摘With regard to the failure and cancellation of business logic of web services composition(WSC),this paper propose a novel web services transaction compensation mechanism based on paired net which can dynamically establish agile compensation-triggered process(CSCP-Nets),and satisfy prospective compensation requirements.The related execution semantics of five usual composition compensation patterns based on paired net are analyzed in the situations of successful execution,failure compensation and failure recovery.Paired net based application of trip reservation process(TRP) shows that it is feasible. | Xiao-Yong Mei 1,2 Yi-Yan Fan 2 Chang-Qin Huang 3 Ai-Jun Jiang 1 Shi-Xian Li 1 1 School of Information Science and Technology,Sun Yat-sen University,Guangzhou 510006,China 2 School of Computer Science and Technology,Hunan University of Arts and Science,Changde 415000,China 3 Department of Electrical Engineering and Computer Science,University of California,Irvine,CA,92697,USA | 2012 | International Journal of Automation and computing2012，9，5： | 0 |
| 14 | User Behavior Path Analysis Based on Sales Data显示文摘With the rapid development of science and technology and the increasing popularity of the Internet,the number of network users is gradually expanding,and the behavior of network users is becoming more and more complex.Users’actual demand for resources on the network application platform is closely related to their historical behavior records.Therefore,it is very important to analyze the user behavior path conversion rate.Therefore,this paper analyses and studies user behavior path based on sales data.Through analyzing the user quality of the website as well as the user’s repurchase rate,repurchase rate and retention rate in the website,we can get some user habits and use the data to guide the website optimization. | Wangdong Jiang Dongling Zhang Yapeng Peng Guang Sun Ying Cao Jing Li Hunan | 2020 | Journal of New Media2020，2，2： | 0 |
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