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| 1 | Positive correlation between PPARγ/PGC-1α and γ-GCS in lungs of rats and patients with chronic obstructive pulmonary disease显示文摘氧化应力是长期的妨碍的肺的疾病(COPD ) 的主要致病之一。-Glutamylcysteine 合成酶(-GCS) 是在 COPD 的首要的抗氧化剂酶之一。Peroxisome 激活 proliferator 的 receptor-gamma (PPAR ) 是一个激活 ligand 的抄写因素,它被象 rosiglitazone (RGZ ) 那样的特定的 ligands 激活,施加多重生物效果。PPAR coactivator-1 (PGC-1 ) 是 PPAR 激活剂,它由 PPAR ligands 的正式就职绑在 PPAR,共同激活 PPAR 目标基因。成长证据建议了 PPAR/PGC-1 能调整多重抗氧化剂基因。然而, -GCS 上的 PPAR/PGC-1 的效果在 COPD 的发展期间仍然保持不清楚。这里,我们在 + lipopolysaccharide (LPS ) 和 CS +LPS + RGZ,以及病人的肺受不了的香烟烟(CS ) 对待的老鼠的肺测量了 PPAR, PGC-1 和 -GCS,-GCS 活动和反应的氧种类(ROS ) 内容的表示层次 COPD。与从 CS +对待 LPS 的老鼠的肺相比,对待 RGZ 的老鼠的肺表明了 -GCS 活动的显著地更低的 ROS 内容,和显著增加和 PPAR, PGC-1,和 -GCS 的表示层次的增加。与控制相比,而且, PPAR, PGC-1,和 -GCS 的表达式层次显著地在温和 COPD 病人的肺增加了,并且日益增多地与中等、严重的 COPD 在病人的肺减少了。-GCS 蛋白质断然与 FEV1% 被相关。PPAR 和 PGC-1 蛋白质断然与 -GCS 活动和 mRNA 水平被相关。在结论, -GCS 在 COPD 的早阶段显示出补偿 upregulation,它日益增多地与增加 COPD 严厉患心脏代偿失调。PPAR/PGC-1 小径的激活可以由 upregulating -GCS 免于 COPD 前进并且减轻氧化应力。 | Jie Li Aiguo Dai Ruicheng Hu Liming Zhu Shuangxiang Tan | 2010 | Acta Biochimica et Biophysica Sinica2010，42，9： | 13 |
| 2 | Hypoxia Induces Transforming Growth Factor-β1 Gene Expression in the Pulmonary Artery of Rats via Hypoxia-inducible Factor-1α显示文摘现在的学习被承担调查组织缺氧的动态表示可诱导的 factor-1a (HTF-1a ) 和在老鼠的 hypoxia-inducedpulmonary 高血压的转变生长 factor-beta1 (TGF-beta1 ) 。意味着在组织缺氧的 7 d 以后显著地增加的肺的动脉的压力(mPAP ) ,这被发现。肺的动脉改变索引和恰好室的肥大在 hypoxia.HIF-1 高山的 14 d 以后变得明显哈染色的 mRNA 在控制,为 3 d 的组织缺氧和为 7 d 的组织缺氧是不太积极的,但是开始在组织缺氧的 14 d 以后显著地提高了,然后仍然是的马厩。在控制的 HIF-1alpha 蛋白质的表示是不太积极的,但是在肺的动脉的大桶集成通信适配器是起来调整的在肺的动脉的墙中的所有 hypoxic rats.TGF-beta1 mRNA 表达式的 intima 在组织缺氧的 14 d 以后显著地被增加,但是没在组织缺氧的 3 或 7 d 以后显示出明显的变化。在肺的大桶集成通信适配器外膜和大桶集成通信适配器媒介, TGF-beta1 蛋白质染色在控制老鼠是不太积极的,但是显著地在组织缺氧的 3 d 以后被提高,到达它在组织缺氧的 7 d 以后的山峰,然后在组织缺氧的 14 和 21 d 以后变弱。西方的弄污显示出层次在组织缺氧的 7 d 以后显著地增加了然后在高 level.TGF-beta1 蛋白质水平留下了的那 HIF-1alpha 蛋白质,到达它是显著地在 3 以后提高了组织缺氧的 d 在组织缺氧的 7 d 以后说,然后在组织缺氧的 14 和 21 d 以后减少。线性关联分析显示出那 HIF-1alpha mRNA , TGF-beta1 mRNA , TGF-beta1 蛋白质断然与 mPAP ,容器 morphometry 和权利被相关室的肥大 index.TGF-beta1 蛋白质( tunicaadventitia )否定地一起与 HIF-1alpha mRNA.Taken 被相关,我们的结果建议在在组织缺氧以后的 HIF-1alpha 和 TGF-beta1 表示的变化起一个重要作用老鼠的 导致inhypoxia 的肺的高血压。 | Yongliang JIANG Aiguo DAI Qifang LI and Ruicheng HU Depoptment of Respiratory Medicine,Hunan Institute of Gerontology,Hunan Province Geriatric Hospital,Changsha 410001,China | 2007 | Acta Biochimica et Biophysica Sinica2007，39，1： | 10 |
| 3 | Climate Changes in the 21st Century over the Asia-Pacific Region Simulated by the NCAR CSM and PCM显示文摘The Climate System Model (CSM) and the Parallel Climate Model (PCM), two coupled global climate models without flux adjustments recently developed at NCAR, were used to simulate the 20th century climate using historical greenhouse gas and sulfate aerosol forcing. These simulations were extended through the 21st century under two newly developed scenarios, a business-as-usual case (BAU, CO2≈710 ppmv in 2100) and a CO2 stabilization case (STA550, CO2≈540 ppmv in 2100). The simulated changes in temperature, precipitation, and soil moisture over the Asia-Pacific region (10°-60°N, 55°-155°) are analyzed, with a focus on the East Asian summer monsoon rainfall and climate changes over the upper reaches of the Yangtze River. Under the BAU scenario, both the models produce surface warming of about 3-5℃ in winter and 2-3℃ in summer over most Asia. Under the STA550 scenario, the warming is reduced by 0.5-1.0℃ in winter and by 0.5℃ in summer. The warming is fairly uniform at the low latitudes and does not induce significant changes in the zonal mean Hadley circulation over the Asia-Pacific do- main While the regional precipitation changes from single CSM integrations are noisy, the PCM ensemble mean precipitation shows 10%-30% increases north of ~ 30°N and~10% decreases south of ~ 30°N over the Asia-Pacific region in winter and 10%-20% increases in summer precipitation over most of the region. Soil moisture changes are small over most Asia The CSM single simulation suggests a 30% increase in river runoff into the Three Gorges Dam, but the PCM ensemble simulations show small changes in the | Aiguo Dai, G.A. Meehl, W.M. Washington, and T.M.L. Wigley National Center for Atmospheric Research P.O. Box 3000, Boulder, CO 80307 ) Email: adai@ ucar. edu The National Center for Atmospheric Research is sponsored by the U S National Science Foundation. | 2001 | Advances in Atmospheric Sciences2001，18，5： | 9 |
| 4 | Expression and role of factor inhibiting hypoxia-inducible factor-1 in pulmonary arteries of rat with hypoxia-induced hypertension显示文摘组织缺氧可诱导的 factor-1α 子单元(HIF-1α) 由它是的 transactivating 在导致组织缺氧的肺的高血压(HPH ) 的发展期间起一个枢轴的作用目标基因。作为一个氧敏感的衰减器,因素禁止 HIF-1 (FIH ) 氢氧根 ates 在在 normoxia 和中等组织缺氧下面的 HIF-1α 的 C 终端 transactivation 领域以内的保存天门冬素残余。FIH 蛋白质低在 HPH 遗体的开发期间响应组织缺氧,而是它的动态表达式和角色调整了不清楚。在这研究,一个 HPH 老鼠模型被建立。吝啬的肺的动脉的压力在组织缺氧的 7 d 以后显著地增加了。改变索引的肺的动脉在组织缺氧的 7 d 以后变得明显,当恰好室的肥大索引在组织缺氧的 14 d 以后变得重要时。送信人 RNA (mRNA ) 和 HIF-1α 和脉管的 endothelial 生长因素(VEGF ) 的蛋白质表示, HIF-1α 的描绘得好的目标基因,显著地起来在肺的动脉在暴露以后调整了到组织缺氧。在肺纸巾的 FIH 蛋白质在组织缺氧的 7 d 以后衰退了并且继续通过组织缺氧的持续时间衰退。FIH mRNA 在暴露以后有很少变化到组织缺氧与相比在到 normoxia 的暴露以后。在 hypoxic 老鼠, FIH 蛋白质与 VEGF mRNA 和 VEGF 蛋白质显示出重要否定关联。FIH 蛋白质否定地与吝啬的肺的动脉的压力,肺的动脉改变索引和恰好室的肥大索引被相关。总起来说,我们的结果建议在暴露节制组织缺氧的老鼠的肺的动脉,在 FIH 蛋白质的时间依赖者减少可以由提高象 VEGF 那样的 HIF-1α 目标基因的 transactivation 贡献老鼠 HPH 的发展。 | Daiyan Fu Aiguo Dai Ruicheng Hu Yunrong Chen Liming Zhu | 2008 | Acta Biochimica et Biophysica Sinica2008，40，10： | 9 |
| 5 | Low-temperature activation of methane over rare earth metals promoted Zn/HZSM-5 zeolite catalysts in the presence of ethylene显示文摘At low temperature of 723 K, methane can be easily activated in the presence of ethylene in the feed, and converted to higher hydrocarbons (C2–C4) and aromatics (C6–C10), through its reaction over rare metals modified Zn/HZSM-5 zeolite catalysts without undesirable carbon oxides formation. Methane can get 37.3% conversion over the above catalysts under low temperature, and the catalysts show a longer lifetime than usual metal supported HZSM-5 zeolite catalysts without adding any rare earth metals. The effects of methane activation over various rare earth metal promoted Zn/HZSM-5 catalysts on the products and influences of several reaction conditions such as temperature, catalyst lifetime and molar ratio of CH4/C2H4 have been discussed. | Hengqiang Zhang Aiguo Kong Yongjie Ding Chengyong Dai Yongkui Shan | 2011 | Journal of Natural Gas Chemistry2011，20，3： | 4 |
| 6 | Establishment of the South Asian High over the Indo-China Peninsula During Late Spring to Summer显示文摘The establishment of the upper-level South Asian high(SAH) over the Indo-China Peninsula(ICP) during late boreal spring and its possible causes are investigated using long-term NCEP–NCAR and ERA-40 reanalysis and satellite-observed OLR data. Results show that, from early March to mid-April, deep convection stays south of ~6?N over the northern Sumatran islands. As the maximum solar radiation moves over the latitudes of the ICP(10?–20?N) in late April, the air over the ICP becomes unstable. It ascends over the ICP and descends over the adjacent waters to the east and west. This triggers deep convection over the ICP that induces large latent heating and strong updrafts and upper-level divergence, leading to the formation of an upper-level anticyclonic circulation and the SAH over the ICP. During early to mid-May, deep convection over the ICP intensifies and extends northwards to the adjacent waters. Strong latent heating from deep convection enhances and maintains the strong updrafts and upper-level divergence, and the SAH is fully established by mid-May. Thus, the seasonal maximum solar heating and the land–sea contrast around the ICP provide the basic conditions for deep convection to occur preferentially over the ICP, which leads to the formation of the SAH over the ICP from late April to mid-May. Simulations using Reg CM4 also indicate that the diabatic heating over the ICP is conducive to the generation and development of upperlevel anticyclonic circulation, which leads to an earlier establishment of the SAH. | Lijuan WANG Aiguo DAI Shuaihong GUO Jing GE | 2017 | Advances in Atmospheric Sciences2017，34，2： | 3 |
| 7 | Removal of copper(II) ions by a biosorbent— Cinnamomum camphora leaves powder显示文摘 | Hao Chen Guoliang Dai Jie Zhao Aiguo Zhong Junyong Wu Hua Yan | 2009 | Journal of Hazardous Materials2009，，1： | 2 |
| 8 | Responses of East Asian summer monsoon to historical SST and atmospheric forcing during 1950–2000显示文摘 | Hongmei Li Aiguo Dai Tianjun Zhou Jian Lu | | Climate Dynamics0，，： | 2 |
| 9 | Removal of copper(II) ions by a biosorbent— Cinnamomum camphora leaves powder显示文摘 | Hao Chen Guoliang Dai Jie Zhao Aiguo Zhong Junyong Wu Hua Yan | 2009 | Journal of Hazardous Materials2009，，1： | 1 |
| 10 | A global dataset of Palmer drought severity index for 1870-2002: relationship with soil moisture and effects of surface warming 显示文摘 | Dai Aiguo Trenberth K T Qian Taotao | 2004 | Journal of Hydrometeorology2004，5，： | 1 |
| 11 | Effects of rare earth compounds on growth and apoptosis of leukemic cell lines显示文摘 | Yucheng Dai Jian Li Jie Li Li Yu Ge Dai Aiguo Hu Liya Yuan Zhu Wen | 2002 | In Vitro Cellular & Developmental Biology - Animal2002，，7： | 1 |
| 12 | 1870~2002年全球Palmar干旱指数集——PDSI与土壤湿度及地表增温效应的关系显示文摘用历史降水和温度资料得到全球陆地区域(分辨率为2.5°×2.5°)1870~2002年间的月Palmar干旱指数(PDSI)。伊利诺斯州、蒙古及中国与前苏联部分地区有土壤湿度资料,暖季的PDSI与实测土壤湿度(土层厚度为1m)呈显著相关(r=0.5~0.7),夏末和秋季相关最好,而春季由于融雪的影响相关最差。对世界最长河流(其中7条)及几条其他河流进行分析,各流域平均的年PDSI变化与径流相关很好(r=0.6~0.8),表明PDSI可以很好地表征地表土壤湿度状况与径流。对PDSI进行经验正交函数(EOF)分析,揭示了由降水、温度趋势及ENSO引起的年际内变率所产生的线性趋势。全球严重干旱区(PDSI〈-3.0)面积白20世纪70年代以来增加了1倍多,其中80年代初由于ENSO引起的降水减少造成干旱区面积的突增,后来的增加主要归因于地表增温;全球非常湿润区(PDSI〉+3.0)面积80年代减少不明显。白1972年以来,全球极干或极湿地区面积从20%增加到了38%。80年代中期以后地表增温是其主要原因。这些结果为日益增加的干旱风险提供了观测证据,干旱风险的增加是人类活动导致全球变暖的结果。 | AIGUO DAI KEVIB E TAOTAO QIAN 王涓力 | 2006 | 干旱气象2006，24，3： | 1 |
| 13 | Summer Precipitation Frequency, Intensity, and Diurnal Cycle over China: A Comparison of Satellite Data with Rain Gauge Observations显示文摘 | Zhou Tianjun Yu Rucong Chen Haoming Dai Aiguo Pan Yang | 2008 | Journal of Climate2008，，16： | 1 |
| 14 | A global dataset of Palmer Drought Severity index for 1870-2002: relationship with soil moisture and effects of surface warming 显示文摘 | Dai Aiguo Trenberth K E Qian Taotao | 2004 | Journal of Hydrometeorology2004，5，6： | 1 |
| 15 | The frequency, intensity, and diurnal cycle of precipitation in surface and satellite observations over low- and mid-latitudes显示文摘 | Aiguo Dai Xin Lin Kuo-Lin Hsu | 2007 | Climate Dynamics (-)2007，，7： | 1 |
| 16 | A global dataset of Palmer Drought Severity Index for 1870~2002:Relationship with soil moisture and effects of surface warming显示文摘 | Dai Aiguo Trenberth K E Qian T | 2004 | Journal of Hydrometeorol2004，5，6： | 1 |
| 17 | Observed and modelsi mulated diurnal cycles of precipitation over the contiguous U nited States显示文摘 | Dai Aiguo Giorgi F Trenberth K E | 1999 | Journal of Geophysical Research: Atmos pheres1999，104，6： | 1 |
| 18 | Changes in continental freshwater discharge from 1948 to 2004显示文摘 | Dai Aiguo Qian Taotao Trenberth Kevin E | 2009 | Journal of Climate2009，22，10： | 1 |
| 19 | A Near-global, 2-hourly Data Set of Atmospheric Precipitable Water from Ground-based GPS Meas- urements 显示文摘 | Wang Junhong Zhang Liangying Dai Aiguo | 2007 | Journal of Geophysical Research2007，112，11： | 1 |
| 20 | How often does it rain?显示文摘 | Ying Sun Susan Solomon and Dai Aiguo | 2006 | J Climate2006，19，： | 1 |
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